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Usefulness of artificial intelligence in gastric neoplasms

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World Journal of Gastroenterology 2021年第24期27卷 3543-3555页

作者： Ji Hyun kim Seung-joo Nam Sung Chul Park Division of Gastroenterology and Hepatology Department of Internal MedicineKangwon National University School of MedicineChuncheon 24289Kangwon DoSouth Korea

Recently,studies in many medical fields have reported that image analysis based on artificial intelligence(AI)can be used to analyze structures or features that are difficult to identify with human *** diagnose early gastric cancer,related efforts such as narrow-band imaging technology are ***,diagnosis is often ***,a diagnostic method based on AI for endoscopic imaging was developed and its effectiveness was confirmed in many *** gastric cancer diagnostic program based on AI showed relatively high diagnostic accuracy and could differentially diagnose non-neoplastic lesions including benign gastric ulcers and *** AI system has also been developed that helps to predict the invasion depth of gastric cancer through endoscopic images and observe the stomach during endoscopy without blind ***,if AI is used in the field of endoscopy,it is expected to aid in the diagnosis of gastric neoplasms and determine the application of endoscopic therapy by predicting the invasion depth.

关键词： Artificial intelligence Convolutional neural network Gastric neoplasm Esophagogastroduodenoscopy Diagnosis Invasion depth

Basic analysis of rock mechanical and thermal properties in South Korea

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Rock Mechanics Bulletin

Rock Mechanics Bulletin 2023年第3期2卷 66-77页

作者： Byung-Gon Chae eui-Seob Park Hyoung-Chan kim Korea Institute of Geoscience and Mineral Resources(KIGAM) Deep Subsurface Storage and Disposal Research Center34132DaejeonSouth Korea Korea Institute of Geoscience and Mineral Resources(KIGAM) Groundwater Environment Research Center34132DaejeonSouth Korea

This study analyzed the mechanical and thermal properties of various rock types found in South *** results showed that both igneous and metamorphic rocks possess higher strength compared to sedimentary *** Young's modulus of rocks is dependent on the extent of weathering they have *** average cohesion of granites was found to be relatively higher compared to other rock types,and their friction angle also exhibited a relatively high value with a considerable *** results of uniaxial compression strength testing with respect to depth revealed that rock strength generally increased with depth,however,there was a large variance in strength distribution in each depth *** on these findings,it can be concluded that South Korea can also secure HLW disposal sites and facilities in terms of rock mechanics by using crystalline rocks,similar to countries such as Sweden and Finland where disposal facilities are being *** the thermal properties of rocks,they are influenced by the distribution of the parent *** thermal conductivity is highly concentrated in the southwest and central regions of South Korea,while the geothermal gradient is high in the northeast,west,and some parts of the southeast *** southeast region of Korea has a high geothermal heat flow,and some central northern regions also exhibit relatively high geothermal heat *** light of these distributional characteristics,it is crucial to continue conducting precise studies on the mechanical and thermal properties of rocks in the future disposal depths of spent nuclear fuel.

关键词： Rock mechanics Thermal properties HLW disposal Crystalline rocks

Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice

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World Journal of Gastroenterology 2015年第28期21卷 8580-8587页

作者： Seong-joon Koh Ji Won kim Byeong Gwan kim Kook Lae Lee joo Sung kim Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

AIM:To investigate the effects of restraint stress on chronic colitis in interleukin(IL)-10 deficient(IL-10^(-/-))***:The first experiment compared the effect of restraint stress on the development of intestinal inflammation in wild-type and IL-10^(-/-) *** wildtype and IL-10^(-/-) mice were physically restrained in a well-ventilated,50 cm3 conical polypropylene tube for2 h per day for three consecutive *** second experiment was performed to assess the effect of restraint stress on exacerbation of colitis induced by piroxicam in IL-10^(-/-) *** IL-10^(-/-) mice were exposed to restraint stress for 2 h per day for 3consecutive days,and then treated with piroxicam for4 d at a dose of 200 ppm administered in the rodent ***:In the first experiment,none of the wildtype mice with or without restraint stress showed clinical and histopathological abnormality in the ***,IL-10^(-/-) mice exposed to restraint stress exhibited histologically significant intestinal inflammation as compared to those without restraint *** the second experiment,restraint stress significantly reduced body weight and increased the severity of intestinal inflammation assessed by histopathologic grading in IL-10^(-/-) *** IL12p40 mRNA expression was strongly increased in mice exposed to restraint ***:This novel animal model could be useful in future study of psychological stress in the pathogenesis of inflammatory bowel disease.

