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Applicability and variability of liver stiffness measurements according to probe position

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World Journal of Gastroenterology 2009年第27期15卷 3398-3404页

作者： Patrick Ingiliz Kim Pav Chhay Mona Munteanu Pascal Lebray Yen Ngo dominique Roulot Yves Benhamou dominique Thabut Vlad Ratziu Thierry Poynard dominique Thabut Vlad Ratziu Thierry Poynard AP-HP Hospital Group Pitié-Salpêtrière Hepatology Department47-83 Hospital Boulevard Paris 75651 France BioPredictive 40 Bac street Paris 75007 France AP-HP Hepatology Department Avicenne hospitalBobigny 93000France AP-HP Hospital Group Pitié-Salpêtrière Hepatology Department47-83 Hospital Boulevard Paris 75651 France

AIM: To investigate the liver stiffness measurement (LSM) applicability and variability with reference to three probe positions according to the region of liver biopsy. METHODS: The applicability for LSM was defined as at least 10 valid measurements with a success rate greater than 60% and an interquartile range/median LSM < 30%. The LSM variability compared the inter-position concordance and the concordance with FibroTest. RESULTS: Four hundred and forty two consecutive patients were included. The applicability of the anterior position (81%) was significantly higher than that of the reference (69%) and lower positions (68%), (both P = 0.0001). There was a signif icant difference (0.5 kPa, 95% CI 0.13-0.89; P < 0.0001) between mean LSM estimated at the reference position (9.3 kPa) vs the anterior position (8.8 kPa). Discordance between positions was associated with thoracic fold (P = 0.008). The discordance rate between the reference position result and FibroTest was higher when the 7.1 kPa cutoff was used to define advanced fibrosis instead of 8.8 kPa (33.6% vs 23.5%, P = 0.03).CONCLUSION: The anterior position of the probe should be the fi rst choice for LSM using Fibroscan, as it has a higher applicability without higher variability compared to the usual liver biopsy position.

关键词： Fibroscan Fibrotest Liver fibrosis Variability Concordance

Regulation of Plant Vitamin Metabolism:Backbone of Biofortification for the Alleviation of Hidden Hunger

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Molecular Plant 2021年第3期14卷 40-60页

作者： Ling Jiang Simon Strobbe dominique Van Der Straeten Chunyi Zhang Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Laboratory of Functional Plant Biology Ghent UniversityK.L.Ledeganckstraat 359000 GhentBelgium These authors contributed equally to this work

Micronutrient deficiencies include shortages of vitamins and *** affect billions of people and are associated with long-range effects on health,learning ability,and huge economic *** of multiple micronutrients can play an important role in combating *** challenge,however,is to balance plant growth with nutrient requirements for ***,we summarize the major progress about vitamin biosynthesis and its response to the changing *** discuss the interactions among vitamins as well as possible strategies for vitamin ***,we propose to integrate new breeding technologies with metabolic pathway modification to facilitate the biofortification of crops,thereby alleviating the hidden hunger of target populations.

关键词： vitamins biosynthesis regulatory mechanisms biofortification hidden hunger

Simultaneous field-free molecular orientation and planar delocalization by THz laser pulses[Invited]

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Chinese Optics Letters 2022年第10期20卷 42-48页

作者： dominique Sugny Laboratoire Interdisciplinaire Carnot de Bourgogne(ICB) UMR 6303 CNRS-UniversitéBourgogne Franche ComtéF-21078 DijonFrance

This study shows the unexpected and counterintuitive possibility of simultaneously orienting a molecule while delocalizing its molecular axis in a plane in field-free *** corresponding quantum states are characterized,and different control strategies using shaped terahertz(THz)laser pulses are proposed to reach such states at zero and nonzero *** robustness against temperature effects of a simple control procedure combining a laser and a THz pulse is *** control strategies can be applied not only to linear molecules but also to symmetric top molecules.

