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costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis c

World Journal of Gastroenterology 2009年第41期15卷 5129-5140页

作者： Juan Ramón Larrubia Selma Benito-martínez Joaquín Miquel Miryam calvino Eduardo Sanz-de-Villalobos Trinidad Parra-cid Translational Hepatology Unit Guadalajara University Hospital University of Alcalá

Hepatitis c virus（HcV）-specific cD8^＋ T cells play an important role in the resolution of HcV infection. nevertheless, during chronic hepatitis c these cells lack their effector functions and fail to control the virus. HcV has developed several mechanisms to escape immune control. One of these strategies is the upregulation of negative co-stimulatory molecules such us programmed death-1 （PD-1）. This molecule is upregulated on intrahepatic and peripheral HcV-specific cytotoxic T cells during acute and chronic phases of the disease, whereas PD-1 expression is low in resolved infection. PD-1 expressing HcV-specific cD8^＋ T cells are exhausted with impairment of several effector mechanisms, such as： type-1 cytokine production, expansion ability after antigen encounter and cytotoxic ability. However, PD-1 associated exhaustion can be restored by blocking the interaction between PD-1 and its ligand （PD-L1）. After this blockade, HcV-specific cD8^＋ T cells reacquire their functionality. nevertheless, functional restoration depends on PD-1 expression level. High PD-l-expressing intrahepatic HcV-specific cD8^＋ T cells do not restore their effector abilities after PD-1/ PD-L1 blockade. The mechanisms by which HcV is able to induce PD-1 up-regulation to escape immune control are unknown. Persistent TcR stimulation by a high level of HcV antigens could favour early PD-1 induction, but the interaction between HcV core protein and gclq receptor could also participate in this process. The PD-1/PD-L1 pathway modulation could be a therapeutic strategy, in conjunction with the regulation of others co-stimulatory pathways, in order to restore immune response aclainst HcV to succeed in clearing the infection.

关键词： chronic hepatitis Exhaustion Hepatitis c virus core Hepatitis c virus Programmed death-1 Programmed death-1 ligand

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Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells

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World Journal of Gastroenterology 2021年第41期27卷 7025-7040页

作者： María Belén novoa Díaz Pedro Matías carriere María Julia martín natalia calvo claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Departamento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina

colorectal cancer(cRc)remains one of the leading causes of mortality from malignant diseases *** general terms,cRc presents high heterogeneity due to the influence of different genetic and environmental factors;also,the neoplastic cells are strongly influenced by the extracellular matrix and several surrounding cells,known together as the tumor microenvironment(TME).Bidirectional communication takes place between the tumor and the TME through the release of autocrine and paracrine *** hormone-related peptide(PTHrP)is a cytokine secreted by a wide variety of tissues and is able to regulate several cellular functions both in physiological as well as in pathological *** exerts its effects as a paracrine/autocrine factor,although its mode of action is mainly *** has been shown that this peptide is expressed by several tumors and that the tumor secretion of PTHrP is responsible for the malignant humoral *** years ago,when our research group started studying PTHrP effects in the experimental models derived from intestinal tumors,the literature available at the time addressing the effects of PTHrP on colorectal tumors was limited,and no articles had been published regarding to the paracrine action of PTHrP in cRc *** on this and on our previous findings regarding the role of PTH in cRc cells,our purpose in recent years has been to explore the role of PTHrP in *** analyzed the behavior of cRc cells treated with exogenous PTHrP,focalizing in the study of the following events:Survival,cell cycle progression and proliferation,migration,chemoresistance,tumor-associated angiogenesis,epithelial to mesenchymal transition program and other events also associated with invasion,such us the induction of cancer stem cells *** work summarizes the major findings obtained by our investigation group using in vitro and in vivo cRc models that evidence the participation of PTHrP in the acquisition of an aggressiv

关键词： Parathyroid hormone-related protein colorectal cancer Tumor biomarkers neoplastic processes Drug resistance Tumor microenvironment

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Synchronized bioluminescence behavior of a set of fireflies involving fractional operators of Liouville-caputo type

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International Journal of Biomathematics 2018年第3期11卷 221-245页

