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Targeting CXCR4 and EDN1 for the treatment of recurrent miscarriage using stearic acid from traditional Chinese medicine

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Traditional Medicine Research 2024年第11期9卷 65-75页

作者： Fang Liu dong-mei shi Wen-Ye Ma Da-Wei Tang Gang Bai Xin-You Yu Reproductive Center of Yinchuan Maternal and Child Health Hospital Yinchuan 750001China Prenatal Diagnosis Center of Ningxia Medical University General Hospital Yinchuan 750004China

Background:Recurrent miscarriage(RM)affects an estimated 1-3%of couples attempting to conceive,and its molecular components stay ineffectively caught *** study aims to explore potential therapeutic targets for RM by examining gene expression patterns and biological pathways in both mouse and human RM ***,explore relevant traditional Chinese medicine(TCM)components targeting potential therapeutic ***:We utilized the GSE211251 mouse and the GSE26787 human datasets,employing gene set enrichment analysis and gene metaphysics analysis to examine differentially expressed genes and enriched ***-cell RNA analysis uncovered cellular heterogeneity and arranged pharmacology-mapped potential drug-target *** employed molecular docking strategies to assess the affinity of TCM components for key ***:In the mouse model,genes such as Ly6f1 and Gpr26 were upregulated,while Stc5a and Galca exhibited *** set enrichment analysis identified key pathways,including the tumor necrosis factor-mediated signaling *** human samples,Gene Ontology analysis highlighted processes such as apoptosis and cell ***-cell RNA analysis revealed distinct cellular populations between normal and RM *** pharmacology identified C-X-C motif chemokine receptor 4(CXCR4)and endothelin 1(EDN1)as potential key targets,and molecular docking confirmed that stearic acid from TCM appears to regulate these ***:This study presents a comprehensive analysis of the genetic and cellular underpinnings of RM,identifying CXCR4 and EDN1 as promising therapeutic *** acid from TCM could provide targeted treatment by modulating these key proteins,paving the way for new RM treatment strategies.

关键词： RM gene expression single-cell RNA analysis CXCR4 EDN1 stearic acid

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Malignant syphilis accompanied with neurosyphilis in a malnourished patient: A case report

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World Journal of Clinical Cases 2019年第16期7卷 2406-2412页

作者： Gai Ge dong-mei Li Ying Qiu Hong-Jun Fu Xiang-Yu Zhang dong-mei shi Jining Medical University Jining 272067Shandong ProvinceChina Georgetown University Medical Center WashingtonDC 20057United States Department of Dermatology Jining No. 1 People’s HospitalJining 272067Shandong ProvinceChina Department of Pathology Jining No. 1 People’s HospitalJining 272067Shandong ProvinceChina Department of Dermatology and Laboratory of Medical Mycology Jining No. 1 People’s HospitalJining 272067Shandong ProvinceChina

BACKGROUND Syphilis is a common sexually transmitted disease caused by the Treponema pallidum (***).Malignant syphilis is a rare presentation of secondary ***,we present a case diagnosed with malignant syphilis accompanied with *** SUMMARY A 56-year-old man present with a 2-mo history of spreading ulcerous and necrotic papules and nodules covered with thick crusts over the face,trunk,extremities,and *** patient was diagnosed with malignant syphilis accompanied by neurosyphilis based on the characteristic morphology of the lesions,positive serological and cerebrospinal fluid tests for syphilis,brain magnetic resonance imaging,and histopathology,along with resolution of the lesions following the institution of penicillin *** lesions and neurological condition successfully resolved after a course of treatment with *** We suggest that neurosyphilis should be considered whenever people have psychiatric symptoms without cutaneous lesions or human immunodeficiency virus.

关键词： Malignant syphilis Secondary syphilis Neurosyphilis Jarisch-Herxheimer reaction Case report

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Nitric oxide induced by polyamines involves antioxidant systems against chilling stress in tomato (Lycopersicon esculentum Mill.) seedling

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第12期17卷 916-930页

作者： Qian-nan DIAO Yong-jun SONG dong-mei shi Hong-yan QI Collaborative Innovation Center of Protected Vegetable Surround Bohai Gulf Region Key Laboratory of Protected Horticulture of Ministry of Education and Liaoning Province College of Horticulture Shenyang Agricultural University

