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The Drosophila adult neuromuscular junction as a model for unravelling amyloid peptide influence on synapse dynamics

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Neural Regeneration Research 2017年第12期12卷 1987-1989页

作者： Begona López-Arias Ignacio Monedero enrique Turiégano Laura Torroja Department of Biology Universidad Autonoma de MadridMadrid Spain Department of Clinical and Experimental Medicine (IKE) Linkoping University Sweden

Amyloid peptide（Aβ）oligomers are considered one of the primary causal factors for the synaptic loss characteristic of Alzheimer’s disease（AD）（Karran and De Strooper,2016）.However,Aβis generated in normal brai... 详细信息

关键词： The Drosophila adult neuromuscular junction a model for unravelling amyloid peptide influence synapse dynamics

Selective suspension of single layer graphene mechanochemically exfoliated from carbon nanofibres

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Nano Research 2014年第7期7卷 963-972页

作者： Antonio Esau Del Rio-CastilloI Cesar Merino enrique Diez-Barra Ester Vazquez Departamento de Quimica Orgdnica Facultad de Ciencias y Tecnologfas Qufmicas-IRICA Universidad de Castilla-La Mancha 13071 Ciudad Real Spain Grupo Antolin Ingenieria S.A. Burgos E09007 Spain

This paper presents the first report of the successful ball-milling exfoliation of graphitic filaments （GANF~ carbon nanofibres） into single layer graphene. The addition of small amounts of solvent during the milling process makes it possible to enhance the intercalation of the exfoliating agent （melamine） between the graphene layers, thus promoting exceptional exfoliation. Advantage has also been taken of the fact that the Hansen solubility parameters of graphene are different from those of carbon fibres, which allows single and few-layer graphene to be suspended in a particular solvent, thus discriminating them from poorly exfoliated carbon nanofibres.

关键词： carbon fibre graphene ball-milling exfoliation Hansen solubilityparameters

Intraexaminer repeatability and agreement in stereoacuity measurements made in young adults

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 374-381页

作者： Beatriz Antona Ana Barrio Isabel Sanchez enrique gonzalez Guadalupe gonzalez Department of Optics II (Optometry and Vision) Faculty of Optics and Optometry Complutense University of Madrid

AIM: To determine the repeatability and agreement of stereoacuity measurements made using some of the most widely used clinical tests: Frisby, TNO, Randot and ***: Stereoacuity was measured in two different sessions separated by a time interval of at least 24 h but no longer than 1wk in 74 subjects of mean age 20.6y using the four methods. The study participants were divided into two groups: subjects with normal binocular vision and subjects with abnormal binocular ***: Best repeatability was shown by the Frisby and Titmus [coefficient of repeatability(COR): ±13 and±12s arc respectively] in the subjects with normal binocular vision though a clear ceiling effect was *** the subjects with abnormal binocular vision, best repeatability was shown by the Frisby(COR: ±69s arc)and Randot(COR: ±72s arc). In both groups, the TNO test showed poorest agreement with the other ***:Therepeatabilityofstereoacuitymeasures was low in subjects with poor binocular vision yet fairly good in subjects with normal binocular vision with the exception of the TNO test. The reduced agreement detected between the tests indicates they cannot be used interchangeably.

关键词： stereoacuity repeatability agreement tereopsis

Shallow water equations for power law and Bingham fluids Dedicated to the NSFC-CNRS Chinese-French summer institute on fluid mechanics in 2010

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Science China Mathematics 2012年第2期55卷 277-283页

作者： FERNANDEZ-NIETO enrique D. NOBLE Pascal VILA Jean-Paul Departamento de Matemdtica Aplicada I Universidad de Sevilla 41012 Sevilla Spain Universite de Lyon Universitd Lyon1 Institut Camille Jordan UMR CNRS 520843 blvd du 11 novembre 1918 F-69622 ViUeurbanne Cedex France Institut de Mathdmatiques de Toulouse UMR CNRS 5219 INSA de Toulouse 135 avenue de Rangueil 31077 Toulouse Cedex 4 France

In this note, we provide a consistant thin layer theory for power law and Bingham incompressible fluids flowing down an inclined plane under the effect of gravity. The derivation of such equations is based on formal asymptotic expansions of solutions of Cauchy momentum equations in the shallow water scaling and in the neighbourhood of steady solutions so that we can close the average equations on the fluid height h and the total discharge rate q.

