检索结果-南通市图书馆

Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography

引用

World Journal of Gastroenterology 2012年第12期18卷 1385-1390页

作者： Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino Kenichiro Enooku eriko goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of Tokyo Department of Clinical Laboratory The University of Tokyo Hospital Yamanashi Prefectural Hospital Organization

METHODS： Between December 2006 and June 2008, a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled, Liver stiffness was obtained noninvasively by using Fibroscan （Echosens, Paris, France）, The date of blood transfusion was obtained by interview, Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement （LSM）. Patients were stratified into four groups based on the duration of infection （17-29 years; 30-39 years; 40-49 years; and 50-70 years）. The difference in liver stiffness between patients with and without HCC was assessed in each group. Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS： A total of 524 patients underwent LSM. Eight patients were excluded because of unsuccessful measurements. Thus 516 patients were included in the current analysis （225 with HCC and 291 without）. The patients were 244 men and 272 women, with a mean age of 67.8 ±9.5 years. The median liver stiffness was 14.3 kPa （25.8 in HCC group and 7.6 in non HCC group）. The patients who developed HCC in short duration of infection were male dominant, having lower platelet count, with a history of heavier alcohol consumption, showing higher liver stiffness, and receiving blood transfusion at an old age. Liver stiffness was positively correlated with duration of infection in patients without HCC （r = 0.132, P = 0.024） but not in patients with HCC （r = -0.103, P = 0.123）. Liver stiffness was significantly higher in patients with HCC than in those without in each duration group （P 〈 0.0001）. The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion （P 〈 0.0001）, duration of infection （P = 0.0015）, and heavy alcohol consumption （P = 0.043）CONCLUSION： Although liver stiffness gradually increases over time, HCC develops in patients with high stiffness value regardle

关键词： Transfusion-associated hepatitis C Transientelastography Hepatocellular carcinoma Liver stiffness Ultrasonography Liver fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between outcomes and relative dose intensity of lenvatinib treatment in patients with advanced hepatocellular carcinoma

引用

Liver Research 2020年第4期4卷 199-205页

作者： Takamasa Ohki Koki Sato Mayuko Kondo eriko goto Takahisa Sato Yuji Kondo Masatoshi Akamatsu Shinpei Sato Hideo Yoshida Yukihiro Koike Shuntaro Obi Department of Gastroenterology Mitsui Memorial HospitalTokyoJapan Department of Gastroenterology Kanto Central HospitalTokyoJapan Department of Gastroenterology Teikyo University Medical CenterChiba PrefectureJapan Department of Gastroenterology and Hepatology Kyoundo HospitalTokyoJapan Department of Gastroenterology JR Tokyo General HospitalTokyoJapan Department of Gastroenterology Japanese Red Cross Medical CenterTokyoJapan

Background and aims:Lenvatinib(LEN)is a newly developed tyrosine kinase inhibitor,and is approved as a first-line treatment for advanced hepatocellular carcinoma(HCC)in *** retrospective multi-center study investigated the effect of the relative dose intensity(RDI)of LEN on response rate,progression-free survival(PFS),and overall survival(OS).Methods:This retrospective study enrolled 123 patients with advanced HCC who were treated with LEN at six hospitals in Japan between March 2018 and December *** patients were divided into two groups:RDI≥70%(RDI 70 group,N=70)or RDI<70%(control group,N=53)in the first 30 *** following data were compared between groups:patient backgrounds,adverse events,treatment out-comes,PFS,and *** and OS were analyzed using the Kaplan-Meier method,followed by the log-rank *** identify significant factors that contributed to response,PFS,and OS,multivariate analysis was performed using factors for which P-values were<0.10 in univariate ***:The proportion of patients with Child-Pugh class 5A was significantly greater in the RDI 70 group than that in the control group(64.3%vs.28.3%,P<0.01).Dose interruption due to adverse events was significantly more common in the control *** response rate was significantly higher in the RDI 70 group than that in the control group(35.7%vs.11.3%,P<0.01).Median PFS was significantly longer in the RDI 70 group(9.4 vs.4.7 months,P<0.01).Multivariate analysis showed that RDI≥70%(hazard ratio(HR)=0.55,P=0.025),hypertension grade≥2(HR=0.47,P=0.019),and response(HR=0.52,P=0.033)were independently associated with improved *** OS was also significantly longer in the RDI 70 group(20.0 vs.13.3 months,P=0.045).Multivariate analysis showed that female sex(HR=0.33,P=0.034)and disease control(HR=0.31,P<0.01)were independently associated with improved ***≥70%was not statistically significant in multivariate ***:Our study revealed the importance of achieving

