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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2596-2618页

作者： Kwan Yi Yap HongHui Chi Sherryl ng doris hl ng Vishal G Shelat Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Gastroenterology and Hepatology Tan Tock Seng HospitalSingapore 308433Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 636921Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore

performed independently by authors(Yap KY,Chi H,ng S)identified 50 studies for full-text ***,12 prospective RCTs and 4 non-randomised studies(1 non-randomised trial and 3 observational studies)were included.A detailed PRISMA diagram is shown in Figure *** studies included were assessed for risk of bias,with a summary of the assessment shown in Figure 2 and Table 1 for trials and non-interventional studies,*** PRISMA checklist is appended in Supplementary Figure 1.

关键词： Branched-chain amino acid Liver cancer Liver surgery Nutritional supplement Perioperative supplementation

Evolvement of left ventricular assist device： the implications on heart failure management

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Journal of Geriatric Cardiology 2016年第5期13卷 425-430页

作者： Sek Ying Chair doris SF Yu Michael Timothy ng Qun Wang Ho Yu Cheng Eliza ML Wong Janet WH Sit The Nethersole School of Nursing Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Department of Psychology Faeulty of Social Science The Chinese University of Hong Kong Hong Kong China

Heart failure （HF） is a potentially fatal disease that affects increasing number of people worldwide. Although heart transplant is the ＂gold standard＂ therapy for HF, due to the limited availability of organs, many patients died when waiting for the transplant. Left ventricular assist device （LVAD）, as a mechanical circulatory support, has become a new light for patients with HF. With the technical advancements, LVADs work not only as a bridge to transplant, but also assist heart recovery and even as a destination therapy in long-term treatment. This observation paper reviewed the development of LVAD and its clinical roles. The challenges and possible solutions in nursing care for pa- tients with LVAD at different stage of implantation were discussed. The healthcare professionals could obtain a better understanding about the LVAD treatment for HF patients.

关键词： Destination therapy Heart failure Left ventricular assist device Nursing

Nature’s fight against plastic pollution:Algae for plastic biodegradation and bioplastics production

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Environmental Science and Ecotechnology 2020年第4期4卷 47-56页

作者： Wen Yi Chia doris Ying Ying Tang Kuan Shiong Khoo Andrew ng Kay Lup Kit Wayne Chew School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul Ehsan43900Malaysia College of Chemistry and Chemical Engineering Xiamen UniversityXiamen361005FujianChina Department of Chemical and Environmental Engineering Faculty of Science and EngineeringUniversity of Nottingham MalaysiaJalan Broga43500SemenyihSelangor Darul EhsanMalaysia

The increased global demand for plastic materials has led to severe plastic waste pollution,particularly to the marine *** critical issue affects both sea life and human beings since microplastics can enter the food chain and cause several health *** recycling,chemical treatments,incineration and landfill are apparently not the optimum solutions for reducing plastic ***,this review presents two newly identified environmentally friendly approaches,plastic biodegradation and bioplastic production using algae,to solve the increased global plastic ***,particularly microalgae,can degrade the plastic materials through the toxins systems or enzymes synthesized by microalgae itself while using the plastic polymers as carbon *** algae for plastic biodegradation has been critically reviewed in this paper to demonstrate the mechanism and how microplastics affect the *** the other hand,algae-derived bioplastics have identical properties and characteristics as petroleum-based plastics,while remarkably being biodegradable in *** review provides new insights into different methods of producing algae-based bioplastics(e.g.,blending with other materials and genetic engineering),followed by the discussion on the challenges and further research direction to increase their commercial feasibility.

