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Rectal carcmosarcoma: A case report and review of literature

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World Journal of Gastroenterology 2006年第9期12卷 1481-1484页

作者： dimitrios Konstantinos Tsekouras Stylianos Katsaragakis dimitrios Theodorou Georgia Kafiri Fotis Archontovasilis Panagiotis Giannopoulos Panagiotis Drimousis John Bramis University De partment of General Surgery Athens School of Medicine Ippokration HospitalAthensGreece Department of Pathology Ippokration Hospital AthensGreece

A 60-years old male was admitted to our department for investigation of constipation and hypogastric discomfort intensified during defecation of a few weeks duration. The cause proved to be a rectal carcinosarcoma that was treated by abdominoperineal resection and postoperative chemo-radiotherapy. The patient died 6 months later due to hepatic failure, showing evidence of disseminated disease. In general colonic carcinosarcomas constitute a rare category of malignant neoplasms whose nature is still incompletely understood. No specific treatment guidelines exist. Surgery is the mainstay of treatment and regardless of the addition of adjuvant therapy the prognosis is very poor. Systematic genetic analysis may be the clue for understanding the pathogenesis of these mysterious tumors.

关键词： Carcinosarcoma Rectum

A methodology for the performance evaluation of low-cost accelerometer and magnetometer sensors in geomatics applications

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Geo-Spatial Information Science 2018年第2期21卷 139-148页

作者： Photis Patonis Petros Patias Ilias N.Tziavos dimitrios Rossikopoulos Engineering School of Rural and Surveying Engineering Aristotle University of ThessalonikiThessalonikiGreece

This paper presents a methodology and its software implementation for the performance evaluation of low-cost accelerometer and magnetometer sensors for use in geomatics applications.A known mathematical calibration model has been *** method was completed with statistical methodologies for adjusting observations and has been extended to calculate accuracies for the attitude,heading,and tilt angles estimation that are of interest to geomatics *** evaluation method consists of two ***,the evaluation method reviews the total magnitude of acceleration or the strength of the magnetic ***,the evaluation is more detailed and concerns the determination of mathematical parameters that describe both accelerometer and magnetometer working model.A software tool that implements the evaluation model has been developed and is applied both in accelerometer and magnetometer measurement data-sets acquired from a low-cost sensor system.

关键词： Low-cost sensors evaluation methodology accelerometers magnetometers attitude heading

S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine's chemistry, physiology and pharmacokinetics

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World Journal of Gastroenterology 2017年第40期23卷 7343-7346页

作者： dimitrios Tsikas Erik Hanff Alexander Bollenbach Core Unit Proteomics Hannover Medical School

S-Adenosyl-L-methionine(SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells at millimolar concentrations. The efficacy of SAM at micromolar concentrations and the underlying mechanisms remain to be demonstrated.

关键词： S-Adenosyl-L-methionine Bioavailability Concentration Liver

Atrial fibrillation in patients with systolic heart failure:pathophysiology mechanisms and management

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Journal of Geriatric Cardiology 2021年第5期18卷 376-397页

作者： Ioanna Koniari Eleni Artopoulou dimitrios Velissaris Nicholas Kounis Grigorios Tsigkas Manchester Heart Institute Manchester University Foundation TrustManchesterUnited Kingdom Department of Internal Medicine University Hospital of PatrasPatrasGreece Department of Cardiology University Hospital of PatrasPatrasGreece

Heart failure(HF)and atrial fibrillation(AF)demonstrate a constantly increasing prevalence during the 21st century worldwide,as a result of the aging population and the successful interventions of the clinical practice in the deterioration of adverse cardiovascular *** and AF share common risk factors and pathophysiological mechanisms,creating the base of a constant *** impairs systolic and diastolic function,resulting in the increasing incidence of HF,whereas the structural and neurohormonal changes in HF with preserved or reduced ejection fraction increase the possibility of the AF *** temporal relationship of the development of either condition affects the diagnostic algorithms,the prognosis and the ideal therapeutic strategy that leads to euvolaemia,management of noncardiovascular comorbidities,control of heart rate or restoration of sinus rate,ventricular synchronization,prevention of sudden death,stroke,embolism,or major bleeding and maintenance of a sustainable quality of *** indicated treatment for the concomitant HF and AF includes rate or/and rhythm control as well as thromboembolism prophylaxis,while the progress in the understanding of their pathophysiological interdependence and the introduction of the genetic profiling,create new paths in the diagnosis,the prognosis and the prevention of these diseases.

