Impact of preterm birth and low birth weight on medical conditions, medication use and mortality among neonates: a prospective observational cohort study

作     者：Krishna Undela Bashar Talal Saad Mohammed Parthasarathi Gurumurthy Srinivasa Murthy Doreswamy 

作者机构：Department of Pharmacy PracticeJSS College of Pharmacy.JSS Academy of Higher Education and ResearchSS NagaraMysuru.Karnataka 570 015.India Department of PediatricsJSS Medical College and Hospital.JSS Academy of Higher Education and ResearchMahatma Gandhi RoadMysuruKarnataka 570 004India 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2019年第15卷第3期

页      面：281-288页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：University of Adelaide 

主　　题：Low birth weight Medical conditions Medications Mortality Preterm birth 

摘      要：Background There is a paucity of studies conducted in India on neonatal outcomes of preterm birth and low birth ***,we aimed to assess the impact of preterm birth and low birth weight on medical conditions,medication use and mortality among *** A prospective observational cohort study was conducted at the neonatal intensive care unit (NICU) over a period of 9 *** of either sex,admitted to NICU and who received at least one medication were enrolled in the *** and demographic data,reason(s) for NICU admission,diagnoses,medications prescribed,medication-related problems,discharge status and the direct medical cost were documented and *** Four hundred and five neonates Were included in the study:60.5% were boys,32.7% were preterm and 44.2% were born *** sepsis (n =125,16.7%),unconjugated hyperbilirubinemia (n =83,11.1%) and respiratory distress syndrome (n =62,8.3%) were the most common medical conditions and were significantly more common among preterm and underweight *** half of the medications prescribed were anti-infectives for systemic use (n =1310,47.4%).The mean number of medications received by neonates increased from term to extremely preterm (5.2-15.0) and normal birth weight to extremely low birth weight (5.0-14.9).Mortality rate was significantly higher among extremely preterm (66.7%),and very preterm (15.2%) neonates compared to term (2.9%) *** median direct medical cost for NICU admission was INR 21,430 (USD 331).Conclusion Medical conditions,medications prescribed and mortality rate were significantly higher among preterm and underweight neonates admitted to NICU.