Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation
作者机构：Department of UrologyThe First Affiliated Hospital of Anhui Medical University230000HefeiChina Bio-XStanford University94303StanfordCaliforniaUSA Department of UrologyTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430000WuhanChina Department of UrologyThe Second Affiliated Hospital of Kunming Medical University650000KunmingChina Department of UrologyThe First Affiliated Hospital of Guangxi Medical University530000NanningChina Division of UrologyDepartment of Clinical SciencesIntervention and TechnologyKarolinska Institutet13820StockholmSweden Department of UrologyThe First Affiliated Hospital of Xiamen University361000XiamenChina Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center430000WuhanChina Department of Biological RepositoriesZhongnan Hospital of Wuhan University430000WuhanChina Department of UrologyZhongnan Hospital of Wuhan University430000WuhanChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第2期
页 面：373-376页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(82070726,82060137,81970604,and 82100808) the Key Project of the Guangxi Natural Science Foundation(2020GXNSFDA297013) the China Postdoctoral Science Foundation(2021M690185) the Anhui Postdoctoral Science Foundation(2021A482) the Anhui Provincial Department of Education Research Project(KJ2020A0167)
摘 要：Dear Editor,Kidney stones are one of the most common clinical diseases in *** 80%of renal calculi are composed of calcium oxalate(CaOx)crystals,which are gradually deposited in the medullary collecting duct or in the renal interstitium,causing nephrocalcinosis.1 Although CaOx nephrocalcinosis is usually asymptomatic.
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