关键词： Advanced hepatocellular carcinoma Lenvatinib(LEN) Relative dose intensity(RDI) Chemotherapy Tyrosine kinase inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Holographic 3D imaging through random media: methodologies and challenges

引用

Light(Advanced Manufacturing) 2022年第2期3卷 123-135页

作者： Mitsuo Takeda Wolfgang Osten eriko Watanabe Center for Optical Research and Education Utsunomiya University7-1-2YotoUtsunomiyaTochigi321-8585Japan Institut für Technische Optik Universität StuttgartPfaffenwaldring 970569 StuttgartGermany The University of Electro-Communications 1-5-1ChofugaokaChofuTokyo 182-8585Japan

Imaging through random media continues to be a challenging problem of crucial importance in a wide range of fields of science and technology,ranging from telescopic imaging through atmospheric turbulence in astronomy to microscopic imaging through scattering tissues in *** meet the scope of this anniversary issue in holography,this review places a special focus on holographic techniques and their unique functionality,which play a pivotal role in imaging through random *** review comprises two *** first part is intended to be a mini tutorial in which we first identify the true nature of the problems encountered in imaging through random *** then explain through a methodological analysis how unique functions of holography can be exploited to provide practical solutions to *** second part introduces specific examples of experimental implementations for different principles of holographic techniques,along with their performance results,which were taken from some of our recent work.

关键词： Holography Imaging Scattering Random Media Statistical Optics Coherence Speckles Correlation Digital Holography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SCR-22 of pollen-dominant S haplotype class is recessive to SCR-44 of pollenrecessive S haplotype class in Brassica rapa

引用

Horticulture Research 2019年第1期6卷 1596-1606页

作者： Chun-Lei Wang Zhi-Ping Zhang eriko Oikawa Hiroyasu Kitashiba Takeshi Nishio School of Horticulture and Plant Protection Joint International Research Laboratory of Agriculture and Agri-Product SafetyKey Laboratory of Plant Functional Genomics of the Ministry of EducationYangzhou University48 Wenhui East RoadYangzhou 225009People’s Republic of China Graduate School of Agricultural Science Tohoku University468-1 Aza-AobaAramakiAoba-kuSendaiMiyagi 980-0845Japan

SCR/SP11 encodes the male determinant of recognition specificity of self-incompatibility(SI)in Brassica species and is sporophytically expressed in the anther *** on dominance relationships in pollen and nucleotide sequence similarity,the S haplotypes in Brassica have been classified as class I or class II,with class-I S haplotypes being dominant over class-II S ***,we revealed that S-22 in *** belonging to class I is recessive to class-II S-44 and class-I S-36 in pollen,whereas it is dominant over S-60,S-40,and S-29 based on pollination ***/SP11 of S-22(SCR-22)was sequenced,revealing that the deduced amino-acid sequence of SCR-22 has the longest C-terminal domain among the SCR/SP11 *** expression of SCR-22 was found to be suppressed in S-22/S-44 and S-22/S-36 *** transcription of SCR-44 was considered to be due to the transcription suppression of Smi sRNA of the S-22 haplotype and a very low methylation state of the SCR-44 promoter region in the tapetum of S-22/S-44 *** SCR-22,only the cytosine residue located at the–37 bp position of the promoter region was hypermethylated in the tapetum of S-22/S-44 heterozygotes,and few methylated cytosines were detected in the promoter and coding regions of SCR-22 in S-22/S-36 ***-22 was also expressed in microspores in S-22 homozygotes but not in S-22/S-44 and S-22/S-36 *** results suggest that a mechanism different from class-II SCR/SP11 suppression may operate for the suppression of recessive class-I SCR-22 in S heterozygotes.

