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Successful treatment of tubulointerstitial nephritis in immunoglobulin G4-related disease with rituximab: A case report

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World Journal of Clinical Cases 2019年第16期7卷 2309-2315页

作者： eray eroglu Murat Hayri Sipahioglu Soner Senel Sule Ketenci Ertas Seyma Savas Figen Ozturk Ismail Kocyigit Bulent Tokgoz Oktay Oymak Division of Nephrology Department of Internal MedicineErciyes University School of MedicineKayseri 38039Turkey Division of Rheumatology Department of Internal MedicineErciyes University School of MedicineKayseri 38039Turkey Department of Internal Medicine Erciyes University School of MedicineKayseri 38039Turkey Department of Pathology Erciyes University School of MedicineKayseri 38039Turkey

BACKGROUND Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition that consisted of disorders that share particular clinical,serologic and pathologic *** common presentation of disease includes tumor-like swelling of involved organs and the histopathological findings are a lymphoplasmacytic infiltrate enriched with IgG4-positive plasma cells,and a variable degree of fibrosis that has a characteristic "storiform" pattern in biopsy specimens of tumorlike *** presentations of this disease,which often affects more than one organ,include autoimmune pancreatitis,salivary gland disease (sialadenitis),orbital disease and retroperitoneal *** steroid treatment is essential for the treatment of the disease however,other immunosuppressive drugs including cyclophosphamide or rituximab could be an option in resistant *** SUMMARY Herein,we reported a 34-year-old woman whom previously had diagnosed with asthma,rheumatoid arthritis and Sj?gren’s syndrome (SS) referred our nephrology department due to acute kidney failure development at the last rheumatology *** kidney biopsy she has been diagnosed with IgG4-RD and tubuluointerstitial *** had been accepted resistant to steroid,mycophenolate mofetil,methotrexate and azathioprine therapies due to receiving in last two *** refused to receive cyclophosphamide due to potential gonadotoxicity of the ***,rituximab therapy was *** received 1000 mg infusion,15 d apart and 6 mo later it has been administered same *** one year from the last rituximab dose serum creatinine decreased from 4.4 mg/dL to 1.6 mg/dL,erythrocyte sedimentation rate decreased from 109 mm/h to 13 mm/h [reference range (RR) 0-20],and Creactive protein decreased from 55.6 mg/L to 5 mg/L (RR 0–6).All pathologic lymph nodes and masses were also *** Patients with IgG4-RD usually misdiagnosed with rheumatologic diseases including systemic lupus erythem

关键词： Immunoglobulin G4-related disease Tubulointerstitial nephritis Rituximab Case report

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Unicentric Castleman's disease associated with end stage renal disease caused by amyloidosis

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World Journal of Clinical Cases 2017年第3期5卷 119-123页

作者： eray eroglu Ismail Kocyigit Aydin Unal Murat Hayri Sipahioglu Hulya Akgun Leylagul Kaynar Bulent Tokgoz Oktay Oymak Division of Ne-phrology Department of Internal MedicineErciyes University School of Medicine Department of Pathology Erciyes University School of Medicine Division of Hematology Department of Internal MedicineErciyes University School of Medicine

Castleman's disease(CD), also known as angiofolicular lymph node hyperplasia, is a rare heterogenous group of lymphoproliferative disorders. Histologically, it can be classified as hyaline vascular type, plasma cell type, or mixed type. Clinically two different subtypes of the CD are present: Unicentric and multicentric. Unicentric CD is generally asymptomatic and associated with hyaline vascular type, and its diagnoses depend on the localized lymphadenopathy on examination or imaging studies. However, multicentric CD presents with generalized lymphadenopathy and systemic symptoms including malaise, fever, night sweats, weight loss, and it is associated with the plasma cell type and mix type. Herein, we report a patient with unicentric CD of the plasma cell type without systemic symptoms, who developed end stage renal failure caused by amyloidosis 6 years after onset of CD.

