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Discussion 2 on "Introspection on improper seismic retrofit of Basilica Santa Maria di Collemaggio after 2009 Italian earthquake" by ***,*** and *** Stefano

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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 289-290页

作者： enzo Cartapati Department of Structural & Geotechnical Engineering(DISG) University of Rome 'La Sapienza'RomeItaly

This discussion will address two aspects found in the paper:lack of proper information and some mistakes. Lack of proper information In Section 2 of the paper,a short review of the seismic events suffered by the Basilica and of the interventions of reconstruction which have followed is presented,but the main effects of these events are not

关键词： by G.P.Cimellaro,A.M.Reinhorn and A.De Stefano Discussion 2 on De

A Grain of Dust Falling Through a Sierpinski Gasket

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Acta Mathematica Sinica,English Series 2007年第6期23卷 1095-1108页

作者： Samantha LEORATO enzo ORSINGHER Dipartimento di Statistica Probabilitd e Statistiche ApplicateUniversity of Rome "La Sapienza"P.le A.Moro5-00185 RomaItaly

In this paper we analyze the downward random motion of a particle in a vertical, bounded, Sierpinski gasket G, where at each layer either absorption or delays are considered. In the case of motion with absorption the explicit distribution of the position of the descending particle in the pre-gasket Gn is obtained and the limiting case of the Sierpinski gasket discussed. For the delayed downward motion we derive a representation of the random time needed to arrive at the base of Gn in terms of independent binomial random variables （containing the contribution of delays at different layers with different geometrical structures）.

关键词： Binomial random variables fractals Hausdorff dimension random walks self-similarity

Magnitude of the contralateral efferent olivocochlear effect as a function of the frequency

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Journal of Otology 2022年第2期17卷 67-71页

作者： Fernanda Anza Miranda enzo Aguilar-Vidal Laboratorio de Audiología y Percepcion Auditiva Facultad de MedicinaUniversidad de ChileChile Escuela de Tecnología Medica Facultad de MedicinaUniversidad de ChileChile Departamento de Tecnología Medica Facultad de MedicinaUniversidad de ChileChile

Background:The activation of the medial olivocochlear reflex reduces the cochlear gain,which is manifested perceptually as decreased auditory ***,it has remained unclear whether the extent of this suppression varies according to the cochlear region *** we aims to assess the magnitude of contralateral efferent suppression across human cochlea,at low levels,and its impact on hearing ***:Assuming that acoustic stimulation activates the contralateral medial olivocochlear reflex,we evaluated the magnitude of the suppressive effect as a function of frequency in 17 subjects with normal *** thresholds were measured for bursts tones of various durations(10,100,and 500 ms)and frequencies(250,500,1000,4000,and 8000 Hz)in the presence or absence of contralateral white noise at 60 d B ***:We found that contralateral noise raised the absolute threshold for the burst tones *** effect was greater at lower than higher frequencies(3.85 d B at 250 Hz vs.2.22 d B at 8000 Hz).Conclusions:Our findings suggest that in humans,the magnitude of this suppression varies according to the cochlear region stimulated,with a greater effect towards the apex(lower frequencies)than the base(higher frequencies)of the cochlea.

关键词： Auditory perception Efferent system Medial olivocochlear reflex Absolute threshold

Management of liver cirrhosis between primary care and specialists

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World Journal of Gastroenterology 2011年第18期17卷 2273-2282页

作者： Ignazio Grattagliano enzo Ubaldi Leonilde Bonfrate Piero Portincasa Italian College of General Practitioners (SIMG) Via del Pignoncino 9-11 50142 Firenze Italy Clinica Medica "A. Murri" Department of Internal and Public Medicine University Medical School of Bari

This article discusses a practical, evidence-based approach to the diagnosis and management of liver cirrhosis by focusing on etiology, severity, presence of complications, and potential home-managed treatments. Relevant literature from 1985 to 2010 (PubMed) was reviewed. The search criteria were peer-reviewed full papers published in English using the following MESH headings alone or in combination: "ascites", "liver fibrosis", "cirrhosis", "chronic hepatitis", "chronic liver disease", "decompensated cirrhosis", "hepatic encephalopathy", "hypertransaminasemia", "liver transplantation" and "portal hypertension". Forty-nine papers were selected based on the highest quality of evidence for each section and type (original, randomized controlled trial, guideline, and review article), with respect to specialist setting (Gastroenterology, Hepatology, and Internal Medicine) and primary care. Liver cirrhosis from any cause represents an emerging health issue due to the increasing prevalence of the disease and its complications worldwide. Primary care physicians play a key role in early identification of risk factors, in the management of patients for improving quality and length of life, and for preventing complications. Specialists, by contrast, should guide specific treatments, especially in the case of complications and for selecting patient candidates for liver transplantation. An integrated approach between specialists and primary care physicians is essential for providing better outcomes and appropriate home care for patients with liver cirrhosis.

