死海盐光浴疗法与窄波紫外线B单一疗法治疗慢性斑块型银屑病的随机对照研究

作     者：Dawe R.S. Yule S. Cameron H. 王琼 

作者机构：Department of Dermatology University of Dundee Ninewells Hospital and Medical School Dundee DD1 9SY United Kingdom 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2005年第1卷第12期

页      面：50-50页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：斑块型银屑病 浴疗法 严重度 复发时间 盐浸 配对设计 研究人群 盐溶液 时间曲线 

摘      要：Background: Dead Sea (DS) salt solution soaks are used in combination with narrowband ultraviolet B (NB- UVB) to treat psoriasis in many centres, particularly in continental Europe. No previously published controlled study has assessed DS salt + NB- UVB balneophototherapy. Objectives: To compareDS salt balneophototherapy with NB- UVB monotherapy for chronic plaque psoriasis. Methods: Sixty patients with chronic plaque psoriasis participated in this paired, controlled study, with pretreatment DS salt soaks randomly allocated to each participant’ s right or left study limb. Psoriasis severity was assessed with a Scaling, Erythema and Induration score by a blinded observer. Assessments were weekly during the therapy course, and thereafter 8- weekly until relapse or for up to 1 year after clearance. Results: The mean area under the psoriasis severity- time curves during treatment was not detectably lower with DS salt balneophototherapy than with NB- UVB monotherapy (P=0.099). The psoriasis severity score fell slightly more from beginning to end of courses with DS salt balneophototherapy than with NB- UVB monotherapy (P=0.019). There was no detectable difference in times to relapse. Conclusions: In this population the addition of pretreatment DS salt soaks to NB- UVB did not result in a clinically important improvement in clearance of psoriasis.