关键词： Castleman’s disease Amyloidosis Plasma cell Inflammation End stage renal disease

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Marker-Based,3-D Adaptive Cartesian Grid Method for Multiphase Flow Around Irregular Geometries

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Communications in Computational Physics 2009年第1期5卷 1-41页

作者： eray Uzgoren Jaeheon Sim Wei Shyy Department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA24060USA Department of Aerospace Engineering University of MichiganAnn ArborMI48109USA

Computational simulations of multiphase flow are challenging because many practical applications require adequate resolution of not only interfacial physics associated with moving boundaries with possible topological changes,but also around three-dimensional,irregular solid *** this paper,we highlight recent efforts made in simulating multiphase fluid dynamics around complex geometries,based on an Eulerian-Lagrangian *** approach uses two independent but related grid layouts to track the interfacial and solid boundary conditions,and is capable of capturing interfacial as well as multiphase *** particular,the stationary Cartesian grid with time dependent,local adaptive refinement is utilized to handle the computation of the transport equations,while the interface shape and movement are treated by marker-based triangulated surface meshes which freely move and interact with the Cartesian *** markers are also used to identify the location of solid boundaries and enforce the no-slip condition *** related to the contact line treatment,topological changes of multiphase fronts during merger or breakup of objects,and necessary data structures and solution techniques are also *** test cases including spacecraft fuel tank flow management and liquid plug flow dynamics are presented.

关键词： Multiphase flows irregular geometry interface tracking adaptive Cartesian grid non-conforming boundary methods contact line treatment

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Clustering Seismic Activities Using Linear and Nonlinear Discriminant Analysis

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Journal of Earth Science 2014年第1期25卷 140-145页

作者： H Serdar Kuyuk eray Yildirim Emrah Dogan Gunduz Horasan Department of Civil Engineering Faculty of EngineeringSakarya University Department of Geophysical Engineering Faculty of EngineeringSakarya University

Identification and classification of different seismo-tectonic events with similar character- istics in a region of interest is one of the most important subjects in seismic hazard studies. In this study, linear and nonlinear discriminant analyses have been applied to classify seismic events in the vicinity of Istanbul. The vertical components of the digital velocity seismograms are used for seismic events with magnitude （Md） between 1.8 and 3.0 that occurred between 2001 and 2004. Two, time dependent pa- rameters, complexity and S/P peak amplitude ratio are selected as predictands. Linear, quadratic, diag- linear and diagquadratic discriminant functions are investigated. Accuracy of methods with an addi- tional adjusted quadratic models are 96.6%, 96.6%, 95.5%, 96.6%, and 97.6%, respectively with a vari- ous misclassified rate for each class. The performances of models are justified with cross validation and resubstitution error. Although all models remarkably well performed, adjusted quadratic function achieved the best success rate with just 4 misclassified events out of 179, even better compared to com- plex methods such as, self organizing method, k-means, Gaussion mixture models that applied to same dataset in literature.

关键词： discriminant analysis clustering analysis self organizing map k-means Gaussion mix- ture models.

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Protective effect of basic fibroblast growth factor on laser induced retinopathy

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 744-751页

作者： Unal Kartal Emel Koptagel H.eray Bulut Haydar Erdogan Department of Histology and Embryology Faculty of MedicineCumhuriyet University Department of Ophtalmology Faculty of MedicineCumhuriyet University

AIM:To investigate the side effects of the commonly used laser treatment along with testing the neuroprotective effect of bFGF on a potential retinal ***:To do this,30 chinchilla pigmented adult male rabbits were divided into the control and experimental *** control and experimental groups underwent both laser application and bFGF *** retinal tissue impairment and its renewal rate were tested under the light and electron microscopical ***:The focal laser application on rabbit eyes caused morphological alterations both in the application region and in the neighbouring *** the damaged areas,the outer nuclear layer of the neural retina was almost disappeared,retina pigment epithelium was interrupted,the retina pigment epithelium migrated intraretinally,and the damaged region along with neighbouring areas seemed to be not *** application just after the laser photocoagulation,revealed better results in application ***:It could be suggested that the bFGF application following laser photocoagulation might have protective,repairing and wound healing effects on the retina.

