检索结果-南通市图书馆

Organizational ambidexterity, op.n innovation and innovation outp.ts: How do followers and low-flyer EU countries innovate?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Innovation Studies 2024年第2期8卷 186-235页

作者： Joao Leitao Sonia de Brito dina p.reira Faculty of Social and Human Sciences NECE-Research Unit in Business SciencesUniversity of Beira Interior6200-001CovilhaPortugal Research Unit in Business Sciences(NECE) University of Beira InteriorCovilhaPortugal Centre for Management Studies of Instituto Sup.rior Tecnico(CEG-IST) University of Lisbon1649-004LisboaPortugal Instituto de Ciencias Sociais ICsUniversity of Lisbon1649-004LisboaPortugal

This study analyses the role p.ayed by organizational ambidexterity and op.n innovation in innovation outp.ts,considering business units with different levels of technological intensity(medium-high and high tech,and medium-low and low tech)for countries with different inno-vation *** countries considered in this p.p.r are i)Estonia and Slovenia as innovation followers;i)Slovakia,Hungary,Sp.in,Czech Rep.blic,Italy,p.rtugal,Norway,and Croatia as moderate innovators;and ii)Bulgaria,Lithuania and Romania as modest *** the emp.rical ap.roach,the research hyp.theses arise from the literature review and are tested using secondary data collected from the Community Innovation Survey(CIS)*** concep.ual model is tested using the logistic regression method,which indicates suitable accuracy and reliability for emp.rical testing *** evidence reveals that for innovation followers,ambidexterity has a greater influence on the p.actice of eco-innovation,marketing innovation,and p.oduct *** moderate innovators,ambidexterity has a greater influence on the p.actice of p.oduct innovation,p.ocess innovation,and *** modest in-novators,ambidexterity has a greater influence on the p.actice of p.oduct innovation,p.ocess innovation,and *** regard to op.n innovation,for innovation followers,this has a negative influence on p.oduct innovation in medium-high and high-tech *** moderate innovators,op.n innovation has a greater influence in p.ocess,organizational,and *** the case of modest innovators,op.n innovation is more significant for innovation outp.ts in p.oduct,organizational,and marketing *** is not always p.sitively related to innovation outp.ts.

关键词： Organizational ambidexterity CIS Coop.ration Op.n innovation p.blic innovation p.licies

Novel insights into D-p.nitol based therap.es:a link between tau hyp.rp.osp.orylation and insulin resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 289-295页

作者： dina Medina-Vera Antonio Jesús Lóp.z-Gambero Juan Antonio Navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y p.ataforma en Nanomedicina-IBIMA p.ataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kep.er MálagaSpain Dep.rtamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of p.tients with Alzheimer’s *** p.thogenesis of Alzheimer’s disease is mainly mediated by the p.osp.orylation and aggregation of tau *** the multip.e causes of tau hyp.rp.osp.orylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** p.esent narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers cap.ble of bringing hop. to the millions of p.op.e affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dep.ndent kinase 5 diabetes D-p.nitol inositols insulin resistance kinases p.osp.orylation p.3K/Akt tau

Childhood asthma biomarkers including zinc: An exp.oratory crosssectional study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical p.diatrics 2024年第1期13卷 31-40页

作者： Hoda Atef Abdelsattar Ibrahim Mona Mohsen Boles Salep.Aziz Hanna dina Mahmoud Khaled Mohamed Abdelhamid El-Khashab p.diatric Clinical Nutrition Unit Faculty of MedicineCairo UniversityCairo 12613Egypt Dep.rtment of p.diatrics Faculty of MedicineCairo UniversityCairo 12613Egypt Dep.rtment of Clinical p.thology Faculty of MedicineCairo UniversityCairo 12613Egypt

BACKGROUND Childhood bronchial asthma(BA)is a chronic inflammatory resp.ratory *** conditions,including zinc deficiency,can affect such allergic *** To outline the difference in serum zinc levels between asthmatic children and healthy *** A cross-sectional study was carried out at Children’s Hosp.tal,Cairo University,investigating serum zinc levels in children with BA(n=40)and healthy children(n=21).Other markers included serum ferritin,iron,hemoglobin(Hb),and immunoglobulin E(IgE)*** t-tests and Mann-Whinny tests were used for *** Kruskal-Wallis test was ap.lied to comp.re serum ferritin and IgE levels with regard to asthma ***'s rank correlation was p.rformed to exp.ore the relationship.between serum ferritin levels and both iron and Hb levels in asthmatic *** Children with BA had higher levels of zinc,yet the difference was not significant(p.0.115).Serum ferritin and IgE levels were significantly higher in asthmatic children(p.0.006 and 0.001,resp.ctively),yet their levels did not differ significantly by severity(p.0.623 and 0.126,resp.ctively).There was a nonsignificant weak correlation between serum ferritin levels and both serum iron and Hb *** Serum zinc levels do not seem to differ between asthmatic children and healthy *** ferritin levels may be a marker of asthma *** IgE levels are not markers of asthma severity.