关键词： shallow water equations asymptotic analysis non-Newtonian fluids

Automatic Detection of Nephrops Norvegicus Burrows from Underwater Imagery Using Deep Learning

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Computers, Materials & Continua 2022年第3期70卷 5321-5344页

作者： Atif Naseer enrique Nava Baro Sultan Daud Khan Yolanda Vila Jennifer Doyle ETSI Telecomunicación Universidad deMálagaMálaga29071Spain Department of Computer Science National University of TechnologyIslamabad44000Pakistan Instituto Espanol de Oceanografía Centro Oceanográfico de CádizCádiz39004Spain Marine Institute Rinville OranmoreIreland

The Norway lobster,Nephrops norvegicus,is one of the main commercial crustacean fisheries in *** abundance of Nephrops norvegicus stocks is assessed based on identifying and counting the burrows where they live from underwater videos collected by camera systems mounted on *** Spanish Oceanographic Institute(IEO)andMarine Institute Ireland(MIIreland)conducts annual underwater television surveys(UWTV)to estimate the total abundance of Nephrops within the specified area,with a coefficient of variation(CV)or relative standard error of less than 20%.Currently,the identification and counting of the Nephrops burrows are carried out manually by the marine *** is quite a time-consuming *** a solution,we propose an automated system based on deep neural networks that automatically detects and counts the Nephrops burrows in video footage with high *** proposed system introduces a deep-learning-based automated way to identify and classify the Nephrops *** research work uses the current state-of-the-art Faster RCNN models Inceptionv2 and MobileNetv2 for object detection and *** conduct experiments on two data sets,namely,the Smalls Nephrops survey(FU 22)and Cadiz Nephrops survey(FU 30),collected by Marine Institute Ireland and Spanish Oceanographic Institute,*** the results,we observe that the Inception model achieved a higher precision and recall rate than *** best mean Average Precision(mAP)recorded by the Inception model is 81.61%compared to MobileNet,which achieves the best mAP of 75.12%.

关键词： Faster RCNN computer vision nephrops norvegicus nephrops norvegicus stock assessment underwater videos classification

Surface chemistry of carbon nanoparticles functionally select their uptake in various stages of cancer cells

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Nano Research 2017年第10期10卷 3269-3284页

作者： Indrajit Srivastava Santosh K. Misra Fatemeh Ostadhossein enrique Daza Jasleena Singh Dipanjan Pan Department of Bioengineering University of Illinois Urbana-Champaign Urbana Illinois 61801 USA Biomedical Research Center Carle Foundation Hospital Urbana Illinois 61801 USA Department of Materials Science and Beckman Institute University of illinois Urbana-Champaign Urbana Illinois 61801 USA

Relationship of the surface physicochemical characteristics of nanoparticles with their interactions with biological entities may provide critical information for nanomedicinal application. Here, we report the systematic synthesis of sub-50 nm carbon nanoparticles （CNP） presenting neutral, anionic, and cationic surface functionalities. A subset of CNPs with -10, 20, and 40 nm hydrodynamic sizes were synthesized with neutral surface headgroups. For the first time, the cellular internalization of these CNPs was systematically quantified in various stages of breast cancer cells （early, late, and metastatic）, thereby providing a parametric assessment of charge and size effects. Distinct activities were observed when these systems interacted with cancer cells in various stages. Our results indicated that metastatic breast cancer could be targeted by a nanosystem presenting anionic phosphate groups. On the contrary, for patients in late stage of cancer, drugs could be delivered with sulfonate functionalized carbon nano- particles, which have higher probability of intracellular transport. This study will facilitate the better understanding of nanoparticle-biological entity interaction, and the integration of this knowledge with pathophysiology would promote the engineering of nanomedicine with superior likelihoods of crossing the endocytic ＂barrier＂ for drug delivery inside cancerous cells.