关键词： rotational dynamics quantum control molecular orientation and alignment THz laser pulses

Stool characteristics of infants receiving short-chain galactooligosaccharides and long-chain fructo-oligosaccharides:A review

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World Journal of Gastroenterology 2014年第37期20卷 13446-13452页

作者： Petra AMJ Scholtens dominique AM Goossens Annamaria Staiano Nutricia Research Section of Pediatrics Department of Translation Medical ScienceFederico ⅡUniversity of Naples

Human milk is considered to be the optimal source of infant nutrition. Some of the benefits of breastfeeding have been ascribed to human milk oligosaccharides(HMO). For instance, HMO can affect faecal characteristics such as stool consistency and stool frequency. Such effects on stool characteristics can be beneficial for young infants as hard stools and even constipation is common in that age group. Prebiotics in infant milk formulas have been introduced to exert similar functionalities. A specific mixture of prebiotics consists of a combination of short chain galacto-oligosaccharides and long-chain fructo-oligosaccharides(scGOS/lcFOS) in a ratio of 9:1. This specific mixture has been developed to closely resemble the molecular size composition of HMO. Many studies have been done with scGOS/lcFOS, and indicators for digestive comfort have often been included as secondary outcomes. This review summarizes the effects of scGOS/lcFOS(9:1) on stool consistency,stool frequency and transit time in healthy term and preterm infants. In several of the studies with scGOS/lcFOS in a ratio of 9:1 in infant milk formulas, positive effects of this mixture on stool characteristics such as stool consistency and stool frequency were observed. As stool consistency was shown to be correlated to whole gut transit time, scGOS/lcFOS can be hypothesised to have a role in reducing the risk of constipation.

关键词： Short-chain galactooligosaccharides Long-chain fructooligosaccharides Stool consistency Stool frequency Infants

Liquid encapsulation in a freezing sessile drop

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Droplet 2023年第4期2卷 120-126页

作者： Sijia Lyu Xun Zhu dominique Legendre Chao Sun Center for Combustion Energy Key Laboratory for Thermal Science and Power Engineering of Ministry of EducationDepartment of Energy and Power EngineeringTsinghua UniversityBeijingChina Institut de Mécanique des Fluides de Toulouse(IMFT) Universitéde ToulouseCNRS‐ToulouseFrance Department of Engineering Mechanics School of Aerospace EngineeringTsinghua UniversityBeijingChina

During the solidification of a sessile drop,the effect of heat exchange from the gaseous environmental medium is generally ***,by combining experimental observations,direct numerical simulations,and a theoretical model,we have demonstrated that the environmental medium,particularly one with high thermal conductivity such as a liquid,has nonnegligible heat exchange with both the drop and the substrate,leading to accelerated cooling of the outer surface of the sessile ***,it causes alterations in the geometry of the freezing front and ultimately results in the formation of a solidified shell that encloses the ***,the encapsulated liquid continues to solidify,which induces volume change and consequently changes the final outcome of the freezing *** study highlights the importance of considering the properties of the environmental medium and provides novel strategies to manipulate the freezing rate and reshape the morphology of the solidified drop.

关键词： solidification freezing outer

HLA and lung transplantation

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Frontiers of Medicine 2019年第3期13卷 298-313页

作者： Liya Ju Caroline Suberbielle Xiaofan Li Nuala Mooney dominique Charron HLA et Medecine "Jean Daus set" Laboratory NetworkHopital Saint-LouisParisFrance Laboratoire Histocompatibilité Hopital Saint-LouisParisFrance INSERM U1160 Hopital Saint-LouisUniversité Paris DiderotSorbonne Paris CitéFrance Labex Transplantex StrasbourgFrance Shanghai Jiao Tong University School of Medicine Shanghai 200025China

Lung transplantation is increasingly practiced for patients with end-stage lung *** successful outcome of solid organ transplantation today is severely impeded by the production of alloantibodies,mainly directed against the protein products of the HLA complex of the organ *** the association between antibody mediated rejection and ailograft damage has been well established in renal and heart transplantation,it has not yet been well characterized in lung *** review addresses the question of HLA matching in lung transplantation and current knowledge of the allogenicity of different HLA class Ⅰ and Ⅱ *** role of the antibody mediated immune response is discussed as well as the importance of pre-transplant or de novo posttransplant circulating ***,potential mechanisms,which may act individually or in combination,of antibody mediated damage to solid organ transplants are considered.

关键词： human leukocyte antigen class I and II lung transplantation mismatch obliterans bronchiolitis alloantibody antibody mediated rejection

Metal-free regioselective construction of 2-aryl-2H-tetrazol-5-yl difluoromethylene phosphonates

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Chinese Chemical Letters 2022年第2期33卷 863-866页

作者： Shi-Jing Zhai dominique Cahard Fa-Guang Zhang Jun-An Ma Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesFrontiers Science Center for Synthetic Biology(Ministry of Education)and Tianjin Collaborative Innovation Centre of Chemical Science&EngineeringTianjin UniversityTianjin 300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China CNRS UMR 6014 COBRA Normandie UniversitéMont Saint Aignan 76821France

Three bench-stable difluoromethylene phosphonate hydrazones were prepared from simple diethyl(difluoromethyl)phosphonate within two steps in good yields. The [3 + 2] cycloaddition reaction of these diazo precursors with aryl diazonium salts has been accomplished under metal-free conditions with exclusive regioselectivity. This transformation provides practical access to a broad panel of 2-aryl-2 H-tetrazol-5-yl difluoromethylene phosphonates, including the corresponding derivatives of amino acid(phenylalanine) and drug cores(Pomalidomide and Lapatinib fragment).

