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Soluble interleukin 23 receptor gene therapy with adeno-associated vectors for the treatment of multiple sclerosis

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Neural Regeneration Research 2017年第10期12卷 1605-1606页

作者： ángel Edo Juan Francisco espinosa-Parrilla Gene Therapy for Central Nervous System Group Vall d'Hebron Institut de Recerca Hospital Universitari Vall d'HebronBarcelonaSpain

Gene therapy as strategy against autoimmune diseases： In the last century, human societies have witnessed remarkable improvements in wellness and life expectancy, thanks to the consolidation of mod- ern science and medicine. But, while some infectious and other dis- eases, have been almost fully controlled, pathologies associated with intrinsic factors and longevity have increased in incidence.

关键词：基因治疗多发性硬化白细胞介素腺相关病毒自身免疫性疾病可溶性受体人类社会

Evidences of hydroxytyrosol as an anti-inflammatory agent in Parkinson’s disease:insights into the mechanisms of action

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Neural Regeneration Research 2021年第5期16卷 992-993页

作者： Ruth Hornedo-Ortega Ana María espinosa-Oliva Axe Molécules d’Intérêt Biologique(MIB) Unitéde Recherche OenologieEA4577USC 1366 INRAISVVUniversitéde BordeauxBordeauxFrance Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaUniversidad de Sevillaand Instituto de Biomedicina de Sevilla(IBiS)Hospital Universitario Virgen del Rocío/CSICSevilleSpain

Neuroinflammation in neurodegenerative diseases:Inflammatory processes play a critical role in neurodegenerative diseases,such as Parkinson’s disease(PD).Thus,neuroinflammation is involved in the progression and development of these diseases,becoming an important pathological *** cells,the“macrophages”from central nervous system,are the initiating cells of the innate immune response against different stimuli in the brain.

关键词： inflammation diseases insight

Increased locomotor activity in estrogen-treated ovariectomized rats is associated with nucleus accumbens dopamine and is not reduced by dietary sodium deprivation

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Integrative Zoology 2018年第6期13卷 783-794页

作者： Enith espinosa Kathleen S.CURTIS Oklahoma State University-Center for Health Sciences TulsaOklahomaUSA

Estrogens are well known to increase locomotor activity in laboratory rodents;however,the underlying mechanism remains *** used voluntary wheel running by female rats as an index of locomotor behavior to investigate this *** first determined whether the estrogen-induced increase in locomotion was susceptible to inhibition by a physiological challenge,and next whether it was associated with dopaminergic activation in the central reward area,nucleus *** rats were given estradiol or the oil vehicle and housed in cages with or without running *** rats were given regular rodent chow for 1 week,a sodium-deficient diet for the next week,and then were returned to a regular diet for another *** the end of the last week,all rats were killed,brains were extracted and dopamine levels in the nucleus accumbens were *** expected,estradiol treatment increased distance ***,dietary sodium deprivation further increased running,but this appeared to be related to experience with wheel running,rather than to sodium deprivation,per *** was greater in the nucleus accumbens of estradiol-treated rats that ran compared to all other ***,the estrogen-induced increase in locomotion is a robust phenomenon that is not inhibited by a body sodium challenge and is associated with elevated levels of dopamine in reward *** findings raise the possibility that the estrogen-induced increase in locomotor activity,which occurs during a hormonal milieu conducive to reproduction,may reflect mate-seeking behavior and,thereby,maximize reproductive success.