关键词： Algal polymers Microalgae Microplastics Polyhydroxyalkanoate(PHA) Polyhydroxybutyrate(PHB)

High spectro-temporal compression on a nonlinear CMOS-chip

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Light(Science & Applications) 2021年第7期10卷 1347-1361页

作者： Ju Won Choi Ezgi Sahin Byoung-Uk Sohn George F.R.Chen doris K.T.ng Anuradha M.Agarwal Lionel C.Kimerling Dawn T.H.Tan Photonics Devices and System Group SUTD-MIT International Design CenterSingapore University of Technology and DesignSingapore 487372Singapore Institute of Microelectronics A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis Way#08-02Innovis TowerSingapore 138634Singapore Microphotonics Center Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Materials Research Laboratory Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA

Optical pulses are fundamentally defined by their temporal and spectral *** ability to control pulse properties allows practitioners to efficiently leverage them for advanced metrology,high speed optical communications and attosecond ***,we report 11×temporal compression of 5.8 ps pulses to 0.55 ps using a low power of 13.3 *** result is accompanied by a significant increase in the pulse peak power by 9.4×.These results represent the strongest temporal compression demonstrated to date on a complementary metal–oxide–semiconductor(CMOS)*** addition,we report the first demonstration of on-chip spectral compression,3.0×spectral compression of 480 fs pulses,importantly while preserving the pulse *** strong compression achieved at low powers harnesses advanced on-chip device design,and the strong nonlinear properties of backend-CMOS compatible ultra-silicon-rich nitride,which possesses absence of two-photon absorption and 500×larger nonlinear parameter than in stoichiometric silicon nitride *** demonstrated work introduces an important new paradigm for spectro-temporal compression of optical pulses toward turn-key,on-chip integrated systems for all-optical pulse control.

关键词： pulse optical nonlinear

使用安捷伦J＆W DB-35ms超高惰性色谱柱和DB-XLB色谱柱对水中低于μg·L^-1级的有机氯农药和除草剂进行GC/μECD法分析

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环境化学 2016年第10期35卷 2211-2214页

作者： doris Smith Ken Lynam Agilent Technologies Inc.2850 Centerville Rd WilmingtonDE 19808

本文中使用安捷伦SPEC C18AR固相萃取膜盘成功萃取了水中的有机氯农药残留和除草剂.使用双柱配置的GC/μECD系统进行检测,安捷伦J&W DB-35ms UI超高惰性色谱柱作为分析柱,DB-XLB色谱柱为确认柱.该方法为浓度接近或低于最大污染限值的含... 详细信息

本文中使用安捷伦SPEC C18AR固相萃取膜盘成功萃取了水中的有机氯农药残留和除草剂.使用双柱配置的GC/μECD系统进行检测,安捷伦J&W DB-35ms UI超高惰性色谱柱作为分析柱,DB-XLB色谱柱为确认柱.该方法为浓度接近或低于最大污染限值的含氯有机物提供了高度灵敏的分析方法.根据预估的分析物萃取浓度,方法使用的校准范围为1—100 ng·mL^(-1).分别对0.01μg·L^(-1)的加标水样和一个自来水水样进行了萃取和分析,结果证明可满足水中的有机氯农药残留和除草剂的测定.

关键词：有机氯农药除草剂色谱柱

使用Agilent J&W DB-35ms超高惰性色谱柱和DB-XLB色谱柱在GC/μECD上进行水中卤乙酸的测定

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环境化学 2016年第9期35卷 1968-1971页

作者： doris Smith Ken Lynam 安捷伦科技公司

使用安捷伦Bond Elut SAX固相萃取吸附剂提取和浓缩水样中卤乙酸(HAAs)后,使用双色谱柱GC/μECD方法对其进行分析.安捷伦J&W DB-35ms超高惰性色谱柱和DB-XLB色谱柱,提供对衍生的HAAs进行一致和灵敏的分析.结果表明,对大多数的HAAs的检... 详细信息

使用安捷伦Bond Elut SAX固相萃取吸附剂提取和浓缩水样中卤乙酸(HAAs)后,使用双色谱柱GC/μECD方法对其进行分析.安捷伦J&W DB-35ms超高惰性色谱柱和DB-XLB色谱柱,提供对衍生的HAAs进行一致和灵敏的分析.结果表明,对大多数的HAAs的检测限是0.05—5 ng·m L^(-1).在3个强化水平(0.2—2、1—10、4—40 ng·m L^(-1))的回收率为82.5%到116.5%,相对标准偏差(RSDs)小于3.5%.

