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The effect of high temperature induced variation of specific heat on the hypersonic turbulent boundary layer and its computation

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Science China(Physics,Mechanics & Astronomy) 2010年第11期53卷 2103-2112页

作者： dong ming & zhou Heng Department of Mechanics,Tianjin University,Tianjin 300072,China 1. Department of Mechanics Tianjin University Tianjin 300072 China

For hypersonic vehicles,as the temperature in its boundary layer usually exceeds 600 K,for which the molecular vibrational degree of freedom is excited,the perfect gas model is no longer *** this paper,the effect of high temperature induced variation of specific heat on the hypersonic turbulent boundary layer of flat plates is investigated by direct numerical simulations with the perfect gas model,*** constant specific heat,as well as with a variable specific heat gas *** comparison of the results from the two gas models has found that the effect of the variation of specific heat on the velocity of the turbulent boundary layers is relatively small,while its effect on temperature,such as the mean temperature,the temperature fluctuations,is *** is also found that the mean specific heat is quite close to the specific heat calculated by using the mean temperature,indicating that it is possible to do turbulence *** modeling is done under the variable specific heat gas model with the mean temperature as the *** feasibility of such consideration is verified by applying the SST model for variable specific heat turbulence computation.

关键词： hypersonic turbulent boundary layer specific heat direct numerical simulation SST model

Self-assembled sialyllactosyl probes with aggregation-enhanced properties for ratiometric detection and blocking of influenza viruses

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Science Bulletin 2019年第24期64卷 1902-1909页

作者： Wei-Tao Dou Zhao-Yang Qin Jun Li dong-ming zhou Xiao-Peng He Key Laboratory for Advanced Materials Feringa Nobel Prize Scientist Joint Research CenterSchool of Chernistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Vaccine Research Center Key Laboratory of Molecular Virology&ImmunologyInstitut Pasteur of ShanghaiChinese Acadermy of SciencesShanghai 200031China

Infection and dissemination of influenza viruses(IVs) causes serious health concerns ***, effective tools for the accurate detection and blocking of IVs remain elusive. Here, we develop a new sialyllactosyl probe with self-assembled core-shell structure for the ratiometric detection and blocking of IVs. N,N'-diaryl-dihydrodibenzo[a,c]phenazines were used to form the core structure by hydrophobic assembly in an aqueous solution with an aggregation-enhanced blue fluorescence ***, dicyanomethylene-4 H-pyran-based sialyllactosides were used for self-assembly with the core structure, producing the sialyllactosyl probe that emits a red fluorescence due to Forster resonance energy transfer. The probe developed has been proven to be available for(1) the fluorescence ratiometric detection of IVs through selective interaction with the sialyllactosyl-binding proteins on the virus surface,and(2) effectively blocking the invasion of human-infecting IVs towards host cells as accentuated by the sialyllactosides on the surface of the probes.

关键词： Vibration-induced emission Influenza viruses Ratiometric Fluorescence Glycoprobe

Green Oxidation of Isochromans to Isochromanones with Molecular Oxygen Catalyzed by a Tetranuclear Vanadium Cluster

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Chinese Journal of Chemistry 2023年第16期41卷 1967-1972页

作者： Huixin Huang Baokuan Chen Yiru Fu Jing Sun Yanfeng Bi ming-dong zhou School of Petrochemical Engineering Liaoning Petrochemical UniversityFushunLiaoning 113001China College of Chemical Engineering Shenyang University of Chemical TechnologyShenyangLiaoning 110142China

Comprehensive Summary Isochromanone is the core structure of many bioactive *** oxidation of isochromans is one of leading methods for the construction of isochromanones,while most established processes remain suffering from the use of environmentally unfriendly metal oxidants,harsh reaction conditions,and the difficulty in catalyst recycling and product ***,we report a convenient,cost-effective,and green method for the synthesis of high-value added isochromanones via isochroman oxidations with O_(2) by a novel heterogeneous vanadium cluster catalyst(Cat.1)under mild *** reaction protocol demonstrates high catalytic activity with good catalyst recyclability and reusability for a wide scope of substrates.