关键词： locomotor activity reproductive hormones reward pathways

Digestibility and metabolism of copper in diets for pigs and influence of dietary copper on growth performance,intestinal health,and overall immune status:a review

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Journal of Animal Science and Biotechnology 2021年第2期12卷 426-437页

作者： Charmaine D.espinosa Hans H.Stein Department of Animal Sciences University of IllinoisUrbana 61801USA Division of Nutritional Sciences University of IllinoisUrbana 61801USA

The current contribution reviews absorption and metabolism of copper(Cu),Cu deficiency,Cu toxicity,Cu bioavailability,and effects of pharmacological levels of Cu on growth performance and intestinal health of *** is a micro mineral involved in metabolic reactions including cellular respiration,tissue pigmentation,hemoglobin formation,and connective tissue *** is mostly absorbed in the upper gastrointestinal tract,particularly in the duodenum,but some Cu is absorbed in the *** way to evaluate the efficacy of sources of Cu is to measure relative bioavailability where responses include tissue concentrations of Cu,concentrations of metalloproteins,and enzymatic activity of animals fed test diets containing graded levels of *** requirement for Cu by pigs is 5 to 10 mg/kg diet,however,Cu can be included at growth-promoting levels(i.e.,75 to 250 mg/kg diet)in diets for weanling and growing pigs to reduce post-weaning diarrhea and improve growth *** consistently observed improvement in growth performance upon Cu supplementation is likely a result of increases in lipase activity,growth hormone secretion,and expression of genes involved in postabsorptive metabolism of *** growth-promoting effects of dietary Cu have also been attributed to its bacteriostatic and bactericidal properties because Cu may change bacterial populations in the intestine,and thereby reduce inflammation caused by ***,further research is needed to determine potential interactions between Cu and non-nutritive feed additives(e.g.,enzymes,probiotics,phytobiotics),and the optimum quantity of Cu as well as the optimum duration of feeding supplemental Cu in diets for pigs should be further *** gaps needs to be addressed to maximize inclusion of Cu in diets to improve growth performance while minimizing diseases and mortality.

关键词： Copper Copper nutrition Intestinal health Metabolism Pharmacological concentrations Pigs

Machine learning assisted design of shape-programmable 3D kirigami metamaterials

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npj Computational Materials 2022年第1期8卷 1817-1828页

作者： Nicolas A.Alderete Nibir Pathak Horacio D.espinosa Theoretical and Applied Mechanics Northwestern UniversityEvanstonIL60208USA Department of Mechanical Engineering Northwestern UniversityEvanstonIL60208USA

Kirigami-engineering has become an avenue for realizing multifunctional metamaterials that tap into the instability landscape of planar surfaces embedded with ***,it has been shown that two-dimensional Kirigami motifs can unfurl a rich space of out-of-plane deformations,which are programmable and controllable across spatial *** Kirigami’s versatility,arriving at a cut layout that yields the desired functionality remains a ***,we introduce a comprehensive machine learning framework to shed light on the Kirigami design space and to rationally guide the design and control of Kirigami-based materials from the meta-atom to the metamaterial *** employ a combination of clustering,tandem neural networks,and symbolic regression analyses to obtain Kirigami that fulfills specific design constraints and inform on their control and *** systematic approach is experimentally demonstrated by examining a variety of applications at different hierarchical levels,effectively providing a tool for the discovery of shape-shifting Kirigami metamaterials.

关键词： shape hierarchical shifting

TET2, an “ambiguous” player in inflammation

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Neural Regeneration Research 2020年第8期15卷 1481-1482页

作者： Ana María espinosa-Oliva Miguel Angel Burguillos Departamento de Bioquímica y Biología Molecular Facultad de Farmacia Universidad de Sevilla and Instituto de Biomedicina de Sevilla (IBiS) Hospital Universitario Virgen del Rocío/CSIC

Microglial cells,the“macrophages”from the central nervous system(CNS),perform a variety of roles necessary to keep the homeostasis in the healthy ***,microglial cells are best known for their role as“first responders”through initiation of an innate immune response against a wide variety of deleterious stimuli in the *** controlled inflammatory response is beneficial and disappears once the deleterious stimuli are gone.

