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Signal Transduction and Targeted Therapy 2023年第2期8卷 373-376页

作者： Haoran Liu chen duan Xiaoqi Yang Jianhe Liu Yaoliang Deng Hans-Göran Tiselius Zhangqun Ye Tao Wang Jinchun Xing Hua Xu Department of Urology The First Affiliated Hospital of Anhui Medical University230000HefeiChina Bio-X Stanford University94303StanfordCaliforniaUSA Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430000WuhanChina Department of Urology The Second Affiliated Hospital of Kunming Medical University650000KunmingChina Department of Urology The First Affiliated Hospital of Guangxi Medical University530000NanningChina Division of Urology Department of Clinical SciencesIntervention and TechnologyKarolinska Institutet13820StockholmSweden Department of Urology The First Affiliated Hospital of Xiamen University361000XiamenChina Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center 430000WuhanChina Department of Biological Repositories Zhongnan Hospital of Wuhan University430000WuhanChina Department of Urology Zhongnan Hospital of Wuhan University430000WuhanChina

Dear Editor,Kidney stones are one of the most common clinical diseases in *** 80%of renal calculi are composed of calcium oxalate(CaOx)crystals,which are gradually deposited in the medullary collecting duct or in the ... 详细信息

关键词： Kidney clinical diseases

Study on Shear Strength Characteristics of Basalt-Concrete Bonding Interface Based on in-situ Direct Shear Test

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Journal of Earth Science 2024年第2期35卷 553-567页

作者： Peng Xia Xinli Hu Chunye Ying Shuangshuang Wu Chu Xu Xuan Wang Hao chen Hang duan College of Harbour and Coastal Engineering Jimei UniversityXiamen361021China Faculty of Engineering China University of GeosciencesWuhan430074China China Three Gorges Construction Group Ltd.Beijing100038China

In rock engineering,the shear strength of the basalt-concrete bonding interface is a key factor affecting the shear performance of hydroelectric dam foundations,embedded rock piles and rock *** this study,30 sets of in-situ direct shear tests were conducted on the basalt-concrete bond interface in the Baihetan dam area to investigate the shear strength characteristics of the basalt-concrete bonding *** bonding interface contains two states,i.e.,the bonding interface is not sheared,termed as se(symbolic meaning see Table 1);the bonding interface is sheared with rupture surface,termed as *** effects of lithology,Joints structure,rock type grade and concrete compressive strength on the shear strength of the concrete-basalt contact surface were *** test results show that the shear strength of the bonding interface(s_(e)&s_(i))of columnar jointed basalt with concrete is greater than that of the bonding interface(s_(e)&s_(i))of non-columnar jointed one with the same rock type *** the rock type grade isⅢ_(2),fcol is 1.22 times higher than fncol and ccol is 1.13 times greater than *** shear strength parameters of the basalt-concrete bonding interface differ significantly for different *** cohesion of the bonding interface(s_(i))of cryptocrystalline basalt with concrete is 2.05 times higher than that of the bonding interface(s_(i))of breccia lava with concrete under the same rock type grade *** type grade has a large influence on the shear strength of the non-columnar jointed basalt-concrete bonding interface(s_(e)&s_(i)).cnol increases by 33%when the grade of rock type rises fromⅢ_(1)toⅡ_(1).the rock type grade has a greater effect on bonding interface(s_(i))cohesion than the coefficient of *** the rock type grade is reduced fromⅢ_(2)toⅢ_(1),f_(ncol)′increases by 2%and c_(ncol)′improves by 44%.The shear strength of the non-columnar jointed basalt-concrete bonding interface(s_(e)&s_(i))increases wit

关键词： direct shear test basalt-concrete bonding interface shear strength parameters engineering geogolgy

Enriching Iodine and Regulating Grain Aroma,Appearance Quality,and Yield in Aromatic Rice by Foliar Application of Sodium Iodide

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Rice science 2024年第3期31卷 328-342,I0046-I0054页

作者： HONG Weiyuan duan Meiyang WANG Yifei chen Yongjian MO Zhaowen QI Jianying PAN Shenggang TANG Xiangru State Key Laboratory for Conservation and Utilization of Subtropical Agricultural Bioresources South China Agricultural UniversityGuangzhou 510642China Scientific Observing and Experimental Station of Crop Cultivation in South China Ministry of Agriculture and Rural AffairGuangzhou 510642China Guangzhou Key Laboratory for Science and Technology of Aromatic Rice Guangzhou 510642China