关键词： Stress Colitis Interleukin-10 Inflammatorybowel disease Mouse model

Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice

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World Journal of Gastroenterology 2017年第15期23卷 2705-2715页

作者： Hyoyeon kim Iksung kim Min Cheol Lee Hyun Jung kim Guem San Lee Hyungwoo kim Byung joo kim Division of Longevity and Biofunctional Medicine Healthy Aging Korean Medical Research CenterSchool of Korean MedicinePusan National University Wonkwang University College of Korean Medicine Division of Pharmacology School of Korean MedicinePusan National University

AIM To investigate the effects of Hwangryunhaedok-tang(HHT) on gastrointestinal(GI) motility in *** The effects of a boiling water extract of HHT(HHTE) on GI motility were investigated by calculating percent intestinal transit rates(ITR%) and gastric emptying(GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction(GMD). In addition, the effects of the four components of HHT, that is, Gardeniae Fructus(GF), Scutellariae Radix(SR), Coptidis Rhizoma(CR), and Phellodendri Cortex(PC), on GI motility were also *** In normal ICR mice, ITR% and GE values were significantly and dose-dependently increased by the intragastric administration of HHTE(0.1-1 g/kg). The ITR% values of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose-dependently inhibited by HHTE(0.1-1 g/kg). Additionally, GF, CR, and PC dosedependently increased ITR% and GE values in normal and GMD *** These results suggest that HHT is a novel candidate for the development of a gastroprokinetic agent for the GI tract.

关键词： Hwangryunhaedok-tang Gastrointestinal motility Intestinal transit rate Gastric emptying Gastroprokinetic

Recurrent abducens nerve palsy with optic perineuritis

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International Journal of Ophthalmology(English edition) 2012年第2期5卷 249-250页

作者： joo Yeon kim Seung-Hee Baek Ungsoo Samuel kim Department of Ophthalmology Kim's Eye Hospital Konyang University College of Medicine Seoul Korea

Dear Sir, I am joo Yeon kim, from the department of Ophthalmology of kim’s Eye Hospital in Seoul, Korea. I write to present a case report of recurrent abducens nerve palsy with optic perineuritis Abducens nerve palsy is associated with trauma, viral infection or inoculation, central nervous system tumors, elevated intracranial pressure and idiopathic cause [1]. Optic perineuritis is an uncommon noninfectious inflammation of the optic nerve sheath and perineural fat. Optic perineuritis

关键词： Recurrent abducens nerve palsy with optic perineuritis Figure

Characterization of flexible copper laminates fabricated by Cu electro-plating process

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中国有色金属学会会刊：英文版 2009年第4期19卷 965-969页

作者： Chang-Min LEE Jun-Hyung LIM Soo-Min HWANG eui-Cheol PARK Jong-Hyun SHIM Jin-Hyun PARK Jinho joo Seung-Boo JUNG School of Advanced Materials Science and Engineering Sungkyunkwan University

Flexible copper clad laminates(FCCLs) were fabricated using the electro-plating process and the combined effect of the current density and plating time on their surface morphology,texture,hardness,electrical resistivity and folding behavior was *** achieve Cu layers with similar thicknesses,the current density was varied in the range of 0.2-3 A/dm2 and the plating time was controlled in the range of 0.5-7.5 h to compensate for the variation of the current *** surface morphology,hardness,and folding behavior were characterized by atomic force microscopy,nanoindentation technique and Massachusett Institute of Technology folding endurance test,*** X-ray diffraction patterns indicated that the Cu phase was formed without any secondary phases;however,the preferred orientation changed from(220) to(111) as the current density increased over 1 A/*** addition,it was observed that the root-mean-square and hardness values decreased when the current density increased and the plating time decreased *** electrical resistivity was as low as approximately 21 nΩ·m and the number of cycles without failure in the folding test was over 15 000,which were comparable to those of commercial FCCLs.