关键词： prevention diagnosis management

Reasons of PEG failure to eliminate gastroesophageal reflux in mechanically ventilated patients

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World Journal of Gastroenterology 2009年第43期15卷 5455-5460页

作者： Emmanuel E Douzinas Ilias Andrianakis Olga Livaditi dimitrios Bakos Katerina Flevari Nikos Goutas dimitrios Vlachodimitropoulos Marios-Konstantinos Tasoulis Alex P Betrosian 3rd Department of Critical Care Evgenidion HospitalUniversity of Athens Medical School Athens 115 28Greece The Laboratory of Pathology Evgenidion HospitalUniversity of Athens Medical SchoolAthens 115 28Greece

AIM： To investigate factors predicting failure of percutaneous endoscopic gastrostomy （PEG） to eliminate gastroesophageal reflux （GER）. METHODS： Twenty-nine consecutive mechanically ventilated patients were investigated. Patients were evaluated for GER by pH-metry pre-PEG and on the 7th post-PEG day. Endoscopic and histologic evidence of reflux esophagitis was also carried out. A beneficial response to PEG was considered when pH-metry on the 7th post-PEG day showed that GER was below 4%. RESULTS： Seventeen patients responded （RESP group） and 12 did not respond （N-RESP） to PEG. The mean age, sex, weight and APACHE II score were similar in both groups. GER （%） values were similar in both groups at baseline, but were significantly reduced in the RESP group compared with the N-RESP group on the 7th post-PEG day [2.5 （0.6-3.8） vs 8.1 （7.4-9.2, P 〈 0.001）]. Reflux esophagitis and the gastroesophageal flap valve （GEFV） grading differed significantly between the two groups （P = 0.031 and P = 0.020, respectively）. Histology revealed no significant differences between the two ***： Endoscopic grading of GEFV and the presence of severe reflux esophagitis are predisposing factors for failure of PEG to reduce GER in mechanically ventilated patients.

关键词： Esophagitis Gastroesophageal reflux Percutaneous endoscopic gastrostomy

How can ecosystem engineer plants boost productivity in east Mediterranean drylands

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Ecological Processes 2023年第1期12卷 425-437页

作者： Elena Constantinou dimitrios Sarris Magda Psichoudaki Javier Cabello Ioannis N.Vogiatzakis Faculty of Pure&Applied Sciences Open University of Cyprus2252 NicosiaCyprus KES Research Centre 1055 NicosiaCyprus KES College 1055 NicosiaCyprus Nireas-International Water Research Center University of CyprusP.O.Box 205371678 NicosiaCyprus Andalusian Center for the Assessment and Monitoring of Global Change University of Almería04120 AlmeríaSpain Department of Biology and Geology University of Almería04120 AlmeríaSpain.

Background Water availability is the key limiting factor for plant productivity in drylands covering ca.40%of Earth’s land *** such ecosystems to retain productivity and biodiversity under climatic change,it would be valu-able to identify/promote keystone plant species that(i)have developed strategies to more efficiently utilize moisture resources not easily accessible and(ii)improve moisture conditions for neighboring *** very deep-rooted Ziziphus lotus,considered an ecosystem engineer,is one such ***,it is not known which biotic traits:(a)canopy interception of moisture/rainfall,(b)hydraulic redistribution of deep ground moisture by roots,or non-biotic factors:(c)soil’s volume,and(d)organic matter content,*** activates/modulates to play such a ***,thus,selected dryland ecosystems where the plant dominates and measured for potential effects on the less deep-rooted Thymbra *** assessing impacts on ecosystem productivity,we measured the spatial aggregation of ca.3600 *** *** a proxy for soil moisture availability and its spatial variability,we conducted a 7-year-long study using thymes’nighttime *** extended up to 15 m away from *** The density of *** plants growing up to 5 m around *** *** growing 10-15 m away was found significantly increased(2.5-4.5 times),while their stem/leaf moisture was ca.10%higher at predawn compared to nightfall during the dry *** suggests that ecosystem productivity is driven by a greater soil moisture avail-ability around *** permitting more thyme daytime transpiration,in contrast to thymes growing further *** phenomenon appeared only under dry topsoil(during the dry season;becoming stronger during dry years).Morning dew/rainfall interception from the canopy or soil depth/organic matter did not show significant effects,leaving only the hydraulic lift properties of *** as the most likely driver for soil moisture avail

关键词： Plant–plant interaction Desertification Mediterranean Dryland Moisture content Deep root Ziziphus lotus Stress-gradient

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Polydactyly:Clinical and molecular manifestations

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World Journal of Orthopedics 2023年第1期14卷 13-22页

作者： Zisis Kyriazis Panagoula Kollia Ioanna Grivea Nikolaos stefanou Sotirios Sotiriou Zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece Department of Genetics and Biotechnology Faculty of BiologyUniversity of AthensAthens 15701Greece Department of Paediatrics Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece Laboratory of Histology and Embryology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece

