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Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA

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World Journal of Gastroenterology 2018年第21期24卷 2261-2268页

作者： Kazuma Sekiba Motoyuki Otsuka Motoko Ohno Mari Yamagami Takahiro Kishikawa Tatsunori Suzuki Rei Ishibashi Takahiro Seimiya eri tanaka Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of Tokyo

Hepatitis B virus(HBV) is still a worldwide health concern. While divergent factors are involved in its pathogenesis, it is now clear that HBV RNAs, principally templates for viral proteins and viral DNAs, have diverse biological functions involved in HBV pathogenesis. These functions include viral replication, hepatic fibrosis and hepatocarcinogenesis. Depending on the sequence similarities, HBV RNAs may act as sponges for host mi RNAs and may deregulate mi RNA functions, possibly leading to pathological consequences. Some parts of the HBV RNA molecule may function as viralderived mi RNA, which regulates viral replication. HBV DNA can integrate into the host genomic DNA and produce novel viral-host fusion RNA, which may have pathological functions. To date, elimination of HBVderived covalently closed circular DNA has not been achieved. However, RNA transcription silencing may be an alternative practical approach to treat HBVinduced pathogenesis. A full understanding of HBV RNA transcription and the biological functions of HBV RNA may open a new avenue for the development of novel HBV therapeutics.

关键词： Hepatitis B virus Hepatitis B virus RNA MicroRNA Smc5/6 Viral replication Hepatic fibrosis Genome integration Hepatocellular carcinoma

Angioimmunoblastic T-cell lymphoma accompanied by pure red cell aplasia:A case report

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World Journal of Clinical Oncology 2020年第6期11卷 405-411页

作者： Teiko Kawahigashi Izumi Kitagawa eri tanaka Department of General Internal Medicine Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Hematology Shonan Kamakura General HospitalKanagawa 247-8533Japan

BACKGROUND Angioimmunoblastic T-cell lymphoma(AITL)is a peripheral T-cell lymphoma,which is a rare subtype of *** with AITL often have skin lesions,which are observed in 50%of all cases;the chief complaint of this patient was palpable *** often complicates autoimmune or hematological disorders;however,among these,pure red cell aplasia(PRCA)is a very rare complication of *** herein report a case of AITL with *** SUMMARY A 77-year-old Japanese man presented to our hospital with complaints of loss of appetite for 2 mo and a 10-d history of palpable *** physical examination,the patient was afebrile but had bilateral multiple palpable purpuric lesions over the lower extremities,lower abdomen,and part of the upper ***,lymphadenopathy of the bilateral inguinal,cervical,and supraclavicular nodes was *** and imaging studies and skin biopsy were conducted but were *** on inguinal lymph node excisional biopsy,we diagnosed the patient with ***,the patient developed progressive normocytic normochromic anemia that necessitated almost daily blood *** clinical presentations and results of bone marrow assessment were consistent with those of PRCA,which is associated with *** was initiated but was not *** patient refused further chemotherapy and opted to continue receiving best supportive *** PRCA is an extremely rare complication of *** the pathophysiology remains unclear,further research is warranted.

关键词： Palpable purpura Lymphoma Pure red cell aplasia Case report

Intravascular lymphoma with hypopituitarism: A case report

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World Journal of Clinical Oncology 2020年第8期11卷 673-678页

作者： Teiko Kawahigashi Shinichi Teshima eri tanaka Department of General Internal Medicine Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Histopathology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Hematology Shonan Kamakura General HospitalKanagawa 247-8533Japan

BACKGROUND Intravascular lymphoma(IVL)is a rare subtype of lymphoma involving the growth of lymphoma cells within the vessel lumina without *** of various modes of presentation and its rarity,IVL is often diagnosed ***,we report a case of intravascular B-cell lymphoma with hypopituitarism,an extremely rare complication,that was successfully treated with *** SUMMARY An 80-year-old Japanese woman presented with a 7-mo history of a tingling sensation in the lower *** also presented with various other symptoms such as pancytopenia,high fever daily,and unconsciousness with *** the doctor who previously treated her diagnosed hypoglycemia as being due to hypopituitarism,the cause of the other symptoms remained uncertain despite a 7-mo evaluation *** performed bone marrow aspiration to evaluate pancytopenia and found that she had hemophagocytic lymphohistiocytosis(HLH).On the basis of a random skin biopsy for assessing the cause of HLH,she was diagnosed with intravascular B-cell *** and hypopituitarism were considered secondary to *** her clinical findings matched the presentations of *** was immediately treated with chemotherapy and achieved complete *** was relapse free two years after *** IVL should be included in the differential diagnosis of hypopituitarism,which although life-threatening,is treatable through prompt diagnosis and appropriate chemotherapy.