关键词： Ascites Family medicine Hepatic encephalopathy Hypertransaminasemia Portal hypertension

Intraepithelial lymphocytes: bystanders or causative factors in functional gastrointestinal disorders?

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Cellular & Molecular Immunology 2021年第7期18卷 1620-1621页

作者： Giuseppe Losurdo Domenico Piscitelli enzo Ierardi Alfredo Di Leo Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBariItaly Ph.D.Course in Organs and Tissues Transplantation and Cellular Therapies Department of Emergency and Organ TransplantationUniversity of BariBariItaly Section of Pathology Department of Emergency and Organ TransplantationUniversity of BariBariItaly

Intraepithelial lymphocytes(IELs)are immune cells located in the epithelium of the mucosal layer of the gastrointestinal tract that typically show a CD3-positive *** are T lymphocytes that are involved in the primary immune response to several luminal antigens,such as food proteins and infectious *** this reason,their increase may be pathogenetic in several diseases,the most important being celiac ***,an increase above 25 IELs/100 enterocytes in the duodenum,which is considered the cutoff value for celiac disease,may occur in several conditions,such as nonceliac gluten sensitivity,food allergy,Helicobacter pylori(***)infection,gastroenteritis,and even irritable bowel syndrome(IBS).Therefore,the generic term“microscopic enteritis”or“duodenal lymphocytosis”has been proposed for this condition.

关键词： lymphocytes gastrointestinal epithelium

Combined use of lactoferrin and vitamin D as a preventive and therapeutic supplement for SARS-CoV-2 infection: Current evidence

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World Journal of Clinical Cases 2022年第32期10卷 11665-11670页

作者： Massimiliano Cipriano enzo Ruberti Marcos Roberto Tovani-Palone Department of Laparoscopic Surgery Umberto I General HospitalMedical School Sapienza UniversityRome 161Italy Department of Human Neuroscience Sapienza University of RomeRome 00185Italy Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India

Lactoferrin is a multifunctional protein that exhibits anti-inflammatory,immune regulating and anti-infective *** of its receptor sites is located on severe acute respiratory syndrome coronavirus *** binding of lactoferrin with heparin sulfate proteoglycans may prevent the first contact between the virus and host cells,thus preventing subsequent *** that lactoferrin may act as a natural mucosal barrier,an intranasal treatment together with its oral intake can be hypothesized to prevent the spread,infection and inflammation caused by coronavirus disease 2019(COVID-19).Moreover,the literature reports that vitamin D plays an essential role in promoting immune *** its antiinflammatory and immunoregulatory properties,vitamin D is critical for activating the immune system’s defenses,improving immune cell *** studies also demonstrate that lactoferrin is a potential activator of the vitamin D *** this sense,the combined use of lactoferrin(through an association of oral intake and a nasal spray formulation)and vitamin D could represent a valuable therapy for COVID-19 treatment and ***,further randomized clinical trials are needed before recommending/prescribing them.

关键词： Lactoferrin Vitamin D SARS-CoV-2 COVID-19 Pandemics

Male accessory gland inflammation prevalence in type 2 diabetic patients With symptoms possibly reflecting autonomic neuropathy

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Asian Journal of Andrology 2014年第5期16卷 761-766,I0010,I0011页

作者： Rosita A Condorelli enzo Vicari Aldo E Calogero Sandro La Vignera Department of Medical and Pediatric Sciences Section of Endocrinology Andrology and Internal Medicine University of Catania Catania Italy

Male accessory gland inflammation or infection （MAGI） is a potentially underdiagnosed complication of type 2 diabetes （DM2）; specifically, we reported in a recent study that the frequency of MAGI was 43% among DM2 patients. In previous studies, we have demonstrated that diabetic autonomic neuropathy （DAN） is associated with a peculiar ultrasound characterization of the seminal vesicles （SVs） in DM2 patients. The aim of the present study was to evaluate the frequency of MAGI in two different categories of DM2 patients （i.e. patients with and without symptoms that possibly reflect DAN） and the respective ultrasound characterizations. Sixty DM2 patients with a mean （± s.e.m.） age of 42.0 ± 6.0 years （range： 34-47 years） were classified according to the presence or the absence of symptoms that could possibly reflect DAN （group A： DM2 with symptoms possibly reflecting DAN, n = 28 patients and group B： DM2 without symptoms possibly reflecting DAN, n = 32 patients）. The patients in Group A exhibited a significantly higher frequency of MAGI compared with those in group B patients （P 〈 0.05）; moreover, the Group A patients exhibited a significantly higher frequency of ultrasound signs suggestive of vesiculitis （P 〈 0.05）. Finally, the concentrations of lymphocytes but not the concentrations of the leukocytes in the semen were significantly higher （P 〈 0.05） in group A compared with group B.

