High density lipoprotein as a therapeutic target:Focus on its functionality

作     者：LEONARDO GÓMEZ ROSSO BELÉN DAVICO EZEQUIEL LOZANO CHIAPPE WALTER TETZLAFF LAURA BOERO FERNANDO BRITES MAXIMILIANO MARTÍN 

作者机构：School of Pharmacy and BiochemistryLaboratory of Lipids and AtherosclerosisDepartment of Clinical BiochemistryUniversity of Buenos AiresNational Scientific and Technical Research Council(CONICET)Buenos Aires1113Argentina 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2023年第47卷第11期

页      面：2361-2383页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：HDL Cholesterol efflux rHDL Apo A-I mimetics Statins Paraoxonase 

摘      要：Cardiovascular diseases(CVDs)are the leading cause of death *** are a group of disorders of the heart and blood vessels and include coronary heart disease,cerebrovascular disease and rheumatic heart disease among other *** are multiple independent risk factors for CVD,including hypertension,age,smoking,insulin resistance,elevated low-density lipoprotein cholesterol(LDL-C)levels,and triglyceride ***-C levels have traditionally been the target for therapies aimed at reducing CVD *** density lipoprotein(HDL)constitutes the only lipoprotein fraction with atheroprotective *** HDL-targeted therapies have focused on increasing HDL-C ***,clinical trials have shown that raising HDL-C with niacin failed to achieve CVD reduction.A possible explanation for these findings is that these drugs could interfere with lipid metabolism and cause alterations in HDL structure and composition,leading to loss of *** a result,targeting HDL-C levels would be insufficient to achieve CVD risk reduction,making HDL functionality a more desirable focus for HDL-directed *** are several drugs which show the potential to improve HDL *** drugs include molecules already approved for human use,such as statins and niacin,and particularly,compounds currently undergoing development such as apolipoprotein A-I mimetics and reconstituted HDL *** therapies show promising potential to improve HDL functionality *** therapeutic strategies should incorporate HDL functionality as a main target of interest.