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Effect of norepinephrine on host immunity and bacterial infection

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Chinese Medical Journal 2024年第3期137卷 362-364页

作者： Jia wang Zhiyao Fang Xue dong Wenwen Li Xianyao wan Department of Critical Care Medicine The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116021China

To the Editor:Norepinephrine(NE),which belongs to the catecholamine family,is increasingly produced by the sympathetic nervous system and adrenal medulla when the host is under stress.It has been demonstrated that NE has a significant anti-inflammatory effect.In addition,increasing evidence has indicated that stress hormones are directly involved in the interaction between bacteria and the host.A variety of bacteria can exhibit changes in growth,virulence,and biofilm by high concentrations of NE.Therefore,this article aimed to summarize the main research developments regarding the effects of NE on host immunity and bacterial infection,as well as the attendant molecular mechanisms[Figure 1].

关键词： effect. Figure stress

Review on inorganic and polymeric materials-coordinated metal-organic-framework photocatalysts for green hydrogen evolution

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Journal of Energy Chemistry 2024年第5期92卷 322-356页

作者： dong-Eun Lee Mohtaram Danish Umair Alam wan-Kuen Jo School of Architecture CivilEnvironmental and Energy Engineering Kyungpook National University80 Daehak-roBuk-guDaegu 41566Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea

Metal-organic frameworks(MOFs)possess a distinct advantage over conventional heterogeneous photocatalysts because of their carefully defined architecture and particular pores,which facilitate the targeted incorporation of other efficient cocatalysts or semiconductor materials.The integration of MOFs with other materials has resulted in significant breakthroughs,as the coupled materials improve the performance due to the combined effect.The unique MOF structures allow them to host foreign materials,which results in harvesting the visible region of the solar spectrum and effectively mitigating charge recombination by promoting charge separation.The review presents an evaluation of the latest developments in the utilization of surface and/or pore chemistry of MOF-supported heterojunctions for photocatalytic green-hydrogen generation with a basic understanding of the mechanism involved.The review begins with the basic principles of photocatalysis,the significance of MOFs,their optical properties,the methods used for synthesizing MOFs,and their coordination with other inorganic and polymeric materials.Furthermore,methods to increase photocatalytic H2 evolution using MOF-supported heterojunction have been proposed as standard practice.Lastly,to address environmental challenges,we highlight the future potential of MOF-supported heterojunctions for use in green-energy production.We hope that this review provides guidance to researchers in the development of effective heterojunctions based on MOFs to address challenges in energy applications and catalytic processes.

关键词： Renewable energy Environmental challenge Heterojunction Water splitting Photocatalysis

Working condition recognition of sucker rod pumping system based on 4-segment time-frequency signature matrix and deep learning

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Petroleum Science 2024年第1期21卷 641-653页

作者： Yun-Peng He Hai-Bo Cheng Peng Zeng Chuan-Zhi Zang Qing-Wei dong Guang-Xi wan Xiao-Ting dong State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016LiaoningChina Key Laboratory of Networked Control Systems Chinese Academy of SciencesShenyang 110016LiaoningChina Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang 110169LiaoningChina University of Chinese Academy of Sciences Beijing100049China School of Artifcial Intelligence Shenyang University of TechnologyShenyang 110870LiaoningChina