Polyamines（PAs） and nitric oxide（NO） are vital signals in modulating plant response to abiotic stress. However, to our knowledge, studies on the relationship between NO and PAs in response to cold stress in tomato are limited. Accordingly, in this study, we investigated the effects of putrescine（Put） and spermidine（Spd） on NO generation and the function of Spd-induced NO in the tolerance of tomato seedling under chilling stress. Spd increased NO release via the nitric oxide synthase（NOS）-like and nitrate reductase（NR） enzymatic pathways in the seedlings, whereas Put had no such effect. Moreover, H2O2 might act as an upstream signal to stimulate NO production. Both exogenous NO donor（sodium nitroprusside（SNP）） and Spd enhanced chilling tolerance in tomato, thereby protecting the photosynthetic system from damage. Compared to chilling treatment alone, Spd enhanced the gene expressions of superoxide dismutase（SOD）, peroxidase（POD）, catalase（CAT）, and ascorbate peroxidase（APX）, and their enzyme activities in tomato leaves. However, a scavenger or inhibitor of NO abolished Spd-induced chilling tolerance and blocked the increased expression and activity due to Spd of these antioxidant enzymes in tomato leaves under chilling stress. The results showed that NO induced by Spd plays a crucial role in tomato＇s response to chilling stress.

关键词： Antioxidant enzymes Chilling tolerance Hydrogen peroxide Nitric oxide Spermidine Tomato

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Feasibility and clinical benefits of the double-ProGlide technique for hemostasis after cryoballoon atrial fibrillation ablation with uninterrupted oral anticoagulants

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Journal of Geriatric Cardiology 2023年第4期20卷 268-275页

作者： Jia-Yin SUN Chang-Bo XUAN Hai-Liang YU Hai-Yang WANG Hong-Ya HAN Zhi-Ming ZHOU De-An JIA dong-mei shi Yu-Jie ZHOU shi-Wei YANG Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel Diseasethe Key Laboratory of Remodeling-Related Cardiovascular DiseaseMinistry of EducationBeijingChina Department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina Department of Cardiology Tangshan Fengrun District Second People’s HospitalHebeiChina Department of Cardiology Qingdao Municipal HospitalQingdaoChina

OBJECTIVE To access the efficacy and safety of the double-ProGlide technique for the femoral vein access-site closure in cryoballoon ablation with uninterrupted oral anticoagulants(OAC),and its impact on the electrophysiology laboratory time as well as hospital stay after the procedure in this observational *** Patients with atrial fibrillation undergoing cryoballoon ablation with uninterrupted OAC at Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing,China from May 2019 to May 2021 were enrolled in this *** October 2020,double-ProGlide technique was consistently used for hemostasis(ProGlide group),and before that conventional manual compression was utilized(manual compression group).The occurrence of vascular and groin complications was accessed during the hospital stay and until the three-month *** A total of 140 participants(69.30%of male,mean age:59.21±10.29 years)were evaluated,70 participants being in each *** hemostasis was achieved in all the patients with ProGlide *** major vascular complications were found in the ProGlide group while two major vascular complications were occurred in the manual compression *** incidence of any groin complication was obviously higher in subjects with manual compression than patients with ProGlide devices(15.71%vs.2.86%,P=0.009).In addition,compared with the manual compression group,the ProGlide group was associated with significantly shorter total time in the electrophysiology laboratory[112.0(93.3–128.8)min vs.123.5(107.3–158.3)min,P=0.006],time from sheath removal until venous site hemostasis[3.8(3.4–4.2)min vs.8.0(7.6–8.5)min,P<0.001],bed rest time[8.0(7.6–8.0)h vs.14.1(12.0–17.6)h,P<0.001]and hospital stay after the procedure[13.8(12.5–17.8)h vs.38.0(21.5–41.0)h,P<0.001].CONCLUSIONS Utilization of the double-ProGlide technique for hemostasis after cryoballoon ablation with uninterrupted OAC is feasible and safe,which has the clinical

关键词： balloon interrupted closure

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Diagnostic accuracy of a deep learning approach to calculate FFR from coronary CT angiography

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Journal of Geriatric Cardiology 2019年第1期16卷 42-48页

作者： Zhi-Qiang WANG Yu-Jie ZHOU Ying-Xin ZHAO dong-mei shi Yu-Yang LIU Wei LIU Xiao-Li LIU Yue-Ping LI Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Clinical Center for Coronary Heart Disease Capital Medical University

Background The computational fluid dynamics(CFD)approach has been frequently applied to compute the fractional flow reserve(FFR)using computed tomography angiography(CTA).This technique is *** developed the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value out of CTA images in five *** study is to evaluate the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value from CTA images as an efficient *** A single-center,prospective study was conducted and 63 patients were enrolled for the evaluation of the diagnostic performance of *** quantification method for the three-dimensional coronary arterial geometry and the deep learning based prediction of FFR were developed to assess the ischemic risk of the stenotic coronary *** performance of the DEEPVESSEL-FFR was assessed by using wire-based FFR as reference *** primary evaluation factor was defined by using the area under receiver-operation characteristics curve(AUC)*** For per-patient level,taking the cut-off value<0.8 referring to the FFR measurement,DEEPVESSEL-FFR presented higher diagnostic performance in determining ischemia-related lesions with area under the curve of 0.928 compare to CTA stenotic severity ***-FFR correlated with FFR(R=0.686,P<0.001),with a mean di&ference of-0.006士0.0091(P=0.619).The secondary evaluation factors,indicating per vessel accuracy,sensitivity,specificity,positive predictive value,and negative predictive value were 87.3%,97.14%,75%,82.93%,and 95.45%,*** DEEPVESSEL-FFR is a novel method that allows efficient assessment of the functional significance of coronary stenosis.

