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Feature selection approach using ensemble learning for network anomaly detection

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CAAI Transactions on Intelligence Technology 2020年第4期5卷 283-293页

作者： doreswamy Mohammad Kazim Hooshmand Ibrahim Gad Department of Computer Science Mangalore UniversityMangaloreIndia

Feature selection is essential for prioritising important attributes in data to improve prediction quality in machine learning *** different selection techniques identify different feature sets,relying on a single method may result in risky *** authors propose an ensemble approach using union and quorum combination techniques with five primary individual selection methods which are analysis of variance,variance threshold,sequential backward search,recursive feature elimination,and least absolute selection and shrinkage *** proposed method reduces features in three rounds:(i)discard redundant features using pairwise correlation,(ii)individual methods select their own feature sets independently,and(iii)equalise individual feature *** equalised individual feature sets are combined using union and quorum *** the combined and individual sets are tested for network anomaly detection using random forest,decision tree,K-nearest neighbours,Gaussian Naive Bayes,and logistic regression *** experimental results on the UNSW-NB15 data set show that random forest with union and quorum feature sets yields 99 and 99.02% f1_score with minimum 6 and 12 features,*** results on the NSL-KDD data set show that random forest with union and quorum gets 99.34 and 99.21% f1_score with a minimum of 28 and 18 features.

关键词： union ensemble network

The biochemical pathways of central nervous system neural degeneration in niacin deficiency

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Neural Regeneration Research 2014年第16期9卷 1509-1513页

作者： Linshan Fu Venkatesh doreswamy Ravi Prakash Department of Neurosurgery the First People’s Hospital of Yancheng Department of Physiology M.S.Ramaiah Medical College

Neural degeneration is a very complicated process. In spite of all the advancements in the molecular chemistry, there are many unknown aspects of the phenomena of neurodegeneration which need to be put together. It is a common sequela of the conditions of niacin deficiency. Neural degeneration in Pellagra manifests as chromatolysis mainly in pyramidal followed by other neurons and glial cells. However, there is a gross lack of understanding of biochemi- cal mechanisms of neurodegeneration in niacin deficiency states. Because of the necessity of niacin or its amide derivative NAD in a number of biochemical pathways, it is understandable that several of these pathways may be involved in the common outcome of neural degener- ation. Here, we highlight five pathways that could be involved in the neuraldegeneration for which evidence has accumulated through several studies. These pathways are： 1） the trypto- phan-kyneurenic acid pathway, 2） the mitochondrial ATP generation related pathways, 3） the poly （ADP-ibose） polymerase （PARP） pathway, 4） the BDNF-TRKB Axis abnormalities, 5） the genetic influences of niacin deficiency.

关键词： Niacin deficiency neural degeneration chromatolysis biochemical pathways ofdegeneration kyneurenic acid BDNF- TRKB pathway

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Impact of preterm birth and low birth weight on medical conditions, medication use and mortality among neonates: a prospective observational cohort study

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World Journal of Pediatrics 2019年第3期15卷 281-288页

作者： Krishna Undela Bashar Talal Saad Mohammed Parthasarathi Gurumurthy Srinivasa Murthy doreswamy Department of Pharmacy Practice JSS College of Pharmacy.JSS Academy of Higher Education and ResearchSS NagaraMysuru.Karnataka 570 015.India Department of Pediatrics JSS Medical College and Hospital.JSS Academy of Higher Education and ResearchMahatma Gandhi RoadMysuruKarnataka 570 004India

Background There is a paucity of studies conducted in India on neonatal outcomes of preterm birth and low birth ***,we aimed to assess the impact of preterm birth and low birth weight on medical conditions,medication use and mortality among *** A prospective observational cohort study was conducted at the neonatal intensive care unit (NICU) over a period of 9 *** of either sex,admitted to NICU and who received at least one medication were enrolled in the *** and demographic data,reason(s) for NICU admission,diagnoses,medications prescribed,medication-related problems,discharge status and the direct medical cost were documented and *** Four hundred and five neonates Were included in the study:60.5% were boys,32.7% were preterm and 44.2% were born *** sepsis (n =125,16.7%),unconjugated hyperbilirubinemia (n =83,11.1%) and respiratory distress syndrome (n =62,8.3%) were the most common medical conditions and were significantly more common among preterm and underweight *** half of the medications prescribed were anti-infectives for systemic use (n =1310,47.4%).The mean number of medications received by neonates increased from term to extremely preterm (5.2-15.0) and normal birth weight to extremely low birth weight (5.0-14.9).Mortality rate was significantly higher among extremely preterm (66.7%),and very preterm (15.2%) neonates compared to term (2.9%) *** median direct medical cost for NICU admission was INR 21,430 (USD 331).Conclusion Medical conditions,medications prescribed and mortality rate were significantly higher among preterm and underweight neonates admitted to NICU.

