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Inter-sexual multimodal communication during mating in wild geladas:the leading role of females

Current Zoology 2022年第5期68卷 570-580页

作者： Anna Zanoli Marco Gamba Alban Lemasson Ivan Norscia elisabetta Palagi 无 Department of Life Sciences and Systems Biology University of TurinVia Accademia Albertina 13Torino 10123Italy University of Rennes University of NormandieCNRSEthoS(Éthologie Animale et Humaine)263 Av.Général LeclercRennes 35700France Institut Universitaire de France 1 Rue DescartesParis 75005France Natural History Museum University of PisaVia Roma 79Calci(Pisa)56011Italy Department of Biology Unit of EthologyUniversity of Pisa Via Alessandro Volta 6Pisa 50126Italy

Female primates can emit vocalizations associated with mating that can function as honest signals of ***,we investigated the role of mating calls and visual signals in female geladas(Theropithecus gelada).Because females have a central role in the gelada society and seem to solicit sexual interactions,we answered whether they emit vocalizations in conjunction with gazing to increase mating success *** and during copulations,females can emit pre-copulation calls and copulation *** the first time,we identified a new female vocalization emitted at the final stage of copulations(end-copulation call),possibly marking the occurrence of *** found that longer pre-copulation call sequences were followed by both prolonged copulations and the presence of end-copulation calls,thus suggesting that females use pre-copulation calls to ensure successful copula ***,we found that different combinations of female vocal types and gazing had different effects on male vocal behavior and motivation to complete the *** analysis of the vocal and visual signals revealed a complex inter-sexual multimodal chattering with the leading role of females in the signal *** chattering,led by females,modulates male sexual arousal,thus increasing the probability of the copula success.

关键词： copulation calls female end-copulation call inter-sexual coordination mating success multimodal communication Theropithecus gelada

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Spouting behaviour of binary mixtures in square-based spouted beds

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Particuology 2019年第2期17卷 193-201页

作者： Cristina Moliner Filippo Marchelli Massimo Curti Barbara Bosio Giorgio Rovero elisabetta Arato Department of Civil Chemical and Environmental Engineering (DICCA) University of Genova (UNIGE) Genova Italy Faculty of Science and Technology Free University of Bolzano (UNIBZ) Bolzano Italy Department of Applied Science and Technology (DISAT) Polytechnic University of Turin (POLITO) Turin Italy

From experime nts, the influe nee of the physical characteristics of different bin ary mixtures of solids on the spouting regime of a pyramidal square-based spouted bed reactor is assessed. The applied methodology permits a more precise evaluation of the effects of the tested variables (diameter, density, sphericity) on the response variables (minimum air flows at which spouting begins and at which to maintain spouting con ditions). The associated pressure drops along the bed of particles a nd the height of the formed fountai n are analysed in each case. During the initial stages of fluidisation, binary mixtures containing different density ratios show dead zones. Segregation becomes more evident at large-size and high-density ratios. The lack of sphericity was found to be the main reason leading to blocking, channelling, and start-up problems when system failures occur. Nevertheless, the extent of segregation in all cases decreases with increasing the spouting velocity. In addition, a computational fluid dynamic model based on the discrete element method, previously validated for a single solid bed, is proposed as a tool to predict and evaluate potential segregation phenomena in binary mixtures. This model reproduced with high accuracy the encountered segregation phenomena. Its use may help define the technical limts inherent in the pyramidal spouted bed reactor.

关键词： Spouted bed reactor Segregation Computational fluid dynamics

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Application of PROTAC strategy to TTR-Aβ protein-protein interaction for the development of Alzheimer's disease drugs

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Neural Regeneration Research 2021年第8期16卷 1554-1555页

作者： NicolóTonali Susanna Nencetti elisabetta Orlandini Lidia Ciccone Université Paris-Saclay CNRSBioCISChâtenay-MalabryFrance Department of Pharmacy University of PisaPisaItaly Department of Earth Sciences Research Center“E.Piaggio”University of PisaPisaItaly

Alzheimer's disease(AD) is a complex and multifaced neurodegenerative disorder for which the precise pathological molecular mechanisms are still not completely known. In last years, rational multi-target drug design methods, which combine multiple molecules having complementary modes of action, have been increasingly used in the development of anti-AD drugs.