关键词： Computed tomography angiography Coronary artery Deep learning Fractional flow reserve

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Association of serum complement C1q with cardiovascular outcomes among patients with acute coronary syndrome undergoing percutaneous coronary intervention

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Journal of Geriatric Cardiology 2022年第12期19卷 949-959,1007-1010页

作者： Qiu-Xuan LI Xiao-Teng MA Qiao-Yu SHAO Zhi-Qiang YANG Jing LIANG Li-Xia YANG dong-mei shi Yu-Jie ZHOU Zhi-Jian WANG Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina

OBJECTIVE To determine the association of serum complement C1q levels with cardiovascular outcomes among patients with acute coronary syndrome(ACS)undergoing percutaneous coronary intervention(PCI),and evaluate the value of C1q modified by high-sensitivity C-reactive protein(hs-CRP)levels as an independent *** As a single-center prospective observational study,we analyzed 1701 patients who had received primary or elective PCI for ACS at Beijing Anzhen Hospital,Capital Medical University,Beijing,China between June 1,2016 and November 30,*** associations of C1q modified by hs-CRP with major adverse cardiovascular events(MACE)were determined in survival *** Patients with the lowest C1q tertile had the highest cumulative risk of MACE(log-rank P=0.007).In fully adjusted Cox regression models,stratifying the total population according to hs-CRP dichotomy,C1q was significantly associated with MACE in patients with hs-CRP levels less than 2 mg/L but not in those with 2 mg/L or more(P_(interaction)=0.02).In patients with hs-CRP levels less than 2 mg/L,with the lowest C1q tertile as reference,the risk of MACE was reduced by 40.0%in the middle C1q tertile[hazard ratio(HR)=0.600,95%CI:0.423–0.852,P=0.004]and by 43.9%in the highest C1q tertile(HR=0.561,95%CI:0.375–0.840,P=0.005).CONCLUSIONS Serum complement C1q is significantly associated with cardiovascular outcomes in patients with ACS undergoing PCI,only when hs-CRP levels are less than 2 mg/*** finding implicates the usefulness of C1q for the risk stratification in ACS patients with reduced systemic inflammation.

关键词： C1q patients coronary

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New predictors of in-stent restenosis in patients with diabetes mellitus undergoing percutaneous coronary intervention with drug-eluting stent

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Journal of Geriatric Cardiology 2018年第2期15卷 137-145页

作者： Jian-Long WANG Zheng QIN Zhi-Jian WANG dong-mei shi Yu-Yang LIU Ying-Xin ZHAO Li-Xia YANG Wan-Jun CHENG Yu-Jie ZHOU Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing China

Background Percutaneous coronary intervention （PCI） had become the major therapeutic procedure for coronary artery disease （CAD）, but the high rate of in-stent restenosis （ISR） still remained an unsolved clinical problem in clinical practice. Increasing evidences suggested that diabetes mellitus （DM） was a major risk factor for ISR, but the risk predictors of ISR in CAD patients with DM had not been well characterized. The aim of this study was to investigate the clinical and angiographic characteristic predictors significantly associated with the occurrence of ISR in diabetic patients following coronary stenting with drug-eluting stent （DES）. Methods A total of 920 patients with diabetes who diagnosed CAD and underwent coronary DES implantation at Beijing Anzhen Hospital in China were consecutively enrolled from January 2012 to December 2012. Of these, 440 patients underwent the second angiography within ≥ 6 months due to the progression of treated target lesions. Finally, 368 of these patients who met the inclusion and exclusion criteria were followed up by angiography after baseline PCI. According to whether ISR was detected at follow-up angiography, patients were divided into the ISR group （n = 74） and the non-ISR group （n = 294）. The independent predictors of ISR in patients with DM were explored by multivariate Cox＇s proportional hazards regression models. Results A total of 368 patients （260 women and 108 men） with a mean ages of 58.71 ± 10.25 years were finally enrolled in this study. Of these, ISR occurred in 74/368 diabetic patients （20.11%） by follow-up angiography. Univariate analysis showed that most baseline characteristics of the ISR and non-ISR group were similar. Patients in the ISR group had significantly higher serum very low density lipoprotein cholesterol （VLDL-C）, triglyceride （TG） and uric acid （UA） levels, more numbers of target vessel lesions, higher prevalence of multi-vessel disease, higher SYNTAX score, higher rate of previous but lower r

