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Towards an actionable One Health approach

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贫困所致传染病(英文) 2024年第2期13卷 77-82页

作者： Zhang Xiao-Xi Lederman Zohar Han Le-Fei Schurer Janna M. Xiao Li-Hua Zhang Zhi-Bing Chen Qiu-Lan Pfeiffer Dirk Ward Michael P. Sripa Banchob Gabri?l Sarah Dhama Kuldeep Acharya Krishna Prasad Robertson Lucy J. Deem Sharon L. Aenishaenslin Cécile Dantas-Torres Filipe Otranto domenico Grace Delia Wang Yang Li Peng Fu Chao Poeta Patrícia Rahman Md. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun Liu Jiming Wang Zhao-Jun Guo Xiao-Kui Gong Wen-Feng Schwartl?nder Bernhard Ren Ming-Hui Zhou Xiao-Nong Sydney School of veterinary Science The University of Sydney Camden Australia Tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand Laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of Livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémiologie des Zoonoses et Santé Publique (GREZOSP) Faculté de médecine vétérinaire Université de Montréal Saint-Hyacinthe Québec Canada Centre de recherche en santé publique de l Université de Montréal et du CIUSSS du Centre-Sud-de-l’?le-de-Montréal Montréal Québec Canada Department of Immunology Aggeu Magalh?es Institute Oswaldo Cruz Foundation (Fiocruz) Recife Brazil School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Department of veterinary Medicine University of Bari Valenzano Italy Department of Pathobiology Faculty of Veterinary Science Bu-Ali Sina University Hamedan Iran Natural Resources Institute University of Greenwich Chatham Maritime UK International Livestock Research Institute Nairobi Kenya Director of Key Laboratory of Animal Antimicrobial Resistance Surveillance Ministry of Agriculture and Rural Affairs Beijing People’s Republic of China Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing People’s Republic of China Key Laboratory of Ecosystem Network O

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action Commission Research agenda

Cannabidiol preferentially binds TRPv2: a novel mechanism of action

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Neural Regeneration Research 2022年第12期17卷 2693-2694页

作者： Elisa Landucci domenico E.Pellegrini-Giampietro Alessandra Gianoncelli Giovanni Ribaudo Department of Health Sciences Section of Clinical Pharmacology and OncologyUniversity of FlorenceFirenzeItaly Department of Molecular and Translational Medicine University of BresciaBresciaItaly

Plants from the genus Cannabis,and strains of Cannabis sativa in particular,have been used in medicine since ancient *** Cannabis plant contains more than 500 chemical compounds,with two main phytocannabinoids consisting of Δ9-tetrahydrocannabinol(THC),the psychoactive constituent,and cannabidiol(CBD),which does not bear this *** paper aims at providing a perspective on the potential therapeutic effects of CBD based on its preferential interaction with transient potential receptor v2(TRPv2).Many formulations based on Cannabis extract have been licensed for therapeutic use in some Western *** these,the most relevant are Sativex(THC+CBD,used mainly for the treatment of spasticity in multiple sclerosis)and Epidyolex(purified plant-derived CBD,used for some rare childhood epilepsies).

关键词： effect mechanism formulation

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Giant photoinduced reflectivity modulation of nonlocal resonances in silicon metasurfaces

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Advanced Photonics 2023年第6期5卷 83-91页

作者： Andrea Tognazzi Paolo Franceschini Olga Sergaeva Luca Carletti Ivano Alessandri Giovanni Finco Osamu Takayama Radu Malureanu Andrei v.Lavrinenko Alfonso C.Cino domenico de Ceglia Costantino De Angelis University of Palermo Department of EngineeringPalermoItaly National Institute of Optics-National Research Council PalermoItaly University of Brescia Department of Information EngineeringPalermoItaly ITMO University School of Physics and EngineeringSaint-PetersburgRussia ETH Zurich Institute for Quantum ElectronicsDepartment of PhysicsOptical Nanomaterial GroupZurichSwitzerland Technical University of Denmark Department of Electrical and Photonics EngineeringKongens LyngbyDenmark

