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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 4-4页

作者： lamb j.D. Garcia R.L. Goff B.A. E.M. Swisher 朱磊 Departments of Obstetrics and Gynecology Dr.

Objective: The purpose of this study was to define the rate of neoplasia in prophylactic surgical specimens with the use of a careful surgical and pathologic protocol in a prospective study of high-risk women who were undergoing risk-redu-cing salpingo-oophorectomy. Outcomes of interest were neoplasia that was identified in surgical specimens and clinical outcomes of women who were undergoing risk-re-ducing salpingo-oophorectomy. We hypothesized that older age and having a BRCA1 mutation would be predictors for tubal or ovarian neoplasia and that a careful surgical and pathologic protocol would lead to a low rate of subsequent primary peritoneal cancer. Study design: A prospective tissue and research database enrolled patients who underwent risk-reducing salpingo-oophorectomy for prevention of ovarian cancer. Clinical and pathologic data were extracted for those patients after the initiation of a de- fined surgical and pathologic protocol in 1999. Results: One hundred thirteen women met the high-risk criteria; 40 of the women (45% ) who were tested had a deleterious mutation in BRCA1, and 22 women (25% ) had a mutation in BRCA2. Seven women had ovarian or tubal neoplasia (6.2% ). One woman had occult endometrial cancer. Age ≥ 45 years and having a BRCA1 or BRCA2 mutation were significant predictors of occult neoplasia. Two patients with neoplasia that was identified at risk-reducing salpingo-oophorectomy experienced recurrence. Three patients with BRCA1 mutations have subsequent new diagnoses of breast cancer. No patients had primary peritoneal cancer after risk-reducing salpingo-oophorectomy. Conclusion: Age ≥ 45 years and mutations in BRCA1 or BRCA2 predict occult neoplasia in women who undergo risk-reducing salpingo-oophorectomy. A thorough pathologic and surgical protocol at the time of risk-reducing salpingo-oophorectomy may improve the risk of subsequent primary peritoneal cancer.

关键词： BRCA 输卵管卵巢临床结局腹膜癌病理检查基因突变病理学检查癌发生率研究设计试验计划

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用磁化转移率评价克罗恩病病人肛瘘的活动性

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国际医学放射学杂志 2017年第2期 228-228页

作者： C.Pinson M.dolores Y.Cruypeninck E.Koning j.N.Dacher G.Savoye 刘炜 Department of Radiology Rouen University Hospital -Charles Nicolle

摘要目的肛瘘的评价对于指导克罗恩病(CD)的治疗有重要意义。本研究旨在分析磁化传递(MT)成像评估肛瘘的可行性,并评价其对于评估疾病活动性的价值。方法 15

关键词：活动性克罗恩病局限性回肠炎肠炎肛瘘肛门疾病转移率病人

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MULTI-PARAMETER SENSING IN LIQUID USING A lamb WAVE BASED MICROSENSOR

MULTI-PARAMETER SENSING IN LIQUID USING A LAMB WAVE BASED MI...

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第三届全国压电和声波理论及器件技术研讨会

作者： j.F.Manceau F.Bastien FEMTO-ST Institute MN2S DepartmentUTBM-32 avenue de l'Observatoire25044 BesanconFrance FEMTO-ST Institute MN2S DepartmentUTBM-32 avenue de l'Observatoire25044 BesanonFrance

The characters of zero anti-symmetric(A) and zero symmetric modes(S) of lamb wave sensor loaded with liquid were investigated and compared in the *** was found that due to the their different acoustic penetration depths inside the liquid the changes of the surface characteristics of the sensor and the characteristics of liquid near the surface can be identified respectively by combined A and S modes *** the same time,the mass sensitivities of both A mode and S mode of a 2μm lamb wave sensor were demonstrated *** was proved that S mode has higher sensitivity to surface mass changes and the mass sensitivity of the acoustic sensor can be improved further.

关键词： lamb wave sensor symmetric mode anti-symmetric multi-parameter

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松花粉抗氧化性的体外实验研究

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营养学报 2005年第6期27卷 487-490页

作者：鲍善芬丛涛 j Illig H Schempp E F Elstner 解放军总医院营养科微量元素研究室北京100853 德国慕尼黑技术大学植物病理研究所

目的:通过体外试验对马尾松花粉的消炎、抗氧化性能进行评价。方法:四个模拟人类疾病过程中的生化反应系统为(1)MPO/H2O2系统主要模拟炎症反应,使中性粒细胞活化产生次氯酸;(2)Xan-XOD系统:模拟缺血再灌注,主要产生过氧化氢,超氧自由基... 详细信息

