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1-[2-(2-Methoxyphenylthio) benzyl]-4-arylpiperazines derivatives:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

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Chinese Chemical Letters 2008年第1期19卷 37-39页

作者： Xin Wang dong zhi liu Ai Jun Li School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China School of Pharmaceutical Science and technology Tianjin University Tianjin 300072 China

A series of 1-[2-（2-methoxyphenylthio） benzyl]-4-arylpiperazines derivatives was designed and synthesized based on 5-HT1A/ SSRI drugs design strategies. The synthesized compounds were evaluated for their dual 5-HT1A/5-HTT activities. 2007 Ai Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Antidepressants 5-HT1A/5-HTT Serotonin transporter 5-HT1A receptor Diphenylsulfide

1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3-aryloxypropan-2-ols:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

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Chinese Chemical Letters 2008年第1期19卷 40-42页

作者： Xin Wang dong zhi liu Ai Jun Li School of Chemical Engineering and Technology Ttanjin University 7ianjin 300072 China School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China

A series of 1-（N-（2-（2-methoxyphenylthio）benzyl）-N-methylamino-3-aryloxypropan-2-ols derivatives were designed and synthesized based on 5-HT1A/SSRI drugs design strategies. The synthesized compounds were evaluated for their dual 5-HT1A/ 5-HTT activities. 2007 Ai Jun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： 5-HT1A/SSRI Serotonin transporter 5-HT1A receptor Diphenylsulfide

Facile Synthesis of Five-membered Phosphoroheterocycles Bearing N-P-N and S-P-N Moieties

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Chinese Chemical Letters 2001年第12期12卷 1065-1068页

作者： Sheng Lou DENG dong zhi liu Ru Yu CHEN School of Chemical Engineering Tianjin UniversityTianjin 300072 Institute of Elemento-Organic Chemistry Nankai UniversityTianjin 300071

New reactions of Lawesson reagent (LR) with alpha -hydroxy (amino)nitriles have been studied. The experimental results showed that the five-membered phosphoroheterocycles 2 and 4 bearing N-P-N or S-P-N moiety could be... 详细信息

关键词： new reactions Lawesson reagent nitriles phosphoroheterocycle mechanism

Approach to N-Alkoxy-2-oxoindole for Mimicing SERMs Structure

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Chinese Chemical Letters 2005年第12期16卷 1593-1596页

作者： Ji Cheng CHU dong zhi liu Hong Sheng GUO Kang ZHAO School of Chemical Engineering and Technology Tianjin University Tianjin 300072 Medical College Chinese People＇s Armed Police Force Tianjin 300071 College of Pharmaceutical and Biotechnology Tianjin UniversityTianjin 300072

Treatment of N-alkoxyamides with bis（trifluoroacetoxy）iodobenzene generated electron deficient nitrogen species, which readily cyclized onto aromatic ring to give N-alkoxy-2- oxoindoles. The effect of different subs... 详细信息

关键词： N-Alkoxyamides bis(trifluoroacetoxy)iodobenzene intramolecular cyclization

New 3-(4-arylpiperazin-1-yl)-1-(benzo[b]thiophen-3-yl)-2-methylpropanol derivatives:Synthesis and evaluation for dual 5-HT1A/SSRI activities

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Chinese Chemical Letters 2008年第4期19卷 412-414页

作者： Ai Jun Li Xiao Hua Zhang Xue Qin Zhou dong zhi liu School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China

A series of 3-（4-arylpiperazin-1-yl）-1-（benzo[b]thiophen-3-yl）-2-methylpropanol derivatives were designed and synthesized based on 5-HT1A/SSRI drugs design *** synthesized compounds were evaluated for their dual 5... 详细信息

关键词： Antidepressants Arylpiperazines 5-HT1A/SSRI 5-HT transporter 5-HT1A receptor

N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

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Chinese Chemical Letters 2008年第3期19卷 295-298页

作者： Xue Dan Wu dong zhi liu Ai Jun Li Xue Qin Zhou School of Chemical Engineering and Technology lianjin University lianjin 300072 China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018 China

The design, synthesis and biological evaluation of N-（2-（2-methoxyphenylthio） benzyl）-2-aryloxyethyl amines with dual 5-HT1A/SSR/activities are reported. Compound 8e displays the best dual activities and is a prom... 详细信息

关键词： Antidepressants 5-HT1A/5-HTT 5-HT1A receptor Diphenylsulfide Aryloxyethylamines

Arylpiperazine derivatives of diphenylsulfide:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

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Chinese Chemical Letters 2008年第3期19卷 291-294页

作者： Xue Dan Wu dong zhi liu Ai Jun Li Xue Qin Zhou School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China College of Chemical and Pharmaceutical Engineering Hebei University of Science and Technology. Shijiazhuang 050018 China

The design, synthesis and biological evaluation of a novel series of arylpiperazine derivatives of diphenylsulfide with dual 5- HT1A/SSRI activities are reported. The target compounds exhibit low to moderate 5-HT transporter affinity and moderate to high 5- HT1A affinity, Compound 13a shows moderate dual activities and is a promising lead compound for further structure-activity relationships studies.

关键词： Antidepressants 5-HT1A/SSRI Arylpiperazines 5-HT1A receptor Diphenylsulfide

Cellular model of neuronal atrophy induced by DYNC111 deficiency reveals protective roles of RAS-RAF-MEK signaling

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Protein & Cell 2016年第9期7卷 638-650页

作者： zhi-dong liu Su Zhang Jian-Jin Hao Tao-Rong Xie Jian-Sheng Kang Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200231 China University of Chinese Academy of Sciences Beijing 100049 China

Neuronal atrophy is a common pathological feature occurred in aging and neurodegenerative diseases. A variety of abnormalities including motor protein mal- function and mitochondrial dysfunction contribute to the loss of neuronal architecture; however, less is known about the intracallular signaling pathways that can pro- tect against or delay this pathogenic process. Here, we show that the DYNClll deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons. With this cellular model, we are able to find that activation of *** signaling protects against neuronal atrophy induced by DYNClll deficiency, which relies on MEK-dependent autophagy in neuron. Moreover, we further reveal that BRAF also protects against neuronal atrophy induced by mitochondrial impairment. These findings demon- strate protective roles of the RAS-RAF-MEK axis against neuronal atrophy, and imply a new therapeutic target for clinical intervention.

关键词： RAS-RAF-MEK pathway atrophy dyneinintermediate chain mitochondria hippocampal neuron,autophagy

Stereoselective Addition of N-Alkylhydroxylamines to α,β-Unsaturated Nitro Compounds

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Chinese Chemical Letters 2006年第7期17卷 859-862页

作者： Ai Jun LI Ji Cheng CHU Hong Sheng GUO Xue Qin ZHOU dong zhi liu School of Chemical Engineering and Technology Tianjin University Tianjin 300072 Medical College Chinese People＇s Armed Police Force Tianjin 300071

N-Alkylhydroxylamines have been shown to undergo a stereospecific cis addition to 1-phenyl-2 -nitropropene compounds, whereas the corresponding O-alkylhydroxylamines give no diastereoselectivity. The concerted additio... 详细信息

关键词： N-Alkylhydroxylamines O-alkylhydroxylamines concerted addition mechanism α,β-unsaturated nitro compounds stereoselectivity.