关键词： drugs Alzheimer Aβ

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Urban Place and Media Space ——A Study on the Framing of the Chinese Online Media Coverage on 'Songjiang New City'

Urban Place and Media Space ——A Study on the Framing of th...

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作者： elisabetta Crovara 复旦大学

学位级别：硕士

根据“世界城镇化计划”(2011修订版,联合国),中国的城镇化在过去的20年中发展迅速。尤其是2008北京奥运会与2010上海世博会等大型活动的举办,推进了新城镇计划的发展。通过全面分析中国的城镇化发展,本文旨在阐明网络媒体对这一现象的... 详细信息

根据“世界城镇化计划”(2011修订版,联合国),中国的城镇化在过去的20年中发展迅速。尤其是2008北京奥运会与2010上海世博会等大型活动的举办,推进了新城镇计划的发展。通过全面分析中国的城镇化发展,本文旨在阐明网络媒体对这一现象的报道。经过对文化方式和媒介构建的文献回顾,本文将重点集中在“松江新城”这一案例。调查问题是：中央力量如何运用网络媒体报道松江新城的发展。为解决这一问题,采用框架／主题分析的方式分析了五篇中国网络新闻平台的文章(英语)。分析表明经济发展是中国城镇化强调最多的方面,而背后则是强大的政治意识形态作为支撑,关于中国建筑与遗产的“美学”话语的报道在媒体上十分常见。因此,我认为城市形象是城市研究的中心点之一,也应当置于城镇化研究之中。此外,媒介分析已经证明是研究这一议题的恰当工具。因此,本文只是研究媒介空间对城市构建的一个起点。

关键词：中国城市化重大事件媒介框架

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Effects of full replacement of dietary fishmeal with insect meal from Tenebrio molitor on rainbow trout gut and skin microbiota

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1042-1055页

作者： Genciana Terova elisabetta Gini Laura Gasco Federico Moroni Micaela Antonini Simona Rimoldi Department of Biotechnology and Life Sciences University of InsubriaVia J.H.Dunant321100 VareseItaly Department of Agricultural Forest and Food SciencesUniversity of TurinLargo P.Braccini 2-10095 GrugliascoTorinoItaly

Background:Aquaculture must continue to reduce dependence on fishmeal(FM)and fishoil in feeds to ensure sustainable sector ***,the use of novel aquaculture feed ingredients is *** this regard,insects can represent a new world of sustainable and protein-rich ingredients for farmed fish ***,we investigated the effects of full replacement of FM with Tenebrio molitor(TM)larvae meal in the diet of rainbow trout(Oncorhynchus mykiss)on fish gut and skin ***:A feeding trial was conducted with 126 trout of about 80 g mean initial weight that were fed for 22 weeks with two isonitrogenous,isolipidic,and isoenergetic extruded experimental *** defatted TM meal was included in one of the diets to replace 100%(TM 100)of FM,whereas the other diet(TM 0)was without *** analyse the microbial communities,the Illumina MiSeq platform for sequencing of 16S rRNA gene and Qiime pipeline were used to identify bacteria in the gut and skin mucosa,and in the ***:The data showed no major effects of full FM substitution with TM meal on bacterial species richness and diversity in both,gut mucosa-and skin mucus-associated *** microbiome was dominated by phylum Proteobacteria and especially by Gammaproteobacteria class that constituted approximately half of the bacterial taxa *** two dietary fish groups did not display distinctive features,except for a decrease in the relative abundance of Deefgea genus(family Neisseriaceae)in trout fed with insect *** metagenomic analysis of the gut mucosa indicated that Tenericutes was the most abundant phylum,regardless of the ***,within this phylum,the Mollicutes,mainly represented by Mycoplasmataceae family,were the dominant ***,we observed only a weak dietary modulation of intestinal bacterial *** only changes due to full FM replacement with TM meal were a decreased number of Proteobacteria and a reduced number of taxa assigned to

