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International Journal of Disaster Risk Science 2017年第4期8卷 390-401页

作者： Victor Marchezini Rachel Trajber Dbora Olivato Viviana Aguilar muoz Fernando de Oliveira Pereira Andra eliza Oliveira Luz Cemaden–National early Warning and Monitoring Center of Natural Disasters Distrito de Eugênio de MeloSo JosDos Campos

Building national people-centered early warning systems(eWS) is strongly recommended by the United Nations International Strategy for Disaster Reduction(UNISDR). Most of the scientific literature is critical of the conventional view of eWS as a linear model with a topdown approach, in which technological features are given more attention than human factors. It is argued that eWS should be people-centered, and used for risk prevention,with an emphasis on resilience, rather than only being triggered when a hazard occurs. However, both the UNISDR and the literature fail to say how a people-centered eWS should be built, and what steps are needed to put eWS into effect. This article examines the obstacles and measures required to promote people-centered eWS,with a focus on the situation in Brazil. After assessing the institutional vulnerability of eWS, we analyze some measures that can be taken to reduce institutional vulnerability,based on experiences with a participatory citizen science educational project that involved high school *** guidelines are developed for adopting a bottom-up approach towards achieving the four elements of eWS—risk knowledge, monitoring, communication of warnings,and response capability—with the help of school curricula.

关键词： Brazil Capacity building Citizen science Disaster risk reduction early warning systems Resilient schools

定向钢纤维增强水泥基复合材料准脆性断裂分析

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东南大学学报（自然科学版） 2024年第2期54卷 294-302页

作者：慕儒王晶晶卿龙邦李杨管俊峰河北工业大学土木与交通学院天津300401 天津城建大学土木工程学院天津300384 华北水利水电大学土木与交通学院郑州450045

基于边界效应模型基本理论,建立了钢纤维长度与特征裂缝长度之间的关系,计算了定向钢纤维增强水泥基复合材料(ASFRC)的等效断裂韧度和拉伸强度,进而得到了ASFRC材料的断裂破坏曲线.结果表明,当离散系数分别取0.4~0.7和0.2~0.4时,可得到... 详细信息

基于边界效应模型基本理论,建立了钢纤维长度与特征裂缝长度之间的关系,计算了定向钢纤维增强水泥基复合材料(ASFRC)的等效断裂韧度和拉伸强度,进而得到了ASFRC材料的断裂破坏曲线.结果表明,当离散系数分别取0.4~0.7和0.2~0.4时,可得到较为合理的等效断裂韧度和拉伸强度值.对比分析ASFRC和随机乱向钢纤维增强水泥基复合材料(SFRC)的断裂破坏曲线可以发现,满足线弹性断裂力学的最小试件尺寸随着离散系数的增大而增大;ASFRC和SFRC的拉伸强度和考虑初始裂缝影响的名义应力随着离散系数的增大而减小.此外,改进的简化解析公式不仅可确定材料的等效断裂韧度和拉伸强度,还可预测试件的破坏.

关键词：定向钢纤维增强水泥基复合材料边界效应模型等效断裂韧度拉伸强度断裂破坏曲线

Anchoring of 10-phenylphenothiazine to mesoporous silica materials:A water compatible organic photocatalyst for the degradation of pollutants

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Journal of Materials Science & Technology 2022年第8期103卷 134-143页

作者： Daniel González-muñoz Almudena Gómez-Avilés Carmen B.Molina Jorge Bedia Carolina Belver Jose Alemán Silvia Cabrera Organic Chemistry Department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain Chemical engineering Department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain Institute for Advanced Research in Chemical Sciences(IAdChem) Universidad Autónoma de Madrid28049 MadridSpain Inorganic Chemistry Department Science FacultyUniversidad Autónoma de Madrid28049 MadridSpain

The application of organic photocatalysts towards the oxidation of pollutants in water is hampered by different limitations such as their insolubility in the ***,we report that the grafting of a photoorganocatalyst into mesoporous silica materials is an ideal approach to obtain effective ***,the photocatalyst 10-phenylphenothiazine(PTH)was easily anchored into three different mesoporous silica-based materials(MSN,MSU-2 and SBA-15)with different particle sizes and pore sizes through an amide bond *** materials were characterized using IR analysis,solid-state X-ray diffraction,porosity and microscopy(SeM and TeM)techniques,showing that PTH is immobilized inside the pores of the materials and its optical properties are maintained after the *** homogeneous PTH was inactive in water media,the three photocatalytic materials were active for the degradation of ***-15-AP-PTH exhibited the highest catalytic performance towards the degradation of acetaminophen and diclofenac under solar irradiation,finding in this manner a new strategy for the decontamination of pollutants.