关键词： similarity residue dominance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Voltammetric response of ferroceneboronic acid to diol and phenolic compounds as possible pollutants

引用

Journal of Environmental Sciences 2011年第6期23卷 1027-1032页

作者： Shigehiro Takahashi Naoyuki Abiko Nobuhiro Haraguchi Hiroyuki Fujita eriko Seki Tetsuya Ono Kentaro Yoshida Jun-ichi Anzai Graduate School of Pharmaceutical Sciences Tohoku UniversityAramakiAoba-kuSendai 980-8578Japan School of Pharmaceutical Sciences Ohu University31-1 MisumidoTomita-machiKoriyamaFukushima 963-8611Japan

A voltammetric determination of possible organic pollutants such as diol and phenolic compounds in water was studied using ferroceneboronic acid（FBA） as a redox-active marker.A cyclic voltammogram of FBA exhibited a pair of oxidation and reduction peaks at 230 and 170 mV at pH 7.0,respectively,while another pair of redox peaks was observed in the presence of diol or phenolic compounds *** results were rationalized based on the formation of boronate esters of FBA with the added *** changes in the redox peak currents were dependent on the concentration of the additives,suggesting a usefulness of FBA in the electrochemical determination of these compounds in water.

关键词： ferroceneboronic acid sugar phenolic compound cyclic voltammetry pollutants in water electrochemical determination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predicting Visible Image Degradation by Colour Image Difference Formulae

引用

仪器仪表学报 2004年第S3期 121-124页

作者： eriko Bando,Jon Y. Hardeberg,David Connah,Ivar Farup The Norwegian Color Research Laboratory Gjovik University College Gjovik Norway The Norwegian Color Research Laboratory Gjovik University College Gjovik Norway The Norwegian Color Research Laboratory Gjovik University College Gjovik Norway The Norwegian Color Research Laboratory Gjovik University College Gjovik Norway

It carried out a CRT monitor based psychophysical experiment to investigate the quality of three colour image difference metrics, the CIEΔE ab equation, the iCAM and the S-CIELAB metrics. Six original images were reproduced through six gamut mapping algorithms for the observer experiment. The result indicates that the colour image difference calculated by each metric does not directly relate to perceived image difference.

关键词： Colour image difference Image consistency CRT display iCAM S-CIELAB

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Coptidis Rhizoma Water Extract Stimulates 5'-AMP-Activated Protein Kinase in Rat Skeletal Muscle

引用

中国天然药物 2011年第3期9卷 215-221页

作者： Tatsuro Egawa Rieko Oshima eriko Kurogi Hiroko Tanabe Satoshi Tsuda Tatsuya Hayashi Laboratory of Sports and Exercise Medicine Graduate School of Human and Environmental StudiesKyoto University

AIM:Coptidis Rhizoma(CR),the dried rhizomes of Asian herbs(including Coptis chinensis Franch),has been used to treat diabetes mellitus for thousands of *** explored the possibility that CR acts directly on skeletal muscle,the major organ responsible for glucose homeostasis,and activates 5'-AMP-activated protein kinase(AMPK),a signaling intermediary leading to metabolic enhancement of skeletal ***:Isolated rat epitrochlearis and soleus muscles were incubated in a buffer containing a CR water extract(CE),and activation of AMPK and related events were ***:In response to CE treat-ment,phosphorylation of Thr172 at the catalyticαsubunit of AMPK,an essential step for full kinase activation,increased in both *** of Ser79 of acetyl CoA carboxylase(ACC),an endogenous substrate of AMPK,increased *** of isoform-specific AMPK activity revealed that CE activated both the α1 and α2 isoforms of the catalytic ***,the maximal effect of CE on AMPK phosphorylation was significantly greater than that of berberine(BBR),indicating that the action of CE is not totally ascribed to ***:We propose that CE is an acute activator of AMPK in both fast-and slow-twitch skeletal muscles.