关键词： retina bFGF laser photocoagulation rabbit light microscopy electron microscopy

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Modification of Moufarrege Total Posterior Pedicle Mammaplasty: Conical Plicated Central U Shaped (COPCU's) Mammaplasty

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Surgical Science 2011年第2期2卷 80-88页

作者： eray Copcu 不详

Reduction mammaplasty and mastopexy is one of the biggest operation groups which have many techniques and their modifications. Generally accepted that, new modifications are the results of improvements of existing techniques. In this study we present a new modification of Moufarrege total posterior pedicle mammaplasty. We performed central plication to achieve a juvenile look in the superior pole of the breast and to prevent postoperative pseudoptosis and used central U shaped flap to achieve maximum NAC safety and to preserve lactation and nipple sensation. Sixty-nine patients were operated with the above mentioned tech-nique. Out of 69 patients, 52 underwent reduction mammaplasty (11 had gigantomastia), eleven mastopexy, and six oncoplastic. All of the patients were satisfied with functional and aesthetic results and none of them had major complications such as total NAC loss. Only six patients had wound healing problems on the suture line and two patients had minimal hematoma. Since we performed conical plication we would like to evalu-ate long term effects of the plication in the breast parenchyma. Breast parenchyma was visualized with USG in younger patients and mammography in older patient in postoperative 6 months and 1 year. We never observed any problem related with our sutures and retroareolar part of the areola examination for ductal patency was performed and interestingly all the patients had very clear ductal patency. Our modification is a safe, reliable technique which creates the least scar, avoids previously described disadvantages, provides maximum preservation of functions, can be employed in all breasts regardless of their sizes and is appropriate for oncoplastic surgery and revision surgery.

关键词： Breast Reduction Mammaplasty Pedicle

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Acupuncture Enhances Chances of Pregnancy in Unexplained Infertile Patients Who Undergo A Blastocyst Transfer in A Fresh-Cycle

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Chinese Journal of Integrative Medicine 2019年第4期25卷 298-302页

作者： Hakan ?oksüer Mert Ula Barut Murat BozkurT Elif Agacayak Sibel Sak Mustafa Demir eray Cal?skan Diyarlife IVF Center Department of Obstetrics and Gynecology Harran University School of Medicine Department of Obstetrics and Gynecology Bahcesehir University Department of Obstetrics and GynecologyVM Medikalpark Pendik Hospital Dicle University School of Medicine Department of Obstetrics and Gynecology Bahcesehir University Department of Obstetrics and Gynecology

Objective: To analyze the effects of acupuncture on in vitro fertilization patients with unexplained ***: We retrospectively analyzed the charts of a total of 302 cycles performed in 273 patients attending Assisted Reproductive Technology(ART) Centre from August 2013 to August *** the study period,embryo transfer with acupuncture(Acupuncture group,46 cases) and without acupuncture(Control group,42 cases) were *** to embryo transfer,the following points were used in the acupuncture group: Neiguan(CX 6),Diji(SP 8),Taichong(Liv 3),Baihui(Gv 20),and Guilai(S 29).These sessions were carried out two times before and after embryo transfer in a single *** addition,auricular acupuncture was also performed at ear points,including ear point 55(Shenmen),ear point 58(Zhigong),ear point 22(Neifenmi)and ear point 34(Naodian).The biochemical pregnancy rate and clinical pregnancy rate after transplantation were compared between two ***: The clinical pregnancy rate in the acupuncture group was higher than that in the control group [60.9%(28/46) vs.33.3%(14/42),respectively,P<0.05].Likewise,the live birth rate in the acupuncture group was also higher than that in the control group [71.7%(33/46) vs.31.0%(12/42),P<0.01).Conclusion: Administration of acupuncture on the day of embryo transfer dramatically improved fertility results in women who underwent in vitro fertilization/intra-cytoplasm sperm injection for reproduction.