关键词： Isochromanone Vanadium cluster Green catalysis Isochroman oxidation Heterogeneous Crystal engineering Organocatalysis C-H activation

Visible-light-promoted Radical Cyclization/Arylation Cascade for the Construction of α,α-Difluoro-γ-Lactam-Fused Quinoxalin-2(1H)-Ones

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Chinese Journal of Chemistry 2022年第6期40卷 713-718页

作者： Yun-Chao Zhang Yang Chen Jing Sun Jing-Yun Wang ming-dong zhou School of Petrochemical Engineering Liaoning Petrochemical UniversityFushunLiaoning 113001China

A visible-light-induced tandem radical intramolecular cyclization/arylatiion of quinoxalin-2(1H)-ones with bromodifluoroacetamides is *** protocol allows efficient access to a variety of valuableα,α-difluoro-y-lactam-fused quinoxalin-2(1H)-ones in moder-ate to good yields under metal-free,mild and redox neutral reaction *** strategy is tolerant of various functional groups and a broad range of *** mechanism experiments suggested an involvement of 5-exo-trig cyclization and a radical pro-cess in this transformation.

关键词： Photocatalysis Cyclization Radicals Fluoro-γ-lactams Quinoxalin-2(1H)-ones

Visible-Light-Promoted[3+2]Cycloaddition of 2H-Azirines with Quinones:Access to Substituted Benzo[f]isoindole-4,9-diones

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Chinese Journal of Chemistry 2022年第6期40卷 719-724页

作者： Lijia Wang Chuang Liu Lei Li Xin Wang Ran Sun ming-dong zhou He Wang School of Petrochemical Engineering Liaoning Petrochemical UniversityFushunLiaoning 113001China

A visible-light-promoteded[3+2]cycloaddition reaction of 2H-azirines with quinones has been developed under mild reaction *** reaction provides a general and efficient strategy for the synthesis of the benzo[f]isoindole-4,9-diones scaffold via a tandem[3+2]cyclization/oxidative aromatization with molecular ***,preliminary studies for photocatalytic prop-erties show that the benzo[f]isoindole-4,9-diones 3 can be used as photocatalysts in several organic transformations.

关键词： Photocatalysis Cycloaddition Quinones 2H-Azirines Benzo[f]isoindole-4,9-diones

Establishment of an efficient reverse genetic system of Mumps virus S79 from cloned DNA

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World Journal of Pediatrics 2019年第5期15卷 499-505页

作者： Duo zhou Meng-Ying Zhu Yi-Long Wang Xiao-Qiang Hao dong-ming zhou Rong-Xian Liu Chu-Di Zhang Chu-Fan Qu Zheng-Yan Zhao Zhejiang University School of Medicine HangzhouChina Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China

Background Mumps is a common type of respiratory infectious disease caused by mumps virus(MuV),and can be effectively prevented by *** this study,a reverse genetic system of MuV that can facilitate the rational design of safer,more efficient mumps vaccine candidates is *** MuV-S79 cDNA clone was assembled into a full-length plasmid by means of the GeneArtTM High-Order Genetic Assembly System,and was rescued via reverse genetic ***-PCR,sequencing,and immunofluorescence assays were used for rMuV-S79 *** replication kinetics and in vivo experimental models were used to evaluate the replication,safety,and immunogenicity of *** A full-length cDNA clone of MuV-S79 in the assembly process was generated by a novel plasmid assemble strategy,and a robust reverse genetic system of MuV-S79 was successfully *** established rMuV-S79 strain could reach a high virus titer in *** average viral titer of rMuV-S79 in the lung tissues was 2.68±0.14 log10PFU/g lung tissue,and rMuV-S79 group did not induce inflammation in the lung tissues in cotton *** antibody titers induced by rMuV-S79 were high,long-lasting and could provide complete protection against MuV wild strain *** We have established a robust reverse genetic system of MuV-S79 which can facilitate the optimization of mumps ***-S79 rescued could reach a high virus titer and the safety was proven in *** could also provide complete protection against MuV wild strain challenge.

