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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez jose j.Gil-Cosano esther Ubago-Guisado Francisco j.Llorente-Cantarero juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

Mid-term survival of the Optimys short stem: A prospective case series of 500 patients

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World journal of Orthopedics 2024年第3期15卷 257-265页

作者： Bryan Hamans Sheryl de Waard Sjoerd Kaarsemaker esther R C janssen Inger N Sierevelt Gino M M j Kerkhoffs Daniël Haverkamp Department of Orthopaedic Surgery Xpert ClinicAmsterdam 1101EANetherlands Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands esther R C janssen Department of Orthopaedic SurgeryViecuri Medisch CentrumVenlo 5912 BLNetherlands Centre for Orthopaedic Research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Department of Orthopaedic Surgery and Sports Medicine Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands Department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands

BACKGROUND In recent years,there has been an increase in the number of total hip arthroplasty procedures in the younger patient *** active group has higher expectations of their prosthesis in comparison to the older population,and there is a greater physical demand for the *** femoral stems were in-troduced to retain proximal bone stock and joint biomechanics and became more common to implant in this specific ***,the long-term survival and functional outcomes of various short stems are still being investigated in different *** To determine the 5-year survival of the Optimys hip *** This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the *** patients received the Optimys short stem(Mathys Ltd,Bettlach,Switzerland).The primary outcome measure was survival of the hip stem,with revision as the *** secondary outcome measurements included patient-reported outcome measures(PROMs).Kaplan-Meier analysis was used to calculate the 5-year survival ***-minus-log transformation was performed to calculate the 95%confidence interval(95%CI).Mixed model analyses were performed to assess the course of the PROMs during the 1st 2 years after *** were modeled separately for the 1st and 2nd years to calculate the yearly change in PROMs during both follow-up periods with accompanying 95%*** The mean age of the total 500 patients was 62.3 years(standard deviation:10.6)and 202 were male(40%).At a median follow-up of 5.5 years(interquartile range:4.5-6.7),7 patients were deceased and 6 revisions were registered,for infection(n=3),subsidence(n=2)and malposition(n=1).This resulted in an overall 5-year survival of 98.8%(95%CI:97.3-99.5).If infection was left out as reason for revision,a stem survival of 99.4%(95%CI:98.1-99.8)was *** questionnaires were completed by 471 patients(94%),317 patients(63%)completed the 1-year follow-up questionna

关键词： Total hip arthroplasty Femoral stem Short stem Optimys Survival 5-year survival Revision PROMs

ITPK1 is an InsP/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

作者： esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider Adolfo Saiardi Dorothea Fiedler Henning j.jessen Gabriel Schaaf Ricardo F.H.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects Figures 2D,3C,4C,and 7D and Figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

A One Health approach to fight antimicrobial resistance in Uganda: Implementation experience, results, and lessons learned

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Biosafety and Health 2024年第2期6卷 125-132页

作者： Reuben Kiggundu j.P.Waswa Niranjan Konduri Hassan Kasuja Marion Murungi Patrick Vudriko Harriet Akello Eric Lugada Cecilia Muiva esther Were Dinah Tjipura Henry Kajumbula Kate Kikule Emmanuel Nfor Mohan P.joshi USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthArlingtonVA 22203USA College of Veterinary Medicine Animal Resources and BiosecurityMakerere UniversityKampala 256Uganda Ministry of Health Uganda Kampala 256Uganda USAID Strengthening Supply Chain Systems Activity Management Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthNairobi 254Kenya Department of Microbiology College of Health SciencesMakerere UniversityKampala 256Uganda

Uganda has been implementing the Global Health Security Agenda(GHSA)since 2015 to build its capacity according to World Health Organization(WHO)Benchmarks on International Health Regulations *** country remains prone to outbreaks,with more than 20 disease outbreaks reported in the past five years,including Ebola virus disease,Crimean-Congo haemorrhagic fever,Marburg haemorrhagic fever,measles,yellow fever,coronavirus disease 2019(COVID-19),and *** resistance(AMR)is an ongoing *** scored capacity level 3 on infection prevention and control(IPC)and antimicrobial stewardship(AMS)in the 2017 joint External Evaluation(jEE)*** gaps were being addressed after a self-assessment in *** paper describes the technical assistance approaches provided to Uganda by the Medicines,Technologies,and Pharmaceutical Services Program,funded by the United States(U.S.)Agency for International Development,and implemented by Management Sciences for *** program,through a One Health approach,supported systematic capacity strengthening based on the jEE's capacity advancement framework for global health security,specifically relating to *** program's interventions impacted 32 WHO benchmark actions(7 for AMR multisectoral coordination,16 for IPC,and 9 for AMS),contributing to Uganda's strengthened GHSA *** success built on the AMR platform,the program trained 745 health workers in IPC for the Ebola virus and provided support for simulation exercises by eight district IPC *** program also worked with the Ministry of Health to coordinate IPC for the COVID-19 response in five health regions,covering 45 districts and reaching 5,452 health workers at 858 health facilities.

