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Chinese Science Bulletin 2014年第25期59卷 3127-3133页

作者： Jinwon Lim Hyo-Jung Lee Bonglee Kim jeong-Un Choi Yoeok Shin eun Jung Sohn Sung-Hoon Kim Cancer Preventive Material Development Research Center College of Oriental Medicine Kyung Hee University

Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains ***,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in *** significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 ***,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 *** addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in ***,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated ***,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.

关键词：前列腺素E2 炎性细胞因子和镇痛抗炎单核细胞趋化蛋白-1 鸡尾酒 IFN-γ

Sojucktang induces apoptosis via loss of mitochondrial membrane potential and caspase-3 activation in KLE human endometrial cancer cells

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Chinese Science Bulletin 2009年第23期54卷 4387-4392页

作者： OH Yeon-Suk KWON Hee-Young jeong Soo-Jin PARK Ki-Young KIM Sun-Young LEE Hyo-Jung LEE Hyo-jeong LEE eun-Ok AHN Kwang Seok KIM Sung-Hoon Cancer Preventive Material Development Research Center Oriental Medical CollegeKyunghee University College of Medicine Kyunghee University

Sojucktang (SJT) has long been used for the treatment of endometrial diseases in Korea. However, the mechanisms responsible for the SJT-induced apoptosis in endometrial cancer cells remain unclear. In the present study, SJT was demonstrated to show cytotoxic effect and induce apoptotic cell death via mitochondrial regulation in KLE endometrial cancer cells. Linderae Radix, Glycyrrhizae Radix, Zedoariae Rhizoma, Trogopterorum Faeces and Agelicae Gigantis Radix were found to be the potent constituent herbs of SJT to significantly decrease the viability of KLE cells by a tetra zolium salt (XTT) assay. Apoptotic bodies were observed in SJT-treated KLE cells by 4′-6-diamidino-2-phenylindole (DAPI) and TdT-mediated-dUTP nick-end labeling (TUNEL) assay. SJT also increased sub-G1 DNA contents of the cell cycle undergoing apoptosis in a dose-dependent manner. Furthermore, it was observed that SJT activated caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), and decreased mitochondrial membrane potential in a dose-dependent manner. Taken together, this study shows that SJT exerts anti-tumor activity against KLE endometrial cancer cells via mitochondrial dependent apoptosis induction.

关键词：线粒体膜电位 caspase 子宫内膜癌细胞凋亡活化癌细胞诱导细胞毒作用

Increased incidence of chemoport-related thrombosis in patients with colorectal cancer receiving bevacizumab: A single-institutional experience

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Chinese Journal of Cancer Research 2018年第4期30卷 460-467页

作者： Jwa Hoon Kim jeong eun Kim Yong Sang Hong Sun Young Kim Kyu-pyo Kim Ki eun Choi Ji Hoon Shin Tae Won Kim Department of Oncology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

Objective： Chemoport-related thrombosis （CRT） is a serious complication that causes morbidities and interruptsadministration of intravenous cancer therapy. We investigated the incidence and risk of CRT in colorectal cancer（CRC） patients treated with bevacizumab （BEV）.Methods： We retrospectively reviewed 1,534 CRC patients who received chemotherapy with or without BEVusing a chemoport between 2014 and ***： The participants had a median age of 58 （18-85） years, and 60.3% were male. All participants werestratified into three groups： adjuvant chemotherapy （AC）（n=670）, palliative chemotherapy （PC） without BEV（n=356）, and PC with BEV （n=508）. The median follow-up was 20.19 （interquartile range, 14.07-27.19） *** occurred in 3.8% of all patients; incidence of symptomatic and asymptomatic CRT was 2.9% and 0.9%,respectively. CRT occurred more in patients with BEV （5.7%） than in patients without BEV （2.9%, P=0.008）. Thecumulative incidence of CRT in patients administered PC with BEV was significantly higher than that in thoseadministered AC （P=0.011） and there was a trend toward increased CRY in patients administered PC with BEVcompared with those administered PC without BEV （P=0.044）. Multivariate analysis found that BEV treatment wasthe only variable that was significandy associated with CRT （hazard ratio, 2.06; 95% confidence interval, 1.24-3.43;P=0.006）.Conclusions： BEV treatment was significandy associated with increased incidence of CRT in CRC patients.

关键词： Bevacizumab central venous catheters thrombosis colorectal neoplasms

Is the AIM65 score useful in predicting outcomes in peptic ulcer bleeding?