目的:通过体外试验对马尾松花粉的消炎、抗氧化性能进行评价。方法:四个模拟人类疾病过程中的生化反应系统为(1)MPO/H2O2系统主要模拟炎症反应,使中性粒细胞活化产生次氯酸;(2)Xan-XOD系统:模拟缺血再灌注,主要产生过氧化氢,超氧自由基和羟自由基;(3)Fenton系统,模拟体内炎性反应,从转铁蛋白或铁蛋白中释放出铁而产生羟自由基;(4)ABTS系统,用于总抗氧化能力的评估。结果:松花粉对以上反应系统所产生的过氧化氢、超氧自由基、羟自由基和次氯酸等活性氧系具有较好的清除作用,以浓度依赖关系抑制反应的发生并发挥抗氧化作用,对涉及炎症反应的MPO酶活性有一定的抑制作用。

关键词：松花粉活性氧过氧化氢超氧阴离子羟基自由基次氯酸

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Neonatal lamb mortality:major risk factors and the potential ameliorative role of melatonin

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journal of Animal Science and Biotechnology 2021年第2期12卷 451-461页

作者： Tom Flinn David O.Kleemann Alyce M.Swinbourne jennifer M.Kelly Alice C.Weaver Simon K.Walker Kathryn L.Gatford Karen L.Kind William H.E.j.van Wettere Davies Livestock Research Centre School of Animal and Veterinary SciencesThe University of AdelaideRoseworthySAAustralia Turretfield Research Centre South Australian Research and Development InstituteRosedaleSAAustralia Robinson Research Institute Adelaide Medical SchoolThe University of AdelaideAdelaideSAAustralia

High incidences of pre-weaning mortality continue to limit global sheep production,constituting a major economic and welfare *** significant advances in genetics,nutrition,and management,the proportion of lamb deaths has remained stable at 15–20%over the past four *** is mounting evidence that melatonin can improve outcomes in compromised ovine pregnancies via enhanced uterine bloodflow and neonatal *** review provides an overview of the major risk factors and underlying mechanisms involved in perinatal lamb mortality and discusses the potential of melatonin treatment as a remedial *** pregnant ewes with melatonin enhances uterine bloodflow and fetal oxygenation,and potentially birthweight and neonatal thermogenic *** freely crosses the ovine placenta and blood-brain barrier and provides neuroprotection to the fetal lamb during periods of chronic and acute hypoxia throughout gestation,with improved behavioural outcomes in hypoxic *** current literature provides strong evidence that maternal melatonin treatment improves outcomes for lambs which experience compromised in utero development or prolonged parturition,though to date this has not been investigated in livestock production *** such there is a clear basis for continued research into the effects of maternal melatonin supplementation during gestation on pre-weaning survival under extensive production conditions.

关键词： lamb survival Melatonin Neonatal mortality Reproduction Sheep

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大豆粗蛋白对新生羔羊空肠粘膜生长发育的影响

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营养学报 2008年第3期30卷 290-293页

作者：何军 Schnhusen U. Voigt j. 沈赞明南京农业大学农业部动物生理生化重点开放实验室 Research Institut efor the Biology of Farm Animals D-181196Germany

目的研究大豆粗蛋白(soybean protein,SP)取代部分乳源蛋白对新生羔羊空肠粘膜生长发育的影响,为大豆代乳品的合理利用和开发提供依据。方法17只7日龄羔羊随机分为SP组(n=8)和CS组(n=9),人工哺乳。SP组用大豆粗蛋白取代30%乳源蛋白;CS... 详细信息

目的研究大豆粗蛋白(soybean protein,SP)取代部分乳源蛋白对新生羔羊空肠粘膜生长发育的影响,为大豆代乳品的合理利用和开发提供依据。方法17只7日龄羔羊随机分为SP组(n=8)和CS组(n=9),人工哺乳。SP组用大豆粗蛋白取代30%乳源蛋白;CS组用与大豆蛋白等氮的酪蛋白取代,作为对照。每日哺乳2次,1W适应期。饲喂4W后宰杀取空肠组织样,扫描电镜观察空肠绒毛形态;以玻片刮取空肠各段粘膜用于蛋白质、RNA/DNA含量及碱性磷酸酶(ALP)含量测定。结果SP和CS两组羔羊采食量和体增重没有差别。SP组羔羊空肠绒毛明显萎缩;前段(127.2±4.6vs143.6±7.3mg/g粘膜,P=0.07)和中段(111.2±6.3vs132.7±8.5mg/g,P=0.06)粘膜总蛋白含量有降低的趋势;前段粘膜RNA/DNA(1.40±0.10vs1.68±0.08)及蛋白质/DNA(41.3±3.2vs51.5±2.8)比率均显著低于CS组(P<0.05);各段粘膜ALP含量均显著下降(P<0.05)。结论短期以大豆蛋白取代30%的乳源蛋白饲喂新生羔羊,延缓空肠粘膜生长和发育,但未影响摄食和体增重。