关键词：双色谱柱水中卤乙酸痕量

C-reactive protein is differentially modulated by co-existing infections,vitamin deficiencies and maternal factors in pregnant and lactating indigenous Panamanian women

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Infectious Diseases of Poverty 2017年第1期6卷 819-832页

作者： doris Gonzalez-Fernandez Emerita del Carmen Pons Delfina Rueda Odalis Teresa Sinisterra Enrique Murillo Marilyn E.Scott Kristine G.Koski School of Dietetics and Human Nutrition Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3V9Canada Department of Nutritional Health Ministry of HealthAnconPanama CityPanama “Comarca ngabe-Bugle”Health Region Ministry of HealthSan FelixChiriqui ProvincePanama “Panama Norte”Health Region Ministry of HealthLas Cumbres SquareTransithmian HighwayPanama CityPanama Department of Biochemistry University of PanamaSimon Bolivar Avenue(Transithmian Highway)Panama CityPanama Department of Biochemistry University of PanamaManuel Espinoza Batista and Jose De Fabrega AvenuesPanama CityPanama Institute of Parasitology and Centre for Host-Parasite Interactions Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada School of Dietetics and Human Nutrition and Centre for Host-Parasite Interactions Macdonald CampusMcGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada

Background:The usefulness of C-reactive protein(CRP)as a non-specific marker of inflammation during pregnancy and lactation is unclear in impoverished populations where co-existing infections and vitamin deficiencies are ***:This cross-sectional study in Panama recruited 120 pregnant and 99 lactating ngäbe-Buglewomen from 14 communities in rural *** history,indoor wood smoke exposure,fieldwork,BMI,vitamins A,B_(12),D,and folic acid,and inflammation markers(CRP,neutrophil/lymphocyte ratio(NLR),plateletcrit and cytokines)were *** regressions explored both associations of CRP with other inflammatory markers and associations of CRP and elevated CRP based on trimester-specific cut-offs with maternal factors,infections and vitamin ***:CRP was higher in pregnancy(51.4±4.7 nmol/L)than lactation(27.8±3.5 nmol/L)and was elevated above trimester specific cut-offs in 21%of pregnant and 30%of lactating *** deficiencies were common(vitamin A 29.6%;vitamin D 68.5%;vitamin B1268%;folic acid 25.5%)and over 50%of women had two or more concurrent deficiencies as well as multiple *** regression models highlighted differences in variables associated with CRP between pregnancy and *** pregnancy,CRP was positively associated with greater indoor wood smoke exposure,caries and hookworm and negatively associated with Ascaris and vaginal Lactobacillus and Bacteroides/Gardnerella *** with this,greater wood smoke exposure,caries as well as higher diplococcal infection score increased the odds of trimester-elevated CRP concentrations whereas longer gestational age lowered the likelihood of a trimester-elevated *** lactation,folic acid deficiency was associated with higher CRP whereas parity,number of eosinophils and Mobiluncus score were associated with lower ***,a higher BMI and Trichomonas vaginalis score increased the likelihood of an elevated CRP whereas higher parity and numbe

关键词： CRP Intestinal parasites Caries Vaginal infections Folic acid deficiency Wood smoke Neutrophil/lymphocyte ratio Plateletcrit Pregnancy Lactation

Urotensin II levels in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2021年第36期27卷 6142-6153页

作者： Damir Alicic Dinko Martinovic doris Rusic Piero Marin Zivkovic Ivana Tadin Hadjina Marino Vilovic Marko Kumric Daria Tokic Daniela Supe-Domic Slaven Lupi-Ferandin Josko Bozic Department of Gastroenterology University Hospital of SplitSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Pharmacy University of Split School of MedicineSplit 21000Croatia Department of Anesthesiology and Intensive care University Hospital of SplitSplit 21000Croatia Department of Health Studies University of SplitSplit 21000Croatia Department of Maxillofacial Surgery University Hospital of SplitSplit 21000Croatia