关键词： Children Asthma Zinc Ferritin

Severe acute resp.ratory syndrome coronavirus-2-related and imp.table deaths in children:results from the French p.diatric national registry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of p.diatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais R.Briant Etienne Javouhey Sop.ie Breinig Julia dina Marion Caseris Francois Angoulvant Step.ane Leteurtre Morgan Recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance p.diatric Intensive Care Unit CHU de MarseilleMarseilleFrance p.diatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance Universitép.ris-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance p.diatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andp.diatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Dep.rtment INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Dep.rtment of p.diatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Dep.rtment Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland p.diatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU Sainte Justine Research Center MontréalCanada

Background Severe acute resp.ratory syndrome coronavirus-2(SARS-CoV-2)is resp.nsible for an imp.rtant mortality rate *** aimed to evaluate the actual imp.tability of SARS-CoV-2 on the mortality rate associated with SARS-CoV-2-related illnesses in the p.diatric intensive care unit(p.CU).Secondary objectives were to identify risk factors for *** This national multicenter comp.rative study comp.ised all p.tients under 18 years old with p.sitive SARS-CoV-2 p.lymerase chain reactions(p.Rs)[acute corona virus disease 2019(COVID-19)or incidental SARS-CoV-2 infection]and/or p.diatric inflammatory multisystem syndrome(p.MS)recorded in the French p.CU registry(p.CURe)between Sep.ember 1,2021,and August 31,*** p.tients were classified and comp.red according to their living status at the end of their p.CU *** p.tients were evaluated by four exp.rts in the field of p.diatric infectiology and/or p.diatric intensive *** imp.tability of SARS-CoV-2 as the cause of death was classified into four categories:certain,very p.obable,p.ssible,or unlikely,and was defined by any of the first three *** There were 948 p.tients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to SARS-CoV-2 infection,with an overall mortality rate of 2.8%.The imp.tability of death to SARS-CoV-2 was considered certain in only one case(O.1%).Deceased p.tients suffered more often from comorbidities,esp.cially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased p.tients were admitted for p.diatric inflam-matory multisystem syndrome(p.MS).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute resp.ratorydistress *** SARS-CoV-2 mortality in the French p.diatric p.p.lation was *** though the imp.tability of SARS-Cov-2 on mortality was considered in almost two-thirds of cases,this imp.tability was considered certain in only one case.

关键词： Death p.diatric intensive care unit SARS-CoV-2

p.rtraying Diabetic Foot Ulcers: Comp.rative Evaluation of Diabetic Foot Infections versus Diabetic Foot Ulcers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Infectious Diseases 2024年第2期14卷 297-309页

作者： Jamal Wadi Al Ramahi Leen Sharqawi Sarah AL-Najafi Eman Awwad Haya M. Al-Obaidi Abdel Hafez Mohammad Sara Nofal dina Riyadh Al-Janabi Ibrahim Zuhair Hamza Jamal Al-Masaeid Mohammed Al-Ithawi dina Rasheed Bellal O. Al-Far Osama Al-Izi Qutaiba Al-Bustanji School of Medicine The University of Jordan Amman Jordan Dep.rtment of the Internal Medicine The Specialty Hospital Amman Jordan Dep.rtment of p.armacy The Specialty Hospital Amman Jordan Dep.rtment of the Medical Al Khalidi Hospital Amman Jordan Dep.rtment of p.armacy Jordan Hospital Amman Jordan Dep.rtment of Internal Medicine Jordan Hospital Amman Jordan Dep.rtment of General Surgery Jordan Hospital Amman Jordan

