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COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells

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World Journal of Gastroenterology 2023年第3期29卷 425-449页

作者： Fares E M Ali mostafa K Abd el-Aziz Mahmoud M Ali Osama M Ghogar Adel G Bakr Department of Pharmacology and Toxicology Faculty of PharmacyAl-Azhar UniversityAssiut 71524Egypt Department of Pharmacology Al-Azhar UniversityAssiut 71524Egypt Department of Biochemistry Faculty of Pharmacy Badr University in AssiutEgypt

The coronavirus disease 2019(COVID-19)represents a global health and economic *** injuries have been approved to be associated with severe acute respiratory syndrome coronavirus(SARS-CoV-2)*** viral tropism pattern of SARS-CoV-2 can induce hepatic injuries either by itself or by worsening the conditions of patients with hepatic ***,other factors have been reported to play a crucial role in the pathological forms of hepatic injuries induced by SARS-CoV-2,including cytokine storm,hypoxia,endothelial cells,and even some treatments for *** the other hand,several groups of people could be at risk of hepatic COVID-19 complications,such as pregnant women and *** present review outlines and discusses the interplay between SARS-CoV-2 infection and hepatic injury,hepatic illness comorbidity,and risk ***,it is focused on the vaccination process and the role of developed vac-cines in preventing hepatic injuries due to SARS-CoV-2 infection.

关键词： COVID-19 Hepatic injury Viral tropism COVID-19 comorbidity Vaccination

Macrosegregation Quality Criteria and Mechanical Soft Reduction for Central Quality Problems in Continuous Casting of Steel

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Materials Sciences and Applications 2014年第10期5卷 724-744页

作者： mostafa Omar el-Bealy Companies Chair of Metals Processing & Technology MTC/Egypt CTU/Germany KTH/Sweden MIT/USA Sweden Branch: Division of Casting of Metals Department of Materials Science and Engineering Royal Institute of Technology Stockholm Sweden

In order to study the central quality of continuously cast tool steel slabs, the simple model has been developed to simulate the macrosegregation quality criteria. The model calculates different quality criteria such as average macro-segregation level criterion “ASL”, its fluctuation level “FSL” and its segregation quality number “SQN”. These criteria are calculated based on the previous measurements of carbon and sulfur concentrations distributions in final region of spray zones and centerline area of lower and upper slab sides. The effect of mechanical soft reduction Technique “MSR” on the slab centerline quality is examined and analyzed. The model results show that MSR affects the quality of centerline areas significantly by different ways based on the casting speed. The experimental and theoretical results clarify that the qualities of different slab sides are different for all collected samples. The model results show also that the accuracy of the macro-segregation quality criteria increases quantitatively with increasing the number of analyzed segregated elements. Therefore, the macrosegregation quality criteria and their distributions can be considered as the most simple and vital tool to evaluate the various slab qualities. Finally, the mechanism of centerline segregation formation with mechanical soft reduction is discussed in this study.

关键词： Continuous Casting of Steel Macrosegregation Centerline Segregation Macrosegregation Quality Criteria Mechanical Soft Reduction Technique

Identification of novel bioactive proanthocyanidins with potent antioxidant and anti-proliferative activities from kiwifruit leaves

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Food Bioscience 2022年第2期46卷 539-549页

作者： Ji-Min Lv mostafa Gouda Alaa el-Din Bekhit Ya-Ke He Xing-Qian Ye Jian-Chu Chen College of Biosystems Engineering and Food Science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Technology and EquipmentZhejiang UniversityHangzhou310058China Department of Nutrition and Food Science National Research CentreDokki12622GizaEgypt Department of Food Science University of OtagoOtagoNew Zealand

Agro-wastes contribute major social,economic,and environmental challenges for food production and circular economy *** current increasing demand for clean label food production and use of natural bioactive compounds could turn these challenges into opportunities providing avenues for proper utilization of agro-wastes to produce valuable *** study aimed to investigate the potential use of kiwifruit(Actinidia chinensis)leaves as a source of proanthocyanidins(PAs)bioactive phenolic *** leaves PAs were extracted,purified,identified,and evaluated for their antioxidant and anti-proliferative *** structural composition of the purified PAs was characterized using HPLC-QTOF-MS/MS and *** results showed that purified kiwifruit leaves PAs(PKLPs)comprised mainly procyanidins,propelargonidins,and prodelphindins ranging from dimers to hexamers with(epi)catechin as terminal units and(epi)afzelechin or(epi)gallocatechin as dominant extension *** study reports the structure of novel PKLPs monomer fractions was unique compared to the PAs that extracted from the other plant *** PKLPs exhibited higher phenolic content than the skin and flesh of several kiwifruit ***,the PKLPs exhibited higher in vitro antioxidant activity in chemical-based(DPPH,ABTS,and FRAP)assays and H2O2-induced injury cell model than ascorbic,Trolox,and catechin(pells was *** conclusion,this study demonstrated that kiwifruit leaves waste could serve as a sustainable and low-cost source of PAs,a group of multi-functional bioactive compounds that plays a key role in the food and pharmaceutical industries.