关键词： acupuncture assisted reproduction embryo transfer pregnancy rate

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Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 795-799页

作者： Osman Sevki Arslan Ceyhun Arici Mustafa Unal Erdogan Cicik Mehmet Serhat Mangan eray Atalay Department of Ophthalmology Cerrahpasa Medical FacultyIstanbul University Department of Ophthalmology Medical FacultyAkdeniz University

AIM:To determine the safety of prophylactic intracameral moxifloxacin after cataract surgery in patients with penetrating keratoplasty(PKP).METHODS:In this retrospective study of consecutive patients who had phacoemulsification cataract surgery after PKP, were treated with intracameral moxifloxacin0.5% ophthalmic solution(0.5 mg/0.1 mL). The main outcome measures were anterior chamber reaction, best corrected visual acuity(BCVA), corneal endothelial cell count(ECC), and central corneal thickness(CCT).RESULTS:Fifty-five patients were recruited(26 males,29 females). The mean age was 54.36±4.97y(range 45-64y).All eyes had improved postoperative BCVA. The mean BCVA was 0.25 preoperatively and 0.57 postoperatively,which was statistically significant(P <0.001). One eye had 3+, 7 eyes had 2+, 12 eyes had 1+ and 8 eyes had trace amount of aqueous cells on the first day after surgery. All eyes had no anterior chamber cells at subsequent follow up examinations. Effective phacoemulsification time was 4.33 ±1.01 s. The mean ECC was 2340.20 cells/mm2 preoperatively and 1948.75 cells/mm21 mo postoperatively(P <0.001). The increase of21.09 μm in postoperative pachymetry 1mo after surgery was statistically significant(P <0.001).CONCLUSION:Nountowardeffectswereobservedafter intracameral injection of moxifloxacin(0.5 mg/0.1 mL) in terms of anterior chamber reaction, CCT, ECC, and visual rehabilitation at the conclusion of cataract surgery in patients with PKP.

关键词： cataract surgery intracameral injection moxifloxacin penetrating keratoplasty phacoemulsification

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Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

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World Journal of Diabetes 2020年第7期11卷 309-321页

作者： Banu Buyukaydin eray Metin Guler Tahsin Karaaslan Atilla Olgac Mehmet Zorlu Muharrem Kiskac Abdurrahim Kocyigit Department of Internal Medicine Bezmialem Vakif University Medical FacultyIstanbul 34093Turkey Department of Medical Biochemistry Bezmialem Vakif University Medical FacultyIstanbul 34093Turkey Department of Nephrology Istanbul Medeniyet University Medical FacultyIstanbul 34093Turkey

BACKGROUND Diabetic polyneuropathy is a very common complication of *** studies are available in terms of *** examination methods with low reliability are still not standardized and generally time ***,easy-to-access methods are *** markers are one of the subjects of *** aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of *** To determine the place and availability of visfatin and thiol-disulfide homeostasis in this *** A total of 392 patients with type 2 diabetes mellitus were included in the *** polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and *** biochemical parameters,oxidative stress markers,visfatin,and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical *** Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration(P<0.005).Neuropathy related symptoms were present in 20.7%of the patients,but neuropathy related findings were observed in 43.9%of the *** glucose,glycated hemoglobin,and visfatin were positively correlated with each ***,these parameters were positively correlated with the total oxidative stress *** and native thiol was positively correlated with total antioxidant status and negatively with oxidant *** thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status(P<0.005).There was no correlation between visfatin and thiol-disulphide(P=0.092,r=0.086).However,a significant negative correlation was observed between visfatin and total with native thiol(P<0.005,r=-0.

关键词： Diabetic neuropathy Diabetic foot Early detection Oxidative stress Thioldisulfide Visfatin protein

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Design of the Model Predictive Control Education and Application Interface

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Journal of Software Engineering and Applications 2012年第9期5卷 677-681页

作者： eray Yilmazlar Erkan Kaplanoglu Department of Mechatronics Technical Education FacultyMarmara UniversityIstanbulTurkey

In this study, an education and application interface was designed for model predictive control (MPC). For this design, MPC Toolbox and MATLAB GUI in the MATLAB software were used. Developed interface includes model predictive control methods, such as single-input single-output, multi-input multi-output, constrained or unconstrained systems. The interface, developed for education of model predictive control methods, was tested in class by the students attending to the Process Dynamic and Control course.

关键词： Model Predictive Control MATLAB MPC MPC Toolbox MPC Interface

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