Intraepithelial lymphocytes: bystanders or causative factors in functional gastrointestinal disorders?

作     者：Giuseppe Losurdo Domenico Piscitelli Enzo Ierardi Alfredo Di Leo 

作者机构：Section of GastroenterologyDepartment of Emergency and Organ TransplantationUniversity of BariBariItaly Ph.D.Course in Organs and Tissues Transplantation and Cellular TherapiesDepartment of Emergency and Organ TransplantationUniversity of BariBariItaly Section of PathologyDepartment of Emergency and Organ TransplantationUniversity of BariBariItaly 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第7期

页      面：1620-1621页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：lymphocytes gastrointestinal epithelium 

摘      要：Intraepithelial lymphocytes(IELs)are immune cells located in the epithelium of the mucosal layer of the gastrointestinal tract that typically show a CD3-positive *** are T lymphocytes that are involved in the primary immune response to several luminal antigens,such as food proteins and infectious *** this reason,their increase may be pathogenetic in several diseases,the most important being celiac ***,an increase above 25 IELs/100 enterocytes in the duodenum,which is considered the cutoff value for celiac disease,may occur in several conditions,such as nonceliac gluten sensitivity,food allergy,Helicobacter pylori(***)infection,gastroenteritis,and even irritable bowel syndrome(IBS).Therefore,the generic term“microscopic enteritisor“duodenal lymphocytosishas been proposed for this condition.