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Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19

Journal of Geriatric Cardiology 2021年第5期18卷 338-345页

作者： Vincenzo De Marzo Antonio Di Biagio Roberta Della Bona Antonio Vena eleonora arboscello Harusha Emirjona Sara Mora Mauro Giacomini Giorgio Da Rin Paolo Pelosi Matteo Bassetti Pietro Ameri Italo Porto GECOVID study group Cardiovascular Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Internal Medicine University of GenovaGenovaItaly Infectious Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Health Sciences University of GenovaGenovaItaly Emergency Department IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Informatics BioengineeringRobotics and System EngineeringUniversity of GenovaGenovaItaly Laboratory Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Anesthesia and Intensive Care Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Surgical Sciences and Integrated Diagnostics University of GenovaGenovaItaly

BACKGROUND Increases in cardiac troponin(cTn)in coronavirus disease 2019(COVID19)have been associated with worse ***,data about the significance of cTn in elderly subjects with COVID19 are *** From a registry of consecutive patients with COVID19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020,we selected those≥60 yearold and with cTnI measured within three days from the molecular diagnosis of SARSCoV2 *** available,a second cTnI value within 48 h was also *** relationship between increased cTnI and allcause inhospital mortality was evaluated by a Cox regression model and restricted cubic spline functions with three *** Of 343 included patients(median age:75.0(68.0−83.0)years,34.7%men),88(25.7%)had cTnI above the upperreference limit(0.046μg/L).Patients with increased cTnI had more comorbidities,greater impaired respiratory exchange and higher inflammatory markers on admission than those with normal ***,they died more(73.9%vs.37.3%,P<0.001)over 15(6−25)days of *** association of elevated cTnI with mortality was confirmed by the adjusted Cox regression model(HR=1.61,95%CI:1.06−2.52,P=0.039)and was linear until 0.3μg/L,with a subsequent *** 191(55.7%)patients with a second cTnI measurement,49(25.7%)had an increasing trend,which was not associated with mortality(univariate HR=1.39,95%CI:0.87−2.22,P=0.265).CONCLUSIONS In elderly COVID19 patients,an initial increase in cTn is common and predicts a higher risk of *** cTn testing may not confer additional prognostic information.

关键词： patients mortality admitted

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Human Toxocariasis Presenting with Fever and Colestatic Hepatitis: An Underestimated but Current Zoonosis

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International Journal of Clinical Medicine 2012年第7期3卷 595-597页

作者： Vera Sicbaldi Andrea Bellodi Valerio Del Bono eleonora arboscello Riccardo Ghio Clinic of Infectious Disease IRCSS San Martino IST Genoa Italy Clinic of Internal Medicine 3 IRCSS San Martino IST Genoa Italy

Human toxocariasis is a widespread parasitic disease caused by ingestion of Toxocara canis or catis larvae or eggs. Parasitic diseases are uncommon in industrialized countries, yet this problem has not disappeared. Parasitic diseases can cause different syndrome (visceral larva migrans, ocular larva migrans) and the clinical features can be confusing. Severe organ involvement affecting the liver, lungs, nervous central system and eyes can lead to serious damage. We present a case of toxocariasis presenting with fever, desaturation and cholestatic hepatitis. Only the subsequent appearance of eosinophilia helped us to arrive at the correct diagnosis. Prompt diagnosis allowed specific therapy avoiding permanent complications.