关键词： Proanthocyanidins Agro-waste valorisation HPLC-QTOF-MS/MS Antioxidant potential Anti-proliferative activity

Molecular study on Y chromosome microdeletions in Egyptian males with idiopathic infertility

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Asian Journal of Andrology 2004年第1期6卷 53-57页

作者： mostafa K. el Awady Sohair F. el Shater Ehab Ragaa Khaled Atef Ibrahim M. Shaheen Nagwa A. Megiud Department of Biomedical Technology Children with Special Needs National Research Center Dokki Cairo 12622 Egypt Department of Research on Children with Special Needs National Research Center Dokki Cairo 12622 Egypt Department of Dermatology Venereology and Andrology Faculty of Medicine Al-Azhar University Cairo Egypt

Aim: To determine the frequency of genetic deletions within the azoospermia factors in Egyptian infertile males. Methods: The Yq microdeletions in 33 infertile males with undetectable chromosomal anomalies were examined by mutiplex polymerase chain reaction (PCR). Deletions were confirmed using single PCR amplifications. Results: Four out of the total 33 (12 %) men had Yq11 microdeletions, thus supporting the average reported figures in other populations. Three of those 4 cases had single short tandem sequence deletions with discrete histological findings of their testes. Single sY272 deletion within AZFc was associated with Sertoli cell only syndrome, whereas a patient with isolated sY84 deletion within AZFa had immature testicular structure. The remaining case had a large deletion in AZFa-c and short stature. Conclusion: The present study supports the hypothesis that the Yqn encompasses genetic determinants of stature besides genes controlling spermatogenesis.

关键词： AZF Y microdeletions multiplex polymerase chain reaction male infertility azoospermia

Correlation between IL28B/TLR4 genetic variants and HCC development with/without DAAs treatment in chronic HCV patients

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Genes & Diseases 2020年第3期7卷 392-400页

作者： Ghada M.Salum Reham M.Dawood Mai Abd el-Meguid Noha E.Ibrahim Ashraf O.Abdel Aziz mostafa K.el Awady Department of Microbial Biotechnology Genetic Engineering DivisionNational Research Centre33 EL Bohouth St.(former El Tahrir St.)DokkiGizaP.O.12622Egypt Department of Tropical Medicine Faculty of MedicineCairo UniversityGizaP.O.12622Egypt

In Egypt,Sofosbuvir(SOF)in combination with Dataclasvir(DCV)is the broadly used DAAs with excellent therapeutic *** study is designed to explore the relation between IL28B/TLR4 genetic variants and each of the followings;HCC development post SOF/DCV treatment,progression to HCC in naı¨ve patients and SOF/DCV therapy outcome.A total of 493 blood samples were collected(controls(n = 70);HCV patients treated with SOF/DCV(n = 252)of whom 65 patients developed HCC,187 patients didn’t develop HCC(125 responders,62 relapsers);naı¨ve HCV patients(n = 171)had early(n = 48),late liver fibrosis(n = 21)and HCC(n = 102)).Both SNPs were genotyped using a TaqMan 50 allelic discrimination *** IL28B rs12979860 SNP,the C allele was significantly correlating with the response rate more than T allele(OR 1.9,95%CI 1.29e2.9,p=0.004),while at TLR4 rs4986791 SNP,no association was found(OR 6.5,95%0.57e75.28,p = 0.09).Both SNPs couldn’t detect the probability for HCC emergence after *** naı¨ve patients,the protective alleles were detected in their lowest frequency in HCC patients(p = 0.1,for rs12979860 and,p = 0.001 for rs4986791).SOF/DCV combination improved SVR rates in HCV genotype 4a infected patients regardless of IL28B genotype,with the best rates in those lacking the T allele.

关键词： DAAs DCV HCV HCC IL28B SOF TLR4

Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases

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World Journal of Gastroenterology 2017年第38期23卷 7025-7036页

作者： ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab gastroenterology surgical center mansoura university

AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary *** This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. Hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the *** Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%.

关键词： Pancreaticoduodenectomy Pancreaticogastrostomy Pancreaticojejunostomy Postoperative pancreatic fistula Periampullary tumor

Therapeutic interventions of acute and chronic liver disorders:A comprehensive review

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World Journal of Hepatology 2023年第1期15卷 19-40页

作者： Fares EM Ali mostafa K Abd el-Aziz elham I Sharab Adel G Bakr Department of Pharmacology and Toxicology Faculty of PharmacyAl-Azhar UniversityAssiut BranchAssiut 71524Egypt Faculty of Pharmacy Al-Azhar UniversityAssiut BranchAssiut 71524Egypt

Liver disorders are one of the most common pathological problems *** affects more than 1.5 billion *** types of hepatic cells have been reported to be involved in the initiation and propagation of both acute and chronic liver diseases,including hepatocytes,Kupffer cells,sinusoidal endothelial cells,and hepatic stellate cells(HSCs).In addition,oxidative stress,cytokines,fibrogenic factors,microRNAs,and autophagy are also *** the molecular mechanisms of liver diseases leads to discovering new therapeutic interventions that can be used in ***,antioxidant,anti-inflammatory,anti-HSCs therapy,gene therapy,cell therapy,gut microbiota,and nanoparticles have great potential for preventing and treating liver ***,we explored the recent possible molecular mechanisms involved in the pathogenesis of acute and chronic liver ***,we overviewed the recent therapeutic interventions that targeted liver diseases and summarized the recent studies concerning liver disorders therapy.