Polydactyly is a malformation during the development of the human limb,which is characterized by the presence of more than the normal number of fingers or *** is considered to be one of the most common inherited hand *** can be divided into two major groups:Non-syndromic polydactyly or syndromic *** to the anatomical location of the duplicated digits,polydactyly can be generally subdivided into pre-,post-axial,and mesoaxial ***-syndromic polydactyly is often inherited with an autosomal dominant trait and defects during the procedure of anterior-posterior patterning of limb development are incriminated for the final phenotype of the *** are several forms of polydactyly,including hand and foot extra digit *** deformity affects upper limbs with a higher frequency than the lower,and the left foot is more often involved than the *** treatment is always *** the clinical presentation is highly diverse,the treatment combines single or multiple surgical operations,depending on the type of *** research attention that congenital limb deformities have recently attracted has resulted in broadening the list of isolated gene mutations associated with the *** generation sequencing technologies have contributed to the correlation of phenotype and genetic profile of the multiple polydactyly manifestations and have helped in early diagnosis and screening of most nonsyndromic and syndromic disorders.

关键词： Polydactyly Gene Syndromic Non-syndromic Preaxial Postaxial

Trends of nanotechnology in type 2 diabetes mellitus treatment

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 62-76页

作者： Yannis V.Simos Konstantinos Spyrou Michaela Patila Niki Karouta Haralambos Stamatis dimitrios Gournis Evangelia Dounousi dimitrios Peschos Department of Physiology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110Greece Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Biotechnology Laboratory Department of Biological Applications and TechnologiesUniversity of IoanninaIoannina 45110Greece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110Greece Nanomedicine and Nanobiotechnology Research Group University of IoanninaIoannina 45110Greece

There are several therapeutic approaches in type 2 diabetes mellitus(T2DM).When diet and exercise fail to control hyperglycemia,patients are forced to start therapy with antidiabetic ***,these drugs present several drawbacks that can affect the course of *** major disadvantages of current oral modalities for the treatment of T2DM are mainly depicted in the low bioavailability and the immediate release of the drug,generating the need for an increase in frequency of *** conjugation with the manifestation of adverse side effects,patient compliance to therapy is *** the past few years nanotechnology has found fertile ground in the development of novel delivery modalities that can potentially enhance anti-diabetic regimes *** efforts have been targeted towards two main vital steps:(a)to protect the drug by encapsulating it into a nano-carrier system and(b)efficiently release the drug in a gradual as well as controllable ***,only a limited number of studies published in the literature used in vivo techniques in order to support *** we discuss the current disadvantages of modern T2DMmarketed drugs,and the nanotechnology advances supported by in vivo in mouse/rat models of glucose *** generation of drug nanocarriers may increase bioavailability,prolong release and therefore reduce dosing and thus,improve patient *** novel approach might substantially improve quality of life for *** ofmetal nanoformulations as indirect hypoglycemic agents is also discussed.

关键词： Type 2 diabetes mellitus Nanotechnology Hyperglycemia Controlled release In vivo

Concept of histone deacetylases in cancer:Reflections on esophageal carcinogenesis and treatment

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World Journal of Gastroenterology 2018年第41期24卷 4635-4642页

作者： dimitrios Schizas Aikaterini Mastoraki Leon Naar Eleftherios Spartalis Diamantis I Tsilimigras Georgia-Sofia Karachaliou George Bagias dimitrios Moris 1^st Department of Surgery Laikon General HospitalNational and Kapodistrian University of AthensAthens 11527Greece 4^th Department of Surgery Attikon University HospitalNational and Kapodistrian University of AthensAthens 12462Greece Laboratory of Experimental Surgery and Surgical Research National and Kapodistrian University of AthensAthens 11527Greece Department of General Visceral and Transplant SurgeryUniversity Hospital EssenEssen 45141Germany Department of Surgery Duke University Medical CenterDurhamNC 27710United States

Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type world-wide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and altering expression of genes important in the cell cycle, differentiation and apoptosis. Based on this knowledge, histone acetylation was addressed as a potential novel chemotherapy drug target to repress cancer cell proliferation. There are four classes of histone deacetylases (HDACs) inhibitors with a variety of different mechanisms of actions that render them possible anticancer drugs. They arrest the cell cycle, inhibit differentiation and angiogenesis and induce apoptosis. They do not necessarily act on histone proteins, since they can also exert indirect anti-cancer effects, by modifying various cellular *** addition,HDACs have also been associated with increased chemotherapy *** on the literature,HDACs have been associated with EC,with surveys revealing that increased expression of certain HDACs correlates with advanced TNM stages,tumor grade,metastatic potential and decreased 5-year overall and disease-free *** aim of this survey is to elucidate the molecular identity and mechanism of action of HDAC inhibitors as well as verify their potential utility as anti-cancer agents in esophageal cancer.

关键词： Esophageal cancer Histone deacatylases Inhibitors Drugs