Urotensin II levels in patients with inflammatory bowel disease

作     者：Damir Alicic Dinko Martinovic Doris Rusic Piero Marin Zivkovic Ivana Tadin Hadjina Marino Vilovic Marko Kumric Daria Tokic Daniela Supe-Domic Slaven Lupi-Ferandin Josko Bozic 

作者机构：Department of GastroenterologyUniversity Hospital of SplitSplit 21000Croatia Department of PathophysiologyUniversity of Split School of MedicineSplit 21000Croatia Department of PharmacyUniversity of Split School of MedicineSplit 21000Croatia Department of Anesthesiology and Intensive careUniversity Hospital of SplitSplit 21000Croatia Department of Health StudiesUniversity of SplitSplit 21000Croatia Department of Maxillofacial SurgeryUniversity Hospital of SplitSplit 21000Croatia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第36期

页      面：6142-6153页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Inflammatory bowel disease Crohn’s disease Ulcerative colitis Urotensin II Cardiovascular risk Endoscopic activity 

摘      要：BACKGROUND Patients with inflammatory bowel disease(IBD)are associated with increased cardiovascular risk and have increased overall cardiovascular *** the other hand,urotensin II(UII)is one of the most potent vascular constrictors with immunomodulatory effect that is connected with a number of different cardiometabolic disorders as ***,patients with ulcerative colitis have shown increased expression of urotensin II receptor in comparison to healthy *** the features of IBD includes chronic inflammation and endothelial dysfunction as well,it is plausible to assume that there is connection between increased cardiac risk in IBD and *** To determine serum UII levels in patients with IBD and to compare them to control subjects,as well as investigate possible associations with relevant clinical and biochemical *** This cross sectional study consecutively enrolled 50 adult IBD patients(26 with Crohn’s disease and 24 with ulcerative colitis)and 50 age and gender matched *** assessment was performed by the same experienced gastroenterologist according to the latest *** Colitis Endoscopic Index of Severity and Simple Endoscopic Score for Crohn’s Disease were used for endoscopic *** levels of UII were determined using the enzyme immunoassay kit for human UII,according to the manufacturer’s *** IBD patients have significantly higher concentrations of UII when compared to control subjects(7.57±1.41 vs 1.98±0.69 ng/mL,P0.001),while there were no significant differences between Crohn’s disease and ulcerative colitis patients(7.49±1.42 vs 7.65±1.41 ng/mL,P=0.689).There was a significant positive correlation between serum UII levels and high sensitivity C reactive peptide levels(r=0.491,P0.001)and a significant negative correlation between serum UII levels and total proteins(r=-0.306,P=0.032).Additionally,there was a significant positive correlation between serum UII leve