High-precision and real-time diagnosis of sucker rod pumping system(SRPS)is important for quickly mastering oil well operations.Deep learning-based method for classifying the dynamometer card(DC)of oil wells is an efficient diagnosis method.However,the input of the DC as a two-dimensional image into the deep learning framework suffers from low feature utilization and high computational effort.Additionally,different SRPSs in an oil field have various system parameters,and the same SRPS generates different DCs at different moments.Thus,there is heterogeneity in field data,which can dramatically impair the diagnostic accuracy.To solve the above problems,a working condition recognition method based on 4-segment time-frequency signature matrix(4S-TFSM)and deep learning is presented in this paper.First,the 4-segment time-frequency signature(4S-TFS)method that can reduce the computing power requirements is proposed for feature extraction of DC data.Subsequently,the 4S-TFSM is constructed by relative normalization and matrix calculation to synthesize the features of multiple data and solve the problem of data heterogeneity.Finally,a convolutional neural network(CNN),one of the deep learning frameworks,is used to determine the functioning conditions based on the 4S-TFSM.Experiments on field data verify that the proposed diagnostic method based on 4S-TFSM and CNN(4S-TFSM-CNN)can significantly improve the accuracy of working condition recognition with lower computational cost.To the best of our knowledge,this is the first work to discuss the effect of data heterogeneity on the working condition recognition performance of SRPS.

关键词： Sucker-rod pumping system Dynamometer card Working condition recognition Deep learning Time-frequency signature Time-frequency signature matrix

Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer:Unravelling challenges and future directions

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World Journal of Gastroenterology 2024年第13期30卷 1815-1835页

作者： Samantha Sharma Naresh Singh Anita Ahmed Turk Isabella wan Akshay Guttikonda Julia Lily dong Xinna Zhang Mateusz Opyrchal Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States Division of Hematology/Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202United States Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202United States

Colorectal cancer(CRC)is a complex disease with diverse etiologies and clinical outcomes.Despite considerable progress in development of CRC therapeutics,challenges remain regarding the diagnosis and management of advanced stage metastatic CRC(mCRC).In particular,the five-year survival rate is very low since mCRC is currently rarely curable.Over the past decade,cancer treatment has significantly improved with the introduction of cancer immunotherapies,specifically immune checkpoint inhibitors.Therapies aimed at blocking immune checkpoints such as PD-1,PD-L1,and CTLA-4 target inhibitory pathways of the immune system,and thereby enhance anti-tumor immunity.These therapies thus have shown promising results in many clinical trials alone or in combination.The efficacy and safety of immunotherapy,either alone or in combination with CRC,have been investigated in several clinical trials.Clinical trials,including KEYNOTE-164 and CheckMate 142,have led to Food and Drug Administration approval of the PD-1 inhibitors pembrolizumab and nivolumab,respectively,for the treatment of patients with unresectable or metastatic microsatellite instability-high or deficient mismatch repair CRC.Unfortunately,these drugs benefit only a small percentage of patients,with the benefits of immunotherapy remaining elusive for the vast majority of CRC patients.To this end,primary and secondary resistance to immunotherapy remains a significant issue,and further research is necessary to optimize the use of immunotherapy in CRC and identify biomarkers to predict the response.This review provides a comprehensive overview of the clinical trials involving immune checkpoint inhibitors in CRC.The underlying rationale,challenges faced,and potential future steps to improve the prognosis and enhance the likelihood of successful trials in this field are discussed.

关键词： Colorectal cancer Immune checkpoint inhibitors Clinical trials Immunotherapy Microsatellite instability Microsatellite stability DNA mismatch repair

Visible-light-activated aziridination reaction enables simultaneous resolving of C=C bond location and the sn-position isomers in lipids

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Chinese Chemical Letters 2024年第4期35卷 481-485页

作者： Qiongqiong wan Yanan Xiao Guifang Feng Xin dong Wenjing Nie Ming Gao Qingtao Meng Suming Chen The Institute for Advanced Studies Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China

There is a close relationship between the biological functions of lipids and their structures, and various isomers greatly increases the complexity of lipid structures. The C=C bond location and sn-position are two of the essential attributes that determine the structures of unsaturated lipids. However, simultaneous identification of both attributes remains challenging. Here, we develop a visible-light-activated aziridination reaction system, which enables the dual-resolving of the C=C bond location and sn-position isomerism of in lipids when combines with liquid chromatography-mass spectrometry(LC-MS). Based on the derivatization of C=C bonds with Ph I=NTs, their location in lipids could be easily identified by tandem MS. Especially, the sn-position isomers of unsaturated phosphatidylcholine(PC) can be separated and quantified by LC-MS after the derivatization. By using the proposed method, the significant changes of the sn-position isomers ratios of PC in mouse brain ischemia were revealed. This study offers a powerful tool for deep lipid structural biology.