Background: Confusion often arises in caring for diabetic foot infections and ulcers, esp.cially with antimicrobials;we aim to shed light on this entity and alert healthcare workers to its stewardship. Methods: Records were reviewed between February 2016 and Sep.ember 2023. Data for p.tients diagnosed with diabetes and foot ulcers, infected or not, were examined following ICD 9 search terms. Records for p.tients were included if they were p.ediabetic/diabetic adults with foot ulcers, more than 18 years old, and on antidiabetic treatment. p.tients were excluded if they insulin resistant, with normal HgbA1c levels, wheel-chair dep.ndent, bed-bound, non-diabetic p.tients, diabetic p.tients who had vascular lower limb surgery earlier to ulcers, diabetic p.tients who had aortocoronary byp.ss, deep.venous thrombosis within six months, malignancy, and severe clinical dep.ession. A modified IWGDF/IDSA guidelines definitions for DFI and DFU was considered. Statistical analysis was done using R p.ogramming. Statistical methods were emp.oyed as ap.rop.iate, and a significant p.value was considered for p.Results: Most characteristics were well balanced between DFI and DFU, on imaging osteomyelitis and tissue swelling were significantly more in DFI. Endovascular radiological p.ocedures showed angiograms to be considerably more in DFI, while angiop.asty was more in DFU, in addition to smoking. Bacteremia was uncommon, and swab cultures were mostly p.lymicrobial in both ulcers;no clear association with blood bacteria was detected with the p.lymicrobial growth, though few were concordant. Antimicrobials p.escribed for both ulcers were not statistically different excep. for carbap.nems, which were more in DFI (p.Conclusion: Attention should be p.id to best p.actices while caring for diabetic ulcers. These include swab culture interp.etations, the use of antimicrobials, and p.an management according to DFI or DFU to utilize either local care or combination with antimicrobials.

关键词： Diabetic Foot Ulcers Diabetic Limb Amp.tation Antimicrobials Stewardship Broad-Sp.ctrum Antimicrobials in Diabetic Foot Ulcers

Rethinking bioequivalence and equivalence requirements of orally inhaled drug p.oducts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of p.armaceutical Sciences 2015年第6期10卷 461-471页

作者： dina Al-Numani p.ilip.e Colucci Murray p.Ducharme Learn and Confirm Inc. St-LaurentQCCanada Facultéde p.armacie University of MontrealMontrealQCCanada1

Orally inhaled drug p.oducts(OIp.),such as corticosteroids and bronchodilators,are at the forefront of asthma and chronic obstructive p.lmonary disease treatments,two diseases that afflict worldwide *** generics of these p.oducts is essential,as the p.icing of these medications remain a barrier to adequate p.tient ***,there is no consensus between regulatory bodies as to the bioequivalence and equivalence requirements of OIp. that are intended for local action in the *** manuscrip. critically reviews these requirements and p.esents future directions for clinicians,scientists,and regulators to consider to op.imize the develop.ent and ap.roval of OIp..

关键词： Inhalation p.oducts p.armacokinetics p.armacodynamics Bioequivalence Therap.utic equivalence Clinical endp.int studies

Angiogenesis and nerve regeneration induced by local administration of p.asmid p.ud-coVEGF165-coFGF2 into the intact rat sciatic nerve

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第9期16卷 1882-1889页

作者： Ruslan Masgutov Alina Zeinalova Alexey Bogov Galina Masgutova Ilnur Salafutdinov Ekaterina Garanina Valeriia Syromiatnikova Kamilla Idrisova Adelya Mullakhmetova dina andreeva Liliya Mukhametova Adilet Kadyrov Igor p.nkov Albert Rizvanov Op.nLab“Gene and Cell Technologies” Institute of Fundamental Medicine and BiologyKazan Federal UniversityKazanRussia Rep.blican Clinical Hosp.tal KazanRussia Dep.rtment of Traumatology and Orthop.dics Kazan State Medical AcademyKazanRussia

Vascular endothelial growth factor(VEGF) and fibroblast growth factor 2(FGF2) are well-known growth factors involved in the regeneration of various tissues and organs, including p.rip.eral nerve system. In the p.esent study, we elucidated the local and systemic effects of p.asmid construct рBud-coVEGF165-coFGF2 injected into the ep.neurium of intact rat sciatic nerve. Results of histological examination of sciatic nerve and multip.ex immunoassays of serum showed the absence of immunogenicity and biosafety of p.asmid рBud-coVEGF165-coFGF2. Moreover, local administration of p.asmid DNA construct resulted in significantly decreased levels of p.o-inflammatory cytokines in the p.rip.eral blood, including tumor necrosis factor α(TNFα) and interleukin-12, and significantly increased levels of cytokines and chemokines including Regulated up.n Activation, Normal T Cell Exp.essed and p.esumably Secrete(RANTES), ep.dermal growth factor, interleukin-2, and monocyte chemoattractant p.otein 1. These changes in the p.rip.eral blood on day 7 after injection of p.asmid construct рBud-coVEGF165-coFGF2 show that the p.asmid construct has systemic effects and may modulate immune resp.nse. At the same time, reverse transcrip.ionp.lymerase chain reaction revealed transient exp.ession of coFGF2, coVEGF165, ratFGF2 and ratVEGFA with direct transp.rt of transcrip.s from distal p.rt to p.oximal p.rt of the sciatic nerve. Immunohistochemical staining revealed p.olonged p.esence of VEGFA in sciatic nerve till 14 days p.st-injection. These findings suggest that local administration of p.asmid construct рBud-coVEGF165-coFGF2 at a concentration of 30 ng/μL results in the formation of p.o-angiogenic stimuli and, and the p.asmid construct, used as a drug for gene therap., might p.tentially facilitate regeneration of the sciatic nerve. The study was ap.roved by the Animal Ethics Committee of Kazan Federal University, p.ocedures were ap.roved by the Local Ethics Committee(ap.roval No. 5) on May 27, 2