Applying iodine fertilizers to cultivate iodine-rich crops for daily intake is an effective approach for iodine supplementation,especially for aromatic *** experiments were conducted during the early growing seasons of 2021 and 2022 to evaluate the impacts of foliar application of iodine fertilizer on aromatic rice and to explore the optimal iodine fertilizer *** the full heading stage,six different concentrations of sodium iodide solutions of 0%(CK),0.010%(T1),0.025%(T2),0.050%(T3),0.075%(T4),and 0.100%(T5)were applied to indica aromatic rice cultivars Meixiangzhan 2 and *** results showed that sodium iodide treatments significantly increased the iodine and sodium contents in both leaves and *** with the CK,the T1 and T2 treatments increased the 2-acetyl-1-pyrroline(2-AP)content in mature grains by 8.41%-101.66%and 13.58%-74.60%,*** in the contents of 1-pyrroline-5-carboxylic acid,proline,1-pyrroline,and methylglyoxal,as well as the activity of proline dehydrogenase were also ***,sodium iodide treatments remarkably decreased the chalky grain rate,chalkiness area,and chalkiness degree of aromatic rice,with the T2 treatment exhibiting a 17.79%-47.42%decrease in chalkiness degree compared with the ***,T1 and T2 treatments showed beneficial impacts on chlorophyll content,photosynthetic characteristics,and yield components,while T3,T4,and T5 treatments exhibited adverse effects on leaf and grain *** linear discriminant analysis revealed significant differences between *** correlation analysis and piecewise structural equation modeling showed that the iodine and sodium influenced the photosynthetic characteristics and chlorophyll content of the leaves,thereby regulating the 2-AP biosynthesis and yield components,ultimately affecting the 2-AP content and ***,this study suggests that foliar application of 0.025%sodium iodide is an effective method t

关键词： 2-acetyl-1-pyrroline appearance quality aromatic rice foliar application grain yield iodine

Induction of long-term potentiation at Schaffer collateral-CA1 synapses in mice hippocampus after IMPX977 administration

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Chinese Herbal Medicines 2021年第1期13卷 131-135页

作者： Ni Song chen duan Ye Li Tian-xiu Qian Qi Wang Wei Zhao Xiao-ying Wang Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006China Capital Medical University Beijing 100071China

Objective: To investigate the effects of IMPX977 on long term potentiation(LTP) at Schaffer collateralCA1 synapses in vitro and on methyl Cp G binding protein 2(Mecp2) expression in mice cortex and ***: Thirty-two C57 BL/6 mice were randomly divided into four groups: control, olive oil(vehicle),IMPX977 low(5 mg/kg) and high(15 mg/kg) groups. Mice were administrated every other day orally for two weeks. Extracellular recording technique in vitro was used to record the effects of IMPX977 on Schaffer collateral-CA1 LTP pathway in acute mice hippocampal slices. The Mecp2 protein expression level was detected by Western ***: Compared to the control group, vehicle did not alter the synaptic transmission in Schaffer collateral-CA1 synapses, however, IMPX977 at concentrations of 5 mg/kg and 15 mg/kg significantly enhanced f EPSP(field excitatory postsynaptic potential) slope in Schaffer collateral-CA1 pathway to(179.6 ± 17.8)% and(191.4 ± 21.4)%, individually 60 min after HFS, IMPX977 improved LTP induction significantly at Schaffer collateral-CA1 pathway at least. Also, IMPX977 significantly elevated Me CP2 protein level in ***: The effects of IMPX977 on synaptic transmission and Mecp2 protein expression provided convincing evidence that IMPX977 could be promising new drug candidates for Rett syndrome treatment.

关键词： IMPX977 long-term potentiation(LTP) Mecp2 Schaffer collateral-CA1 synapses

A comparison study on structure-function relationship of polysaccharides obtained from sea buckthorn berries using different methods:antioxidant and bile acid-binding capacity

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Food Science and Human Wellness 2024年第1期13卷 494-505页

作者： Qiaoyun Li Zuman Dou Qingfei duan Chun chen Ruihai Liu Yueming Jiang Bao Yang Xiong Fu SCUT-Zhuhai Institute of Modern Industrial Innovation School of Food Science and EngineeringSouth China University of Technology381 Wushan RoadGuangzhou 510640China Guangzhou Institute of Modern Industrial Technology Nansha 511458China Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou 510640China Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health(111 Center) Guangzhou 510640China Department of Food Science Stocking HallCornell UniversityIthaca 14853USA South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China