关键词： Organic semiconductors Silica support Solar photocatalysis Water treatment Pharmaceuticals

effect of protease supplementation on apparent ileal crude protein and amino acid digestibility of over-processed soybean meals in broilers

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1810-1817页

作者： Sergio Salazar-Villanea Maikol Astúa-Ureña Allison Masís-Montoya Juan I.Herrera-muñoz Catalina Salas-Durán escuela de Zootecnia Universidad de Costa RicaSan JoséCosta Rica Centro de Investigación en Nutrición Animal Universidad de Costa RicaSan JoséCosta Rica

Background: Nutritional value of proteins in feed ingredients can be negatively affected by hydrothermal processing, which causes large variation in the bioavailability of amino acids(AA) and negatively affects animal productive performance. Supplementation of exogenous proteases could increase the rate of digestion of damaged proteins, thereby increasing overall AA digestibility and bioavailability. The aim was to determine the effect of exogenous protease supplementation on the apparent ileal digestibility(AID) of crude protein(CP) and AA of soybean meals(SBM) with different degrees of hydrothermal processing in ***: The experiment involved a 3 × 2 factorial arrangement, with SBM processing time(commercial SBM or autoclaved for 30 or 60 min at 120 ℃) and protease supplementation(not supplemented and supplemented) as factors. Protease was included at three times the recommended dose(0.06%) and the experimental diets were fed from 15 to 21 ***: The interaction between the effects of SBM processing and protease supplementation was significant for the AID of CP(P = 0.01), Trp(P = 0.01), Gly(P = 0.03) and Pro(P = 0.03), and also for the average daily gain(P = 0.01)and feed conversion ratio(P = 0.04). Increasing the processing time of SBM decreased(P e AID of all amino acids, whilst the effect of protease supplementation was only significant for the AID of Phe(P = 0.02) and Tyr(P = 0.01).Conclusions: exogenous protease supplementation at three times the commercial dose does not seem to offset the negative effects of hydrothermal processing of SBM on the apparent ileal digestibility of CP and amino acids or performance of broilers. Whilst positive numerical improvements of digestibility and performance(ADG and FCR)were noticed with protease supplementation at relatively mild processing levels, negative results were obtained with the harsh-processed meals.

关键词： Amino acids Apparent ileal digestibility Broilers exogenous protease

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师范生教学基本技能智能实训模型及应用研究

电化教育研究 2024年第6期45卷 113-120页

作者：孙硕胡小勇穆肃刘阳华南师范大学教育信息技术学院广东广州510631 华南师范大学教育人工智能研究院广东广州510631 北京中庆现代技术股份有限公司北京100094

师范生作为教师队伍的储备力量,影响着教育未来的发展。依据《普通高等学校师范类专业认证标准》与教育部两批《人工智能助推教师队伍建设行动试点工作的通知》等政策文件要求,研究针对师范生教学基本技能培养难题与发展要求,结合人工... 详细信息

师范生作为教师队伍的储备力量,影响着教育未来的发展。依据《普通高等学校师范类专业认证标准》与教育部两批《人工智能助推教师队伍建设行动试点工作的通知》等政策文件要求,研究针对师范生教学基本技能培养难题与发展要求,结合人工智能技术潜能构建了面向师范生教学基本技能培养的“四维度18指标”微技能观测指标框架,设计了四层架构的师范生教学基本技能智能实训分析系统模型,提出了智能分析特点及教学基本技能“智学”实训方式,并于所在师范院校开展了试验应用。研究表明,以人工智能技术助推师范生高质量培养为导向,进行师范生教学基本技能智能实训框架模型构建、技术方法实现、实训场景设计和数字画像生成,能够提升师范生实训效果。

关键词：师范生教学基本技能微技能观测指标智能实训数字画像

China and the eU: Rivalry or Cooperation?