作者： J. E. Escalante-martínez J. F. Gómez-Aguilar c. calderón-Ramón A. Aguilar-Meléndez P. Padilla-Longoria Facultad de Ingenierla Mecdnica y Eldctrica Universidad Veracruzana Av. Venustiano Carranza S/N Col. Revolución C.P. 93390 Poza Rica Veracruz Mdéxico cOnAcyT- Tecnoldgico nacional de México/cEnIDET Interior Internado Palmira S/n Col. Palmira C.P. 62490 Cuernavaca Morelos México Facultad de Ingeniería Mecdnica y Eléctrica Universidad Veracruzana Av. Venustiano Carranza S/N Col. Revolución C.P. 93390 Poza Rica Veracruz México Facultad de Ingeniera civil Universidad Veracruzana Av. Venustiano Carranza S/N Col. Revolución C.P. 93390 Poza Rica Veracruz México Instituto de Investigaciones en Matemdticas Aplicadas y Sistemas (IIMAS) UNAM Circuito Escolar Cd. Universitaria Del. Coyoacan México D.F. C.P. 04510 México

In this paper, a system of fractional differential equations that model the synchronized bioluminescence behavior of a set of fireflies put on two spatial arrangements is presented; the alternative representation of these equations contains fractional operators of IAouvillc-caputo type. The objective of the model is to qualitatively recover synchronization and show that it is persistent. It is shown that the effort made by each firefly glow changes with respect to the number of male competitors and the distance between them. The conditions on biological parameters are interpreted.

关键词： Fractional calculus Liouville caputo fractional derivative synchronicity fireflies bioluminescence Adams Bashforth-Moulton method.

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Masting effect on alpha and beta avian diversity in fragmented forests of relict?endangered Mexican Beech(Fagus grandifolia ***)

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Avian Research 2021年第4期12卷 576-590页

作者： Ernesto cRodríguez-Ramírez Levinn camacho-Islas Ana Paola martínez-Falcón Isolda Luna-Vega Pilar carbó-Ramírez Laboratorio de Dendrocronología Universidad ContinentalHuancayoPerú Laboratorio de Biogeografía y Sistemática Universidad Nacional Autonoma de MéxicoCiudad de MéxicoMexico centro de Investigaciones Biológicas Universidad Autónoma de Estado de HidalgoHidalgoMexico Independent Researcher OuluFinland

Background:Tropical montane cloud forests are one of the most important hotspots on Earth and show presence of relict-endemic and endangered species,representing about 14%of the total tropical forest *** seed production or masting in tropical montane cloud tree species is a widespread reproductive strategy of decidu-ous and evergreen broad-leaved tree associations to decrease costs of reproduction and ensure *** event maintains a high avian diversity,which can be modified by phenological process(seed production and non-seed production).Methods:The main aim of this study was to assess alpha and beta avian diversity and whether the composition of the trophic guild modifies among phenological processes and between two fragmented relict-endangered Mexican Beech(Fagus grandifolia ***)forests(Medio Monte and El Gosco)in the Mexican state of *** addi-tion,we evaluated beechnut ***:We recorded 36 bird species,11 of them included in some conservation risk status,and 5 endemic *** diversity values were dissimilar in avian richness(q=0)among phenological processes and between frag-mented beech *** communities among three phenological processes and between fragmented forests were structurally similar,dominated during immature seeds the Brown-backed Solitaire(granivores-insectivores-frugivores);during mature seeds the White-crowned Parrot(Pionus senilis,granivores-frugivores);and the Dwarf Jay(cyanolyca nana,insectivores)was abundant during low seed *** complementarity index was high among phenological processes and low between *** found a high bird turnover value between immature seeds—mature seeds and during mature seeds—low seed ***,a similar pattern was recorded between the two study *** production showed a high number of undamaged beechnuts in Medio Monte,while in El Gosco beechnuts were attacked by ***:Our results reflect that masting

关键词： Avian seed consumers Bird species Synchronous seed production Tropical montane cloud forest Turnover Zentrygon albifacies

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Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants

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Journal of Integrative Agriculture 2015年第3期14卷 526-533页

作者： Mona M Y Elghandour Abdelfattah Z M Salem Jose S martínez castaeda Luis M camacho Ahmed E Kholif Juan c Vázquez chagoyán Faculty of Veterinary Medicine and Animal Science Autonomous University of the State of Mexico Faculty of Veterinary Medicine and Animal Science Autonomous University of Guerrero Dairy Science Department National Research Centre

For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial（DFM） can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria（LAB）, lactic acid utilizing bacteria（LUB）, or other microorganism＇s species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. nonetheless, recent studies have supported the positive effects of DFM on ruminant performance.