关键词：大豆蛋白酪蛋白空肠粘膜碱性磷酸酶羔羊

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Maser radiation from collisionless shocks: application to astrophysical jets

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High Power Laser Science and Engineering 2019年第1期7卷 120-127页

作者： D.C.Speirs K.Ronald A.D.R.Phelps M.E.Koepke R.A.Cairns A.Rigby F.Cruz R.M.G.M.Trines R.Bamford B.j.Kellett B.Albertazzi j.E.Cross F.Fraschetti P.Graham P.M.Kozlowski Y.Kuramitsu F.Miniati T.Morita M.Oliver B.Reville Y.Sakawa S.Sarkar C.Spindloe M.Koenig L.O.Silva D.Q.lamb P.Tzeferacos S.Lebedev G.Gregori R.Bingham Department of Physics SUPA University of Strathclyde Department of Physics West Virginia University School of Mathematics and Statistics University of St.Andrews Department of Physics University of Oxford GoLP/Instituto de Plasmas e Fus?u Nuclear Instituto Superior T'ecnico Universidade de Lisboa STFC Rutherford Appleton Laboratory Laboratoire pour l’Utilisation de Lasers Intenses UMR7605 CNRS CEA Universit'e Paris VI Ecole Polytechnique Departments of Planetary Sciences and Astronomy University of Arizona AWE Aldermaston Reading West Berkshire Department of Physics National Central University Institute of Laser Engineering Osaka University School of Mathematics and Physics Queen’s University Belfast Department of Astronomy and Astrophysics University of Chicago Imperial College London

This paper describes a model of electron energization and cyclotron-maser emission applicable to astrophysical magnetized collisionless shocks. It is motivated by the work of Begelman, Ergun and Rees [Astrophys. j. 625, 51(2005)] who argued that the cyclotron-maser instability occurs in localized magnetized collisionless shocks such as those expected in blazar jets. We report on recent research carried out to investigate electron acceleration at collisionless shocks and maser radiation associated with the accelerated electrons. We describe how electrons accelerated by lower-hybrid waves at collisionless shocks generate cyclotron-maser radiation when the accelerated electrons move into regions of stronger magnetic fields. The electrons are accelerated along the magnetic field and magnetically compressed leading to the formation of an electron velocity distribution having a horseshoe shape due to conservation of the electron magnetic moment. Under certain conditions the horseshoe electron velocity distribution function is unstable to the cyclotron-maser instability [Bingham and Cairns, Phys. Plasmas 7, 3089(2000); Melrose, Rev. Mod. Plasma Phys. 1, 5(2017)].

关键词： laboratory astrophysics plasma physics particle acceleration plasma-wave instabilities

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Postpartum meloxicam administration alters plasma haptoglobin, polyunsaturated fatty acid, and oxylipid concentrations in postpartum ewes

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journal of Animal Science and Biotechnology 2020年第4期11卷 1047-1060页

作者： Katie EOlagaray Barry j.Bradford Lorraine M.Sordillo jeffery C.Gandy Laman K.Mamedova Turner H.Swartz Trey D.jackson Emma K.Persoon Caitlin S.Shugart Curtis R.Youngs Department of Animal Sciences and Industry Kansas State UniversityManhattan 66506USA College of Veterinary Medicine Michigan State University2265K Anthony HallEast LansingMI 48824-1225USA Department of Animal Science Iowa State UniversityAmesIAUSA.

Background: Postpartum inflammation is a natural and necessary response;however, a dysfunctional inflammatory response can be detrimental to animal productivity. The objective of this study was to determine the effects of a non-steroidal anti-inflammatory drug(meloxicam) on ewe postpartum inflammatory response, ewe plasma polyunsaturated fatty acid and oxylipid concentrations, and lamb ***: After lambing, 36 Hampshire and Hampshire × Suffolk ewes were sequentially assigned within type of birth to control(n = 17) or meloxicam orally administered on d 1 and 4 of lactation(MEL;90 mg, n = 19). Milk and blood samples were collected on d 1(prior to treatment) and d 4. Milk glucose-6-phosphate was not affected by MEL. Plasma haptoglobin(Hp) concentrations were less for MEL ewes;control ewes with greater d 1 Hp concentrations had elevated Hp on d 4, but this was not the case for MEL-treated ewes. Treatment with MEL increased plasma arachidonic acid concentration by more than 4-fold in ewes rearing singles but decreased concentrations of 9,10-dihydroxyoctadecenoic acid, prostaglandin F2α, 8-iso-prostaglandin E2, and 8,9-dihydroxyeicosatetraenoic acid. Nine oxylipids in plasma had interactions of treatment with d 1 Hp concentration,all of which revealed positive associations between d 1 Hp and d 4 oxylipid concentrations for CON, but neutral or negative relationships for MEL. MEL decreased 13-hydroxyoctadecadienoic acid:13-oxooctadecadienoic acid ratio and tended to increase 9-hydroxyoctadecadienoic acid:9-oxooctadecadienoic acid ratio(both dependent on d 1 values), indicating progressive metabolism of linoleic acid-derived oxylipids occurred by enzymatic oxidation after MEL treatment. Meloxicam reduced oxylipids generated across oxygenation pathways, potentially due to an improved redox ***: Postpartum MEL treatment of ewes decreased plasma concentrations of Hp and several oxylipids,with the greatest impact in ewes with biomarkers reflecting a greate

