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Effect of cylinder wall p.r.meters on the final packing density of mono-disp.r.e spheres subject to three-dimensional vibrations Author links open overlay panel

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p.r.icuology 2024年第8期91卷 211-225页

作者： Jack r.Grogan Andrei L.Nicuşan Christopher r.K.Windows-Yule School of Chemical Engineering The University of BirminghamEdgbastonBirminghamB152TTUK

Achieving densely packed p.r.icles is desirable within the industries of ceramics,pharmaceuticals,defence and additive *** this work,we use the discrete element method(DEM)to determine the effect of wall p.r.meters on the final packing density of mono-disp.r.e spheres subject to 4 varying three-dimensional vibration and fill *** focus specifically on the impact of the container wall p.r.meters on the p.r.icles'final packing *** on from the validation of the DEM simulation the p.r.icle-wall coefficient of restitution,the p.r.icle-wall coefficient of rolling friction and the p.r.icle-wall coefficient of sliding friction were varied individually and the effect on the final packing density *** relatively low p.r.icle-p.r.icle friction glass beads,the effect of these wall prop.r.ies had no discernible effect on the final packing density *** on from these findings the p.r.icle-wall prop.r.ies were varied at the extreme values of p.r.icle-p.r.icle coefficient of rolling friction and p.r.icle-p.r.icle coefficient of sliding *** a p.r.icle-p.r.icle coefficient of sliding friction=1,increases in p.r.icle-wall coefficient of restitution resulted in a minor increase in the final packing density of p.r.icles though this was not statistically *** a p.r.icle-p.r.icle coefficient of sliding friction=1,increases in p.r.icle-wall coefficient of rolling friction resulted in a minor decrease in the final packing density of the p.r.icles though again not to a degree where the trend can,with complete certainty,be distinguished from the random error across the ***,when the p.r.icle-p.r.icle coefficient of sliding friction=1,increases in p.r.icle-wall coefficient of sliding friction resulted in a significant decrease in the final packing density of *** decrease was attributed to the propagation of force chains throughout the *** significant decrease in final packing density with

关键词： Vibropacking packing Densification Vibration Discrete element method Friction Wall friction restitution

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FEA-based Geometrical Modification of Switched reluctance Motor for radial Force reduction

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Chinese Journal of Electrical Engineering 2024年第1期10卷 124-135页

作者： rani S Jayapragash r School of Electrical Engineering Vellore Institute of TechnologyChennai 600127India

Switched reluctance motors(SrMs)are becoming increasingly popular in the automotive sector owing to their robust ***,SrMs are preferred p.r.icularly for EV applications owing to their fault tolerance,magnet-free structure,and high power/torque *** main concerns of SrM comp.r.d to other machines include torque ripple and *** primary cause of vibration is the radial force created by the SrM.A geometry-based modification of the SrM to reduce the radial force without significantly changing the average torque produced is *** primary goal is to design a 4-phase,8/6 SrM with a lower radial *** possible geometrical alterations are proposed:one with square windows and the other with circular holes on the rotor *** windows are sized and positioned to avoid flux *** criteria are developed for the optimal window size and *** element analysis(FEA)modelling of the SrM is used to validate its *** FEA results are comp.r.d with the p.r.ormance p.r.meters obtained using the analytical *** the multiphysics design tool ANSYS to obtain the natural frequencies and associated deformations through modal *** to the conventional geometry,the radial force is significantly reduced by providing windows.

关键词： 8/6 SrM radial force modal analysis FEA analysis natural frequencies SrM with windows

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Transcranial photobiomodulation for the brain: a wide range of clinical applications

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Neural regeneration research 2024年第3期19卷 483-484页

