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Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits

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Bioactive Materials 2021年第11期6卷 4176-4185页

作者： dick.Ho Kiu Chow j.ali Wang Peng Wan Lizhen Zheng Michael Tim Yun Ong Le Huang Wenxue Tong Lili Tan Ke Yang Ling Qin Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongHong Kong SARChina Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongShatinHong Kong SARChina Institute of Metal Research Chinese Academy of SciencesShenyangChina School of Materials Science and Engineering Dongguan University of TechnologyDongguanChina

Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular *** fixation with biodegradable magnesium(Mg)pins enhanced fracture *** hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically,mechanically,and *** patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White *** fracture was fixed with a pin made of stainless steel or pure Mg,and a figure-of-eight stainless steel band *** were harvested at week 8 or 12,and assessed with microCT,tensile testing,microindentation,and *** analysis showed that Mg group showed 12%higher in the ratio of bone volume to tissue volume at week 8,and 38.4%higher of bone volume at week *** testing showed that the failure load and stiffness of Mg group were 66.9%and 104%higher than the control group at week 8,*** week 12,Mg group was 60.8%higher in ultimate strength than the control *** showed that,compared to the Control group,Mg group showed 49.9%higher Vickers hardness and 31%higher elastic modulus at week 8 and 12,*** week 12,the new bone of Mg group remodelled to laminar bone,but those of the control group remained woven *** of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group.

关键词： Patellar fracture Tension band wire Biodegradable implant Osteogenesis Microindentation

Role of SOX2 in foregut development in relation to congenital abnormalities

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World j.urnal of Medical Genetics 2014年第4期4卷 94-104页

作者： Kim Schilders j.shua K Ochieng Cornelis P van de Ven Cristina Gontan dick.Tibboel Robbert j.Rottier Departments of Pediatric Surgery of The Erasmus MC-Sophia Children’s Hospital 3000 CA RotterdamThe Netherlands The Department of Reproduction and Development of the Erasmus MC 3015 CN RotterdamThe Netherlands Cell Biology of the Erasmus MC 3000 CA RotterdamThe Netherlands

The uptake of the two essential ingredients for life, oxygen and nutrients, occurs primarily through the oral cavity, but these two lifelines need to be separated with high accuracy once inside the body. The two systems, the gas exchange pulmonary system and the gastro-intestinal feeding system, are derived from the same primitive embryonic structure during development, the foregut, which need to be separated before birth. In certain newborns, this separation occurs not or insufficiently, leading to life threatening conditions, sometimes incompatible with life. The development of the foregut, trachea and lungs is influenced and coordinated by a multitude of signaling cascades and transcription factors. In this review, we will highlight the development of the foregut and pulmonary system and focus on associated congenital abnormalities in light of known genetic alterations with specific attention to the transcription factor SOX2.

关键词： SOX2 Congenital foregut abnormalities Lung development

Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

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j.urnal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad Norevik Aleksi M.Huuha Ragnhild N.RФsbj.rgen Linda Hildegard Bergersen Kamilla j.cobsen Rodrigo Miguel-dos-Santos Liv Ryan Belma Skender j.se Bianco N.Moreira Asgeir Kobro-Flatmoen Menno P.witter Nathan Scrimgeour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and Clinical Neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of Molecular Inflammation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems Neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.j.bsen Centre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:Mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(McGill-R-Thyl-APP)were inj.ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(p<0.001)in amyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did increase hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytokines High-intensity interval training Inflammation Neurons Plasma transfusion

From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

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Chinese Chemical Letters 2023年第3期34卷 361-366页

作者： Shuj.ng Xu Lin Sun Waleed A.Zalloum Xuj.e Zhang Tianguang Huang Dang Ding Yucen Tao Fabao Zhao Shenghua Gao Dongwei Kang Erik De Clercq Christophe Pannecouque Alexej.dick.Simon Cocklin Xinyong Liu Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJi’nan 250012China Department of Pharmacy Faculty of Health ScienceAmerican University of MadabAmman 11821Jordan Rega Institute for Medical Research Laboratory of Virology and ChemotherapyK.U.LeuvenLeuven B 3000Belgium Department of Biochemistry&Molecular Biology Drexel University College of MedicinePhiladelphiPA 19102United States