关键词： Aziridination Lipid isomers C=C bond location sn-Position Mass spectrometry

Application of non-mydriatic fundus photography-assisted telemedicine in diabetic retinopathy screening

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World Journal of Diabetes 2024年第2期15卷 251-259页

作者： wan Zhou Xiao-Jing Yuan Jie Li Wei wang Hao-Qiang Zhang Yuan-Yuan Hu Shan-dong Ye Department of Endocrinology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology Anhui Provincial HospitalAffiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND Early screening and accurate staging of diabetic retinopathy(DR)can reduce blindness risk in type 2 diabetes patients.DR’s complex pathogenesis involves many factors,making ophthalmologist screening alone insufficient for prevention and treatment.Often,endocrinologists are the first to see diabetic patients and thus should screen for retinopathy for early intervention.AIM To explore the efficacy of non-mydriatic fundus photography(NMFP)-enhanced telemedicine in assessing DR and its various stages.METHODS This retrospective study incorporated findings from an analysis of 93 diabetic patients,examining both NMFP-assisted telemedicine and fundus fluorescein angiography(FFA).It focused on assessing the concordance in DR detection between these two methodologies.Additionally,receiver operating characteristic(ROC)curves were generated to determine the optimal sensitivity and specificity of NMFP-assisted telemedicine,using FFA outcomes as the standard benchmark.RESULTS In the context of DR diagnosis and staging,the kappa coefficients for NMFPassisted telemedicine and FFA were recorded at 0.775 and 0.689 respectively,indicating substantial intermethod agreement.Moreover,the NMFP-assisted telemedicine’s predictive accuracy for positive FFA outcomes,as denoted by the area under the ROC curve,was remarkably high at 0.955,within a confidence interval of 0.914 to 0.995 and a statistically significant P-value of less than 0.001.This predictive model exhibited a specificity of 100%,a sensitivity of 90.9%,and a Youden index of 0.909.CONCLUSION NMFP-assisted telemedicine represents a pragmatic,objective,and precise modality for fundus examination,particularly applicable in the context of endocrinology inpatient care and primary healthcare settings for diabetic patients.Its implementation in these scenarios is of paramount significance,enhancing the clinical accuracy in the diagnosis and therapeutic management of DR.This methodology not only streamlines patient evaluation but also contributes substantially to the optimi

关键词： Diabetes Diabetic retinopathy Non-mydriatic fundus photography-assisted telemedicine Fundus fluorescein angiography

Intracellular and extracellular enzymatic responsive micelle for intelligent therapy of cancer

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Nano Research 2023年第2期16卷 2851-2858页

作者： Dong Wan Qinan Zhu Jianxin Zhang Xi Chen Fangzhou Li Yi Liu Jie Pan School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China School of Chemistry Tiangong UniversityTianjin 300387China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

