Cannabidiol preferentially binds TRPV2: a novel mechanism of action

作     者：Elisa Landucci Domenico E.Pellegrini-Giampietro Alessandra Gianoncelli Giovanni Ribaudo Elisa Landucci;Domenico E.Pellegrini-Giampietro;Alessandra Gianoncelli;Giovanni Ribaudo

作者机构：Department of Health SciencesSection of Clinical Pharmacology and OncologyUniversity of FlorenceFirenzeItaly Department of Molecular and Translational MedicineUniversity of BresciaBresciaItaly 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第12期

页      面：2693-2694页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：effect mechanism formulation 

摘      要：Plants from the genus Cannabis,and strains of Cannabis sativa in particular,have been used in medicine since ancient *** Cannabis plant contains more than 500 chemical compounds,with two main phytocannabinoids consisting of Δ9-tetrahydrocannabinol(THC),the psychoactive constituent,and cannabidiol(CBD),which does not bear this *** paper aims at providing a perspective on the potential therapeutic effects of CBD based on its preferential interaction with transient potential receptor V2(TRPV2).Many formulations based on Cannabis extract have been licensed for therapeutic use in some Western *** these,the most relevant are Sativex(THC+CBD,used mainly for the treatment of spasticity in multiple sclerosis)and Epidyolex(purified plant-derived CBD,used for some rare childhood epilepsies).