关键词： Toxocariasis Visceral Larva Migrans Ocular Larva Migrans Parasitosis Cholestatic Hepatitis Eosinophilia

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A POSITIVE AND MONOTONE NUMERICAL SCHEME FOR VOLTERRA-RENEWAL EQUATIONS WITH SPACE FLUXES

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Journal of Computational Mathematics 2019年第1期37卷 33-47页

作者： Mario Annunziato eleonora Messina Dipartimento di Matematica Universita degli Studi di Salerno Via G.Paolo II 132.84084 Fisciano (SA)Italy Dipartimento di Matematica e Applicazioni "R.Caccioppoli" Universita degli Studi di Napoli "Federico II"Via CintiaMonte S.Angelo80126 NapoliItaly

We study a numerical method for solving a system of Volterra-renewal integral equations with space fluxes,that represents the Chapman-Kohnogorov equation for a class of piecewise deterministic stochastic *** solution of this equation is related to the time dependent distribution function of the stochastic process and it is a non-negative and non-decreasing function of the *** on the Bernstein polynomials,we build up and prove a non-negative and non-decreasing numerical method to solve that equation, with quadratic convergence order in space.

关键词： Volterra renewal Piecewise deterministic process Monotone positive numerical scheme Bernstein polynomials

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Alzheimer’s disease:a tale of two diseases?

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Neural Regeneration Research 2021年第10期16卷 1958-1964页

作者： eleonora Nardini Ryan Hogan Anthony Flamier Gilbert Bernier Whitehead Institute for Biomedical Research CambridgeMAUSA Stem Cell and Developmental Biology Laboratory Hôpital Maisonneuve-RosemontMontrealQCCanada Department of Neurosciences University of MontrealMontrealQCCanada

Sporadic late-onset Alzheimer’s disease(SLOAD)and familial early-onset Alzheimer’s disease(FEOAD)associated with dominant mutations in APP,PSEN1 and PSEN2,are thought to represent a spectrum of the same disorder based on near identical behavioral and histopathological ***,FEOAD transgenic mouse models have been used in past decades as a surrogate to study SLOAD pathogenic mechanisms and as the gold standard to validate drugs used in clinical ***,such research has yielded little output in terms of therapeutics targeting the disease’s development and *** this short review,we interrogate the widely accepted view of one,dimorphic disease through the prism of the Bmi1+/–mouse model and the distinct chromatin signatures observed between SLOAD and FEOAD brains.

关键词： aging Alzheimer’s disease BMI1 epigenetics familial late-onset sporadic

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COEXISTENCE FOR MULTIPLE LARGEST REPRODUCTION RATIOS OF A MULTI-STRAIN SIS EPIDEMIC MODEL

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Acta Mathematica Scientia 2016年第5期36卷 1524-1530页

作者： Yoshiaki MUROYA eleonora MESSINA Elvira RUSSO Antonia VECCHIO Department of Mathematics Waseda University Dipartimento di Matematica e Applicazioni Università degli Studi di Napoli "Federico Ⅱ"-Via Cintia Istituto per Applicazioni del Calcolo "M. Picone" Sede di Napoli-CNR-Via P.Castellino

In this paper, to complete the global dynamics of a multi-strains SIS epidemic model, we establish a precise result on coexistence for the cases of the partial and complete duplicated multiple largest reproduction rat... 详细信息

关键词： multi-strains SIS epidemic model global attractivity Lyapunov function coexistence

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Compositional Features of Fine Sediments Involved in the Montescaglioso Landslide(Southern Italy)

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Journal of Earth Science 2022年第6期33卷 1513-1525页

作者： Vito Summa Rosa Sinisi eleonora Paris Agnese Emanuela Bonomo National Research Council Institute of Methodologies for Environmental AnalysisC/da S.Loja 85050Tito ScaloItaly School of Science and Technology Geology DivisionUniversity of Camerino62032CamerinoItaly

This paper presents the multidisciplinary study of the southern Italy Plio-Pleistocene sediments involved in the large Montescaglioso *** principal aim of the work is to assess the compositional characters(i.e.,grain-size,mineralogy,petrography and geochemistry)and some rheological features(Atterberg’s limits,plasticity index and activity)of these sediments to enrich our knowledge about the Montescaglioso fine sediments and correlation among the lithological properties *** types of sediments,from a deep geognostic borehole and from the surrounding landslide area,were collected and *** significant compositional differences have been found between the core and landslide area ***,some changes have been detected in sediments along the ***,the-15 to-20 m lithostratigraphic level hosts the highest percentages of phyllosilicates and clay fraction(CF),commonly considered as possible hazard factors for the landslide *** more,in the studied core sediments,the CF contents correlate with the Atterberg’s liquid and plastic limits and a CF value of about 38%was suggested as threshold value for the changing of index properties of *** factors,such as the weathering degree and clay mineral type,do not show significant correlations with the rheological properties of sediments here studied.

