Humanized mice are susceptible to Salmonella typhi infection

作     者：M Firoz Mian Elisabeth A Pek Meghan J Chenoweth Ali A Ashkar 

作者机构：Institute for Infectious Disease ResearchCentre for Gene TherapeuticsDepartment of Pathology and Molecular MedicineMcMaster UniversityHamiltonOntarioCanada 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2011年第8卷第1期

页      面：83-87页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This study was supported by a grant from CIHR to Ali A Ashkar.AAA is a recipient of a Career Award in Health Sciences from Rx&D/CIHR 

主　　题：animal model humanized mice RAG2-/-γc-/- Salmonella typhi 

摘      要：Salmonella enterica serovar Typhi is a pathogen that only infects ***,there is no animal model for studying this ***,alymphoid RAG2^(-/-)/γc^(-/-) mice engrafted with human leukocytes,known as humanized mice,have been successfully utilized to develop experimental models for several human-specific viral infections,including HIV,human-like dengue fever and hepatitis C *** is known about the usefulness and feasibility of the humanized mouse model for the study of human-specific bacterial pathogens,such as *** aim of this study was to determine if Salmonella enterica serovar Typhi could establish productive infection in humanized *** we report that intravenous inoculation of *** into humanized mice,but not controls,established *** *** bacterial loads were found in the liver,spleen,blood and bone marrow of mice reconstituted with human leukocytes,but not in the unreconstituted control ***,***-infected humanized mice lost significant body weight,and some of the infected mice displayed neurological *** data suggest,for the first time,that humanized mice are susceptible to *** challenge and that this model can be utilized to study the pathogenesis of *** develop novel therapeutic strategies.