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China Today 2020年第9期69卷 43-45页

作者： MARCeLO muÑoz Cátedra China

NOTWITHSTANDING Western admiration,suspicion,uneasiness or rejection,the undisputed growth of China brings into question a global status quo that is Western in *** reality,however,of every 10 inhabitants on the planet,two are Chinese,two are Indian,and another two are African,while the other two are from the rest of Asia,America,europe and Oceania *** fact six out of 10 people in the world are *** these facts,we continue believing that everything globally is about the West,that our culture is“the[only]culture,”that our civilization is“the[only]civilization,”and that our values are“universal values.”Oftentimes,when we hear in the media“the most beautiful in the world”or“the most advanced in the world,”we think about our Western small,wealthy,and advanced world,but which in reality only represents 14 percent of the planet.

关键词： planet spite dispute

Role of serendipity in the discovery of classical antidepressant drugs:Applying operational criteria and patterns of discovery

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World Journal of Psychiatry 2022年第4期12卷 588-602页

作者： Francisco López-muñoz Pilar D’Ocón Alejandro Romero JoséA Guerra CecilioÁlamo Faculty of Health University Camilo JoséCelaVillanueva de la Cañada 28692MadridSpain “Hospital 12 de Octubre”Research Institute(i+12) Avda.de Córdobas/nMadrid 28041Spain Department of Pharmacology Faculty of PharmacyUniversity of ValenciaAvda.Vicent Andres Estelless/nValencia 46100Spain Department of Pharmacology and Toxicology Faculty of Veterinary MedicineComplutense UniversityAvda.Puerta de Hierros/nMadrid 28040Spain Department of Pharmacology and Toxicology Faculty of PharmacyComplutense UniversityPl.de Ramón y Cajals/nMadrid 28040Spain Department of Biomedical Sciences(Pharmacology Area) Faculty of Medicine and Health SciencesUniversity of AlcaláCampus Científico-TecnológicoCrta.de Madrid-BarcelonaAlcaláde Henares 28871MadridSpain

The role played by serendipity in the origin of modern psychopharmacology has proven to be controversial in scientific *** its original meaning(Walpole),serendipity refers to discoveries made through a combination of accidents and *** have implemented an operational definition of serendipity based on finding something unexpected or unintended,regardless of the systematic process that led to the accidental observation,and we have established four different patterns of serendipitous *** this paper,we have analyzed the role of serendipity in the discovery and development of classical antidepressant drugs,tricyclic antidepressants and monoamine oxidase inhibitors as well as heterocyclic,“atypical”or“second generation”*** discovery of the antidepressant properties of imipramine and iproniazid,the prototypes of tricyclic antidepressants and monoamine oxidase inhibitors,respectively,fits the mixed type II pattern;initial serendipitous discoveries(imipramine was an antipsychotic and iproniazid was an antituberculosis agent)led secondarily to non-serendipitous *** the other components of these two families of drugs were developed specifically as antidepressants,modifying the chemical structure of the series leaders,thereby allowing all of them to be included in the type IV pattern,characterized by the complete absence of *** the heterocyclic drugs,mianserin(originally developed as an antihistamine)also falls into the type II pattern.

关键词： Serendipity Antidepressants Imipramine Iproniazid Psychopharmacology History of neurosciences

Novel Silver-Copper Mixed Oxides:A Success of Soft-Chemistry Methods

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复旦学报（自然科学版） 2007年第5期46卷 733-,736页

作者： D.muoz-Rojas e.M.Tejada-Rosales P.Góez-Romero N.Casa-Pastor Institut de Ciència de Materials de Barcelona CSICCampus UAB08193 BellaterraSpain

1 Results The discovery of thefamily of mercury cupratesinthe eighties ,which present the highest Curie Temper-ature (Tc) among all known High Temperature Super-Conductors (HTSC) 。