关键词： Low birth weight Medical conditions Medications Mortality Preterm birth

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香蕉的组织培养

世界热带农业信息 1984年第6期 44-46页

作者： R.doreswamy 陈向民

香蕉是用吸芽无性繁殖的植物,但自然繁殖的速度相当慢,为加快繁殖速度,有必要探索一种离体培养的方法。本文报道以香蕉梢尖作外植体进行组织培养并成功地诱导出小植株的情况。

关键词：香蕉吸芽梢尖芭蕉属外植体激动素动力精植物生长调节物质小植株叶基 MSB 小芽

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建立在农用池塘基础上的流域开发

中国水土保持 2002年第7期 45-45页

作者： B.K.Kakade,G.S.Neelam,K.J.Petare,C doreswamy BAIF Development Research Foundation BAIF Bhavan Warje Malwadi BAIF Development Research Foundation BAIF Bhavan Warje Malwadi BAIF Development Research Foundation BAIF Bhavan Warje Malwadi BAIF Development Research Foundation BAIF Bhavan Warje Malwadi

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建立在农用池塘基础上的流域开发

中国水土保持 2002年第7期 41-41页

作者： B.K.Kakade G.S.Neelam K.J.Petare C doreswamy BAIF Development Research Foundation BAIFBhavanWarje MalwadiBAIF Development Research FoundationBAIFBhavanWarje MalwadiBAIF Development Research FoundationBAIFBhavanWarje MalwadiBAIF Development Research FoundationBAIFBhavanWarje Malwadi

星形胶质细胞中连接蛋白43在肌萎缩侧索硬化中促发运动神经元毒性

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神经损伤与功能重建 2016年第4期11卷 F0003-F0003页

作者： Akshata A.Almad Arpitha doreswamy Sarah K.Gross Jean-Philippe Richard Yuqing Huo Norman Haughey Nicholas J.Maragakis 王晶

肌萎缩侧索硬化(ALS)是一种神经退行性疾病,其特征是中枢神经系统中运动神经元的进行性丧失。星形胶质细胞在ALS的疾病进程中起重要作用。星形胶质细胞通过缝隙连接蛋白家族,如连接蛋白(Connexin,Cx)互相连接。Cx43是中枢神经系统中保... 详细信息

肌萎缩侧索硬化(ALS)是一种神经退行性疾病,其特征是中枢神经系统中运动神经元的进行性丧失。星形胶质细胞在ALS的疾病进程中起重要作用。星形胶质细胞通过缝隙连接蛋白家族,如连接蛋白(Connexin,Cx)互相连接。Cx43是中枢神经系统中保持稳态的主要星形胶质细胞连接蛋白。在病理状态下,连接蛋白的表达和功能发生改变。本文发现,在ALS中Cx43异常增高是星形胶质细胞介导的毒性作用机制之一。笔者观察到,在ALS SOD1^(G93A)小鼠模型的疾病进程中,Cx43表达进行性增高。尤其是,在ALS患者的运动皮质和脊髓也能检测到Cx43增高。从SOD1^(G93A)小鼠中分离的星形胶质细胞,与人诱导多能干细胞衍生的星形胶质细胞一样,都检测到Cx43蛋白增高,且为独立于神经元共培养的内源性现象。与对照的星形胶质细胞过表达的野生型SOD1(SOD1^(WT))相比,SOD1^(G93A)星形胶质细胞中增高的Cx43表达可产生重要的功能性影响。本文发现,SOD1^(G93A)星形胶质细胞表现出缝隙连接偶联增强,半通道介导活动升高,细胞内钙离子水平上升。最后,本文检测Cx43蛋白表达升高对MN生存的影响,发现应用pan-Cx43阻滞剂和Cx43半通道阻滞剂均对与SOD1^(G93A)星形胶质细胞共培养的MNs有神经保护作用。这些新发现展示出未被认知的Cx43在ALS相关的运动神经元丢失中所起作用。

关键词：星形胶质细胞连接蛋向运动神经元肌萎缩侧索硬化诱导多能干细胞

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