BACKGROUND Patients with inflammatory bowel disease(IBD)are associated with increased cardiovascular risk and have increased overall cardiovascular *** the other hand,urotensin II(UII)is one of the most potent vascular constrictors with immunomodulatory effect that is connected with a number of different cardiometabolic disorders as ***,patients with ulcerative colitis have shown increased expression of urotensin II receptor in comparison to healthy *** the features of IBD includes chronic inflammation and endothelial dysfunction as well,it is plausible to assume that there is connection between increased cardiac risk in IBD and *** To determine serum UII levels in patients with IBD and to compare them to control subjects,as well as investigate possible associations with relevant clinical and biochemical *** This cross sectional study consecutively enrolled 50 adult IBD patients(26 with Crohn’s disease and 24 with ulcerative colitis)and 50 age and gender matched *** assessment was performed by the same experienced gastroenterologist according to the latest *** Colitis Endoscopic Index of Severity and Simple Endoscopic Score for Crohn’s Disease were used for endoscopic *** levels of UII were determined using the enzyme immunoassay kit for human UII,according to the manufacturer’s *** IBD patients have significantly higher concentrations of UII when compared to control subjects(7.57±1.41 vs 1.98±0.69 ng/mL,Png/mL,P=0.689).There was a significant positive correlation between serum UII levels and high sensitivity C reactive peptide levels(r=0.491,P<0.001)and a significant negative correlation between serum UII levels and total proteins(r=-0.306,P=0.032).Additionally,there was a significant positive correlation between serum UII leve

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Urotensin II Cardiovascular risk Endoscopic activity

Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model

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World Journal of Hepatology 2016年第8期8卷 401-410页

作者： Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk Department of Medicine Ⅱ Liver Center Munich University of Munich Institute of Pathology University of Munich Department of Medicine Ⅰ Krankenhaus Barmherzige Brüder Research Unit for Experimental and Molecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine Hans Popper Laboratory of Molecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine Ⅲ Medical University of Vienna Transplant Center Munich of the University of Munich

AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse ***: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-te

关键词： Cholestasis Primary sclerosing cholangitis The ATP-binding cassette transporter b4 Liver fibrosis Interleukin-1

Estimation of Burden of Kidney Dysfunction in HIV-Infected Pediatrics and Adolescents by Use of Urinary Neutrophil Gelatinase-Associated Lipocalin: A Single Center Experience in Kenya

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Infectious Diseases & Immunity 2022年第1期2卷 9-14页

作者： Anne P.Lomole William M.Macharia Mary S.Limbe doris W.Kinuthia Samuel K.Kabinga Aga Khan University Medical College East AfricaAga Khan University HospitalNairobiKenya University of Nairobi East African Kidney InstituteNairobiKenya

Background:About 75%of patients infected with human immunodeficiency virus(HIV)live in sub-Saharan *** Kenya,about 1.5 million Kenyans are living with HIV,of whom almost 100,000 are children and *** active antiretroviral therapy(HAART)has converted HIV infection to a chronic illness with its attendant *** disease is a common complication of HIV infection and its *** disease in HIV-infected persons can be asymptomatic,insidious onset and may lack specific clinical *** can only be detected on active *** urine albumin-to-creatinine ratio and estimated glomerular filtration rate(eGFR)using serum creatinine are not sensitive in identification of early kidney *** neutrophil gelatinase-associated lipocalin(ungAL)has been used as marker of early kidney ***:This cross-sectional study used ungAL and serum creatinine to determine the prevalence of kidney dysfunction in HIVinfected children and adolescents with HAART at Gertrude’s Children’s Hospital,Nairobi,Kenya,from March 2016 to February *** samples were assayed for ungAL using the Bio Porto®enzyme-linked immunosorbent *** creatinine was assayed using the Jaffe reaction in the Cobas®6000 biochemistry analyzer and eGFR calculated using the Schwartz *** plot of eGFR against log ungAL levles was performed by Statistical Package for Social Sciences and Pearson correlation coefficeint between log ungAL levles and eGFR was ***:Ninety-three patients were *** mean age was 11.8±3.6 years and the median duration on HAART was 72.6 *** were 47(50.5%).The prevalence of kidney dysfunction using ungAL was 15.1%(95%CI 7.6%–22.5%)and 5.4%(95%CI 1.8%–12.1%)by *** mean eGFR was 131±25mL·min1·1.73m2 and median ungAL was 10 ng/*** every one ng/mL increase in ungAL value above the normal value,eGFR decreases by 4.8mL·min1·1.73m2(P=0.038).Patients with elevated ungAL were older when co

关键词： HIV Estimated glomerular filtration rate Highly active antiretroviral therapy Kidney disease Serum creatinine ungAL