Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice

作     者：Hyoyeon Kim Iksung Kim Min Cheol Lee Hyun Jung Kim Guem San Lee Hyungwoo Kim Byung Joo Kim 

作者机构：Division of Longevity and Biofunctional MedicineHealthy Aging Korean Medical Research CenterSchool of Korean MedicinePusan National University Wonkwang University College of Korean Medicine Division of PharmacologySchool of Korean MedicinePusan National University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第15期

页      面：2705-2715页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Supported by the National Research Foundation of Korea Grant funded by the Korean Government(MSIP) No.2014R1A5A2009936 

主　　题：Hwangryunhaedok-tang 胃肠的活动性 肠的运输率 胃的倒空 Gastroprokinetic 

摘      要：AIM To investigate the effects of Hwangryunhaedok-tang(HHT) on gastrointestinal(GI) motility in mice.METHODS The effects of a boiling water extract of HHT(HHTE) on GI motility were investigated by calculating percent intestinal transit rates(ITR%) and gastric emptying(GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction(GMD). In addition, the effects of the four components of HHT, that is, Gardeniae Fructus(GF), Scutellariae Radix(SR), Coptidis Rhizoma(CR), and Phellodendri Cortex(PC), on GI motility were also investigated.RESULTS In normal ICR mice, ITR% and GE values were significantly and dose-dependently increased by the intragastric administration of HHTE(0.1-1 g/kg). The ITR% values of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose-dependently inhibited by HHTE(0.1-1 g/kg). Additionally, GF, CR, and PC dosedependently increased ITR% and GE values in normal and GMD mice.CONCLUSION These results suggest that HHT is a novel candidate for the development of a gastroprokinetic agent for the GI tract.