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Drying of suspensions and solutions on inert particle surface in mechanically spouted bed dryer

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China Particuology 2007年第5期5卷 337-344页

作者： elisabeth Pallai-Varsányi judit Tóth jános Gyenis University of Pannonia Faculty of Information TechnologyResearch Institute of Chemical and Process Engineering Egyetem u. 2H-8200 VeszprémHungary Hungarian Academy of Sciences Chemical Research CentreInstitute of Materials and Environmental ChemistryPusztaszeri u. 59-67H-1025 BudapestHungary

To eliminate some disadvantages of the conventional spouted bed dryers the mechanically spouted bed （MSB） system was developed. This dryer type is convenient to use inert particles providing an increased surface area for drying of materials of high-moisture content and heat sensitive materials. On three different drying tasks are demonstrated the experimental optimization of process parameters to obtain products of demanded quality. The main object was at drying of AIO（OH） suspension to preserve the particle size under 2.5μm and to obtain product with a moisture content of about 0.05 kg/kg （d.b.）. For this reason a very thin particle coating and intensive abrasion had to be assured. At drying of tomato concentrates the thermoplasticity makes the process very difficult. To jump over the deliquescent and sticky state developed at the critical temperature-moisture content values a very short drying time （8-10 s） must be provided. The third task was to form powder-like product from bovine serum albumin （BSA） solution having very low solid content （2-4%）. The selected process parameters given in this paper resulted in a mean particle size of less than 20 μm while the soluble oreserved orotein content was higher than 90%.

关键词： Mechanically spouted bed Film-like drying Inert particles Heat sensitive material

Cuticular hydrocarbons in two parapatric species of ants and their hybrid

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Integrative Zoology 2011年第3期6卷 259-265页

作者： Mohamed EL-SHEHABY Mohamed Sayed SALAMA elisabeth BRUNNER jürgen HEINZE Biologie I University of RegensburgRegensburgGermany Department of Entomology Ain Shams UniversityCairoEgypt

Discrimination between nestmates and non-nestmates in social insects is thought to rely on the pattern of cuticular *** investigated the cuticular hydrocarbon profiles of 2 parapatric sibling ant species,Temnothorax nylanderi(Förster,1850)and Temnothorax crassispinus(Karavaiev,1926),and their *** found that although the profiles show considerable similarities,a discriminant analysis based on the relative peak areas of cuticular hydrocarbons separates the 3 *** profiles of hybrids were not consistently intermediate between those of the paternal species,suggesting either non-additive interactions among the parental biosynthetic pathways or systematic differ-ences in environment-derived odor cues.

关键词： colony odor cuticular hydrocarbons hybridization Temnothorax

Humanized mice are susceptible to Salmonella typhi infection

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Cellular & Molecular Immunology 2011年第1期8卷 83-87页

作者： M Firoz Mian elisabeth A Pek Meghan j Chenoweth Ali A Ashkar Institute for Infectious Disease Research Centre for Gene TherapeuticsDepartment of Pathology and Molecular MedicineMcMaster UniversityHamiltonOntarioCanada

Salmonella enterica serovar Typhi is a pathogen that only infects ***,there is no animal model for studying this ***,alymphoid RAG2^(-/-)/γc^(-/-) mice engrafted with human leukocytes,known as humanized mice,have been successfully utilized to develop experimental models for several human-specific viral infections,including HIV,human-like dengue fever and hepatitis C *** is known about the usefulness and feasibility of the humanized mouse model for the study of human-specific bacterial pathogens,such as *** aim of this study was to determine if Salmonella enterica serovar Typhi could establish productive infection in humanized *** we report that intravenous inoculation of *** into humanized mice,but not controls,established *** *** bacterial loads were found in the liver,spleen,blood and bone marrow of mice reconstituted with human leukocytes,but not in the unreconstituted control ***,***-infected humanized mice lost significant body weight,and some of the infected mice displayed neurological *** data suggest,for the first time,that humanized mice are susceptible to *** challenge and that this model can be utilized to study the pathogenesis of *** develop novel therapeutic strategies.