关键词： Liver disorders Autophagy Gene therapy Anti-hepatic stellate cells Cell therapy

Effect of cholesterol-loaded cyclodextrin enriched extenders on the quality of pre- frozen and frozen buffalo semen

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Asian pacific Journal of Reproduction 2022年第3期11卷 146-152页

作者： Asmaa A.mostafa Mohamed S.el-Belely Sayed T.Ismail Reda I.el-Sheshtawy Mohamed I.Shahba Abassia Frozen Semen Center General Organization for Veterinary ServicesCairoEgypt Department of Theriogenology Faculty of Veterinary MedicineCairo UniversityGizaEgypt Department of Animal Reproduction and Artificial Insemination National Research CentreDokkiGizaEgypt

Objective:To investigate the effects of non-permeable cryoprotectant,cholesterol-loaded cyclodextrin,when added at different concentrations into cooled and frozen-thawed semen extended with Tris-citrate-fructose egg yolk glycerol and lecithin-based ***:A total of 40 ejaculates from four buffalo bulls were collected using artificial *** were extended with one of Tris-citrate-fructose egg yolk glycerol and lecithin-based extenders which contained different concentrations[0(control),0.75,1.50,2.25 and 3.00 mg/mL]of cholesterol-loaded *** extended semen samples were cooled to 5曟and then frozen slowly to-196曟in 0.25 mL ministraws before being stored in liquid nitrogen pending its *** motility,live sperm,normal sperm morphology,sperm membrane integrity and acrosome morphology were ***:Supplementation of cholesterol-loaded cyclodextrin improved progressive motility,viability,morphology and acrosome as well as plasma membrane integrities at 1.50-2.25 mg/mL depending upon types of used extenders and stages of pre-and post-freezing process(P<0.01).The best concentration was 1.50 mg/mL at pre-freeze stage and 2.25 mg/mL at ***,greater concentration(3.00 mg/mL)of cholesterol-loaded cyclodextrin had a detrimental effect compared to the control group with the two evaluated extenders(P<0.01).Conclusions:Cholesterol-loaded cyclodextrin supplementation at 1.50-2.25 mg/mL concentration could improve pre-frozen and post-thawed buffalo sperm *** most suitable concentration is 1.50 mg/mL at pre-freeze stage and 2.25 mg/mL at post-freezing.

关键词： Buffalo Semen Tris Cooling Cryopreservation Cholesterol-loaded cyclodextrin Semen evaluation

An Efficient Indoor Localization Based on Deep Attention Learning Model

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Computer Systems Science & Engineering 2023年第8期46卷 2637-2650页

作者： Amr Abozeid Ahmed I.Taloba Rasha M.Abd el-Aziz Alhanoof Faiz Alwaghid mostafa Salem Ahmed elhadad Department of Computer Science College of Science and ArtsJouf UniversityQurayyatSaudi Arabia Information System Department Faculty of Computers and InformationAssiut UniversityEgypt Computer Science Department Faculty of Computers and InformationAssiut UniversityAssiutEgypt Department of Computer Science Faculty of Computers and InformationSouth Valley UniversityQenaEgypt

Indoor localization methods can help many sectors,such as healthcare centers,smart homes,museums,warehouses,and retail malls,improve their service *** a result,it is crucial to look for low-cost methods that can provide exact localization in indoor *** this context,imagebased localization methods can play an important role in estimating both the position and the orientation of cameras regarding an ***-based localization faces many issues,such as image scale and rotation ***,image-based localization’s accuracy and speed(latency)are two critical *** paper proposes an efficient 6-DoF deep-learning model for image-based *** model incorporates the channel attention module and the Scale PyramidModule(SPM).It not only enhances accuracy but also ensures the model’s real-time *** complex scenes,a channel attention module is employed to distinguish between the textures of the foregrounds and *** model adapted an SPM,a feature pyramid module for dealing with image scale and rotation variance ***,the proposed model employs two regressions(two fully connected layers),one for position and the other for orientation,which increases outcome *** on standard indoor and outdoor datasets show that the proposed model has a significantly lower Mean Squared Error(MSE)for both position and *** the indoor 7-Scenes dataset,the MSE for the position is reduced to 0.19 m and 6.25°for the ***,on the outdoor Cambridge landmarks dataset,the MSE for the position is reduced to 0.63 m and 2.03°for the *** to the findings,the proposed approach is superior and more successful than the baseline methods.

关键词： Image-based localization computer vision deep learning attention module VGG-16