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High-energy collider parameters

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Chinese Physics C 2014年第9期 392-396页

作者： K.A.Olive K.Agashe C.Amsler M.Antonelli J.-f.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.w.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller University of Minnesota School of Physics and Astronomy 116 Church St.S.E. Minneapolis MN 55455 USA University of Maryland Department of Physics College Park MD 20742-4111 USA Albert Einstein Center for fundamental Physics Universitat Bern CH-3012 Bern Switzerland Lab.Nazionali di frascati dell'INfN CP 13 via E.fermi 40 I-00044 frascati(Roma) Italy Departement de physique Universite de Montreal C.P.6128 succ.centre-ville Montreal(Quebec) H3C 3J7 Canada Pacific Northwest National Laboratory 902 Battelle Boulevard Richland wA 99352 USA Department of Physics and Astronomy University of Oklahoma Norman OK 73019 USA Department of Physics University of wisconsin Madison wI 53706 USA Physics Division Lawrence Berkeley National Laboratory 1 Cyclotron Road Berkeley CA 94720 USA CERN European Organization for Nuclear Research CH-1211 Geneve 23 Switzerland Department of Physics The Ohio State University 191 w.woodruff Ave. Columbus OH 43210 COMPAS Group Institute for High Energy Physics RU- 142284 Protvino Russia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7 f-75252 Paris france Max-Planck-Institute of Physics 80805 Munich Germany Department of Physics University of washington Seattle wA 98195 USA Ludwig-Maximilians-Universitat fakultdt für Physik Schellingstr.4 D-80799 München Germany Enrico fermi Institute and Department of Physics University of Chicago Chicago IL 60637-1433 USA Department of Physics Syracuse University Syracuse Ny 13244 USA Department of Physics Columbia University 538 w.120th Street New york Ny 10027 USA High Energy Physics Group Blackett Laboratory Imperial College Prince Consort Road London Sw7 2AZ UK Jefferson Lab 12000 Jefferson Ave. Newport News VA 23606 USA Department of Physics University of Virginia PO Box 400714 Charlottesville VA 22904 USA fermi National Accelerator Laboratory P.O.Box 500 Batavia IL 60510 USA Kavli Institute for Cosmological Physics University of Chicago Chicago IL 60637-1433 USA Department of Physics and Astronomy University of Sussex falmer Brighton BN1 9QH UK Department o

HIGH-ENERGy COLLIDER PARAMETERS:e+e-Colliders（I）Updated in September 2013 with numbers received from representatives of the colliders（contact ***,LBNL）.The table shows parameter values as achieved by July 1,*** are,where appropriate,r.m.s.;unless noted otherwise,energies refer to beam energy;H and V indicate horizontal and vertical directions;*** for *** for the defunct SPEAR,doris,PETRA,PEP,TRISTAN,and VEPP-2M colliders may be found in our 1996 edition（***.D54,1 July 1996,Part I）.

关键词： LHC Pb High-energy collider parameters length CERN BEPC high MHz exp cell KEK

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多边合作:抗疫成功亦经济复苏的关键

新华月报 2020年第11期 99-101页

作者：王培尧(翻译) 约翰·奈斯比特多丽丝·奈斯比特李大巍不详约翰·奈斯比特大学他山石智库

跳出衰退周期有一套总体策略李大巍:首先,向你们请教在后疫情时代全球应对衰退的策略,几周前,国际货币基金组织发布《2020界经济展望报告》,预计今年全球经济将萎缩3%,衰退程度远超2008年国际金融危机引发的经济下滑,是20世纪30年代大... 详细信息

跳出衰退周期有一套总体策略李大巍:首先,向你们请教在后疫情时代全球应对衰退的策略,几周前,国际货币基金组织发布《2020界经济展望报告》,预计今年全球经济将萎缩3%,衰退程度远超2008年国际金融危机引发的经济下滑,是20世纪30年代大萧条以来最糟糕的全球经济衰退。

关键词：经济下滑总体策略展望报告多边合作大萧条国际货币基金组织全球经济衰退国际金融危机

Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair

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Cellular & Molecular Immunology 2022年第11期19卷 1251-1262页

作者： Christopher O.Audu william J.Melvin Amrita D.Joshi Sonya J.wolf Jadie y.Moon frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher Department of Surgery Section of Vascular SurgeryUniversity of MichiganAnn ArborMIUSA Department of Microbiology and Immunology University of MichiganAnn ArborMIUSA Department of Medicinal Chemistry University of MichiganAnn ArborMIUSA Department of Surgery Section of General SurgeryUniversity of MichiganAnn ArborMIUSA Department of Bioengineering University of IllinoisUrbana-ChampaignChampaignILUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Surgery University of Texas Southwestern Medical CenterDallasTXUSA

Macrophage plasticity is critical for normal tissue repair following *** pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are ***,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene ***,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 ***,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NfκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 ***,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound *** limits inflammatory cytokine production by wound macrophages during ***,in diabetic mice,its role changes to limit wound repair and enhance *** finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time ***,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and *** together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds.