HIV-1 capsid protein(CA) has emerged as a promising target for antiviral treatment considering its structural and regulatory roles in HIV-1 replication. Here, we disclose the design, synthesis, biological assessment, and mechanism investigation of a novel series of phenylalanine derivatives gained by further structural modification of PF74. The newly synthesized compounds demonstrated potent anti-HIV activity, represented by 7n displayed anti-HIV-1 activity 6.25-fold better than PF74, and 7h showed anti-HIV-2activity with nearly 139 times improved efficacy over PF74. Surface plasmon resonance(SPR) studies of representative compounds proved that HIV-1 CA was the binding target. Competitive SPR studies using CPSF6 and NUP153 peptides identified that 7n binds to a vital CA assembly interface between the Nterminal and C-terminal domain(NTD-CTD interface). Action stage determination assay revealed that the newly synthesized compounds were antiviral with a dual-stage inhibitory profile. Molecular dynamics(MD) simulations offered the crucial foundation for the hopeful antiviral potency of 7n. Besides, 7m and7n modestly increased metabolic stabilities in human liver microsome(HLM) and human plasma compared to PF74. Overall, these studies offer valuable insights and can regard as the beginning for succedent medicinal chemistry endeavors to discover promising HIV capsid inhibitors with improved efficacy and better drug-like characteristics.

关键词： HIV-1 Capsid inhibitor Assembly NTD-CTD interface Drug design

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既能精确定位又能减振的联轴器

机械制造 2000年第3期38卷 56-57页

作者： j.hn G.dick.j.hannes Deister 凌杰 KTR Corp.USA KTR Kupplungstechnik GmbH Germany 开天贸易(上海)有限公司 200126

机床的精确定位要求传动必须有扭向的刚度，亦意味着必须采用刚性联轴器，但绝大多数的刚性联轴器又往往不能减振。本文介绍一种既有刚性又能减振的联轴器。

关键词：联轴器定位减振直线传动爪形联轴器

A historical re-analysis of the calamitous midget typhoon passing through Hong Kong region on 18 September 1906 and its storm surge impact to Hong Kong region

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Tropical Cyclone Research and Review 2022年第3期11卷 174-218页

作者： Hing Yim Mok Chi Ming Shun Stephen Davies Wing Hong Lui dick.Shum Lau Kai Chun Cheung Kwan Yin Kong Sai Tick Chan Hong Kong Observatory Hong KongChina Hong Kong Maritime Museum Hong KongChina US National Oceanic and Atmospheric Administration USA

A typhoon passed through Hong Kong region suddenly and unexpectedly on 18 September 1906(the“Typhoon 1906”)and had a disastrous impact on Victoria Harbour and its surroundings in j.st a couple of *** the year 1906 was the“Bingwu”year in the Chinese calendar,the typhoon is also known historically as the“Bingwu Typhoon”.Tremendous loss of lives and property resulted,and the shipping and fishing communities were *** mysteries arising from this calamitous typhoon have existed to date:1)Why the Hong Kong region Observatory was not able to provide any forewarning?2)whether the storm surge reported in some contemporary records is entirely credible?This paper will focus on both of *** this paper,we re-analyse historical weather observations recorded in various historical documents and estimate the possible storm size,intensity and track of Typhoon 1906 using tropical cyclone *** on the re-analyses,the storm surges,storm tides and wave heights in Hong Kong region are also estimated using storm surge and wave *** results reveal that Typhoon 1906 was a midget typhoon,with a radius of maximum winds of 11 km or smaller,during its passage through Hong Kong *** explains why it was technically impossible for a forewarning to be given at that time when real-time weather observations from ships,meteorological satellites and radars were *** also estimate that the maximum storm surges(storm tides)in Hong Kong region were not higher than 0.82 m(2.43 mCD)and 1.98 m(4.15 mCD)in Victoria Harbour and Tolo Harbour *** figures are found to be limited by the intensity and the storm size of the ***,we conclude that the previously documented storm surge figures are not supported by the present study.