关键词：电镀工艺层压板铜层制备表征电流密度原子力显微镜纳米压痕技术

Dopant-Tunable Ultrathin Transparent Conductive Oxides for Efficient Energy Conversion Devices

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Nano-Micro Letters 2021年第12期13卷 437-451页

作者： Dae Yun Kang Bo-Hyun kim Tae Ho Lee Jae Won Shim Sungmin kim Ha-Jun Sung Kee joo Chang Tae Geun kim School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Advanced Materials Engineering Kongju National UniversityCheonan 31080Republic of Korea Department of Physics Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

Ultrathin film-based transparent conductive oxides(TCOs)with a broad work function(WF)tunability are highly demanded for e cient energy conversion ***,reducing the film thickness below 50 nm is limited due to rapidly increasing resistance;furthermore,introducing dopants into TCOs such as indium tin oxide(ITO)to reduce the resistance decreases the transparency due to a trade-o between the two ***,we demonstrate dopant-tunable ultrathin(≤50 nm)TCOs fabricated via electric field-driven metal implantation(m-TCOs;m=Ni,Ag,and Cu)without com-promising their innate electrical and optical *** m-TCOs exhibit a broad WF variation(0.97 eV),high transmittance in the UV to visible range(89–93%at 365 nm),and low sheet resistance(30–60Ωcm-2).Experimental and theoretical analyses show that interstitial metal atoms mainly a ect the change in the WF without substantial losses in optical *** m-ITOs are employed as anode or cathode electrodes for organic light-emitting diodes(LEDs),inorganic UV LEDs,and organic photovoltaics for their universal use,leading to outstanding performances,even without hole injection layer for OLED through the WF-tailored *** results verify the proposed m-TCOs enable e ective carrier transport and light extraction beyond the limits of traditional TCOs.

关键词： Transparent conductive oxide Metal implantation High transparency Low sheet resistance Work function

Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun kim Gyeong Min Park HyunAh kim Hyojin kim Eun-Ji kim Yu Kyeong Hwang eui-Cheol Shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

Rice pollen-specific OsRALF17 and OsRALF19 are essential for pollen tube growth

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Journal of Integrative Plant Biology 2023年第9期65卷 2218-2236页

作者： eui‐Jung kim Ji‐Hyun kim Woo‐Jong Hong Eun Young kim Myung‐Hee kim Su Kyoung Lee Cheol Woo Min Sun Tae kim Soon Ki Park Ki‐Hong Jung Yu‐Jin kim Graduate School of Green Bio‐Science&Crop Biotech Institute Kyung Hee UniversityYongin 17104Republic of Korea Department of Life Science and Environmental Biochemistry Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Department of Smart Farm Science Kyung Hee UniversityYongin 17104Republic of Korea School of Applied Biosciences Kyungpook National UniversityDaegu 41566Republic of Korea Genomics Division Department of Agricultural Bio‐ResourcesNational Institute of Agricultural SciencesRural Development AdministrationJeonju 54874Republic of Korea Department of Plant Bioscience Pusan National UniversityMiryang 50463Republic of Korea Research Center for Plant Plasticity Seoul National UniversitySeoul 08826Republic of Korea

Pollen tube growth is essential for successful double fertilization, which is critical for grain yield in crop plants. Rapid alkalinization factors(RALFs) function as ligands for signal transduction during fertilization. However, functional studies on RALF in monocot plants are ***, we functionally characterized two pollen-specific RALFs in rice(Oryza sativa) using multiple clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-induced loss-of-function mutants,peptide treatment, expression analyses, and tag reporter lines. Among the 41 RALF members in rice, OsRALF17 was specifically expressed at the highest level in pollen and pollen *** applied OsRALF17 or OsRALF19peptide inhibited pollen tube germination and elongation at high concentrations but enhanced tube elongation at low concentrations, indicating growth regulation. Double mutants of OsRALF17 and OsRALF19(ralf17/19) exhibited almost full male sterility with defects in pollen hydration, germination, and tube elongation,which was partially recovered by exogenous treatment with OsRALF17 peptide. This study revealed that two partially functionally redundant OsRALF17 and OsRALF19 bind to Oryza sativa male-gene transfer defective 2(OsMTD2) and transmit reactive oxygen species signals for pollen tube germination and integrity maintenance in rice. Transcriptomic analysis confirmed their common downstream genes, in osmtd2 and ralf17/19. This study provides new insights into the role of RALF, expanding our knowledge of the biological role of RALF in regulating rice fertilization.

关键词： CRISPR-Cas9 CrRLK1L monocot Oryza sativa pollen tube growth rapid alkalinization factor(RALF)