关键词： animal model humanized mice RAG2-/-γc-/- Salmonella typhi

Numerical quality control for DFT-based materials databases

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npj Computational Materials 2022年第1期8卷 661-668页

作者： Christian Carbogno Kristian Sommer Thygesen Björn Bieniek Claudia Draxl Luca M.Ghiringhelli Andris Gulans Oliver T.Hofmann Karsten W.jacobsen Sven Lubeck jens jørgen Mortensen Mikkel Strange elisabeth Wruss Matthias Scheffler Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-614195BerlinGermany Center for Atomic-scale Materials Design(CAMD) Department of PhysicsTechnical University of DenmarkFysikvej 12800Kongens LyngbyDenmark Physics Department and IRIS Adlershof Humboldt-Universität zu BerlinZum Großen Windkanal 612489BerlinGermany Institute of Solid State Physics Graz University of TechnologyNAWI GrazPetergasse 168010GrazAustria

Electronic-structure theory is a strong pillar of materials *** different computer codes that employ different approaches are used by the community to solve various scientific ***,the precision of different packages has only been scrutinized thoroughly not long ago,focusing on a specific task,namely selecting a popular density functional,and using unusually high,extremely precise numerical settings for investigating 71 monoatomic crystals^(1).Little is known,however,about method- and code-specific uncertainties that arise under numerical settings that are commonly used in *** shed light on this issue by investigating the deviations in total and relative energies as a function of computational *** typical settings for basis sets and k-grids,we compare results for 71 elemental^(1) and 63 binary solids obtained by three different electronic-structure codes that employ fundamentally different *** the basis of the observed trends,we propose a simple,analytical model for the estimation of the errors associated with the basis-set *** cross-validate this model using ternary systems obtained from the Novel Materials Discovery (NOMAD) Repository and discuss how our approach enables the comparison of the heterogeneous data present in computational materials databases.

关键词： structure precise selecting

Methods for measuring pre-,intra-,and postoperative skin thickness for cochlear implants

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journal of Otology 2022年第2期17卷 72-77页

作者： Lena Zaubitzer Elena Schaefer elisabeth Wallhaeuser-Franke johannes Burkart Katrin Herrmann Beatrice Walter Angela Schell Claudia Scherl jerome Servais Daniel Haeussler Department of Otorhinolaryngology Head and Neck Surgery University Hospital MannheimMedical Faculty MannheimRuprecht-Karls-Universitat HeidelbergGermany Department of Neuroradiology University Hospital MannheimMedical Faculty MannheimRuprecht-Karls-Universitat HeidelbergGermany

Objective:This study was conducted to determine whether there is a reliable method for measuring the thickness of the retroauricular skin before,during,and after cochlear implantation,which allows the assessment of the optimal force of the external magnet of the cochlear implant(CI).Methods:The retroauricular skin thickness of 83 patients who received a CI was measured using three different *** thickness was measured on pre-and postoperative CT images,as well as *** magnet category chosen by the surgeon was recorded when the implant was switched on and during the first follow-up *** analyses were performed on the different skin thickness measurements and between the skin thickness and magnet strength ***:Only six patients required an exchange of the magnet until the *** the median absolute thickness differed significantly between the three measures(p<0.0001),their thickness values showed highly significant correlations(Pearson’s r=0.457-0.585;p<0.01).In addition,magnet strength,was significantly correlated with the flap thickness determined pre-,post-,and during *** lowest correlation with magnet strength was found in the intraoperative needle ***:All three measurements methods provided a suitable base for determining the ideal magnetic ***,of particular interest were the pre-and postoperative CT *** first enabled the early assessment of the required magnetic strength and thus a timely postoperative supply,whereas the latter helped to estimate the need for magnetic strength reduction during follow-up care and the feasibility of an early swith-on.

