Therapeutic interventions of acute and chronic liver disorders:A comprehensive review

作     者：Fares EM Ali Mostafa K Abd El-Aziz Elham I Sharab Adel G Bakr 

作者机构：Department of Pharmacology and ToxicologyFaculty of PharmacyAl-Azhar UniversityAssiut BranchAssiut 71524Egypt Faculty of PharmacyAl-Azhar UniversityAssiut BranchAssiut 71524Egypt 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第1期

页      面：19-40页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Liver disorders Autophagy Gene therapy Anti-hepatic stellate cells Cell therapy 

摘      要：Liver disorders are one of the most common pathological problems *** affects more than 1.5 billion *** types of hepatic cells have been reported to be involved in the initiation and propagation of both acute and chronic liver diseases,including hepatocytes,Kupffer cells,sinusoidal endothelial cells,and hepatic stellate cells(HSCs).In addition,oxidative stress,cytokines,fibrogenic factors,microRNAs,and autophagy are also *** the molecular mechanisms of liver diseases leads to discovering new therapeutic interventions that can be used in ***,antioxidant,anti-inflammatory,anti-HSCs therapy,gene therapy,cell therapy,gut microbiota,and nanoparticles have great potential for preventing and treating liver ***,we explored the recent possible molecular mechanisms involved in the pathogenesis of acute and chronic liver ***,we overviewed the recent therapeutic interventions that targeted liver diseases and summarized the recent studies concerning liver disorders therapy.