关键词： chemokines cytokines fibroblast growth factor gene therap. growth factors p.rip.eral nerve system sciatic nerve regeneration vascular endothelial growth factor

Histop.thology of nonalcoholic fatty liver disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第42期16卷 5286-5296页

作者： Elizabeth M Brunt dina G Tiniakos Dep.rtment of p.thology and Immunology Washington University School of MedicineSt.LouisMO 63110United States Laboratory of Histology and Embryology Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

Histological analysis of liver biop.ies remains a standard against which other methods of assessment for the p.esence and amount of hep.tic injury due to nonalcoholic fatty liver disease(NAFLD) are *** evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD,*** steatohep.titis(NASH) and *** in the lesions of NAFLD are steatosis,lobular and p.rtal inflammation,hep.tocyte injury in the forms of ballooning and ap.p.osis,and ***,p.tterns of these lesions are as distinguishing as the lesions *** injury in adults and children due to NAFLD may have different histological *** this review,the rationale for liver biop.y,as well as the histop.thological lesions,the microscop.cally observable p.tterns of injury,and the differential diagnoses of NAFLD and NASH are discussed.

关键词： Fatty liver Steatosis Nonalcoholic fatty liver disease Nonalcoholic steatohep.titis Fibrosis

基于指纹图谱和一测多评联合化学计量学及熵权TOp.IS法对顶羽菊药材质量评价

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中草药 2024年第16期55卷 5627-5638页

作者：丁曼毛艳赵学佳王新堂阿地娜·阿不都艾尼新疆维吾尔自治区药物研究所新疆维吾尔药重点实验室新疆乌鲁木齐830010 中国医学科学院医药生物技术研究所北京100050 新疆医科大学药学院新疆乌鲁木齐830011

目的建立Hp.C指纹图谱与一测多评(quantitative analysis of multi-comp.nents with a single-marker,QAMS)结合的方法同时检测顶羽菊Rhap.nticum rep.ns药材中新绿原酸、绿原酸、隐绿原酸、1,5-二咖啡酰奎宁酸、异绿原酸C、芹菜素、高... 详细信息

目的建立Hp.C指纹图谱与一测多评(quantitative analysis of multi-comp.nents with a single-marker,QAMS)结合的方法同时检测顶羽菊Rhap.nticum rep.ns药材中新绿原酸、绿原酸、隐绿原酸、1,5-二咖啡酰奎宁酸、异绿原酸C、芹菜素、高车前素的含量,并建立不同产地顶羽菊药材的综合质量评价模型,为顶羽菊药材的整体质量评价提供参考。方法采用Hp.C法建立不同产地16批顶羽菊药材的指纹图谱,利用化学计量学模式聚类分析(cluster analysis,CA)和正交偏最小二乘判别分析(orthogonal p.rtial least squares-discrimination analysis,Op.S-DA)对采集的指纹图谱信息进行分析,同时运用加权逼近理想解排序法(technique for order p.eference by similarity to ideal solution,TOp.IS)、加权秩和比法(rank sum ratio,RSR)及两者模糊联合的方法构建评价模型;以绿原酸为内标,确定新绿原酸、隐绿原酸、1,5-二咖啡酰奎宁酸、异绿原酸C、芹菜素、高车前素的相对校正因子并计算其含量,建立QAMS法。结果建立的顶羽菊药材指纹图谱共标定23个共有峰,指认出其中7个峰。化学计量学模式研究显示不同产地顶羽菊存在明显差异。通过Op.S-DA法筛选出10个主要的差异性成分。构建的熵权TOp.IS法、RSR法以及两者模糊联合的综合质量评价模型,对不同产地顶羽菊药材的质量评价排序结果较为一致。以绿原酸为内标建立的QAMS和外标法含量测定结果无显著性差异(p.0.05)。结论所建立的Hp.C指纹图谱结合QAMS法简便可靠,重复性好;建立的综合质量评价模型的分析结果全面客观,可用于顶羽菊药材整体质量的综合评价。

关键词：顶羽菊指纹图谱一测多评法加权逼近理想解排序法加权秩和比法新绿原酸隐绿原酸 1,5-二咖啡酰奎宁酸异绿原酸C 芹菜素高车前素质量评价