关键词： wound healing epigenetics diabetes JMJD3 STING

Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases

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world Journal of Gastroenterology 2001年第3期7卷 381-386页

作者： Jun Hui Cui~1 Uwe Krueger~2 doris Henne-Bruns~2 Bemd Kremer~2 Holger Kalthoff~2 ~1Department of General Surgery,first Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China ~2Department of General Surgery,Christian-Albrechts-University,Kiel,GermanyDr.Jun Hui Cui graduated from Zhejiang Medical University in 1984,earned master degree in 1990,studied in the Surgical Department of Kiel University and worked in the Lab of Molecular Oncology of Kiel University from 1994-1997achieved M.D.from Kiel University.Germany,now associate professor of surgery,specialized in colorectal oncology.Adviser of graduated student for master degree,having 20 publications published in key Chinese or English journals. Department of General Surgery First Affiliated Hospital College of Medicine Zhejiang University 79 Qingchun Road Hangzhou 310003 Zhejiang ProvinceChina. Cjhui@***

AIM: To establish a relevant animal model of human gastrointestinal cancer, which can be used for repetitive investigations, so as to improve our understanding and management of carcinogenesis and cancer metastasis. METHODS: Intact tissues of human colorectal and pancreatic cancers were transplanted in nude mice. The biological characteristics of the original and the corresponding transplanted tumors were investigated by HE staining, PAS staining and immunostaining. The metastases in the livers and lungs of nude mice were investigated by immunostaining with biotinylated mab KL-1 and by RT-PCR using ck20 specific primers. RESULTS: There were totally 9 of 16 surgical specimens growing in nude mice subcutaneously and/or orthotopically (4 of 6 colorectal and 5 of 10 pancreatic cancer). Tumor cell content of the specimens and freezing of tissue specimens are important factors influencing the growth of transplanted tumor. In the group of fresh tumor tissues with greater than 50% tumor cell content, the success rate of the transplantation was 100% (3 cases of pancreatic cancer and 3 cases of colorectal cancer). The orthotopically trans-planted tumors resemble the original tumor morphologically and biologically, including TAA expression such as CEA by immunohistochemistry, and CEA level in the serum of mice. Ki-67 labeling index and the expression of TAA especially K-ras, 17-1A and RA-96, are associated with the potential of tumor growth in nude mice. Micrometastases in the lungs and livers of tumor bearing mice can be detected by immunostaining with biotinylated mab KL-1 and ck20-specific RT-PCR. CONCLUSION: An orthotopic transplantation model for human colon and pancreatic cancer in nude mice has been set up. we have also established sensitive detection methods with ck-immunohistochemistry and ck20-RT-PCR to study xenotransplanted human cancer and its metastatic cancer cells in the liver and lung of nude mice. This study may be helpful in understanding the mechanism of ca

关键词： Animals Disease Models, Animal female Gastrointestinal Neoplasms Humans Male Mice Mice, Nude Neoplasm Seeding Neoplasm Transplantation Research Support, Non-U.S. Gov't Transplantation, Heterologous

产科并发症能解释30岁以上妇女的高剖宫产率吗?一项回顾性分析

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英国医学杂志中文版 2001年第3期4卷 136-136页

作者： Jacqueline S Bell doris M Campbell wendy J Graham Gillian C Penney Mandy Ryan Marion H Hall 翁梨驹 Dugald Baird Centre for Research in women's Health Department of Obstetrics and Gynaecology Aberdeen Maternity Hospital

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发展,供应,应用和需求——平衡博物馆数字技能生态系统

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博物院 2018年第6期 60-70页

作者：罗斯.帕里多丽丝.鲁思.艾克霍夫萨莉.安妮.巴尼斯埃里卡.基斯彼得朱末寒英国莱斯特大学博物馆学学院英国莱斯特大学CAMEo研究所英国华威大学就业研究所英国华威大学

博物馆从业人员的数字素质仍然是数字化技术在博物馆应用的主要挑战之一。据研究显示,英国超过三分之一的博物馆依然认为内部没有足够的数字化技能来满足数字化需求,博物馆的一些数字技能甚至在退步而不是进步。最新的调查结果表明"缺... 详细信息

