Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

作     者：Banu Buyukaydin Eray Metin Guler Tahsin Karaaslan Atilla Olgac Mehmet Zorlu Muharrem Kiskac Abdurrahim Kocyigit 

作者机构：Department of Internal MedicineBezmialem Vakif University Medical FacultyIstanbul 34093Turkey Department of Medical BiochemistryBezmialem Vakif University Medical FacultyIstanbul 34093Turkey Department of NephrologyIstanbul Medeniyet University Medical FacultyIstanbul 34093Turkey 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2020年第11卷第7期

页      面：309-321页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Diabetic neuropathy Diabetic foot Early detection Oxidative stress Thioldisulfide Visfatin protein 

摘      要：BACKGROUND Diabetic polyneuropathy is a very common complication of *** studies are available in terms of *** examination methods with low reliability are still not standardized and generally time ***,easy-to-access methods are *** markers are one of the subjects of *** aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of *** To determine the place and availability of visfatin and thiol-disulfide homeostasis in this *** A total of 392 patients with type 2 diabetes mellitus were included in the *** polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and *** biochemical parameters,oxidative stress markers,visfatin,and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical *** Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration(P0.005).Neuropathy related symptoms were present in 20.7%of the patients,but neuropathy related findings were observed in 43.9%of the *** glucose,glycated hemoglobin,and visfatin were positively correlated with each ***,these parameters were positively correlated with the total oxidative stress *** and native thiol was positively correlated with total antioxidant status and negatively with oxidant *** thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status(P0.005).There was no correlation between visfatin and thiol-disulphide(P=0.092,r=0.086).However,a significant negative correlation was observed between visfatin and total with native thiol(P0.005,r=-0.