关键词： direct-fed microbial(DFM) mode of action ruminants

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Metabolic determinants of stemness in medulloblastoma

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World Journal of Stem cells 2022年第8期14卷 587-598页

作者： Paula martín-Rubio Pilar Espiau-Romera Alba Royo-García Laia caja Patricia Sancho Hospital Universitario Miguel Servet IIS AragónZaragoza 50009Spain Department of Medical Biochemistry and Microbiology Biomedical CenterUppsala UniversityUppsala SE-751Sweden

Medulloblastomas(MBs)are the most prevalent brain tumours in *** are classified as grade IV,the highest in malignancy,with about 30%metastatic tumours at the time of *** stem cells(cScs)are a small subset of tumour cells that can initiate and support tumour *** MB,cScs contribute to tumour initiation,metastasis,and therapy *** differences among the different MB groups have started to *** hedgehog tumours show enriched lipid and nucleic acid metabolism pathways,whereas Group 3 MBs upregulate glycolysis,gluconeogenesis,glutamine anabolism,and glutathione-mediated anti-oxidant *** differences impact the clinical behaviour of MB tumours and can be exploited *** this review,we summarise the existing knowledge about metabolic rewiring in MB,with a particular focus on ***,we highlight some of the emerging metabolism-based therapeutic strategies for MB.

关键词： Medulloblastoma cancer stem cells Stemness Metabolism Glycolysis Lipids

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One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*reaction reaction

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nuclear Science and Techniques 2024年第6期35卷 120-129页

作者： Gao-Long Zhang Zhen-Wei Jiao Guang-Xin Zhang E.n.cardozo B.Paes Shi-Peng Hu Jian-Qiang Qian Daniele Mengoni Wei-Wei Qu cong-Bo Li Yun Zheng Huan-Qiao Zhang Hui-Bin Sun nan Wang chun-Lei Zhang J.J.Valiente-Dobón D.Testov M.Mazzocco A.Gozzelino c.Parascandolo D.Pierroutsakou M.La commara A.Goasduff D.Bazzacco D.R.napoli F.Galtarossa F.Recchia A.Illana S.Bakes I.Zanon S.Aydin Gde Angelis M.Siciliano R.Menegazzo S.M.Lenzi S.Akkoyun L.F.canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil Laboratorio TAnDAR Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for Advanced Study in nuclear Energy and Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China InFn Sezione di PadovaPaduaItaly Dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China china Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Laboratori nazionali di Legnaro INFN35020 LegnaroItaly InFn Sezione di Napoli80126 NaplesItaly Dipartimento di Farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly Department of natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics Division Argonne National LaboratoryLemontILUSA Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li and^(209)Bi was studied at 28,30,and 34 MeV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)Li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 Li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)Li,^(5)Li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei cross section

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Assessing Post-Storm Forest Dynamics in the Pyrenees Using High-Resolution LIDAR Data and Aerial Photographs

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Journal of Mountain Science 2015年第4期12卷 841-853页

作者： ángela BLáZQUEZ-cASADO José R.GOnZáLEZ-OLABARRIA Santiago martín-ALcón Ariadna JUST Mariló cABRé Lluís cOLL Forest Sciences center of catalonia (cTFc) Institut cartogràfic i Geològic de catalunya (IcGc)

We evaluated how historical storm events have shaped the current forest landscape in three Pyrenean subalpine forests(nE Spain).For this purpose we related forest damage estimations obtained from multi-temporal aerial photographic comparisons to the current forest typology generated from airborne Li DAR data, and we examined the role of past natural disturbance on the current spatial distribution of forest structural *** found six forest structural types in the landscape: early regeneration(T1 and T2), young even-aged stands(T3), uneven-aged stands(T4) and adult stands(T5and T6).All of the types were related to the timing and severity of past storms, with early-regeneration structures being found in areas markedly affected in recent times, and adult stands predominating in those areas that had suffered lowest damage levels within the study *** general, landscapes where high or medium levels of damage were recurrent also presented higher levels of spatial heterogeneity,whereas the opposite pattern was found in the less markedly affected landscape, characterized by thepresence of large regular *** results show the critical role that storm regimes in terms of timing and severity of past storms can play in shaping current forest structure and future dynamics in subalpine *** knowledge gained could be used to help define alternative forest management strategies oriented toward the enhancement of landscape heterogeneity as a measure to face future environmental uncertainty.