关键词： Aquaculture Circular economy Gut microbiome Insect meal Metagenome Next-generation sequencing Rainbow trout Skin microbiome Tenebrio molitor

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Non-invasive investigation in patients with inflammatory joint disease

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World Journal of Gastroenterology 2009年第20期15卷 2463-2468页

作者： elisabetta Dal Pont Renata D’Incà Antonino Caruso Giacomo Carlo Sturniolo Department of Surgical and Gastro-enterological Sciences University of Padova

Gut inflammation can occur in 30%-60% of patients with ***, the presence of such gut inflammation is underestimated, only 27% of patients with histological evidence of gut inflammation have intestinal symptoms, but subclinical gut inflammation is documented in two-thirds of patients with inflammatory joint *** are common genetic and immunological mechanisms behind concomitant inflammation in the joints and intestinal tract.A number of blood tests, *** sedimentation rate, orosomucoid, C-reactive protein, and white cell and platelet counts, are probably the most commonly used laboratory markers of inflammatory disease, however, these tests are difficult to interpret in arthropathies associated with gut inflammation, since any increases in their blood levels might be attributable to either the joint disease or to gut ***, it would be useful to have a marker capable of separately identifying gut *** proteins, which are indirect markers of neutrophil migration in the gut wall, and intestinal permeability, seem to be ideal for monitoring intestinal inflammation:they are easy to measure non-invasively and are specific for intestinal disease in the absence of gastrointestinal *** the traditional markers for characterizing intestinal inflammation, there are also antibodies, in all probability generated by the immune response to microbial antigens and auto-antigens, which have proved useful in establishing the diagnosis and assessing the severity of the condition, as well as the prognosis and the risk of *** short, noninvasive investigations on the gut in patients with rheumatic disease may be useful in clinical practice for a preliminary assessment of patients with suspected intestinal disease.

关键词： Biochemical markers Fecal markers Inflammatory bowel disease Intestinal permeability Serological markers Spondyloarthropathies

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Genotoxicity of gold nanoparticles functionalized with indolicidin towards Saccharomyces cerevisiae

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Journal of Environmental Sciences 2018年第4期30卷 138-145页

作者： elisabetta de Alteriis Annarita Falanga Stefania Galdiero Marco Ouida Valeria Maselli Emilia Galdiero Department of Biology University of Naples "Federico II" 80100 Naples Italy Department of Pharmacy University of Naples "Federico II" 80134 Naples Italy

The toxic effects of gold nanoparticles surface-functionalized with the antimicrobial peptide indolicidin（Au NPs-indolicidin） towards the yeast Saccharomyces cerevisiae, one of the major eukaryotic model organisms, have been evaluated. Growth and survival,genotoxicity, as measured by comet assay, and expression of the YCA1, an apoptosis indicating gene, following 72 hr exposure of yeast to Au NPs-indolicidin, and to Au NPs and indolicidin alone have been examined. The gold nanoparticles exerted toxicity with DNA damage, accompanied by reactive oxygen species production（ROS）, but they do not inhibit yeast growth and viability. Genotoxicity was less pronounced for surface-functionalized nanoparticles, showing that S. cerevisiae is quite resistant to the complex Au NPs-indolicidin.A progressive reduction of the genotoxic effect was observed along 72 hr exposure,presumably due to the activation of DNA repair mechanisms. These findings suggest the occurrence of a physiological protective response of S. cerevisiae towards nanoparticles,thereby providing useful information to the assessment of the environmental impact of metal nanoparticles.

关键词： Ecotoxicity Antimicrobial peptide Comet assay Yeast Nanoparticles Oxidative stress

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The effects of dietary choline

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Neuroscience Bulletin 2011年第5期27卷 330-342页

作者： elisabetta Biasi 杜克大学医学中心药学与肿瘤生物学系退役军人医学中心

Food intake can influence neuronal functions through different modulators expressed in the brain. The present review is a report through relevant experimental findings on the effects of choline, a nutritional component found in the diet, to identify a safe and effective dietary solution that can offer some protection against neurotoxicity and neurological disorders and that can be implemented in animals and humans in a very short period of time.