关键词： Bingwu typhoon Midget typhoon Storm surge Historical re-analysis Hong Kong region

SF-36用于肺结核的信度、效度及敏感性评价

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中国公共卫生 2004年第5期20卷 537-539页

作者：段琼红 dick.Chamla 聂绍发胡家廉华中科技大学同济医学院武汉430030 武汉市江岸区结防所

目的　评价中文版SF - 36量表用于肺结核 (PTB)病人的生命质量测量的信度、效度、敏感性。方法　用自行研制的中文版SF - 36量表对肺结核病人及对照进行测量。采用Cronchbach’sα评价量表的信度 ,因子分析评价量表的效度 ,用配对t检验... 详细信息

目的　评价中文版SF - 36量表用于肺结核 (PTB)病人的生命质量测量的信度、效度、敏感性。方法　用自行研制的中文版SF - 36量表对肺结核病人及对照进行测量。采用Cronchbach’sα评价量表的信度 ,因子分析评价量表的效度 ,用配对t检验比较患者组和对照组的评分来评价量表的敏感性。结果　对于病人组和对照组 ,SF - 36量表效度 (因子分析聚合为 2个公因子 )、信度 (Cronchbach’sα >0 7)较好。肺结核病人各项得分均低于对照组 ,说明量表的敏感性较高。结论　中文版SF - 36量表是测量肺结核病人的生命质量的有效量表 ,但量表中个别词句的翻译仍须改动 ,并且有必要进行更大样本的调查 ,建立中国人的生命质量正常值标准。

关键词：肺结核生命质量 SF-36 信度效度敏感性

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肺结核病人健康教育效果调查分析

中国防痨杂志 2003年第6期25卷 394-396页

作者：段琼红胡家廉 dick.Chamla 聂绍发华中科技大学同济医院武汉430030 武汉市江岸区结防所武汉430030

目的　了解肺结核病人的结核病相关知识和态度的现况及其影响因素 ,改进健康教育的方式。方法　对武汉市江岸区 2 0 0 1年 1 1月至 2 0 0 2年 4月登记的 1 0 2例肺结核病人进行结核病相关知识和态度的调查 ,对性别、年龄、职业、文化水... 详细信息

目的　了解肺结核病人的结核病相关知识和态度的现况及其影响因素 ,改进健康教育的方式。方法　对武汉市江岸区 2 0 0 1年 1 1月至 2 0 0 2年 4月登记的 1 0 2例肺结核病人进行结核病相关知识和态度的调查 ,对性别、年龄、职业、文化水平、居住地等因素与得分关系进行单因素分析。结果　教育前的得分为 3.79± 1 .67,教育后的得分为 5.97± 1 .56 ,两者的差别有极显著性意义(P <0 .0 0 1 ) ,但教育以后病人对肺结核的确诊方式、可疑症状、卡介苗的作用等问题的回答正确率仍然不高。文化水平是影响病人得分的因素。结论　本次健康教育是有效的 ,为了进一步提高健康教育的效果 ,应增加教育次数 ,改进教育方法 ,低文化水平的病人是健康教育的重点。

关键词：肺结核健康教育知识态度流行病学

马立克氏病的新挑战:新的致病型、神经症候和疫苗

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国外畜牧科技 2001年第1期28卷 48-51页

作者： R.L.witter 崔治中美国农业部禽病和肿瘤研究所东兰辛密西根48864

1病毒的致病型1型MDV表现出不同的致病型(pathotypes).一些病毒分离株仅引起轻微的MD症状,而另一些毒株,特别是最近分离的野毒株甚至可在免疫过的鸡群或有遗传抵抗力的鸡群引发非常严重的疾病.根据在免疫鸡和非免疫鸡的致病性试验,将病... 详细信息

1病毒的致病型1型MDV表现出不同的致病型(pathotypes).一些病毒分离株仅引起轻微的MD症状,而另一些毒株,特别是最近分离的野毒株甚至可在免疫过的鸡群或有遗传抵抗力的鸡群引发非常严重的疾病.根据在免疫鸡和非免疫鸡的致病性试验,将病毒划分为若干个致病型.现已确定了特定的标准,以此根据试验毒株和原型参考毒株间引起的发病率上的统计差异的比较,来鉴别任一分离毒株的致病型.

关键词：鸡马立克氏病病毒致病型神经症候疫苗