In this study,the structural characters,antioxidant activities and bile acid-binding ability of sea buckthorn polysaccharides(HRPs)obtained by the commonly used hot water(HRP-W),pressurized hot water(HRP-H),ultrasonic(HRP-U),acid(HRP-C)and alkali(HRP-A)assisted extraction methods were *** results demonstrated that extraction methods had significant effects on extraction yield,monosaccharide composition,molecular weight,particle size,triple-helical structure,and surface morphology of HRPs except for the major linkage *** analysis showed that HRP-U with filamentous reticular microstructure exhibited better thermal *** HRP-A with the lowest molecular weight and highest arabinose content possessed the best antioxidant ***,the rheological analysis indicated that HRPs with higher galacturonic acid content and molecular weight showed higher viscosity and stronger crosslinking network(HRP-C,HRP-W and HRP-U),which exhibited stronger bile acid binding *** present findings provide scientific evidence in the preparation technology of sea buckthorn polysaccharides with good antioxidant and bile acid binding capacity which are related to the structure affected by the extraction methods.

关键词： Sea buckthorn Extraction method Structure Rheological properties Antioxidant activity Bile acid binding capacity

Dietary chenodeoxycholic acid improves growth performance and intestinal health by altering serum metabolic profiles and gut bacteria in weaned piglets

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Animal Nutrition 2021年第2期7卷 365-375页

作者： Min Song Fenglin Zhang Lin chen Qiang Yang Han Su Xiaohua Yang Haiwen He Mingfa Ling Jisong Zheng chen duan Xumin Lai Mushui Pan Xiaotong Zhu Lina Wang Ping Gao Gang Shu Qingyan Jiang Songbo Wang Guangdong Provincial Key Laboratory of Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou510642China National Engineering Research Center for Breeding Swine Industry and ALLTECH-SCAU Animal Nutrition Control Research Alliance South China Agricultural UniversityGuangzhou510642China Sericultural&Agri-Food Research Institute Guangdong Academy of Agricultural SciencesKey Laboratory of Functional FoodsMinistry of AgricultureGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhou510610China

Nutritional diarrhea and subsequent performance degradation in weaned piglets are major challenges for the pig *** acids(BA)can be added to the diet as *** experiment was conducted to investigate the effects of chenodeoxycholic acid(CDCA),a major primary BA,on growth performance,serum metabolic profiles and gut health in weaned piglets.A total of 72 healthy weaned piglets were randomly assigned to the control(CON)and the CDCA groups,which were feed a basal diet and the basal diet supplemented with 200 mg/kg CDCA for 30 d,*** results demonstrated that CDCA significantly increased final BW and average daily gain(ADG),decreased feed-to-gain(F:G)ratio and tended to reduce diarrhea *** addition,CDCA increased the villus height-to-crypt depth(V:C)ratio,elevated goblet cell numbers and the expression of tight junction proteins,suggesting the enhancement of intestinal barrier *** an emulsifier,CDCA increased jejunal lipase activity and the mRNA expression of pancreatic *** supplementation also altered the serum metabolic profiles,including increasing the levels of indole 3-acetic acid,N'-formylkynurenine and theobromine that were beneficial for gut ***,the relative abundance of 2 beneficial gut bacteria,Pre-votella 9 and Prevotellaceae TCG-001,were increased,whereas the relative abundance of a harmful bacteria,Dorea,was decreased in the gut of weaned piglets supplemented with ***,the altered serum metabolic profiles showed a strong correlation with the changed gut *** conclusion,CDCA improved the growth performance of weaned piglets by improving intestinal morphology and barrier function,and enhancing lipid digestion,accompanied by alterations of serum metabolic profiles,and changes in relative abundance of certain gut bacteria.

关键词： chenodeoxycholic acid Weaned piglet Growth performance Gut health Serum metabolite Gut microbiota

A justice and innovative way ahead of consumption-based emission accounting approach

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Science China Earth Sciences 2024年第10期67卷 2999-3010页

作者： Qun SHEN Hongbo duan Yun TANG Linbing TANG Li SHANG Xinyu DOU Wei WEI Weiqiang chen Zhu LIU State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization CAS Key Laboratory of Low-Carbon Conversion Science&EngineeringShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China School of Economics&Management University of Chinese Academy of SciencesBeijing 100190China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Department of Earth System Science Tsinghua UnivesityBeijing 100084China