关键词： Cochlear implant Headpiece Magnet strength Flap thickness

Using compositional data analysis to explore accumulation of sedentary behavior,physical activity and youth health

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journal of Sport and Health Science 2022年第2期11卷 234-243页

作者： Simone j.j.M.Verswijveren Karen E.Lamb josep A.Martín-Fernández elisabeth Winkler Rebecca M.Leech Anna Timperio jo Salmon Robin M.Daly Ester Cerin David W.Dunstan Rohan M.Telford Richard D.Telford Lisa S.Olive Nicola D.Ridgers Institute for Physical Activity and Nutrition School of Exercise and Nutrition SciencesDeakin UniversityGeelongVIC 3216Australia Melbourne School of Population and Global Health University of MelbourneParkvilleVIC 3053Australia Department of Computer Science Applied Mathematics and StatisticsUniversity of GironaGirona 17003Spain School of Public Health University of QueenslandHerstonQLD 4006Australia Mary MacKillop Institute for Health Research Australian Catholic UniversityFitzroyVIC 3065Australia School of Public Health University of Hong KongHong KongChina Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Research Institute for Sport and Exercise University of CanberraBruceACT 2617Australia School of Psychology Deakin UniversityBurwoodVIC 3125Australia IMPACT Research Institute Deakin UniversityBurwoodVIC 3125Australia ANU Medical School Australian National UniversityGarranACT 2605Australia

Purpose:The study aimed to describe youth time-use compositions,focusing on time spent in shorter and longer bouts of sedentary behavior and physical activity(PA),and to examine associations of these time-use compositions with cardiometabolic ***:Accelerometer and cardiometabolic biomarker data from 2 Australian studies involving youths 7-13 years old were pooled(complete cases with accelerometry and adiposity marker data,n=782).A 9-component time-use composition was formed using compositional data analysis:time in shorter and longer bouts of sedentary behavior;time in shorter and longer bouts of light-,moderate-,or vigorous-intensity PA;and"other time"(i.e.,non-wear/sleep).Shorter and longer bouts of sedentary time were defined as5 min,*** bouts of light-,moderate-,and vigorous-intensity PA were defined asjusted models showed that the overall time-use composition was associated with adiposity,blood pressure,lipids,and the summary ***,more time in longer bouts of light-intensity PA relative to shorter bouts of light-intensity PA was significantly associated with greater body mass index z-score(zBMI)(β=1.79;SE=0.68)and waist circumference(β=18.35,SE=4.78).When each activity intensity was considered relative to all higher intensities and"other time",more time in light-and vigorous-intensity PA,and less time in sedentary behavior and moderate-intensity PA,were associated with lower waist ***:Accumulating PA,particularly light-intensity PA,in frequent short bursts may be more beneficial for limiting adi

关键词： Accumulation patterns Cardiometabolic health Children Compositional data analysis Time-use

iGlarLixi用于基础胰岛素联合口服降糖药血糖控制不佳的中国2型糖尿病患者相比甘精胰岛素100 U/ml血糖控制改善且有体重获益:LixiLan-L-CN随机对照试验结果

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中国糖尿病杂志 2023年第12期31卷 953-957页

作者：袁晓勇郭晓蕙张俊清董晓林鲁一兵庞妩燕 elisabeth Niemoeller 年高威 elisabeth Souhami(译) 北京大学第一医院内分泌科 100034 济南市中心医院内分泌科南京医科大学附属第二医院内分泌科河南大学淮河医院内分泌科赛诺菲

LixiLan-L-CN是一项为期30周的随机、阳性对照、开放标签、平行分组、多中心研究,在接受基础胰岛素(BI)±口服降糖药(OADs)治疗血糖控制不佳的中国成人(≥18岁)T2DM患者中,比较甘精胰岛素/利司那肽固定比例复方制剂(iGlarLixi)与甘精胰... 详细信息

LixiLan-L-CN是一项为期30周的随机、阳性对照、开放标签、平行分组、多中心研究,在接受基础胰岛素(BI)±口服降糖药(OADs)治疗血糖控制不佳的中国成人(≥18岁)T2DM患者中,比较甘精胰岛素/利司那肽固定比例复方制剂(iGlarLixi)与甘精胰岛素100U/ml的疗效和安全性(临床研究注册号:NCT03798080)。该研究于2022年发表在《Diabetes,Obesity and Metabolism》(Diabetes Obes Metab 2022 Nov;24:2182-2191),现将其主要结果摘译成中文(License Number:5640380204414)。

关键词：基础胰岛素口服降糖药血糖控制不佳甘精胰岛素多中心研究随机对照试验阳性对照注册号

Responses of 9 lepidopteran species to Bacillus thuringiensis： How useful is phylogenetic relatedness for selecting surrogate species for nontarget arthropod risk assessment？

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Insect Science 2015年第6期22卷 803-812页