博物馆从业人员的数字素质仍然是数字化技术在博物馆应用的主要挑战之一。据研究显示,英国超过三分之一的博物馆依然认为内部没有足够的数字化技能来满足数字化需求,博物馆的一些数字技能甚至在退步而不是进步。最新的调查结果表明"缺乏信心"是障碍所在。为解决这个紧迫的问题,英国设立"一个接一个"国家项目,其目标是在未来两年内为博物馆员工数字素质的培养模式提供转型框架。本文是英国"一个接一个"项目初始阶段的研究成果首次在国际上分享。结合博物馆学和前沿职业发展研究,本文试图阐明英国博物馆数字化技能的发展、供应、需求和应用,确定其主要参与者,探究典型职业发展模式和数字化技能政策的关系。本文从当前数字化技能如何开发和应用、数字化需求如何阐述、存在哪些技能空白,以及数字化技能发展和应用的障碍等几方面做了分享,并探讨了从"科技技能"向"数字素养"转变的意义及转变过程中的促进因素与抑制因素。

关键词：博物馆数字素养技能培训劳动力转型

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模仿敌人声音的领航鲸

环球科学 2021年第5期 17-17页

作者：多丽丝·艾琳·乌鲁蒂亚龚聪(翻译) 不详

鲸类(包括鲸、海豚和鼠海豚)能够利用声音进行社交,寻找食物和伴侣,也能用声音实现导航。不同物种、不同群体的鲸类声音都不相同。有些鲸还能模仿人造声源,比如声呐。不过,此前并没有记录显示它们能够模仿其他鲸类的声音。直到最近,一... 详细信息

鲸类(包括鲸、海豚和鼠海豚)能够利用声音进行社交,寻找食物和伴侣,也能用声音实现导航。不同物种、不同群体的鲸类声音都不相同。有些鲸还能模仿人造声源,比如声呐。不过,此前并没有记录显示它们能够模仿其他鲸类的声音。直到最近,一项新研究发现,一些不同的鲸类似乎能够发出相同的声音。

关键词：鼠海豚声音鲸模仿

学前儿童在游戏中社交和认知类型发展的研究①

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南非农村地区HIV阳性儿童的广泛耐药结核病情况

心理学 1995年第5期

作者：杨丽珠邹晓燕朱玉华伯根D(doris Bergen)

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国际结核病与肺部疾病杂志 2011年第4期6卷 162-168页

作者： T.A.Thomas S.V.Shenoi S.K.Heysell f.J.Eksteen V.B.Sunkari N.R.Gandhi G.friedland N.S.Shah 王冬梅 Tugela ferry Care and Research Collaboration Tugela Ferry KwaZulu-Natal South Africa Department of Medicine Yale University School of Medicine New Haven Connecticut Division of Infectious Disease and International Health University of Virginia Charlottesville Virginia AIDS Program Section of Infectious Diseases Yale University School of Medicine New Haven Connecticut USA Tugela ferry Care and Research Collaboration Tugela Ferry KwaZulu-Natal South AfricaChurch of Scotland Hospital and Philanjalo Care Centre Tugela FerryKwaZulu-Natal Department of Paediatrics King George V Hospital Durban South Africa Department of Medicine Albert Einstein College of Medicine Bronx New York New York USA

背景:全球均有对广泛耐药结核病的文献报道,但对儿童广泛耐药结核病的文献报道非常罕见。目的:报告南非农村地区广泛耐药结核病患儿的特征。设计:在南非共和国图盖拉渡口地区,对2006年1月—2007年12月间登记的经痰培养确诊为广泛耐药结... 详细信息

背景:全球均有对广泛耐药结核病的文献报道,但对儿童广泛耐药结核病的文献报道非常罕见。目的:报告南非农村地区广泛耐药结核病患儿的特征。设计:在南非共和国图盖拉渡口地区,对2006年1月—2007年12月间登记的经痰培养确诊为广泛耐药结核病的患儿进行了回顾性评估。从患儿病案中获得其人口统计学、临床和微生物学信息。结果:4例6～8岁的儿童为广泛耐药结核病患者。其中2例患儿先前有结核病史。4例患儿均为感染了人类免疫缺陷病毒的孤儿,其中3例在诊断患有广泛耐药结核病之前已接受了高效抗逆转录病毒治疗。在接受标准化抗广泛耐药结核病和高效抗逆转录病毒治疗后,所有患儿的临床表现、影像学均改善,痰培养阴转。其中2例患儿较好地耐受了抗广泛耐药结核病和高效抗逆转录病毒同时治疗。另外2例出现了环丝氨酸相关的神经精神系统不良反应。4例患儿的存活时间均超过24个月,广泛耐药结核病均得到治愈。在诊断为广泛耐药结核病之前,这些患儿在儿科病房的平均住院时间为8个月(5～17个月),包括3个月的住院重叠期。结论:广泛耐药结核病依靠微生物学来确诊,合并艾滋病的广泛耐药结核病患者也能被成功诊断。尽管需要对同时接受两种治疗的潜在交叉毒性开展更多的研究,但本研究显示患儿同时接受抗广泛耐药结核病和高效抗逆转录病毒治疗是可行且有效的。

关键词：广泛耐药结核病耐药结核病结核病儿科艾滋病/结核病双重感染

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