关键词： inflammation homeostasis delete

Hydroxytyrosol and Parkinson's disease:protective actions against alpha-synuclein toxicity

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Neural Regeneration Research 2024年第7期19卷 1427-1428页

作者： Ruth Hornedo-Ortega Ana M.espinosa-Oliva Departamento de Nutrición y Bromatología Toxicología y Medicina LegalFacultad de FarmaciaUniversidad de SevillaSevilleSpain Instituto de Biomedicina de Sevilla IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaUniversidad de SevillaSevillaSpain

Parkinson’s disease:Parkinson’s disease(PD) is the second most prevalent neurodegenerative disease,after Alzheimer’s disease,affecting 1%of the general population over the age of *** to data from the World Health Organization(WHO),its prevalence has doubled in the past 25 *** 2019,global estimates indicated over 8.5 million individuals with PD and it is suggested that PD caused 329000 deaths,an increase of over 100% since 2000(WHO,2022).

关键词： protective Alzheimer prevalence

Reviewing the discoverability and accessibility to data and information products linked to Essential Climate Variables

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International Journal of Digital Earth 2020年第2期13卷 236-252页

作者： Maria Teresa Miranda espinosa Gregory Giuliani Nicolas Ray Institute for Environmental Sciences enviroSPACE labUniversity of GenevaGenevaSwitzerland Institute for Environmental Sciences GRID-GenevaUniversity of GenevaGenevaSwitzerland GeoHealth Group Institute of Global HealthFaculty of MedicineUniversity of GenevaGenevaSwitzerland'

Essential Climate Variables(ECVs)are geophysical records generated from systematic Earth Observations associated with climate variations,changes,and *** products support the data and information needs of international frameworks and policies such as the work of the United Nations Framework Convention on Climate Change(UNFCCC)and the Intergovernmental Panel on Climate Change(IPCC).We map the main networks and initiatives publishing ECVs,by presenting an overview of existing satellite-based ECVs,their general data creation characteristics,discoverability and accessibility methods from an end-user *** investigate key initiatives providing or coordinating access to ECV data records,such as the Global Climate Observing System(GCOS),the Committee on Earth Observation Satellites(CEOS),the Coordination Group for Meteorological Satellites(CGMS),Joint Working Group on Climate(WGClimate),the Remote Sensing Systems(REMSS),and the European Space Agency Climate Change Initiative(ESA CCI).We find that ECV data discovery and access is difficult and time consuming due to the lack of common data and metadata *** addition,the selection of fit-for-purpose data records by end-users requires the implementation of interoperable standards and scalable data infrastructures to allow the generation of tailored applications and datadriven information products in support of decision-making processes.

关键词： Essential Climate Variables Climate services discoverability accessibility usability

Winkler Support Model and Nonlinear Boundary Conditions Applied to 3D Elastic Contact Problem Using the Boundary Element Method

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Acta Mechanica Solida Sinica 2019年第2期32卷 230-248页

作者： J.Vallepuga-espinosa Lidia Sanchez-Gonzalez Ivan Ubero-Martinez Departamento de Tecnologia Minera Topografiay de EstructurasUniversidad de LeonCampus de Vegazana s/n24071 LeonSpain Departamento de Ingenierias Mecanica Informatica y AeroespacialUniversidad de LeonCampus de Vegazana s/n24071 LeonSpain

This work presents a numerical methodology for modeling the Winkler supports and nonlinear conditions by proposing new boundary conditions. For the boundary conditions of Winkler support model, the surface tractions and the displacements normal to the surface of the solid are unknown, but their relationship is known by means of the ballast coefficient, whereas for nonlinear boundary conditions, the displacements normal to the boundary of the solid are zero in the positive direction but are allowed in the negative direction. In those zones, detachments of nodes might appear, leading to a nonlinearity, because the number of nodes that remain fixed or of the detached ones (under tensile tractions) is unknown. The proposed methodology is applied to the 3D elastic receding contact problem using the boundary element method. The surface t r actions and the displacements of the common int erface bet ween the two solids in contac t under the influence of different supports are calculated as well as the boundary zone of the solid where the new boundary conditions are applied. The problem is solved by a double-iterative met hod, so in the final solut ion, t here are no t r act ions or pene trations between the two solids or at the boundary of the solid where the nonlinear boundary conditions are Simula ted. The effectiveness of the proposed method is verified by examples.

关键词： Boundary element method Elastic contact problem Winkler support model Nonlinear boundary conditions