作者： elisabeth P. j. Burgess Emma I. Barraclough Aliesha M. Kean Ngaire P. Markwick Louise A. Malone The New Zealand Institute for Plant & Food Research Ltd Private Bag 92 169 Auckland 1142 New Zealand

To evaluate phylogenetic relatedness as a proxy for susceptibility to Bacillus thuringiensis （Bt） when selecting species to act as surrogates for others in prerelease test- ing, we examined the responses of 11 laboratory-reared lepidopteran colonies, comprising members of 2 families, 5 genera, and 9 species, to a commercial Bt preparation. Sur- vival, pupal mass, and timing of pupation and adult emergence of 2 noctuids （Spodoptera litura and Helicoverpa armigera） and 7 tortricids （Cnephasia jactatana, Ctenopseustis obliquana, Ctenopseustis herana, Planotortrix octo, Planotortrix notophaea, Planotor- trix excessana [2 different laboratory colonies], and Epiphyas postvittana [2 colonies]） were examined after feeding first instar larvae with artificial diet containing 5 μL/100 mL Dipel ES （Bt subsp, kurstaki）. Bt caused significant larval mortality in all species except S. litura, in which only pupation was delayed compared with untreated controls. Neither of the noctuid species tested would act as a suitable surrogate for the other in tests of Bt impacts on survival. With the exception of the 2 colonies orE. postvittana, which differed from each other not only in their responses to Bt but also in their development times when not treated with Bt, species within each tortricid genus had similar responses to Bt and thus could act as surrogates for each other. Members of different genera within this family could represent each other only if relatively coarse measurement endpoints （e.g., toxic or not） were considered adequate for assessing risks to nontarget species in the field.

关键词： Bacillus thuringiensis (Bt) subsp, kurstaki Lepidoptera Noctuidae nontar-get impacts risk assessment Tortricidae

Dynamics and origin of cytokinins involved in plant manipulation by a leaf-mining insect

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Insect Science 2017年第6期24卷 1065-1078页

作者： Hui Zhang Antoine Guiguet Geraldine Dubreuil Anna Kisiala Peter Andreas R. j. Neil Emery elisabeth Huguet Melanie Body David Giron Institut de Recherche sur la Biologie de I'lnsecte UMR 7261 CNRSIUniversite Francois-Rabelais de Tours Tours France Departement de Biologie Ecole Normale Superieure de Lyon Lyon France Department of Life and Environmental Sciences Kyoto Prefectural University Kyoto Japan Department of Biology Trent University Peterborough Canada Division of Plant Sciences Christopher S. Bond Life Sciences Center University of Missouri Columbia USA

Several herbivorous insects and plant-associated microorganisms control the phytohormonal balance, thus enabling them to successfully exploit the plant by inhibiting plant defenses and withdrawing plant resources for their own benefit. The leaf-mining moth Phyllonorycter blancardella modifies the cytokinin （CK） profile of mined leaf-tissues, and the insect symbiotic bacteria Wolbachia is involved in the plant manipulation to the benefit of the insect host. To gain a deeper understanding into the possible origin and dynamics of CKs, we conducted an extensive characterization of CKs in larvae and in infected apple leaves. Our results show the enhanced CK levels in mines, both on green and yellow leaves, allowing insects to control their nutritional supply under fluctuating environmental conditions. The spatial distribution of CKs within the mined leaves shows that hormone manipulation is strictly limited to the mine suggesting the absence of CK translocation from distant leaf areas toward the insect feeding site. Mass spectrometry analyses reveal that major CK types accumulating in mines and larvae are similar to what is observed for most gall-inducers, suggesting that strategies underlying the plant manipulation may be shared between herbivorous insects with distinct life histories. Results further show that CKs are detected in the highest levels in larvae, reinforcing our hypothesis that CKs accumulating in the mines originate from the insect itself. Presence of bacteria- specific methylthio-CKs is consistent with previous results suggesting that insect bacterial symbionts contribute to the observed phenotype. Our study provides key findings toward the understanding of molecular mechanisms underlying this intricate plant-insect-microbe interaction.

关键词： cytokinins insect bacterial symbionts leaf-miners phytohormones plantinsect-microbe interactions plant manipulation