Association of serum complement C1q with cardiovascular outcomes among patients with acute coronary syndrome undergoing percutaneous coronary intervention

作     者：Qiu-Xuan LI Xiao-Teng MA Qiao-Yu SHAO Zhi-Qiang YANG Jing LIANG Li-Xia YANG Dong-Mei SHI Yu-Jie ZHOU Zhi-Jian WANG Qiu-Xuan LI;Xiao-Teng MA;Qiao-Yu SHAO;Zhi-Qiang YANG;Jing LIANG;Li-Xia YANG;Dong-Mei SHI;Yu-Jie ZHOU;Zhi-Jian WANG

作者机构：Department of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2022年第19卷第12期

页      面：949-959,1007-1010页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2017 YFC0908800) the China Postdoctoral Science Foundation(2021M692253) the Beijing Postdoctoral Research Foundation(2021-ZZ-023) 

主　　题：C1q patients coronary 

摘      要：OBJECTIVE To determine the association of serum complement C1q levels with cardiovascular outcomes among patients with acute coronary syndrome(ACS)undergoing percutaneous coronary intervention(PCI),and evaluate the value of C1q modified by high-sensitivity C-reactive protein(hs-CRP)levels as an independent *** As a single-center prospective observational study,we analyzed 1701 patients who had received primary or elective PCI for ACS at Beijing Anzhen Hospital,Capital Medical University,Beijing,China between June 1,2016 and November 30,*** associations of C1q modified by hs-CRP with major adverse cardiovascular events(MACE)were determined in survival *** Patients with the lowest C1q tertile had the highest cumulative risk of MACE(log-rank P=0.007).In fully adjusted Cox regression models,stratifying the total population according to hs-CRP dichotomy,C1q was significantly associated with MACE in patients with hs-CRP levels less than 2 mg/L but not in those with 2 mg/L or more(P_(interaction)=0.02).In patients with hs-CRP levels less than 2 mg/L,with the lowest C1q tertile as reference,the risk of MACE was reduced by 40.0%in the middle C1q tertile[hazard ratio(HR)=0.600,95%CI:0.423–0.852,P=0.004]and by 43.9%in the highest C1q tertile(HR=0.561,95%CI:0.375–0.840,P=0.005).CONCLUSIONS Serum complement C1q is significantly associated with cardiovascular outcomes in patients with ACS undergoing PCI,only when hs-CRP levels are less than 2 mg/*** finding implicates the usefulness of C1q for the risk stratification in ACS patients with reduced systemic inflammation.