关键词： One health Antimicrobial resistance Antibiotic resistance jointexternal evaluation Global health security Uganda Africa WHO Benchmarks for International Health Regulations Capacities

Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.G.van Gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos Ronald Cornet Bruna dos Santos Vieira Nawel Lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart esther van Enckevort Chris T.Evelo Alasdair j.G.Gray Marc Hanauer Kristina Hettne joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon L.Willighagen Mascha jansen Barend Mons Marco Roos Annika jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The Leiden Academic Center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

Utilization of waste vanadium-bearing resources in the preparation of rare-earth vanadate catalysts for semi-hydrogenation of α,β-unsaturated aldehydes

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Frontiers of Chemical Science and Engineering 2022年第12期16卷 1793-1806页

作者： Yang Zhang Guowu Zhan Yibo Song Yiping Liu jiale Huang Shu-Feng Zhou kok Bing Tan Qingbiao Li College of Chemical Engineering Integrated Nanocatalysts Institute(INCI)Huaqiao UniversityXiamen 361021China College of Food and Biology Engineering Jimei UniversityXiamen 361021China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China

Recycling industrial solid waste not only saves resources but also eliminates environmental concerns of toxic ***,we proposed a new strategy for the utilization of petrochemical-derived carbon black waste,a waste vanadium-bearing resource(V>30000 ppm(10−6)).Chemical leaching was employed to extract metallic vanadium from the waste and the leachate containing V was used as an alternative raw material for the fabrication of vanadate *** the screening of various metal cations,it was found that the contaminated Na^(+)during the leaching process showed strong competitive coordination with the vanadium ***,by adding foreign Ce^(3+)and Y^(3+)cations,two rare-earth vanadates,viz.,flower-like CeVO_(4)and spherical YVO_(4)nanomaterials,were successfully *** techniques such as scanning electron microscopy,transmission electron microscopy,X-ray diffraction,energy-dispersive X-ray spectroscopy,Fourier-transform infrared,and N2 physisorption were applied to analyze the physicochemical properties of the waste-derived ***,we found that rare-earth vanadate catalysts exhibited good activities toward the semi-hydrogenation ofα,β-unsaturated *** conversion of cinnamaldehyde and cinnamic alcohol selectivity were even higher than those of the common CeVO_(4)prepared using pure chemicals(67.2%vs.27.7%and 88.4%vs.53.5%).Our work provides a valuable new reference for preparing vanadate catalysts by the use of abundant vanadium-bearing waste resources.

关键词： petrochemical solid wastes vanadium recovery resource utilization nanomaterials semi-hydrogenation

Overview of the CHILL-ICE 2021 Science Experiments and Research Campaign

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Space(Science & Technology) 2022年第1期2022卷 27-35页

作者： David j.K.Smith Charlotte R.Pouwels Marc Heemskerk Benedetta M.Cattani esther Konijnenberg Robert Heemskerk Sebasthian Ogalde ICEE Space Netherlands EuroMoonMars An Initiative of ILEWG(International Lunar Exploration Working GroupThe Netherlands)Netherlands Vrije Universiteit Amsterdam Netherlands Lunar Zebro Delft University of TechnologyNetherlands Heemskerk Innovative Technology Netherlands

The main objective of the CHILL-ICE(Construction of a Habitat Inside a Lunar-analogue Lava tube—Iceland;a campaign by ICEE Space and EuroMoonMars)prototype mission was to deploy an inflatable habitat and its systems inside a lunar analogue lava *** took place during an 8-hour extra vehicular activity(EVA)with three analogue astronauts as part of a threeday ***-ICE 2021 was carried out in july/August 2021 and consisted of two missions and was accomplished through successful collaboration of nonprofit research organizations,agencies,companies,and universities across 16 *** pilot campaign successfully reached its main objective:the testing of emergency equipment designed to help astronauts survive when first arriving to a new celestial body and to perform experiments similar to those that would be carried out *** article is a review of the scientific research experiments carried out during and after the mission:SpotNet,an artificial intelligence(AI)astronaut detection vision system;training for studies of the geological surroundings examined during EVAs;astronaut vigilance experiments carried out before,during,and after the mission;and Lunar Zebro,a legged rover intended to assist the crew in traversing and exploring harsh terrain.