Carbon emission accounting is an important basis for global climate *** on the consumption-based accounting(CBA)method,the characteristics of carbon flow between national,regional,and product processes could be more clearly ***,CBA is more conducive to clarifying the attribution of responsibilities between producers and consumers,with the principles of fairness and *** accounting for carbon emissions in typical countries from 1990 to 2019,we found that the CBA emissions are higher than the production-based accounting(PBA)emissions in major developed countries,while the results are reversed for developing *** the past 30 years,the CBA emissions in targeted developed countries generally have shown a downward trend,while in developing countries,they have shown an upward *** emissions in China have shown a continuous growth trend from 1990 to 2019,but the pace has slowed down significantly over the last ***,the embodied carbon intensity of China’s exports continues to decline,indicating that China is providing more green and low-carbon products to the *** the PV industry as an example,this study further reveals the contribution of specific product industries to the country’s carbon transfer through product carbon footprint *** order to provide a scientific basis for global mitigation and climate governance,it is urgent to innovate a scientific,practical,and standardized CBA technology system.

关键词： Consumption-based accounting Production-based accounting Carbon transfer Carbon footprint

Development of lithium-free P2-type high-sodium content cathode materials with enhanced cycle and air stability for sodium-ion batteries

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Rare Metals 2024年第1期43卷 113-123页

作者： Jin-Lv Tian Lin-Rong Wu Hai-Jun Zhao Shou-Dong Xu Liang chen Ding Zhang Xiao-Chuan duan College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China

The effect of partial substitution of Mg for Ni on a high-sodium and lithium-free layered P2-type Na_(45/54)Mg_(6)/_(54)Ni_(12/54)Mn_(34/54)O_(2) cathode with high initial Coulombic efficiency and excellent cyclic stability has been investigated in this *** on the crystal structural analysis,the Mg doping can retain the P2 structure up to 4.3 V,thus restraining the detrimental phase transformation of P2-02during the Na-ion intercalation/deintercalation ***,the obtained Mg-doped P2-type cathode exhibits a reversible specific capacity of 109 mAh·g^(-1) at 0.1C between 2.0 and 4.3 V and a retention rate of 81.5% after 200cycles at *** addition,the full cell consisting of Mg-doped P2-type cathode and hard carbon anode shows a capacity retention rate of 85.6% after 100 *** study provides new insight into the development of durable cathode materials for sodium-ion batteries.

关键词： Sodium-ion batteries Cathode material High sodium content Air stability

Gender, Social Origins and Accumulated Disadvantages Associated with Mid-Life Body Weight in Taiwan

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Health 2014年第18期6卷 2399-2407页

作者： duan-Rung chen Leah M. Frerichs Institute of Health Policy and Management Public Health Building National Taiwan University Taipei Taiwan College of Public Health University of Nebraska Medical Center Nebraska Medical Center Omaha USA

Obesity is a problem with global health and economic consequences. This study assesses the impact of social origins and socio-economic disadvantages on mid-life body weight. Hypotheses of both critical early life period and social trajectory were tested using a sample of 845 adults, aged 45 to 69 years, from a nationally representative sample in 2009 Taiwan Social Change Survey. The study found evidence of a significant gender-specific heterogeneity of social origins on obesity risk. Men with accumulated disadvantage had increased BMI, but no significant accumulative trajectories were found among women. Obesity prevention must consider factors beyond behavioral change, and include a focus on social origins and gender identity.

关键词： Obesity Risk Social Class Social Trajectory

Approaches to Improving Selectivity During Photoelectrochemical Transformation of Small Molecules

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Transactions of Tianjin University 2024年第2期30卷 167-177页

作者： Sipeng Yang Jie Yang Mengyu duan Shirong Kang Shaohua He Chuncheng chen Key Laboratory of Photochemistry CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100190China

Photoelectrochemical (PEC) small-molecule oxidation can selectively transform substrates into high-value-added fine chemicals and increase the rate of cathode hydrogen evolution. Nevertheless, achieving high-selectivity PEC oxidation of small molecules to produce specific products is a very challenging task. In general, selectivity can be improved by changing the surface catalyticsites of the photoanode and modulating the interfacial environments of the reactions. Herein, recent advances in approaches to improving selective PEC oxidation of small molecules are introduced. We first briefly discuss the basic concept and fundamentals of small-molecule PEC oxidation. The reported approaches to improving the performance of selective PEC oxidation of small molecules are highlighted from two aspects: (1) changing the surface properties of photoanodes by selecting suitable materials or modifying the photoanodes and (2) mediating the oxidation reactions using redox mediators. The PEC oxidation mechanism of these studies is emphasized. We also discuss the challenges in this research direction and offer a perspective on the further development of selective PEC-based small-molecule transformation.

关键词： Photoelectrocatalytic Small-molecule oxidation Improving selectivity Surface properties Mediating