Molecular study on Y chromosome microdeletions in Egyptian males with idiopathic infertility

作     者：Mostafa K. El Awady Sohair F. El Shater Ehab Ragaa Khaled Atef Ibrahim M. Shaheen Nagwa A. Megiud MOSTAFA K. EL AWADY;SOHAIR F. EL SHATER;EHAB RAGAA;KHALED ATEF;IBRAHIM M. SHAHEEN;NAGWA A. MEGIUDDEPARTMENT OF BIOMEDICAL TECHNOLOGY;DEPARTMENT OF RESEARCH ON CHILDREN WITH SPECIAL NEEDS;NATIONAL RESEARCHCENTER DOKKI;CAIRO;EGYPT DEPARTMENT OF DERMATOLOGY;VENEREOLOGY AND ANDROLOGY;FACULTY OF MEDICINE AL-AZHAR UNIVERSITY;CAIRO;EGYPT

作者机构：Department of Biomedical TechnologyChildren with Special Needs National Research Center Dokki Cairo 12622 Egypt Department of Research on Children with Special Needs National Research Center Dokki Cairo 12622 Egypt Department of Dermatology Venereology and Andrology Faculty of Medicine Al-Azhar University Cairo Egypt 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志(英文版))

年 卷 期：2004年第6卷第1期

页      面：53-57页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：AZF Y microdeletions multiplex polymerase chain reaction male infertility azoospermia 

摘      要：Aim: To determine the frequency of genetic deletions within the azoospermia factors in Egyptian infertile males. Methods: The Yq microdeletions in 33 infertile males with undetectable chromosomal anomalies were examined by mutiplex polymerase chain reaction (PCR). Deletions were confirmed using single PCR amplifications. Results: Four out of the total 33 (12 %) men had Yq11 microdeletions, thus supporting the average reported figures in other populations. Three of those 4 cases had single short tandem sequence deletions with discrete histological findings of their testes. Single sY272 deletion within AZFc was associated with Sertoli cell only syndrome, whereas a patient with isolated sY84 deletion within AZFa had immature testicular structure. The remaining case had a large deletion in AZFa-c and short stature. Conclusion: The present study supports the hypothesis that the Yqn encompasses genetic determinants of stature besides genes controlling spermatogenesis.