Metasurfaces offer a unique playground to tailor the electromagnetic field at subwavelength scale to control polarization,wavefront,and nonlinear *** of the optical response of these structures is challenging due to the nanoscale size of their constitutive elements.A long-sought solution to achieve tunability at the nanoscale is all-optical modulation by exploiting the ultrafast nonlinear response of ***,the nonlinear response of materials is inherently very weak,and,therefore,requires optical excitations with large values of *** show that by properly tuning the equilibrium optical response of a nonlocal metasurface,it is possible to achieve sizable variation of the photoinduced out-ofequilibrium optical response on the picosecond timescale employing fluences smaller than 250μJ∕cm^(2),which is 1 order of magnitude lower than previous studies with comparable reflectivity variations in silicon *** results pave the way to fast devices with large modulation amplitude.

关键词： nonlocal metasurface nanophotonics ultrafast modulation Fano resonance

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20-Hydroxyecdysone from Dacrycarpus imbricatus bark inhibits the proliferation of acute myeloid leukemia cells

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 151-153页

作者： Trinh Thi Thuy Nguyen Thanh Tam Nguyen Thi Hoang Anh Dang viet Hau Dinh Thi Phong Le Quoc Thang Sabrina Adorisio Tran van Sung domenico v.delfino Institute of Chemistry Vietnam Academy of Science and Technology vietnam National Museum of Nature Vietnam Academy of Science and Technology Hue University’s College of Educations Section of Pharmacology Department of MedicineUniversity of Perugia

Objective:To investigate the anti-proliferative effects of 20-hydroxyecdysone isolated from the bark of Dacrycarpus imbricatus(Blume) de ***:Column chromatography was used for isolation of compounds from plant *** structure of the isolated compound was identified by mass spectrometry and nuclear magnetic resonance techniques,including HSQC,HMBC,NOE-difference *** isolated compound was tested for its anti-proliferative activity in acute myeloid leukemia(AML) and OCI-AML ***:Compound 1 was isolated from the ethyl acetate fraction of Dacrycarpus imbricatus barks by column *** chemical structure was identified as 20-hydroxyecdysone(20HE),a cholestane-type ecdysteroid,by a combination of mass spectrometry and nuclear magnetic resonance spectrometric *** goal was to test the anti-proliferative activity of 20 HE using the OCI-AML cell line.20 HE significantly decreased OCI cell number at a concentration of 1 mg/mL,whereas lower concentrations were ***,this decrease was due to partial blockage of the G_1/S phase of the cell cycle,with a reduction of cells in the G_2M phase,not due to increased ***:This indicates that 20 HE significantly decreases the number of cells in the G_1/S phase of the cell cycle in human AML *** is the first time that the anti-proliferative activity of 20 HE against a human tumor cell line has been reported.

关键词： Dacrycarpus imbricatus Ecdysteroid 20-hydroxyecdysone Proliferation Acute myeloid leukemia

Structural Analysis of TiC and TiC-C Core-Shell Nanostructures Produced by Pulsed-Laser Ablation

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Journal of Materials Science and Chemical Engineering 2023年第7期11卷 1-13页

作者： Luis Enrique Iniesta Piña Miguel Ángel Camacho López Rafael vilchis Néstor víctor Hugo Castrejón Sánchez delfino Reyes Contreras Mestría en Ciencia de Materiales Facultad de Química Campus Rosedal Universidad Autónoma del Estado de México Toluca México Laboratorio de Fotomedicina Biofotónica y Espectroscopía Láser de Pulsos Ultracortos Facultad de Medicina Universidad Autónoma del Estado de México Toluca México Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM Toluca México TecNM/Tecnológico de Estudios Superiores de Jocotitlán Jocotitlán México Laboratorio de Acústica y Nanomateriales Facultad de Ciencias Campus el Cerrillo Universidad Autónoma del Estado de México Toluca México