Recently,the incidence of cancer keeps increasing,seriously endangers human health,and has evolved into the main culprit of human death.Conventional chemotherapeutic drugs,such as paclitaxel and doxorubicin(DOX),have some disadvantages,including low therapeutic effect,poor water solubility,high toxic side effects,short blood circulation time in the body,and so on.To improve the anti-tumor effect of the drug in vivo and reduce its side effects on the body,researchers have designed and developed a variety of responsive nanocarriers.In this work,we synthesized D-α-tocopherol polyethylene glycol 3350 succinate(TPGS3350)-Gly-Pro-Leu-Gly-Val-Arg(GPLGVR)-DOX(TPD)prodrugs in response to extracellular enzymes of matrix metalloproteinase(MMP-9)in the tumor microenvironment and FA-Asp-Glu-Val-Asp(DEVD)-DOX(FPD)prodrugs responsive to intracellular enzymes of caspase-3.Then,intracellular and extracellular enzyme-responsive TPD&FPD micelles with DOX(TPD&FPD&D)were successfully prepared through dialysis method.The outer layer of TPGS3350 can prolong the blood circulation time of micelles in vivo,followed by accumulation of micelles at tumor tissue through enhanced permeability and retention(EPR)effect.The peptide of GPLGVR can be cleaved by MMP-9 enzymes to remove the outer layer of TPGS3350,exposing the targeting molecule of folate,and then the micelles are engulfed by tumor cells through folate receptor-mediated endocytosis.After entering the tumor cells,the free DOX loaded in the micelles is released,which induces tumor cell apoptosis to activate caspase-3 in the cells,cutting the peptide DEVD to accelerate the intracellular release of the DOX,which further enhances cytotoxicity to improve antitumor effect.

关键词： cancer micelle peptide enzyme-responsive folate

Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

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Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae Lim dong Guk Kang Hyeon Gyu Lee Yen Hai Thi Tran Kihun An Junghyun Choi Kwang Chul Roh Do Youb Kim Seung-wan Song Department of Chemical Engineering & Applied Chemistry Chungnam National University Energy Storage Materials Center Korea Institute of Ceramic Engineering & Technology Advanced Energy Materials Research Center Korea Research Institute of Chemical Technology

Incorporation of higher content Si anode material beyond 5 wt%to Li-ion batteries （LIBs） is challenging,owing to large volume change,swelling,and solid electrolyte interphase （SEI） instability issues.Herein,a strategy of diacetoxydimethylsilane （DAMS） additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi2（named as Si-Fe） anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate （FEC）additive and reduce a dependence on FEC.Unprecedented stable cycling performance of highly loaded(3.5 m A h cm-2) pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g-1at 0.5 C and significantly improved capacity retention of 81%after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only additive.DAMS-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： High-energy Li-ion battery Pure Si-Fe anode without graphite SEI layer Silane additive Suppressed swelling

Effect of slow shot speed on externally solidified crystal,porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy

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China Foundry 2024年第1期21卷 11-19页

作者： Wen-ning Liu Wei Zhang Peng-yue wang Yi-xian Liu Xiang-yi Jiao Ao-xiang wan Cheng-gang wang Guo-dong Tong Shou-mei Xiong School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Tsinghua UniversityBeijing 100084Beijing China FAW Group Co. Ltd.Changchun 130013China China FAW Foundry Co. Ltd.Changchun 130013China

The effect of slow shot speed on externally solidified crystal(ESC),porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy was investigated by optical microscopy(OM),scanning electron microscopy(SEM)and laboratory computed tomography(CT).Results showed that the newly developed AlSi9MnMoV alloy exhibited improved mechanical properties when compared to the AlSi10MnMg alloy.The AlSi9MnMoV alloy,which was designed with trace multicomponent additions,displays a notable grain refining effect in comparison to the AlSi10MnMg alloy.Refining elements Ti,Zr,V,Nb,B promote heterogeneous nucleation and reduce the grain size of primaryα-Al.At a lower slow shot speed,the large ESCs are easier to form and gather,developing into the dendrite net and net-shrinkage.With an increase in slow shot speed,the size and number of ESCs and porosities significantly reduce.In addition,the distribution of ESCs is more dispersed and the net-shrinkage disappears.The tensile property is greatly improved by adopting a higher slow shot speed.The ultimate tensile strength is enhanced from 260.31 MPa to 290.31 MPa(increased by 11.52%),and the elongation is enhanced from 3.72%to 6.34%(increased by 70.52%).

关键词： hypoeutectic Al-Si alloy high pressure die casting porosity externally solidified crystal tensile property