关键词： ICE companies planet

Complications associated with energy-based devices during thyroidectomy from 2010–2020

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World journal of Otorhinolaryngology-Head and Neck Surgery 2023年第1期9卷 35-44页

作者： esther Lee jane Y.Tong Luke j.Pasick Daniel A.Benito Arjun joshi Punam G.Thakkar joseph F.Goodman Division of Otolaryngology-Head and Neck Surgery George Washington University School of Medicine&amp Health SciencesWashingtonDCUSA Western University of Health Sciences PomonaCAUSA Department of Otolaryngology-Head and Neck Surgery Drexel University College of MedicinePhiladelphiaPAUSA Department of Otolaryngology-Head and Neck Surgery University of Miami Miller School of MedicineMiamiFLUSA

Objective:Harmonic Focus(Ethicon,johnson and johnson,Cincinnati,OH,USA),LigaSure Small jaw(Medtronic,Covidien Products,Minneapolis,MN,USA),and Thunderbeat Open Fine jaw(Olympus,japan)are electrosurgical instruments used widely in head and neck *** study aims to compare device malfunctions,adverse events to patients,operative injuries,and interventions related to Harmonic,LigaSure,and Thunderbeat use during ***:The US Food and Drug Administration's Manufacture and User Facility Device Experience(MAUDE)database was queried for adverse events associated with Harmonic,LigaSure,and Thunderbeat from january 2005 to August *** were extracted from reports pertaining to ***:Of the 620 adverse events extracted,394(63.5%)involved Harmonic,134(21.6%)LigaSure,and 92(14.8%)*** reported device malfunctions most frequently associated with Harmonic was damage to the blade(110(27.9%)),LigaSure was inappropriate function(47(43.1%)),Thunderbeat was damage to the tissue or Teflon pad(27(30.7%)),*** injury and incomplete hemostasis were the most commonly reported adverse *** operative injury reported most frequently when using Harmonic and LigaSure was burn *** operator injuries were reported with Thunderbeat ***:The most frequently reported device malfunctions were damage to the blade,inappropriate function,and damage to the tissue or Teflon *** most frequently reported adverse events to patients was a burn injury and incomplete *** aimed at improving physician education may help reduce adverse events attributed to improper use.

关键词： Adverse events Harmonic LigaSure Manufacture and User Facility Device Experience Patient safety Quality Thunderbeat Thyroidectomy

Understanding Interfacial Chemistry Interactions in Energy-Dense Lithium-Ion Electrodes

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Accounts of Materials Research 2023年第2期4卷 156-167页

作者： Donghee Gueon Miguel A.Gonzalez Kenneth j.Takeuchi esther S.Takeuchi Amy C.Marschilok Elsa Reichmanis Department of Chemical and Bimolecular Engineering Lehigh UniversityBethlehemPennsylvania 18015United States School of Chemical and Biomolecular Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332United States Interdisciplinary Science Department Brookhaven National LaboratoryUptonNew York 11973United States Institute for Energy Sustainability and Equity Stony Brook UniversityStony BrookNew York 11794United States Department of Material Science and Chemical Engineering Stony Brook UniversityStony BrookNew York 11794United States Department of Chemistry Stony Brook UniversityStony Brook 11794United States

For the past two decades,conversion and alloying-type materials have been heralded as the natural heir to commercially available graphite anodes due to their ability to deliver high gravimetric/volumetric *** of batteries with these high-energy-density active materials could impact a variety of sectors including electric vehicles,grid storage,and consumer electronics and contribute toward an ever-increasing electrified ***,the various failure mechanisms from inherent interfacial chemical instabilities associated with these materials make them unable to be merely substituted into currently available electrode fabrication and formulation processing *** a result,realizing the high theoretical capacity and achieving commercial viability of these materials will rely on the careful manipulation of interfacial chemical interactions that dictate and control various kinetic and transport processes across multiple scales of the composite *** has led to a plethora of research that has focused on systematically understanding properties of the different electrode components and designing carefully constructed electrode formulations to achieve composite electrodes with increased chemical stability,enhanced local mixed conductivities,or improved mechanical *** Account relates recent progress in the understanding of synergetic opportunities for energy-dense,resilient composite *** understanding the interplay between components of the composite electrode,we can construct enhanced well-integrated electrodes with performance metrics that surpass empirically derived *** to the increased complexity of high-volume-expanding electrodes,performance is more than the cumulative contributions of the individual components,and therefore energy and compatibility matching are important for robust electrochemical performance across cycling,rate capability,facile lithium-ion transport,and *** this Account,sy

关键词： composite interfacial electrode