关键词： Diabetes mellitus In-stent restenosis Uric acid SYNTAX score Very low density lipoprotein cholesterol

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Natural product-induced oxidative stress-synergistic anti-tumor effects of chemotherapeutic agents

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Traditional Medicine Research 2024年第3期9卷 10-23页

作者： Shu-Fan Wang shi-Qi dong Quan dong Wen-Xin Lin mei dong Duo Liu Department of Pharmacy Harbin Medical University Cancer HospitalHarbin 150086China

Reactive oxygen species are closely related to tumor *** recent years,reactive oxygen species has become a hot spot in tumor therapy,and many natural substances in nature contain compound components with anti-tumor ***,there is a lack of discussion on the synergistic anti-tumor effects of natural products in combination with chemotherapeutic drugs through reactive oxygen *** terms“natural products”,“reactive oxygen species”,“anti-tumor”,and“chemotherapy”were used to identify the synergistic effects of natural *** conducted a systematic literature search in PubMed and Web of Science databases for relevant research articles and reviews published in recent *** systematically summarized the studies related to anti-tumor active ingredients in natural compounds in the field of reactive oxygen species in recent years.A total of 77 relevant literatures were *** them,45 literatures containing various natural products such as terpenoids,flavonoids,alkaloids,*** anti-tumor effects by regulating reactive oxygen species levels,and 32 literatures regarding adjunctive role of natural products in anti-tumor *** this study,we found that natural products exert anti-tumor effects by elevating reactive oxygen species *** provides strong theoretical support for future clinical studies.

关键词： nature products tumor reactive oxygen species combination chemotherapy oxidative stress

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Concomitant occurrences of pulmonary embolism and acute myocardial infarction in acute coronary syndrome patient undergoing percutaneous coronary intervention:a case report

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Journal of Geriatric Cardiology 2023年第12期20卷 880-885页

作者： Zhi-Qiang YANG Shu-Tong dong Qiao-Yu SHAO Yu-Fei WANG Qiu-Xuan LI Zai-Qiang LIU Xiao-Teng MA Jing LIANG dong-mei shi Yu-Jie ZHOU Fei GAO Zhi-Jian WANG Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

Pulmonary embolism(PE),a form of venous thromboembolism,is a relatively frequent car-diovascular emergency,and a potentially life-threatening condition that needs prompt identification and treatment.[1]PE is often misdiagnosed or unrecogn-ized with many patients experiencing atypical sympt-oms.[2,3]Early diagnosis and treatment of PE are *** this case,PE was found in a 73-year-old male pa-tient with three-vessel coronary artery disease who un-derwent percutaneous coronary intervention(PCI)for concomitant acute myocardial infarction(MI).

关键词： coronary embolism acute

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Projections of summer light rain frequency in typical terrain over eastern China under wind speed constraint

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Science China Earth Sciences 2024年第6期67卷 1885-1894页

作者： Xuechen dong Daoyi GONG Cuicui shi Institute of Disaster Risk Science Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Change and Natural Disaster MOEFaculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China School of National Safety and Emergency Management Beijing Normal UniversityBeijing 100875China School of Systems Science Beijing Normal UniversityBeijing 100875China

The variation in near-surface wind speed is a key dynamic parameter in the orographic effect of precipitation over eastern *** this study,we used the latest high-resolution outputs from six GCMs in CMIP6-HighResMIP to evaluate the performance of high-resolution models in simulating the orographic precipitation characteristics of typical mountainous areas in summer over eastern *** orographic precipitation under warming scenarios was projected and constrained according to observational *** results indicated that during the contemporary climate reference period(1979-2009),although the relationship between model-simulated near-surface wind speed and orographic light rain frequency was consistently stable,the sensitivity of the orographic light rain frequency to surface wind variability was generally underestimated,with a deviation approximately 24.1% lower than the observational *** estimated orographic light rain frequency corrected based on the observed near-surface wind speed under a 1.5℃ warming scenario,was 36.1% lower than that of the contemporary period;this reduction was 8.6 times that without the wind speed constraint(4.2%).The MRI-AGCM3-2-S model,with a longer dataset,demonstrated relatively stable reductions in orographic light rain frequency under different warming scenarios(1.5℃,2℃,3℃,and 4℃)after the application of wind speed *** all cases,the reductions exceeded those for the predictions made without the wind speed constraint.

关键词： Frequency of orographic light rain HighResMIP High-resolution projection Observational constraint Eastern China

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