关键词： grain-size mineralogy geochemistry index properties Plio-Pleistocene sediments

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Review and assessment of different perspectives of vehicle-pedestrian conflicts and crashes:Passive and active analysis approaches

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第5期8卷 681-702页

作者： Abbas Sheykhfard Farshidreza Haghighi eleonora Papadimitriou Pieter Van Gelder Department of Civil Engineering Babol Noshirvani University of TechnologyMazandaran ***Iran Faculty of Technology Policy and ManagementDelft University of TechnologyDelft 2628 BXThe Netherlands

The importance of investigating pedestrian safety has been evaluated repeatedly in safety *** present study attempts to evaluate the various methods used by previous researchers in a hierarchical process,to determine the characteristics,advantages,and limitations of each *** general analysis approaches(passive and active) were taken into account to categorize 169 previous types of *** the passive approach,the studied methods were those based on crash databases,questionnaires,and post-crash field observation data;while,in the active approach,the studied methods were those based on driving simulations and *** result of the passive approach reveals that road users’ features and road characteristics(crash database studies),and error,lapses,intentional and unintentional violations(questionnaire studies) by them were among the most important causes of crashes and ***,road users’ distractions also reported a set of factors affecting the possibility of conflicts and crashes based on postcrash field observation ***,results of the active approach showed that risky behaviors are the most important factor in threatening pedestrian safety such as unauthorized speeding,non-compliance with traffic law,unauthorized overtaking by drivers,and illegal ***,risk perception and decision-making processes are the mostimportant bond between the attitude and behavior of road users in dangerous driving *** studies through passive approach would lead to identifying the causes of crashes,recognizing the attitude of road users towards safety,and determining road users’ behavioral patterns in certain situations,while the active approach has led to a more detailed understanding of behaviors and attitudes of road *** inference of the findings obtained in this study will lead to a better understanding of the behavior of road users for studies on advanced driving assistance systems(ADAS).

关键词： Traffic engineering Conflict Pedestrian Naturalistic driving study Crash Road safety

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Natural compounds may contribute in preventing SARS-CoV-2 infection:a narrative review

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Food Science and Human Wellness 2022年第5期11卷 1134-1142页

作者： Maria eleonora Bizzoca Stefania Leuci Michele Davide Mignogna eleonora Lo Muzio Vito Carlo Alberto Caponio Lorenzo Lo Muzio Department of Clinical and Experimental Medicine University of FoggiaFoggia 71122Italy Department of Neurosciences Reproductive and Odontostomatological SciencesFederico Ⅱ University of NaplesNaples 80131Italy Department of Neuroscience and Rehabilitation University of FerraraFerrara 44121Italy C.I.N.B.O.(Consorzio Interuniversitario Nazionale per la Bio-Oncologia) Chieti 66100Italy

Coronavirus pandemic infection is the most important health issue *** disease 2019 is a contagious disease characterized by severe acute respiratory syndrome coronavirus *** date,excluding the possibility of vaccination,against SARS-CoV-2 infection it is possible to act only with supportive care and non-virus-specific treatments in order to improve the patient’s *** industry is investigating effects of medicinal plants,phytochemical extracts and aromatic herbs to find out natural substances which may act as antiviral *** studies have revealed how these substances may interfere with the viral life cycle,viral entry,replication,assembly or discharge,as well as virus-specific host targets or stimulating the host immune system,reducing oxidative stress and inflammatory response.A natural compound can be used as a prophylaxis by people professionally exposed to the risk of contagion and/or positive patients not in intensive *** aim of this paper is to perform a narrative review of current literature in order to summarize the most studied natural compounds and their modes of action.