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World Journal of Gastroenterology 2014年第7期20卷 1846-1851页

作者： Sung Hoon Jung Jung Hwan Oh Hye Yeon Lee Joon Won jeong Se eun Go Chan Ran You eun Jung Jeon Sang Wook Choi Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 130-709South Korea

AIM:To evaluate the applicability of AIMS65 scores in predicting outcomes of peptic ulcer ***:This was a retrospective study in a single center between January 2006 and December *** enrolled 522 patients with upper gastrointestinal haemorrhage who visited the emergency *** patients were regarded as those who had rebleeding within 30 d from the first endoscopy as well as those who died within 30 d of visiting the Emergency room.A total of 149 patients with peptic ulcer bleeding were analysed,and the AIMS65 score was used to retrospectively predict the high-risk ***:A total of 149 patients with peptic ulcer bleeding were *** poor outcome group comprised 28 patients[male:23(82.1%)vs female:5(10.7%)]while the good outcome group included 121patients[male:93(76.9%)vs female:28(23.1%)].The mean age in each group was not significantly *** mean serum albumin levels in the poor outcome group were slightly lower than those in the good outcome group(P=0.072).For the prediction of poor outcome,the AIMS65 score had a sensitivity of35.5%(95%CI:27.0-44.8)and a specificity of 82.1%(95%CI:63.1-93.9)at a score of *** AIMS65 score was insufficient for predicting outcomes in peptic ulcer bleeding(area under curve=0.571;95%CI:0.49-0.65).CONCLUSION:The AIMS65 score may therefore not be suitable for predicting clinical outcomes in peptic ulcer *** albumin levels may be a risk factor associated with high mortality in peptic ulcer bleeding.

关键词： Gastrointestinal haemorrhage Peptic ulcer Mortalit

Schizonepeta tenuifolia inhibits collagen stimulated platelet function via suppressing MAPK and Akt signaling

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The Journal of Biomedical Research 2019年第4期33卷 250-257页

作者： Bo-Ra Jeon Muhammad Irfan Minki Kim Seung eun Lee jeong Hoon Lee Man Hee Rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu 41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal ScienceEumseong 27709Republic of Korea.

The prevalence of cardiovascular diseases(CVDs)is increasing at a rapid pace in developed countries,and CVDs are the leading cause of morbidity and *** products and ethnomedicine have been shown to reduce the risk of ***(S.)tenuifolia is a medicinal plant widely used in China,Korea,and Japan and is known to exhibit anti-inflammatory,antioxidant,and immunomodulatory *** hypothesized that given herbal plant exhibit pharmacological activities against CVDs,we specifically explored its effects on platelet *** aggregation was evaluated using standard light transmission *** calcium mobilization was assessed using Fura-2/AM,and granule secretion(ATP release)was measured in a *** binding to integrin a_(Ⅱb)β_3,was assessed using flow *** of mitogen-activated protein kinase(MAPK)signaling molecules and activation of the protein kinase B(Akt)was assessed using Western blot ***,extract potently and significantly inhibited platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin a_(Ⅱb)β_***,all extracts significantly inhibited MAPK and Akt *** extract inhibited platelet aggregation and granule secretion,and attenuated collagen mediated GPVI downstream signaling,indicating the potential therapeutic effects of these plant extracts on the cardiovascular system and platelet *** suggest that *** extract may be a potent candidate to treat platelet-related CVDs and to be used as an antiplatelet and antithrombotic agent.

关键词： S.tenuifolia platelet MAPK Akt natural antithrombotic agent

Duodenal obstruction after successful embolization for duodenal diverticular hemorrhage: A case report

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World Journal of Gastroenterology 2009年第30期15卷 3819-3822页

作者： Yu Jin Kwon Ji Hun Kim Seung Hyoung Kim Bong Soo Kim Heung Up Kim eun Kwang Choi In Ho jeong Department of Surgery Seoul National University College of Medicine28 Yeongeon-dongSeoul 110-744South Korea Department of Surgery Ajou University School of MedicineSan-5WonchondongYeongtongguSuwon 442-749South Korea Department of radiology Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea Department of internal medicine Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea Department of surgery Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea

We present a 69-year-old woman with a duodenal obstruction after successful selective transcatheter arterial embolization (TAE) for a duodenal diverticular hemorrhage. Two weeks after TAE, the patient showed abrupt symptoms of duodenal obstruction. Resolving hematomas after successful selective transcatheter arterial embolization should be thoroughly observed because they might result in duodenal fibrotic encasement featuring inflammatory duodenal wall thickening, duodenal deformity, dysmotility, and fi nally obstruction.

关键词：十二指肠肠梗阻栓塞病例报告出血运动障碍肝动脉纤维化

纳入季节性气候数据的厄尔尼诺-南方涛动预报统一深度学习模型

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Science Bulletin 2021年第13期66卷 1358-1366,M0004页

作者： Yoo-Geun Ham jeong-Hwan Kim eun-Sol Kim Kyung-Yun On Department of Oceanography Chonnam National UniversityGwangju 61186South Korea Kakao Brain Bundang-guSeongnam-siGyeonggi-do 13494South Korea

尽管深度学习实现了厄尔尼诺-南方涛动(ENSO)预报的里程碑式发展,但当前模型还无法模拟基于季节变化的ENSO的多种特征.现有模型大多是基于某一特殊季节,未能考虑不同目标季节以及预测提前期的物理约束,从而会导致预测出的时间序列存在... 详细信息

尽管深度学习实现了厄尔尼诺-南方涛动(ENSO)预报的里程碑式发展,但当前模型还无法模拟基于季节变化的ENSO的多种特征.现有模型大多是基于某一特殊季节,未能考虑不同目标季节以及预测提前期的物理约束,从而会导致预测出的时间序列存在随机波动信号.为了克服以上问题,并考虑ENSO的季节性特征,本文发展了一个全季节的卷积神经网络模型(A_CNN).该模型对于预测北半球春季,也就是预测难度最大的季节的ENSO指数相关系数技巧显著提高.此外,随着预测提前期的增加,该模型的激活图值会出现显著的时间演变特征.A_CNN揭示了随时间推移出现的对ENSO事件有不同影响的各种气候前兆的综合作用,有望成为气候预测有效诊断工具.