This paper reports on the ablation process of a pure Ti solid target immersed in a C-enriched acetone solution, leading to the production of titanium carbide (TiC) and Ti-C core-shell nanostructures. The used route of synthesis is generally called pulsed laser ablation in liquid (PLAL). The presence of carbon structures in the solution contributed to the carbon content in the produced Ti-based nanomaterials. The atomic composition of the produced nanostructures was analyzed using SEM-EDS, while TEM micrographs revealed the formation of spherical TiC and core-shell nanostructures ranging from 40 to 100 nm. The identification of atomic planes by HRTEM confirmed a 10 nm diameter C-shell with a graphite structure surrounding the Ti-core. Raman spectroscopy allowed for the identification of D and G peaks for graphite and a Raman signal at 380 and 600 cm−1, assigned to TiC. The results contribute to the state-of-the-art production of TiC and Ti-C core-shell nanostructures using the PLAL route.

关键词： Laser Ablation TiC Nanoparticles Core-Shell Nanoparticles Pulsed Laser

Experimental infection with Yersinia pseudotuberculosis in European brown hare(Lepus europaeus,Pallas)

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 269-274页

作者： Filippo Fratini Ranieri verin valentina v.Ebani Cecilia Ambrogi Fabrizio Bertelloni Barbara Turchi Alessandro Poli domenico Cerri Dipartimento di Scienze veterinarie Universita di PisaPisa Italy Department of veterinary Pathology and Public Health Institute of Veterinary ScienceUniversity of LiverpoolUK Corpo Forestale dello Stato Azienda Faunistica di MontefalconePisaItaly

Objective:To investigate clinicopathological,bacteriological and pathological aspects of an experimental infection with Yersinia pseudotuberculosis(***)in hares in order to verify the efficacy of serology for the in vivo ***,the pathogenicity of two *** strains was investigated in order to detect potential ***:Twelve European brown hares(Lepus europaeus,Pallas)were experimentally infected per os and via conjunctival mucosae with ***:six subjects were infected with a strain isolated from a naturally infected hare(YpH)and six subjects with a strain isolated from a naturally infected rabbit(YpR).Two hares were used as negative *** animals were subjected to clinical,bacteriological and serological examinations during 9 weeks following the infection and,at the end of the control period,subjects still alive were euthanized and submitted to a complete post mortem ***:All faecal samples collected during the control period were positive for bacteriological examinations and to a PCR for the inv gene of ***,while only one Yp H-infected hare showed a positive *** the 2nd to the 9th week post infection(pi),serological analysis revealed specific antibodies with titers ranging from 1:10 to 1:160 in all YpH-infected and two YpR-infected *** the Yp H-infected and two Yp R-infected hares scored positive for *** by means of bacteriological ***,suppurative multifocal lesions were detected in liver,spleen,kidney and sub-mandibular lymph nodes in both YpH-and YpR-infected hares and confirmed with *** lesions were observed only in Yp H-infected *** confirmed the presence of bacterial antigen in all infected ***:Results of this study revealed that YpH strain is more pathogenic for hares than the YpR strain;moreover the serological test performed in

关键词： Yersinia pseudotuberculosis Hare Bacteriology Serology Histopathology Immuno histochemistry

viral manipulation of cellular protein conjugation pathways: The SUMO lesson

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World Journal of virology 2013年第2期2卷 79-90页

作者： domenico Mattoscio Chiara v Segré Susanna Chiocca Department of Experimental Oncology European Institute of Oncology Via Adamello 16 20139 Milan Italy

Small ubiquitin-like modifier(SUMO)ylation is a key posttranslational modification mechanism that controls the function of a plethora of proteins and biological processes. Given its central regulatory role, it is not surprising that it is widely exploited by viruses. A number of viral proteins are known to modify and/or be modified by the SUMOylation system to exert their function, to create a cellular environment more favorable for virus survival and propagation, and to prevent host antiviral responses. Since the SUMO pathway is a multi-step cascade, viral proteins engage with it at many levels, to advance and favor each stage of a typical infection cycle: replication, viral assembly and immune evasion. Here we review the current knowledge on the interplay between the host SUMO system and viral lifecycle.