关键词： Storm regime Forest succession Forest structure Airborne Li DAR Spatial patterns Pyrenean Subalpine forests

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High density lipoprotein as a therapeutic target:Focus on its functionality

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BIOcELL 2023年第11期47卷 2361-2383页

作者： LEOnARDO GÓMEZ ROSSO BELÉn DAVIcO EZEQUIEL LOZAnO cHIAPPE WALTER TETZLAFF LAURA BOERO FERnAnDO BRITES MAXIMILIAnO martÍn School of Pharmacy and Biochemistry Laboratory of Lipids and AtherosclerosisDepartment of Clinical BiochemistryUniversity of Buenos AiresNational Scientific and Technical Research Council(CONICET)Buenos Aires1113Argentina

cardiovascular diseases(cVDs)are the leading cause of death *** are a group of disorders of the heart and blood vessels and include coronary heart disease,cerebrovascular disease and rheumatic heart disease among other *** are multiple independent risk factors for cVD,including hypertension,age,smoking,insulin resistance,elevated low-density lipoprotein cholesterol(LDL-c)levels,and triglyceride ***-c levels have traditionally been the target for therapies aimed at reducing cVD *** density lipoprotein(HDL)constitutes the only lipoprotein fraction with atheroprotective *** HDL-targeted therapies have focused on increasing HDL-c ***,clinical trials have shown that raising HDL-c with niacin failed to achieve cVD reduction.A possible explanation for these findings is that these drugs could interfere with lipid metabolism and cause alterations in HDL structure and composition,leading to loss of *** a result,targeting HDL-c levels would be insufficient to achieve cVD risk reduction,making HDL functionality a more desirable focus for HDL-directed *** are several drugs which show the potential to improve HDL *** drugs include molecules already approved for human use,such as statins and niacin,and particularly,compounds currently undergoing development such as apolipoprotein A-I mimetics and reconstituted HDL *** therapies show promising potential to improve HDL functionality *** therapeutic strategies should incorporate HDL functionality as a main target of interest.

关键词： HDL cholesterol efflux rHDL Apo A-I mimetics Statins Paraoxonase

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Vapor-Liquid Equilibrium of copolymer＋ Solvent Systems： Experimental Data and Thermodynamic Modeling with new UnIFAc Groups

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chinese Journal of chemical Engineering 2008年第4期16卷 605-611页

作者： Roégrio A.G.Sé martín Aznar School of chemical Engineering State University of Campinas UNICAMP EO. Box 6066 13081-970 Campinas- SP Brazil

Vapor-liquid equilibrium （VLE） data for copolymer solutions are necessary for several chemical processes. However, VLE data for copolymer solutions in the published report are rare. In this study, experimental VLE data for binary systems copolymer＋solvent were obtained using a gravimetric-sorption apparatus. The studied systems were hexane＋poly （21% acrylonitrile-co-butadiene）, hexane＋poly （33% acrylonitrile-co-butadiene）, hexane＋poly （51% acrylonitrile-co-butadiene）, hexane＋poly （23% styrene-co-butadiene）, hexane＋poly （45% styrene-co-butadiene）, and benzene＋poly （44% styrene-co-methyl methacrylate） in the range 50-70℃. The experimental data were correlated with the UnIFAc and Elbro-FV group contribution models for the activity coefficient. Two sets of functional groups had been used to represent the monomers in copolymers： literature groups and new proposed groups. The mean deviations between experimental and calculated mass fractions about 2.4% with Elbro- FV and 13.3% with Zhong were observed when the groups proposed in this study were used, and of 3.5% for E1- bro-FV and 13.2% for Zhong, when literature grouns were used.

关键词： copolymers gravimetric sorption vapor-liquid equilibrium

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