关键词： ENSO事件气候预测时间演变特征随机波动气候数据诊断工具季节性特征时间序列

Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression

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Cellular & Molecular Immunology 2016年第6期13卷 862-870页

作者： jeong-Min Lee Young-Saeng Jang Bo-Ra Jin Sun-Jin Kim Hyeon-Jin Kim Bo-eun Kwon Hyun-jeong Ko Sung-il Yoon Geun-Shik Lee Woan-Sub Kim Goo-Young Seo Pyeung-Hyeun Kim Department of Molecular Bioscience School of Biomedical Science Kangwon National University Chuncheon Republic of Korea Laboratory of Microbiology and Immunology College of Pharmacy Kangwon National University Chuncheon Republic of Korea Department of Systems Immunology College of Biomedical Science Kangwon National University Chuncheon 200-701 Republic of Korea College of Veterinary Medicine Kangwon National University Chuncheon Gangwon 200-701 Republic of Korea Department of Animal Life and Environmental Science College of Agriculture and Life Science Hankyong National University Anseong-si 456-749 Republic of Korea

Lactoferrin （LF） and retinoic acid （RA） are enriched in colostrum, milk, and mucosal tissues. We recently showed that LF-induced IgA class switching through binding to betaglycan （transforming growth factor-beta receptor III, TpRIII） and activation of canonical TGF-p signaling. We investigated the combined effect of LF and RA on the overall IgA response. An increase in IgA production by LF was further augmented by RA. This combination effect was also evident in Ig germ-line α （GLa） transcription and GLa promoter activity, indicating that LF in cooperation with RA increased IgA isotype switching. We subsequently found that RA enhanced TβRIII expression and that this increase contributed to LF-stimulated IgA production. In addition to the IgA response, LF and RA in combination also enhanced the expression of the gut-homing molecules C-C chemokine receptor 9 （CCR9） and a4β7 on B cells. Finally, peroral administration of LF and RA enhanced the frequency of CCR9＋ IgA＋ plasma cells in the lamina propria. Taken together, these results suggest that LF in cooperation with RA can contribute to the establishment of gut IgA responses.

关键词： gut homing molecule IgA lactoferrin retinoic acid TGF-β receptor

Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： Young Hyun Shin Chul Min Park Hong Gi Kim Dong-eun Kim Min Suk Choi jeong-ah Kim Byeong-Sun Choi Cheol-Hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(HIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 H)-one that had a potent anti-HIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of HIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 H)-one(Compound 2)exhibited the most potent activity by inhibiting HIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on HIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired HIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： Human immunodeficiency virus type 1(HIV-1) Aristolactam Antiviral activity HIV-1 transcription

Third assessment on impacts of climate change on tropical cyclones in the Typhoon Committee Region-Part Ⅱ:Future projections

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Tropical Cyclone Research and Review 2020年第2期9卷 75-86页

作者： eun jeong Cha Thomas R.Knutson Tsz-Cheung Lee Ming Ying Toshiyuki Nakaegawa National Typhoon Center Korea Meteorological AdministrationJejuRepublic of Korea Geophysical Fluid Dynamics Laboratory/NOAA PrincetonNJUSA Hong Kong Observatory Hong KongChina Shanghai Typhoon Institute China Meteorological AdministrationShanghaiChina Meteorological Research Institute/Japan Meteorological Agency TsukubaJapan

This paper assesses published findings on projections of future tropical cyclone(TC)activity in the ESCAP/WMO Typhoon Committee Region under climate change *** assessment also estimates the projected changes of key TC metrics for a 2℃anthropogenic global warming scenario for the western North Pacific(WNP)following the approach of a WMO Task Team,together with other reported findings for this *** projections of TC genesis/frequency,most models suggest a reduction of TC frequency,but an increase in the proportion of very intense TCs over the WNP in the ***,some individual studies project an increase in WNP TC *** studies agree on a projected increase of WNP TC intensity over the 21 st *** available projections for TC related precipitation in the WNP indicate an increase in TC related precipitation rate in a warmer *** warming may also lead to changes in TC prevailing tracks.A further increase in storm surge risk may result from increases in TC *** most confident aspect of forced anthropogenic change in TC inundation risk derives from the highly confident expectation of further sea level rise,which we expect will exacerbate storm inundation risk in coastal regions,assuming all other factors equal.

关键词： Tropical cyclones Climate change Westerm North Pacifie Typhoon Comitte Projections