SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4(CKAP4)

作     者：Kan Li Liu Yao Jin Wang Hao Song Yan-hong Zhang Xue Bai Kai Zhang Dong-ming Zhou Ding Ai Yi Zhu 

作者机构：The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsDepartment of Physiology and PathophysiologyTianjin Medical UniversityTianjinChina Department of Biochemistry and Molecular BiologyTianjin Medical UniversityTianjinChina Department of Pathogen BiologyTianjin Medical UniversityTianjinChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第10期

页      面：3655-3657页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(82070305)(L.Y.) (81730014)(Y.Z.) and(82130014)(D.A.) 

主　　题：thrombosis mortality respiratory 

摘      要：Dear Editor,Although progressive respiratory failure is the primary cause of death in patients with COVID-19,thromboembolic complications further increased the mortality *** dysfunction,a pro-inflammatory and pro-coagulant state characterized by increased interaction with leukocytes and platelets,is reported to play a key role in COVID-19-associated thrombosis;1 however,its underlying mechanism remains unclear.