关键词： Intravascular lymphoma Random skin biopsy Hypopituitarism General internal medicine Tingling Pancytopenia Case report

Transport, signaling, and homeostasis of potassium and sodium in plants

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Journal of Integrative Plant Biology 2014年第3期56卷 231-249页

作者： eri Adams Ryoung Shin RIKEN Center for Sustainable Resource Science

Potassium （K＋） is an essential macronutrient in plants and a lack of K＋ significantly reduces the potential for plant growth and development. By contrast, sodium （Na＋）, while beneficial to some extent, at high concentrations it disturbs and inhibits various physiological processes and plant growth. Due to their chemical similarities, some functions of K＋ can be undertaken by Na＋ but K＋ homeostasis is severely affected by salt stress, on the other hand. Recent advances have highlighted the fascinating regulatory mechanisms of K＋ and Na＋ transport and signaling in plants. This review summarizes three major topics：（i） the transport mechanisms of K＋ and Na＋ from the soil to the shoot and to the cellular - compartments; （ii） the mechanisms through which plants sense and respond to K＋ and Na＋ availability; and （iii） the components involved in maintenance of K＋/Na＋ homeostasis in plants under salt stress.

关键词： Homeostasis potassium signaling sodium transport

Noise Reduction and Surge Margin Improvement Using Tapered Diffuser Vane in a Centrifugal Compressor

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Journal of Thermal Science 2010年第1期19卷 21-25页

作者： Takashi Goto eri Ohmoto Yutaka Ohta Eisuke Outa Department of Applied Mechanics and Aerospace Engineering Waseda University Graduate Student Graduate School of Applied Mechanical EngineeringWaseda University

Improvement of surge margin and reduction of interaction tone noise radiated from a centrifugal compressor with a vaned diffuser is discussed from experiments and CFD *** types of one-side tapered diffuser vanes,which are shroud-and hub-side tapered vanes,were used in the *** height of the leading edge of the tapered vanes varied from 100% to 10%.Both types of tapered vanes are effective for the reduction of the interaction tone noise radiated from the compressor,because of the smaller interaction area between impeller-discharge flow and diffuser vane ***,the hub-side tapered diffuser vane suppresses the evolution of the leading-edge vortex,which causes reverse-flow in the diffuser ***,the hub-side tapered diffuser vane,which has an optimized diffuser leading edge shape,can improve the compressor pressure-rise characteristics at low-flow operation and can enlarge the surge margin.

关键词： Centrifugal compressor tapered diffuser vane interaction tone noise CFD

Strategies to prevent hypertrophic scar formation:a review of therapeutic interventions based on molecular evidence

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Burns & Trauma 2020年第1期8卷 433-440页

作者： eri Shirakami Sho Yamakawa Kenji Hayashida Division of Plastic and Reconstructive Surgery Shimane University Faculty of Medicine89-1 Enya-choIzumoShimane 693-8501Japan

Once scar tissues mature,it is impossible for the surrounding tissue to regenerate normal dermal ***,it is essential to understand the fundamental mechanisms and establish effective strategies to inhibit aberrant scar *** scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound ***,the underlying mechanisms of hypertrophic scar development are poorly *** purpose of this review was to outline the management in the early stage after wound healing to prevent hypertrophic scar formation,focusing on strategies excluding therapeutic agents of internal *** aimed at molecular targets,including cytokines,will be future options to prevent and treat hypertrophic *** basic studies and clinical trials,including combination therapy,are required to investigate the mechanisms and prevent hypertrophic scar formation.