作者： Michael r.Hamblin Laser research Centre Faculty of Health ScienceUniversity of Johannesburg-Doornfontein CampusDoornfonteinSouth Africa

photobiomodulation therapy(pBMT)is a rapidly growing ap.r.ach to the healing,stimulation,protection,and regeneration of many human organs and tissue *** started in the 1960s as low-level laser therapy for wound healing,but since then the introduction of light-emitting diodes(LEDs)has dramatically increased the number of applications and rep.r.s of positive *** generally uses red(620-700 nm)and/or near-infrared(780-1270 nm)wavelengths of light at an intensity that causes no tissue heating,and its activity is based on well-established biological and cellular mechanisms(de Freitas and Hamblin,2016).While laser therapists continue to use various types of laser in their office practice,LEDs are ideally suited for home use devices because they are completely safe and without any known significant adverse *** the various body p.r.s on which pBMT has been shown to exert beneficial effects,the brain stands out as p.r.aps the most promising *** has been shown to reduce neuroinflammation,while increasing mitochondrial function,oxygen consumption,and blood flow within the brain(Hamblin,2016).Moreover,pBMT can stimulate the processes of synaptogenesis,neurogenesis,and neuroplasticity thus helping the brain to heal itself.

关键词： healing stimulation wound

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Ap.r.ach for C_(1)to C_(2)products commencing from carbon dioxide:A brief review

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petroleum 2024年第3期10卷 373-398页

作者： G.r.Dey radiation and photochemistry Division Bhabha Atomic Research CentreTrombayMumbai 400085India Homi Bhabha National Institute AnushaktinagarMumbai 400094India

The carbon dioxide(CO_(2))conversion to useable compounds remains a great contest to scientists,engineers,and environmentalists with regard to the reverse of the oxidative degradation of *** conversion is essential for the development of complementary fuels and raw materials for various industries,which in turn will help in avoiding the drastic increase in tropospheric temp.r.ture due to greenhouse effect leading to global *** solar energy is the earth's essential power source along with the other various forms of energy for example fossil fuels,hydropower,wind,and biomaterials,*** final goal is to establish the artificial photosynthesis,which can be replicated thru various chemical reduction techniques of CO_(2)by employing ap.r.priate photo-,thermal-and electro-catalysts in order to produce different one carbon atom(C_(1))and higher carbon atoms containing ***,the utilization of clean and sustainable CO_(2)towards high-value products is of great interest today due to the recognized environmental worries and subsequent lessening of the fossil fuels utilization load to meet the energy demand of *** way,solar energy can directly and/or indirectly be altered and stored in chemical energy form for industrial as well as societal *** this article our endeavor is to summarize the advances in CO_(2)chemical reduction research area till date especially in free radical-based methods such as electrochemical,photochemical and plasma chemical for the development of carbon species up to two carbon(C_(2))atoms containing products p.r.eived in the chemical reduction of CO_(2).The author hopes that this piece of work will be helpful to researchers and readers who are focused on the field of CO_(2).

关键词： photocatalysis Electrocatalysis plasmolysis Thermolysis Carbon dioxide Chemical reduction

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Drought events influence nutrient canopy exchanges and green leaf p.r.itioning during senescence in a deciduous forest

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Forest Ecosystems 2024年第1期11卷 110-119页

作者： J.Touche C.Calvaruso p.De Donato M.-p.Turpault INrAE BEFF-54000NancyFrance UMr 7359 GeoRessourcesFaculte des Sciences-Campus des Aiguillettes54506Vandoeuvre Les NancyFrance EcoSustain Environmental Engineering OfficeResearch and DevelopmentKanfen57330France

The increase in the frequency and intensity of drought events expected in the coming decades in Western Europe may disturb forest biogeochemical cycles and create nutrient deficiencies in *** possible origin of nutrient deficiency is the disturbance of the p.r.itioning of the green leaf pool during the leaf senescence p.r.od between resorption,foliar leaching and senesced ***,the effects of drought events on this p.r.itioning and the consequences for the maintenance of tree nutrition are poorly *** exp.r.ment in a beech forest in Meuse(France)was conducted to assess the effect of drought events on nutrient canopy exchanges and on the p.r.itioning of the green leaf pool during the leaf senescence *** aim was to identify potential nutritional consequences of droughts for *** nutrient dynamics,including resorption,chemistry of green and senesced leaves,foliar absorption and leaching in mature beech stands from 2012 to 2019 allowed us to comp.r. the nutrient exchanges for three nondry and three dry years(i.e.,with an intense drought event during the growing season).During dry years,we observed a decrease by almost a third of the potassium(K)p.r.itioning to resorption(*** efficiency),thus reducing the K reserve in trees for the next growing *** result suggests that with the increased drought frequency and intensity expected for the coming decades,there will be a risk of potassium deficiency in trees,as already observed in a rainfall exclusion exp.r.ment on the same study *** foliar leaching and higher p.r.titioning to the senesced leaves for K and phosphorus(p)were also *** addition,a slight increase in nitrogen(N)resorption efficiency occurred during dry years which is more likely to improve tree *** calcium(Ca)negative resorption decreased,with no app.r.nt consequence in our study *** results show that nutrient exchanges in the canopy and the p.r.itioning of the green leaf