关键词： silver-copper mixed oxides soft chemistry methods electrochemistry delafossites

黏蛋白13在肺腺癌组织中的表达及其对A549细胞恶性生物学行为的影响与可能的机制

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中国肿瘤生物治疗杂志 2024年第1期31卷 40-46页

作者：穆培娟赵哲张冬内蒙古科技大学包头医学院第一附属医院呼吸与危重症医学科内蒙古包头014040 内蒙古科技大学包头医学院研究生院内蒙古包头014040

目的:探讨黏蛋白13(muC13)在肺腺癌组织中的表达及其对A549细胞增殖、凋亡、迁移、侵袭及eMT的影响与可能的机制。方法:通过癌症基因组图谱(TCGA)和高通量基因表达(GeO)数据库分析muC13在肺腺癌组织与正常肺组织、癌旁组织中的差异表达... 详细信息

目的:探讨黏蛋白13(muC13)在肺腺癌组织中的表达及其对A549细胞增殖、凋亡、迁移、侵袭及eMT的影响与可能的机制。方法:通过癌症基因组图谱(TCGA)和高通量基因表达(GeO)数据库分析muC13在肺腺癌组织与正常肺组织、癌旁组织中的差异表达。qPCR法和WB法检测人肺腺癌细胞NCI-H1395、NCI-H1975、H1299、A549和人正常肺上皮细胞BeAS-2B中muC13 mRNA和蛋白的表达水平。利用si RNA技术敲低A549细胞中muC13表达,实验分为si-muC13组、NC组和si-muC13+IGF-1组。通过克隆形成实验、流式细胞术和Transwell实验分别检测敲低muC13对A549细胞增殖、细胞周期、凋亡、迁移和侵袭的影响,WB法检测敲低muC13对A549细胞上皮钙黏素(e-cadherin)、神经钙黏素(N-cadherin)、波形蛋白(vimentin)、eGFR、p-eGFR、PI3K、p-PI3K、AKT、p-AKT等蛋白表达的影响。结果:muC13 mRNA和蛋白在肺腺癌组织和细胞中均呈高表达(均PmuC13后,A549细胞的增殖能力显著降低,G0/G1期的细胞数量显著增多、G2/M期及S期的细胞数量显著减少,细胞凋亡率显著升高,细胞迁移及侵袭能力均显著降低(均Pe-cadherin表达显著上调,N-cadherin、vimentin表达显著下调,p-eGFR/eGFR、p-PI3K/PI3K、p-AKT/AKT比值均显著降低(均PeGFR/eGFR、p-PI3K/PI3K、p-AKT/AKT比值均显著升高(均PmuC13在肺腺癌组织和细胞中均呈高表达,其可能通过激活eGFR/PI3K/AKT信号通路促进A549细胞增殖、迁移、侵袭和eMT。

关键词：黏蛋白13 肺腺癌 A549细胞增殖凋亡迁移侵袭上皮间质转化 eGFR/PI3K/AKT信号通路

基于加权马氏距离判别的计算机实验室火灾风险预警方法

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实验技术与管理 2024年第1期41卷 239-244页

作者：沐虹霞朱旭平南京工业职业技术大学国有资产管理处、实验室建设与管理处江苏南京210023

为识别计算机实验室内潜在的火情,并及时发出分级火灾预警信息,该文提出一种基于加权马氏距离判别的计算机实验室火灾风险预警方法,通过部署多种类型传感器采集并分析易引起火灾风险的多项指标数据,判断实验室内火灾风险等级,并针对不... 详细信息

为识别计算机实验室内潜在的火情,并及时发出分级火灾预警信息,该文提出一种基于加权马氏距离判别的计算机实验室火灾风险预警方法,通过部署多种类型传感器采集并分析易引起火灾风险的多项指标数据,判断实验室内火灾风险等级,并针对不同火灾风险等级提出相应的预警处理措施。通过模拟实验证明,基于加权马氏距离判别的计算机实验室火灾风险预警方法具有较高的预警精度。

关键词：加权马氏距离计算机实验室多类型传感器火灾风险预警