关键词： Mumps virus Reverse genetics Plasmid Safety Immunogenicity

Attenuated MuV-S79 as vector stably expressing foreign gene

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World Journal of Pediatrics 2019年第5期15卷 511-515页

作者： Duo zhou Meng-Ying Zhu Yi-Long Wang Xiao-Qiang Hao dong-ming zhou Rong-Xian Liu Chu-Di Zhang Chu-Fan Qu Zheng-Yan Zhao Zhejiang University School of Medicine HangzhouZhejiangChina Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China

Background To describe mumps virus(MuV)used as a vector to express enhanced green fluorescent protein(EGFP)or red fluorescent protein(RFP)*** Molecular cloning technique was applied to establish the cDNA clones of recombinant mumps viruses(rMuVs).rMuVs were recovered based on our reverse genetic system of *** properties of rMuVs were determined by growth curve,plaque assay,fluorescent microscopy and determination of fluorescent *** Three recombinant viruses replicated well in Vero cells and similarly as parental rMuV-S79,expressed heterologous genes in high levels,and were genetically stable in at least 15 *** rMuV-S79 is a promising platform to accommodate foreign genes like marker genes,other antigens and immunomodulators for addressing various diseases.

关键词： Mumps virus Reverse genetic system Foreign genes

SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4(CKAP4)

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3655-3657页

作者： Kan Li Liu Yao Jin Wang Hao Song Yan-hong Zhang Xue Bai Kai Zhang dong-ming zhou Ding Ai Yi Zhu The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Department of Physiology and PathophysiologyTianjin Medical UniversityTianjinChina Department of Biochemistry and Molecular Biology Tianjin Medical UniversityTianjinChina Department of Pathogen Biology Tianjin Medical UniversityTianjinChina

Dear Editor,Although progressive respiratory failure is the primary cause of death in patients with COVID-19,thromboembolic complications further increased the mortality *** dysfunction,a pro-inflammatory and pro-coagulant state characterized by increased interaction with leukocytes and platelets,is reported to play a key role in COVID-19-associated thrombosis;1 however,its underlying mechanism remains unclear.

关键词： thrombosis mortality respiratory

Progress in neuregulin/Erb B signaling and chronic heart failure

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World Journal of Hypertension 2015年第2期5卷 63-73页

作者： Hong-Kun Yin Xin-Yan Li Zheng-Gang Jiang ming-dong zhou Zensun (Shanghai) Sci and Tech Co. Ltd.Zhangjiang Hitech Park

Heart failure is one of the leading causes of death *** is a complex clinical syndrome in which the heart has a reduced contraction ability and decreased viable *** approaches to the clinical management of heart failure have been achieved through an understanding of the molecular pathways necessary for normal heart ***-1(NRG-1) has emerged as a potential therapeutic target based on the fact that mice null for NRG-1 or receptors mediating its activity,Erb B2 and Erb B4,are embryonic lethal and exhibit severe cardiac *** studies performed with animal models of heart failure demonstrate that treatment with NRG-1 significantly improves heart function and *** data further support NRG-1 as a promising drug candidate for the treatment of cardiac dysfunction in *** studies have revealed the mechanism underlying the therapeutic effects of NRG-1/Erb B signaling in the treatment of heart *** activation of upstream signaling molecules such as phosphoinositide 3-kinase,mitogen-activated protein kinase,and focal adhesion kinase,NRG-1/Erb B pathway activation results in increased c MLCK expression and enhanced intracellular calcium *** former is a regulator of the contractile machinery,and the latter triggers cell contraction and *** addition,NRG-1/Erb B signaling also influences energy metabolism and induces epigenetic modification in cardiac myocytes in a way that more closely resembles healthy *** observations reveal potentially new treatment options for heart failure.

关键词： ErbB Epigenetic modification Heart failure Metabolism Neuregulin-1