关键词： Tetrazole Cycloaddition Difluoromethylene phosphonate Regioselectivity Diazonium salt

PM_(2.5) source apportionment in a French urban coastal site under steelworks emission influences using constrained non-negative matrix factorization receptor model

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Journal of Environmental Sciences 2016年第2期28卷 114-128页

作者： Adib Kfoury Frederic Ledoux Cloe Roche Gilles Delmaire Gilles Roussel dominique Courcot Unite de Chimie Environnementale et Interactions sur le Vivant (UCEIV) EA4492 Universite du Littoral Cote d'Opale F-59140 Dunkerque France Laboratoire d'Informatique Signal et Image de la Cote d'Opale (LISIC) EA4491 Universite du Littoral Cote d'Opale F-52228 Calais France

The constrained weighted-non-negative matrix factorization（CW-NMF） hybrid receptor model was applied to study the influence of steelmaking activities on PM_（2.5）（particulate matter with equivalent aerodynamic diameter less than 2.5 μm） composition in Dunkerque,Northern France. Semi-diurnal PM_（2.5）samples were collected using a high volume sampler in winter 2010 and spring 2011 and were analyzed for trace metals, water-soluble ions, and total carbon using inductively coupled plasma – atomic emission spectrometry（ICP-AES）,ICP- mass spectrometry（ICP-MS）, ionic chromatography and micro elemental carbon analyzer. The elemental composition shows that NO_3^-, SO_4^（2-）, NH_4~＋and total carbon are the main PM_（2.5）constituents. Trace metals data were interpreted using concentration roses and both influences of integrated steelworks and electric steel plant were evidenced. The distinction between the two sources is made possible by the use Zn/Fe and Zn/Mn diagnostic ratios. Moreover Rb/Cr, Pb/Cr and Cu/Cd combination ratio are proposed to distinguish the ISW-sintering stack from the ISW-fugitive emissions. The a priori knowledge on the influencing source was introduced in the CW-NMF to guide the calculation. Eleven source profiles with various contributions were identified： 8 are characteristics of coastal urban background site profiles and 3 are related to the steelmaking activities. Between them,secondary nitrates, secondary sulfates and combustion profiles give the highest contributions and account for 93% of the PM_（2.5）concentration. The steelwork facilities contribute in about 2%of the total PM_（2.5）concentration and appear to be the main source of Cr, Cu, Fe, Mn, Zn.

关键词： PM_(2.5) Receptor modeling Non-negative matrix factorization Source apportionment Steelworks

Exosomal lncRNAs: the newest promising liquid biopsy

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Cancer Drug Resistance 2019年第4期2卷 1002-1017页

作者： Marta Tellez-Gabriel dominique Heymann RNA and Molecular Pathology(RAMP)Research Group Department of Medical BiologyThe Artic University of Norway(Tromso)Tromso 9019Norway INSERM Institut de Cancérologie de l’OuestLabCTU1232CRCINAUniversitéde NantesUniversitéd’AngersSaint Herblain 44805France

LncRNAs are defined as RNA transcripts greater than 200 nucleotides in length that have no or limited protein-coding *** expression of lncRNAs appeared important for various homeostatic processes,like gene imprinting cell differentiation and ***,it has been demonstrated that lncRNAs play an important role in tumorigenesis and *** lncRNAs were stably detected in exosomes,which are widely found in body *** studies validated the use of exosomal lncRNAs as minimally invasive diagnostic and prognostic markers in several types of *** addition,exosomal lncRNAs have been associated with drug resistance of tumor cells,suggesting a clinical application in cancer-targeted *** the recent increase of studies on exosomal lncRNAs,their clinical significance in cancer diagnosis,prognosis and treatment needs to be fully *** methodologies for their detection with high purity and accuracy must be also improved in order to implement their use in clinical *** review aims to summarize the main recent technologies available for the isolation of exosomal lncRNAs,their status as a liquid biopsy as well as their future perspectives.

关键词： Liquid biopsy long non-coding RNAs exosomes