关键词： choline neurotoxicity neuroprotection

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ERK1 and ERK2 are involved in recruitment and maturation of human mesenchymal stem cells induced to adipogenic differentiation

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分子细胞生物学报:英文版 2011年第2期3卷 123-131页

作者： elisabetta Donzelli Caterina Lucchini Elisa Ballarini Arianna Scuteri Fabrizio Carini Giovanni Tredici Mariarosaria Miloso Department of Neuroscience and Biomedical Technologies University of Milano-BicoccaVia Cadore 48-20052Monza(MB)Italy Reproductive Medicine Nuova Villa Claudia ClinicVia Flaminia Nuova 280RomeItaly

Adipocytes’biology and the mechanisms that control adipogenesis have gained importance because of the need to develop therapeutic strategies to control obesity and the related *** mesenchymal stem cells(hMSCs),undifferentiated stem cells present in the bone marrow that are physiological precursors of adipocytes,were induced to adipogenic *** molecular mechanisms on the basis of the adipogenesis were evaluated,focusing on the MAPKinases ERK1 and ERK2,which are involved in many biological and cellular ***1 and ERK2 phosphorylation was reduced with different timing and intensity for the two isoforms in treated hMSCs in comparison with control cells until day 10 and then at 14–28 days,it reached the level of untreated *** total amount of ERK1 was also decreased up to day 10 and then was induced to the level of untreated cultures,whereas the expression of ERK2 was not changed following adipogenic *** with the specific ERK1/2 inhibitor U0126 during the whole differentiation period hampered hMSCs’adipogenic differentiation,as lipid droplets appeared in very few cells and were reduced in number and *** U0126 was administered only during the initial phase of differentiation,the number of hMSCs recruited to adipogenesis was reduced while,when it was administered later,hMSCs did not acquire a mature adipocytic ***1 and ERK2 are important for hMSC adipogenic differentiation since any alteration to the correct timing of their phosphorylation affects either the recruitment into the differentiation program and the extent of their maturation.

关键词： mesenchymal stem cells ERK adipogenesis MAPK obesity differentiation

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A Smart Procedure for the Femtosecond Laser-Based Fabrication of a Polymeric Lab-on-a-Chip for Capturing Tumor Cell

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Engineering 2021年第10期7卷 1434-1440页

作者： Annalisa Volpe Udith Krishnan Maria Serena Chiriacò elisabetta Primiceri Antonio Ancona Francesco Ferrara Department of Physics University of Bari“Aldo Moro”Bari 70126Italy Institute for Photonics and Nanotechnologies Bari 70126Italy Institute of Nanotechnology Lecce 73100Italy STMicroelectronics Lecce 73100Italy

Rapid prototyping methods for the design and fabrication of polymeric labs-on-a-chip are on the rise,as they allow high degrees of precision and *** example,a microfluidic platform may require an optimization phase in which it could be necessary to continuously modify the architecture and geometry;however,this is only possible if easy,controllable fabrication methods and low-cost materials are *** this paper,we describe the realization process of a microfluidic tool,from the computer-aided design(CAD)to the proof-of-concept application as a capture device for circulating tumor cells(CTCs).The entire platform was realized in polymethyl methacrylate(PMMA),combining femtosecond(fs)laser and micromilling fabrication *** multilayer device was assembled through a facile and low-cost solvent-assisted method.A serpentine microchannel was then directly biofunctionalized by immobilizing capture probes able to distinguish cancer from non-cancer cells without *** low material costs,customizable methods,and biological application of the realized platform make it a suitable model for industrial exploitation and applications at the point of care.

关键词： Lab-on-a-chip Fs laser Circulating tumor cells Point of care Thermal bonding Polymers

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