关键词： virus Small ubiquitin-like modifier Small ubiquitin-like modifier-ylation Exploitation virus assembly Immune evasion Innate immunity

Management of hepatic metastases of well/moderately differentiated neuroendocrine tumors of the digestive tract

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 294-303页

作者： Anna La Salvia Stefano Partelli Marco Tampellini domenico Tamburrino Massimo Falconi Giorgio v.Scagliotti Maria Pia Brizzi Division of Medical Oncology Department of OncologyUniversity of TurinSan Luigi Gonzaga HospitalRegione Gonzole 1010043 OrbassanoItaly Pancreatic Surgery Unit San Raffaele HospitalVita-Salute San Raffaele University20132 MilanItaly HPB Unit Royal Free HospitalLondon NW32QGUK

In neuroendocrine tumors(NETs),liver metastases(LM)represent the most crucial prognostic factor,irrespective of the primary tumor *** diagnosis,about 65-95%of gastroenteropancreatic neuroendocrine tumors(GEP-NETs)show hepatic *** strategies of LM are heterogeneous and range from systemic therapy to liver-directed *** type of systemic therapy used is dependent on the grade and proliferation of the tumor and includes somatostatin analogues,interferon,m-Tor and tyrosine kinase inhibitors,and *** liver-directed techniques,such as transarterial embolization/chemoembolization and selective internal radiation therapy,offer excellent palliation for patients with liver-predominant *** highly selected cases,liver transplantation and peptide receptor radionuclide therapy are *** relatively low disease incidence and the diversity of presentation have led to a lack of well-conducted randomized controlled trials comparing the efficacy of different treatment *** indicates that surgery is the only treatment that offers potential for *** unresectable lesions,the absence of data from rigorous trials limits the validity of many publications that detail *** this review we will discuss the existing approaches for hepatic metastases from GEP-NETs.

关键词： Gastroenteropancreatic carcinoids metastases systemic treatment

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减少海洋航运环境排放的新方法

Journal of Marine Science and Application 2021年第2期20卷 229-247页

作者： domenico Flagiello Martina Esposito Francesco Di Natale Kent Salo The Sustainable Technologies for Pollution ControlLaboratory Department of ChemicalMaterials and Industrial Production EngineeringUniversity of Naples Federico IIP.le V.Tecchio8080125 NaplesItaly Department of Mechanics and Maritime Science Chalmers University of TechnologyLindholmen Horselgangen441296 GothenburgSweden

Maritime shipping is a strategic sector with a strong international vocation and *** need to define regulations valid for many different countries without generating disparities of treatment slowed down the formulation of environmental regulations,especially for atmospheric *** particular,regulations pertaining to the reduction of sulphur compounds allowed two distinct approaches:the use of low-sulphur fuels or exhaust gas cleaning systems,the so-called *** actual implementation of these solutions presents specific concerns either related to the toxicity of atmospheric by-products and to the fuel cost or to the generation of polluting washwaters that may need treatment before *** this paper we analyzed the potential environmental benefit deriving from the use of a distillate fuel,not compliant with current IMO Sulphur Regulations,together with a *** pilot-scale experimental results indicated that a limited amount of water and/or scrubber volume is needed to reduce sulphur emissions below regulations on maritime shipping,especially with the addition of NaOH reaching a water-saving between 25%-33%compared to the use of pure *** indicated that scrubber washwater PAHs emissions are within the available water quality standards indicated by EU and USA guidelines.A bottom-up analysis on heavy metals concentration shed light on the prominent role of metal-parts corrosion on the washwater *** into account for corrosion phenomena,the actual heavy metals concentration in the washwater deriving from scrubbing was normally below the water quality standards.

关键词： Ships environmental footprint Exhaust gas cleaning system Washwater emissions Marine distillate fuels Marine seawater scrubber Persistent pollutants

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