关键词： Hypertrophic scar Therapy Intervention Cytokines

Acute development of collateral circulation and therapeutic prospects in ischemic stroke

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Neural Regeneration Research 2016年第3期11卷 368-371页

作者： eri Iwasawa Masahiko Ichijo Satoru Ishibashi Takanori Yokota Department of Neurology and Neurological Science Tokyo Medical and Dental University

In acute ischemic stroke,collateral circulation plays an important role in maintaining blood flow to the tissue that is at risk of progressing into ischemia,and in increasing the successful recanalization rate without hemorrhagic *** have reported that well-developed collateral circulation is associated with smaller infarct volume and better long-term neurological outcome,and it disappears promptly once the effective recanalization is *** to the belief that collateral vessels develop over time in chronic stenotic condition,there exists a phenomenon that collateral circulation develops immediately in acute stenosis or occlusion of the arteries and it seems to be triggered by fluid shear stress,which occurs between the territories of stenotic/occluded arteries and those fed by surrounding intact *** believe that this acute development of collateral circulation is a target of novel therapeutics in ischemic stroke and refer our recent attempt in enhancing collateral circulation by modulating sphingosine-1-phosphate receptor 1,which is a known shear-stress mechanosensing protein.

关键词： ischemic stroke collateral S1PR1 shear stress leptomeningeal arteries PCA laterality hyperintensive vessels

Volvulus of the gall bladder diagnosed by ultrasonography,computed tomography,coronal magnetic resonance imaging and magnetic resonance cholangio-pancreatography

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World Journal of Gastroenterology 2006年第28期12卷 4599-4601页

作者： Nobuhisa Matsuhashi Shinichi Satake Kazunori Yawata eri Asakawa Takashi Mizoguchi Masayuki Kanematsu Hiroshi Kondo Ichiro Yasuda Kenichi Nonaka Chihiro tanaka Atsushi Misao Shinji Ogura Department of Emergency and Disaster Medicine Gifu University1-1 Yanagido501-1194Gifu CityJapan Department of Radiology Gifu University1-1 Yanagido501-1194Gifu CityJapan Department of Gastroenterology Gifu University1-1 Yanagido501-1194Gifu CityJapan Department of Surgical Oncology Gifu University1-1 Yanagido501-1194Gifu CityJapan Department of Surgery Misao HospitalYotsuyachou500-8088Gifu CityJapan

A 54-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Upon physical examination the vital signs of the patient were within normal ranges. Ultrasonography and computed tomography （CT） examination of the abdomen was obtained, which demonstrated a large dilatated cystic structure, measuring approximately 68.6 mm × 48.6 mm, with marked distension and inflammation. Additionally, the enhanced CT was characterized by the non-enhanced wall of the gallbladder. As the third examination in this study, magnetic resonance imaging （MRI）, namely coronal MRI and magnetic resonance cholangio-pancreatography （MRCP）, were performed. The MRCP demonstrated a dilatation of the gallbladder but detected no neck of the gallbladder. Simple cholecystectomy was performed. Macroscopic findings included a distended and gangrenous gallbladder, and closer examination revealed a counterclockwise torsion of 360 degrees on the gallbladder mesentery. Coronal MRI and MRCP showing characteristic radiography may be useful in making a definitive diagnosis.

关键词： Volvulus of the gallbladder Computed tomography Magnetic resonance imaging Magnetic resonance cholangio-pa ncreatography

An application of 1D convolution and deep learning to remote sensing modelling of Secchi depth in the northern Adriatic Sea

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Big Earth Data 2024年第1期8卷 82-114页

作者： Antonia Ivanda LjiljanaŠerić DušanŽagar Krištof Oštir Faculty of Electrical Engineering Mechanical Engineering and Naval ArchitectureUniversity of SplitSplitCroatia Faculty of Civil and Geodetic Engineering University of LjubljanaLjubljanaSlovenia

This paper presents a novel approach for predicting the water quality indicator-Secchi disk depth(Z_(SD)).Z_(SD)indirectly reflects water clarity and serves as a proxy for other quality *** study utilizes Deep Neural Network(DNN)trained on satellite remote sensing and measured data from three sources:two datasets obtained from official agencies in Croatia and Slovenia,and one citizen science data source,all covering the northern coastal region of the Adriatic *** proposed model uses 1D Convolutional Neural Network(CNN)in the spectral dimension to predict Z_(SD).The model’s performance indicates a strong fit to the observed data,proving capability of 1D-CNN to capture changes in water *** the test dataset,the model achieved a high R-squared value of 0.890,a low root mean squared error(RMSE)of 0.023 and mean absolute error(MAE)of *** results demonstrate that employing a 1D-CNN in the spectral dimension of Sentinel-3 OLCI data is an effective approach for predicting water *** findings have significant implications for monitoring Z_(SD)in coastal *** integrating diverse data sources and leveraging advanced machine learning algorithms,a more accurate and comprehensive assessment of water quality can be achieved.

关键词： Secchi Sentinel-3 OLCI 1DCNN Adriatic sea