关键词： personalized medicine endocytosis surface charge size carbon nanoparticles

Appraisal of CO2 storage potential in compressional hydrocarbon-bearing basins: Global assessment and case study in the Sichuan Basin(China)

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Geoscience Frontiers 2020年第6期11卷 2309-2321页

作者： Xiaolong Sun Juan Alcalde enrique Gomez-Rivas Lucía Struth Gareth Johnson Anna Travé Department of Mineralogy Petrology and Applied GeologyUniversity of BarcelonaMartíi Franquès s/nBarcelona08028Spain Department of Structure and Dynamics of the Earth Institute of Earth Sciences Jaume AlmeraICTJA-CSICLluis Sole i Sabaris s/nBarcelona08028Spain Department of Civil and Environmental Engineering University of StrathclydeGlasgowG11XZUnited Kingdom

Carbon capture and storage(CCS)has been proposed as a potential technology to mitigate climate ***,there is currently a huge gap between the current global deployment of this technology and that which will be ultimately *** CO2 can be captured at any geographic location,storage of CO2 will be constrained by the geological storage potential in the area the CO2 is *** geological storage potential can be evaluated at a very high level according to the tectonic setting of the target *** date,CCS deployment has been restricted to more favourable tectonic settings,such as extensional passive margin and post-rift basins and compressional foreland ***,to reach the adequate level of deployment,the potential for CCS of regions in different tectonic settings needs to be explored and assessed ***,the potential of compressional basins for carbon storage has not been universally evaluated according to the global and regional carbon emission ***,we present an integrated source-to-sink analysis tool that combines comprehensive,open-access information on basin distribution,hydrocarbon resources and CO2 emissions based on geographical information systems(GIS).Compressional settings host some of the most significant hydrocarbon-bearing basins and 36% of inland CO2 emissions but,to date,large-scale CCS facilities in compressional basins are concentrated in North America and the Middle East *** source-to-sink tool allows identifying five high-priority regions for prospective CCS development in compressional basins:North America,north-western South America,south-eastern Europe,the western Middle East and western *** present a study of the characteristics of these areas in terms of CO2 emissions and CO2 storage ***,we conduct a detailed case-study analysis of the Sichuan Basin(China),one of the compressional basins with the greatest CO2 storage *** results indicate that c

关键词： CO2 storage Compressional basins CO2 emissions Sichuan Basin

Combining anti-inflammatory and unfolding protein responses to fight stroke

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Neural Regeneration Research 2019年第3期14卷 450-451页

作者： Berta Anuncibay-Soto enrique Font-Belmonte Arsenio Fernández-López área de Biología Celular Instituto de Biomedicina Universidad de León Neural Therapies SL Edificio Institutos de Investigación Campus de Vegazana

This perspective shows an attempt to obtain synergy effects to fight ischemic stroke by combining agents acting on two different homeostatic mechanisms:inflammation and unfolded protein response (Anuncibay-Soto et al.,2018).Different pharmacological approaches have been assayed to alleviate cerebrovascular accident (stroke), which represents one of the most devastating diseases in the elderly.

关键词： Combining anti-inflammatory

Tailoring chiral optical properties by femtosecond laser direct writing in silica

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Light(Science & Applications) 2023年第3期12卷 366-378页

作者： Jiafeng Lu Jing Tian Bertrand Poumellec enrique Garcia-Caurel Razvigor Ossikovski Xianglong Zeng Matthieu Lancry Institut de Chimie Moléculaire et des Matériaux d’Orsay UniversitéParis SaclayOrsay91405France Key Laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced CommunicationShanghai Institute for Advanced Communication and Data ScienceShanghai UniversityShanghai200444China LPICM CNRSEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau91128France

An object that possesses chirality,that is,having its mirror image not overlayed on itself by rotation and translation,can provide a different optical response to a left-or right-handed circular polarized *** nanostructures may exhibit polarization-selective optical properties that can be controlled for micro-to-nano optical element *** attractive way to induce such complex nanostructures in three-dimension in glass is femtosecond laser direct ***,the mechanism of femtosecond laser induced chirality remains to be unveiled due to complex physical and chemical processes occurring during the ultrashort light-matter ***,a phenomenological model is proposed and is built on two-layers phase shifters to account for this laser-induced optical chirality in an initially achiral material(silica glass).This model is based on the observation that femtosecond laser induced nanogratings own two principal contributions to its aggregate birefringent response:a form and a stress-related *** refining this formalism,a multilayer approach is developed to imprint on demand optical *** up to+/-60°at 550 nm within an optimal 80μm thickness in silica glass are possible,corresponding to the highest value in a glass to *** results provide new insights of circular-optical control in micro-nano optical manufacturing and open new opportunities for photonics applications.

关键词： polarization silica circular