关键词： diabetic neuropathy male accessory gland inflammation or infection male infertility

Laparoscopic resection vs laparoscopic radiofrequency ablation for the treatment of small hepatocellular carcinomas: A single-center analysis

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World Journal of Gastroenterology 2017年第4期23卷 653-660页

作者： Marco Casaccia Gregorio Santori Giuliano Bottino Pietro Diviacco enzo Andorno Department of Surgery IRCCSSan Martino University Hospital-ISTUniversity of Genoa Department of Surgical Sciences and Integrated Diagnostics School of MedicineUniversity of Genoa

AIMTo compare survival and recurrence after laparoscopic liver resection (LLR) and laparoscopic radiofrequency ablation (LRFA) for the treatment of small hepatocellular carcinoma (HCC).METHODSBetween June 1, 2005 and November 30, 2010, 46 patients (62.26 ± 8.55 years old; female/male: 12/34) treated for small HCC were enrolled following strict criteria. Patients with better liver function and larger tumors were referred for LLR (n = 24), while those with poorer liver function and multiple tumors were referred for LRFA (n = 22), and they were then followed for similar durations (44.74 ± 21.3 mo for LLR vs 40.27 ± 30.8 mo for LRFA).RESULTSThe LLR and LRFA groups were homogeneous with regard to age, sex, etiology of liver cirrhosis, and AFP levels. The overall survival (OS) and disease-free survival (DFS) probability was 0.354 and 0.260, respectively. A significantly higher OS was observed in the LLR group (LLR: 0.442; LRFA: 0.261; P = 0.048), whereas no statistical difference was found for DFS (LLR: 0.206; LRFA: 0.286; P = 0.205). In the LRFA group was treated a greater number of nodules (LLR: 1.41 ± 0.77; LRFA: 2.72 ± 1.54; P *** preliminary results confirm the superiority of hepatic resection on thermoablation in the treatment of small HCC in selected patients, when both approaches are made laparoscopically. LLR showed better results compared to LRFA in terms of OS. These data need to be confirmed by further studies on a larger number of patients.

关键词： Hepatocellular carcinoma Laparoscopic liver resection Laparoscopic radiofrequency ablation Survival Disease-free survival

Does alcohol have any effect on male reproductive Function？ A review of literature

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Asian Journal of Andrology 2013年第2期15卷 221-225,I0006页

作者： Sandro La Vignera Rosita A Condorelli Giancarlo Balercia enzo Vicari Aldo E Calogero Section of Endocrinology Andrology and Internal Medicine Department of Medical and Pediatric Sciences University of Catania Catania 95123 Italy Department of tnternat Medicine and Applied Biotechnologies Politechnic University of Marche Ancona 60100 Italy

Although alcohol is widely used, its impact on the male reproductive function is still controversial. Over the years, many studies have investigated the effects of alcohol consumption on sperm parameters and male infertility. This article reviews the main preclinical and clinical evidences. Studies conducted on the experimental animal have shown that a diet enriched with ethanol causes sperm parameter abnormalities, a number of alterations involving the reproductive tract inhibition, and reduced mouse oocyte in vitro fertilization rate. These effects were partly reversible upon discontinuation of alcohol consumption. Most of the studies evaluating the effects of alcohol in men have shown a negative impact on the sperm parameters. This has been reported to be associated with hypotestosteronemia and low-normal or elevated gonadotropin levels suggesting a combined central and testicular detrimental effect of alcohol. Nevertheless, alcohol consumption does not seem to have much effect on fertility either in in vitro fertilization programs or population-based studies. Finally, the genetic background and other concomitant, alcohol consumption-related conditions influence the degree of the testicular damage. In conclusion, alcohol consumption is associated with a deterioration of sperm parameters which may be partially reversible upon alcohol consumption discontinuation.

关键词： alcohol HPT hypothalamic-pituitary-testicular axis male infertility reproductive function sperm parameters spermatogenesis teratozoospermia