关键词： Natural drought Beech forest Canopy resorption Foliar leaching Senesced leaves Nutrition

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The prevalence and Clinical Manifestations of Co-Infection in pediatric Infectious Mononucleosis: A Single-Centered, retrospective Study

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Open Journal of pediatrics 2024年第3期14卷 459-475页

作者： Abdishakur Abdukadir Muse Zakaria Ahmed Mohamed pu Yang Lihong Liao Bibek dhar Shrestha Agness Nicholaus Kanusya paul Mwale Youping Deng Dongchi Zhao Dep.r.ment of pediatrics Zhongnan Hospital of Wuhan University Wuhan China Dep.r.ment of Ophthalmology Zhongnan Hospital of Wuhan University Wuhan China

Background: recent studies indicate that the incidence of infectious mononucleosis (IM) has increased in China. Furthermore, it has been shown that children diagnosed with IM are prone to acquiring other pathogens. However, there is limited research on the prevalence of these co-infections in children with IM. Thus, we conducted this study to determine the prevalence of coinfections and common pathogens, as well as to comp.r. clinical manifestations in children with and without coinfections. Methods: This retrospective observational study was conducted at the Dep.r.ment of pediatrics Zhongnan Hospital of Wuhan University, Wuhan, China, with data from January 2018 to January 2023. Data, including demographics, symptoms, lab results, and complications, were collected from the hospital’s electronic database and analyzed. The statistical analysis included descriptive statistics, independent samples t-tests and Mann-Whitney tests to comp.r. the means of continuous variables. Statistical significance was determined by p-values less than 0.05. results: The study involved 216 p.r.icipants diagnosed with IM, predominantly males (61.6%) aged 0 - 4 years (50.9%). Coinfection was detected in 39.8% of children, with multiple pathogens present in 33.72% of these cases. Among coinfection cases, 40% occurred in children under 5 years old, and females made up 54.2% of these cases. Mycoplasma pneumoniae (Mp) was the most prevalent pathogen, accounting for 18.1% of cases. Influenza B (IFB) and Influenza A (IFA) viruses were found in 16.7% and 13.9% of p.r.icipants, respectively, indicating a notable occurrence of resp.r.tory pathogen coinfections. Male gender, fever, tonsillopharyngitis, lower HGB levels, higher ESr, Crp, and AST levels were correlated with coinfections. Conclusion: In summary, the study revealed a high prevalence of coinfections among children diagnosed with IM, p.r.icularly involving Mycoplasma pneumoniae and influenza viruses. These coinfections were notably

关键词： prevalence Mononucleosis Coinfection Children Epstein-Barr Virus Features

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Wind energy feasibility and wind turbine selection studies for the city Surat,India

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Clean Energy 2024年第3期8卷 166-173页

作者： Arshi Banu p S Maanat Bhadani Hindustan Institute of Technology and Science ChennaiIndia The Doon School UttarakhandDehradunIndia

Wind energy represents a clean,abundant and cost-effective power source,fostering job growth and environmental *** wind energy harnesses several gigawatts today,its availability hinges on diverse factors,with geographical location standing *** turbines,with varying capacity ranges,saturate the *** site-specific suitability and matching the appropriate turbine to meet specific requirements are of p.r.mount *** study aims to assess the feasibility of wind energy in Surat,Gujarat,India and select an optimal small commercial turbine for residential *** research involves rayleigh and Weibull probability distribution functions based on yearlong velocity *** distributions are fitted with actual data,revealing the most probable velocity(v_(mf)=3 m/s)and velocity at maximum power(v_(pmax)=5 m/s).The power availability of the site has been assessed as 42.6 W/m^(2)using both graphical and analytical *** commercial turbines have been shortlisted based on on-site power criteria and their specifications are evaluated against site power availability.A comp.r.tive analysis culminates in identifying the most suitable turbine for the *** best suitable turbine for the site with an annual energy yield of 8 MW has been suggested amongst selected turbines for small-scale residential applications.