关键词： Eicosanoid Inflammation Lactation Nonsteroidal anti-inflammatory drug Sheep

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Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide

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Health Data Science 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo jordi Salas-Salvadó Miguel A.Martínez-González jan Polak Markku Laakso Arne Astrup Dominique Langin jorg Hager Gabby Hul Torben Hansen Oluf Pedersen jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram jaakko Tuomilehto jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner joan Sabaté dolores Corella j.Alfredo Martinez Lu Qi Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityChina Department of Global Health School of Public HealthPeking UniversityChina Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education China Global Health Institute Peking University China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Endocrinology&Nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain CIBER Fisiopatologia de la Obesidad y Nutrición(CIBERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain Stanford Prevention Research Center Stanford UniversityStanford CAUSA Human Nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain University of Navarra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Department for the Study of Obesity and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Department of Medicine University of Eastern FinlandKuopioFinland University of Copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut National de la Santéet de la Recherche Médicale(Inserm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance NestléInstitute of Health Sciences LausanneSwitzerland Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sorbonne Université Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).*** October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 *** RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese *** treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all *** the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting *** with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk ***,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist ***,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk *** findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.

关键词： TCF7L2 weight finding

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Review of the impact of heat stress on reproductive performance of sheep

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journal of Animal Science and Biotechnology 2021年第3期12卷 859-876页

作者： William H.E.j.van Wettere Karen L.Kind Kathryn L.Gatford Alyce M.Swinbourne Stephan T.Leu Peter T.Hayman jennifer M.Kelly Alice C.Weaver David O.Kleemann Simon K.Walker The University of Adelaide School of Animal and Veterinary SciencesDavies Livestock Research CentreRoseworthy CampusMudla Wirra RdRoseworthySouth Australia 5371Australia The University of Adelaide Robinson Research InstituteAdelaide Medical SchoolNorth TerraceAdelaideSouth Australia 5000Australia The University of Adelaide School of AgricultureFood and WineWaite Research InstituteUrrbraeSouth Australia 5064Australia South Australian Research and Development Institute Primary Industries and Regions SAGovernment of South AustraliaClimate ApplicationsWaite Research PrecinctUrrbraeSouth Australia 5064Australia South Australian Research and Development Institute Primary Industries and Regions SAReproductive BiologyLivestock SciencesTurretfield Research Centre129 Holland RdRosedaleSouth Australia 5350Australia

Heat stress significantly impairs reproduction of sheep,and under current climatic conditions is a significant risk to the efficiency of the meat and wool production,with the impact increasing as global temperatures *** from field studies and studies conducted using environmental chambers demonstrate the effects of hot temperatures(≥32℃)on components of ewe fertility(oestrus,fertilisation,embryo survival and lambing)are most destructive when experienced from 5 d before until 5 d after *** controlled studies also demonstrate that ram fertility,as measured by rates of fertilisation and embryo survival,is reduced when mating occurs during the period 14 to 50 d ***,the contribution of the ram to heat induced reductions in flock fertility is difficult to determine *** primarily on temperature controlled studies,it is clear that sustained exposure to high temperatures(≥32℃)during pregnancy reduces lamb birthweight and will,therefore,decrease lamb survival under field *** is concluded that both ewe and ram reproduction is affected by relatively modest levels of heat stress(≥32℃)and this is a concern given that a significant proportion of the global sheep population experiences heat stress of this magnitude around mating and during *** this,strategies to limit the impacts of the climate on the homeothermy,behaviour,resource use and reproduction of extensively grazed sheep are limited,and there is an urgency to improve knowledge and to develop husbandry practices to limit these impacts.

关键词： Fertility Heat stress Oogenesis Pregnancy Sheep Spermatogenesis

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