关键词： Coptidis Rhizoma Coptis chinensis 5’-AMP-activated protein kinase Skeletal muscle Berberine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lansoprazole-associated collagenous colitis:Diffuse mucosal cloudiness mimicking ulcerative colitis

引用

World Journal of Gastroenterology 2009年第17期15卷 2166-2169页

作者： Mitsuro Chiba Takeshi Sugawara Haruhiko Tozawa Hidehiko Tsuda Toru Abe Takuo Tokairin Iwao Ono eriko Ushiyama Division of Gastroenterology Nakadori General Hospital Akita 010-8577 Japan Department of Pathology Nakadori General Hospital Akita 010-8577 Japan Department of Internal Medicine Nakadori Rehabilitation Hospital Akita 010-8577 Japan

There have only been a few reports on lansoprazole-associated collagenous colitis. Colonic mucosa of collagenous colitis is known to be endoscopically normal. We present a case of collagenous colitis where the mucosa showed diffuse cloudiness mimicking ulcerative colitis. A 70-year-old woman developed watery diarrhea four to nine times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70 years. Lansoprazole 30 mg/d had been prescribed for reflux esophagitis for nearly 6 mo. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/d was started. The patient's diarrhea dramatically disappeared on the following day. However, biopsy specimens showed subepithelial collagenous thickening and infi ltration of inflammatory cells in the lamina propria, confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before, confirming a diagnosis of collagenous colitis relapse. We found that the patient had begun to take lansoprazole again 3 mo ahead of the recent diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved, similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and discontinuation of lansoprazole in the first episode was found to be the same. We conclude that this patient had lansoprazole-associated collagenous colitis.

关键词： Collagenous colitis Microscopic colitis,Lansoprazole Ulcerative colitis Sulfasalazine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applications of quantum computing for investigations of electronic transitions in phenylsulfonyl-carbazole TADF emitters

引用

npj Computational Materials 2021年第1期7卷 619-627页

作者： Qi Gao Gavin O.Jones Mario Motta Michihiko Sugawara Hiroshi CWatanabe Takao Kobayashi eriko Watanabe Yu-ya Ohnishi Hajime Nakamura Naoki Yamamoto Mitsubishi Chemical Corporation Science&Innovation CenterYokohamaJapan Quantum Computing Center Keio UniversityYokohamaJapan IBM Quantum IBM Research-AlmadenSan JoseCAUSA Materials Informatics Initiative Yokkaichi Research CenterJSR CorporationYokkaichiMieJapan IBM Research-Tokyo TokyoJapan Department of Applied Physics and Physico-Informatics Keio UniversityYokohamaJapan

A quantum chemistry study of the first singlet(S_(1))and triplet(T_(1))excited states of phenylsulfonyl-carbazole compounds,proposed as useful thermally activated delayed fluorescence(TADF)emitters for organic light emitting diode(OLED)applications,was performed with the quantum Equation-Of-Motion Variational Quantum Eigensolver(qEOM-VQE)and Variational Quantum Deflation(VQD)algorithms on quantum simulators and *** quantum simulations were performed with double zeta quality basis sets on an active space comprising the highest occupied and lowest unoccupied molecular orbitals(HOMO,LUMO)of the TADF *** differences in energy separations between S_(1) and T_(1)(ΔEST)predicted by calculations on quantum simulators were found to be in excellent agreement with experimental *** of 17 and 88 mHa with respect to exact energies were found for excited states by using the qEOM-VQE and VQD algorithms,respectively,to perform simulations on quantum devices without error *** utilizing state tomography to purify the quantum states and correct energy values,the large errors found for unmitigated results could be improved to differences of,at most,4 mHa with respect to exact ***,excellent agreement could be found between values ofΔEST predicted by quantum simulations and those found in experiments.

关键词： quantum excited occupied

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer

引用

World Journal of Gastroenterology 2009年第20期15卷 2520-2525页

作者： Eiji Oki Yan Zhao Rintaro Yoshida Takanobu Masuda Koji Ando Masahiiko Sugiyama eriko Tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara Department of Surgery and Science Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan Department of Gastroenterology National Kyushu Cancer Center 3-1-1 Notame Minarni-ku Fukuoka 811-1395 Japan

AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric ***:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c *** microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct ***:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological *** found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation ***:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of ***, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis.

关键词： Checkpoint with forkhead-associated and ring finger Methylation Microsatellite instability Gastric cancer p53

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：