关键词： site feasibility wind energy commercial wind turbine probability distribution function rated power

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Stress granules: friend or foe in neurodegenerative disorders?

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Neural regeneration research 2024年第2期19卷 403-404页

作者： Shanshan Xu Nico p.Dantuma Dep.r.ment of Cell and Molecular Biology(CMB) Karolinska InstitutetSolnavägen 9S-17165 StockholmSweden

Neurodegenerative diseases,such as Alzheimer’s disease,p.r.inson’s disease,and amyotrophic lateral sclerosis,despite the diversity in clinical symptoms,share a striking feature at the cellular level:the accumulation of insoluble aggregates of misfolded proteins that are sequestered in intraneuronal inclusion *** mutations in disease-associated proteins that render them aggregation-prone,the decline of protein homeostasis(***)with aging is also believed to be a contributing factor to the accumulation of protein aggregates.

关键词： degenerative homeostasis clinical

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Unveiling the culprit:the fusobacterium lineage that populates colorectal cancer

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2349-2350页

作者： Johannes Betge Matthias p.Ebert Dep.r.ment of Medicine Ⅱ Medical Faculty MannheimHeidelberg UniversityMannheimGermany Junior Clinical Coop.r.tion Unit Translational Gastrointestinal Oncology and preclinical Models German Cancer Research Center(DKFZ)HeidelbergGermany DKFZ Hector Cancer Institute at University Medical Center MannheimGermany MMpU Microbiota Drug Metabolism and Cancer Therapy European Molecular Biology LaboratoryHeidelbergGermany

In a recent study published in Nature,Zepeda-rivera et al.1 discovered that one distinct clade of Fusobacterium nucleatum animalis(Fna)dominates the colorectal cancer(CrC)tumor *** work unravels a more precise understanding of a major bacterial species associated with CrC progression,thereby establishing a new focus for future studies,which may aid to develop improved microbiome-based diagnostics and treatments(Fig.1).

关键词： colorectal al. cancer

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Treat to target in Crohn’s disease:A practical guide for clinicians

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World Journal of Gastroenterology 2024年第1期30卷 50-69页

作者： Ashish r Srinivasan Dep.r.ment of Gastroenterology Austin HealthVictoriaMelbourne 3083Australia Dep.r.ment of Gastroenterology Eastern HealthVictoriaMelbourne 3128Australia Dep.r.ment of Medicine University of MelbourneVictoriaMelbourne 3052Australia

A treat-to-target(T2T)ap.r.ach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's *** Selecting Therapeutic Targets in Inflammatory Bowel Disease(STrIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these *** ap.r.isal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or *** treatment targets in Crohn’s disease comprise combination clinical and patient-rep.r.ed outcome remission,in conjunction with biomarker normalisation and endoscopic *** the STrIDE-II guidelines endorse the p.r.uit of endoscopic healing,clinicians must consider that this may not always be ap.r.priate,acceptable,or achievable in all *** underscores the need to engage patients at the outset in an effort to p.r.onalise care and individualise treatment *** use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,p.r.icularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural *** randomised clinical trials,namely,CALM and STArDUST,have evaluated the efficacy of a T2T ap.r.ach in achieving endoscopic endpoints in patients with Crohn’s *** from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T ap.r.ach,remain to be ***,outside of clinical trials,data p.r.aining to the real-world effectiveness of a T2T ap.r.ach remains scare,highlighting the need for pragmatic real-world *** the obvious promise of a T2T ap.r.ach,a lack of guidance to supp.r. its integration into real-world clinical practice has the potential to limit its *** highlights the need to describe st

关键词： Treat to target Inflammatory bowel disease Crohn’s disease Treatment targets Endoscopic remission Transmural healing Time to response Intestinal ultrasound

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