关键词： Natural compounds SARS-CoV-2 COVID-19 Prevention Infectious disease Phytochemicals Medicinal plants

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Gut microbiota role in irritable bowel syndrome:Newtherapeutic strategies

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World Journal of Gastroenterology 2016年第7期22卷 2219-2241页

作者： eleonora Distrutti Lorenzo Monaldi Patrizia Ricci Stefano Fiorucci S.C.di Gastroenterologia ed Epatologia Azienda Ospedaliera di Perugia06100 PerugiaItaly Dipartimento di Scienze Chirurgiche e Biomediche Universitàdegli Studi di Perugia06100 PerugiaItaly

In the last decade the impressive expansion of our knowledge of the vast microbial community that resides in the human intestine, the gut microbiota, has provided support to the concept that a disturbed intestinal ecology might promote development and maintenance of symptoms in irritable bowel syndrome(IBS). As a correlate, manipulation of gut microbiota represents a new strategy for the treatment of this multifactorial disease. A number of attempts have been made to modulate the gut bacterial composition, following the idea that expansion of bacterial species considered as beneficial(Lactobacilli and Bifidobacteria) associated with the reduction of those considered harmful(Clostridium, Escherichia coli, Salmonella, Shigella and Pseudomonas) should attenuate IBS symptoms. In this conceptual framework, probiotics appear an attractive option in terms of both efficacy and safety, while prebiotics, synbiotics and antibiotics still need confirmation. Fecal transplant is an old treatment translated from the cure of intestinal infective pathologies that has recently gained a new life as therapeutic option for those patients with a disturbed gut ecosystem, but data on IBS are scanty and randomized, placebo-controlled studies are required.

关键词： Irritable bowel syndrome Gut microbiota Probiotics Prebiotics Synbiotics Antibiotics Fecaltransplantation

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Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation

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World Journal of Gastroenterology 2009年第17期15卷 2097-2108页

作者： Barbara Renga Andrea Mencarelli Marco Migliorati eleonora Distrutti Stefano Fiorucci Department of Clinical and Experimental Medicine University of Perugia Via E dal Pozzo 06122 Perugia Italy Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia 06122 Perugia Italy

AIM: To investigate whether the farnesoid X receptor (FXR) regulates expression of liver cystathionase (CSE), a gene involved in hydrogen sulfi de (H2S) generation. METHODS: The regulation of CSE expression in response to FXR ligands was evaluated in HepG2 cells and in wild-type and FXR null mice treated with 6-ethyl chenodeoxycholic acid (6E-CDCA), a synthetic FXR ligand. The analysis demonstrated an FXR responsive element in the 5'-flanking region of the human CSE gene. The function of this site was investigated by luciferase reporter assays, chromatin immunoprecipitation and electrophoretic mobility shift assays. Livers obtained from rats treated with carbon tetrachloride alone, or in combination with 6-ethyl chenodeoxycholic acid, were studied for hydrogen sulphide generation and portal pressure measurement. RESULTS: Liver expression of CSE is regulated by bile acids by means of an FXR-mediated mechanism. Western blotting, qualitative and quantitative polymerase chain reaction, as well as immunohistochemical analysis, showed that expression of CSE in HepG2 cells and in mice is induced by treatment with an FXR ligand. Administration of 6E-CDCA to carbon tetrachloride treated rats protected against the down-regulation of CSE expression, increased H2S generation, reduced portal pressure and attenuated the endothelial dysfunction of isolated and perfused cirrhotic rat livers. CONCLUSION: These results demonstrate that CSE is an FXR-regulated gene and provide a new molecular explanation for the pathophysiology of portal hypertension.

关键词： Nuclear receptor Farnesoid X receptor Cystathionase Hydrogen sulfide Portal hypertension

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