The Drosophila adult neuromuscular junction as a model for unravelling amyloid peptide influence on synapse dynamics

作     者：Begona López-Arias Ignacio Monedero Enrique Turiégano Laura Torroja 

作者机构：Department of Biology Universidad Autonoma de MadridMadrid Spain Department of Clinical and Experimental Medicine (IKE) Linkoping University Sweden 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2017年第12卷第12期

页      面：1987-1989页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported Fundación Reina Sofía Grant PI0006-08 to LT by Ministerio de Ciencia y Tecnología(ES)grant BFU2008-04683-C02-02 to LT 

主　　题：The Drosophila adult neuromuscular junction a model for unravelling amyloid peptide influence synapse dynamics 

摘      要：Amyloid peptide（Aβ）oligomers are considered one of the primary causal factors for the synaptic loss characteristic of Alzheimer’s disease（AD）（Karran and De Strooper,2016）.However,Aβis generated in normal brains and accumulates at synaptic sites,which raises the question whether Aβplays a physiological role in synapses.