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Journal of Traditional Chinese Medicine 2021年第4期41卷 630-635页

作者： wang dexiu XU Yonggang DU Yu wang Hongzhi LI Liu HU Xiaomei YANG Xiupeng MA Rou ZHOU Qingbing Department of Hematology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Institute of Geriatric Medicine Xiyuan HospitalChinese Academy of Chinese Medical SciencesBeijing 100091China

OBJECTIVE:To explore the relationship between the efficacy of realgar for the treatment of myelodysplastic syndromes with multilineage dysplasia(MDS-MLD)and arsenic concentration in the peripheral blood of ***:In this prospective study,a total of 50 MDS-MLD patients were treated with traditional Chinese drugs containing realgar for 3 months in Xiyuan Hospital from March 2018 to January *** blood examination as well as liver and kidney function were monitored before and after *** concentration of arsenic in the peripheral blood was measured using an atomic fluorescence spectrometer after *** correlation between clinical effect and arsenic concentration was analyzed by Spearman’s ***:The treatment response rate was 54%.Two patients(4%)achieved complete remission,50%(25 of 50)showed hematologic improvement,and 23 patients had stable disease(23%).No disease progression was *** concentration in the peripheral blood ranged from 14.60 to 85.96μg/*** efficacy was positively correlated with arsenic concentration(P<0.05).The incidence of mild adverse reactions was 16%.CONCLUSION:A relatively high concentration of arsenic in the peripheral blood may improve the clinical efficacy of realgar in MDS-MLD patients.

关键词： realgar arsenic myelodysplastic syndromes multiline dysplasia

Structure and Classification of Haemocytes in the Bivalve Mollusc Meretrix meretrix

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Journal of Ocean University of China 2006年第2期5卷 132-136页

作者： ZHANG Yanyan REN Sulian wang dexiu SONG Weibo The Key Laboratory of Mariculture Ministry of Education Ocean University of China Qingdao 266003 P.R. China

Light and electron microscopic studies were carried out in order to characterize haemocytes in the bivalve mollusc Meretrix meretrix. According to nucleus and cytoplasm characters, four types of haemocytes were recognized： agranular haemocytes, lymphoid haemocyte, large granular and small granular haemocytes. Agranular hamocyte is the main cell type, accounting for 75%. It is agranular with rich organelles in cytoplasm, including mitochondria, golgi body and endoplasmic reticulum. Glycogen deposits were usually found in this cell type. The number of lymphoid haemocyte accounts for 1% - 2%. This cell type is agranular and shows a high ratio of nucleus to cytoplasm. A few organelles were found. High electrondense granules with diameters of 0.2 - 0.5μm and rich organelles were found in small granular haemocyte. The proportion of this cell type is about 15%. Rich granules of high electron-dense with diameters of 0.8- 2.4μm were found in large granular haemocyte. The proportion of this cell type is about 10%, and the quantity of organelles is the least.

关键词： Meretrix meretrix haemocytes structure classification

血管性痴呆大鼠海马神经元P-GP和胶质细胞GLT-1的表达变化

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神经解剖学杂志 2015年第6期31卷 765-770页

作者：王德秀王玉良王钢潍坊医学院生理学教研室潍坊261053 潍坊医学院认知神经科学实验室潍坊261053

目的:探讨血管性痴呆(VD)模型大鼠海马CA1区P精蛋白(P-GP)及谷氨酸转运体1(GLT-1)长时间表达变化及其神经元保护机制。方法:采用反复脑缺血再灌注复制VD大鼠模型在15 d和1月两个时间点采用Morris水迷宫检测大鼠空间学习记忆能力,用神经... 详细信息

目的:探讨血管性痴呆(VD)模型大鼠海马CA1区P精蛋白(P-GP)及谷氨酸转运体1(GLT-1)长时间表达变化及其神经元保护机制。方法:采用反复脑缺血再灌注复制VD大鼠模型在15 d和1月两个时间点采用Morris水迷宫检测大鼠空间学习记忆能力,用神经颗粒素(Ng)/P-GP和GFAP/GLT-1免疫荧光双标法,观察海马区神经元P-GP和胶质细胞GLT-1的表达变化。结果:(1)模型组大鼠各时间点的Morris水迷宫逃逸潜伏期比假手术组均明显延长(P<0.01)。(2)与假手术组相比,模型组大鼠海马CA1区Ng/P-GP阳性神经元的数量明显降低(P<0.01)而GFAP/GLT-1阳性胶质细胞数以及海马区神经元上P-GP和胶质细胞上GLT-1表达均明显升高(P<0.01);与模型组15 d时间点比较,模型组1月时间点的海马CA1区Ng/P-GP阳性神经元的数量明显降低而GFAP/GLT-1阳性胶质细胞数以及P-GP和GLT-1的表达均明显升高(P<0.01)。(3)积分光密度值测定显示:模型15 d时间点Ng/P-GP和GFAP/GLT-1阳性细胞的IOD值比假手术组各时间点均明显变大(P<0.01);模型1月时间点Ng/P-GP和GFAP/GLT-1阳性细胞的IOD值较15 d时间点更大(P<0.01)。结论:神经元的P-GP和胶质细胞的GLT-1可能参与VD大鼠海马神经元的保护。

关键词：血管性痴呆 P-糖蛋白谷氨酸转运体1 海马神经颗粒素大鼠

银杏叶提取物预处理对VD模型大鼠海马CA1区P-GP和GLT-1表达的影响

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神经解剖学杂志 2016年第3期32卷 314-320页

作者：王德秀高健王玉良潍坊医学院生理学教研室潍坊261053 潍坊医学院认知神经科学实验室潍坊261053

目的:探讨银杏叶提取物(EGB761)预处理对血管性痴呆(VD)模型大鼠海马CA1区P-糖蛋白(P-GP)及谷氨酸转运体1(GLT-1)的影响。方法:大鼠分为假手术组、模型组和EGB761预处理组。EGB761预处理组在造模前7 d给予EGB761生理盐水混悬液灌胃,假... 详细信息

目的:探讨银杏叶提取物(EGB761)预处理对血管性痴呆(VD)模型大鼠海马CA1区P-糖蛋白(P-GP)及谷氨酸转运体1(GLT-1)的影响。方法:大鼠分为假手术组、模型组和EGB761预处理组。EGB761预处理组在造模前7 d给予EGB761生理盐水混悬液灌胃,假手术组和模型组给予等体积的生理盐水灌胃。采用重复夹闭双侧颈总动脉(CCA)同时腹腔注射硝普钠溶液方法复制VD大鼠模型。Morris水迷宫检测大鼠空间学习记忆能力,用神经颗粒素(Ng)/P-GP和胶质细胞酸性蛋白(GFAP)/GLT-1免疫荧光双标法,观察海马CA1区神经元P-GP和胶质细胞GLT-1表达水平的变化,Western Blot技术检测VD大鼠海马区P-GP和GLT-1蛋白的表达量。结果:(1)Morris水迷宫检测显示,与假手术组相比,模型组大鼠的逃逸潜伏期(Escape latency,EL)明显延长(P<0.01),而EGB761预处理组大鼠EL明显缩短(P<0.01)。(2)阳性细胞计数观察到,与假手术组相比,模型组海马CA1区Ng/P-GP的阳性细胞数明显减少,GFAP/GLT-1的阳性细胞数则显著增多(P<0.01),EGB761预处理组海马CA1区Ng/P-GP和GFAP/GLT-1的阳性细胞数较模型组均明显增多(P<0.01)。(3)积分光密度值测定观察到,模型组和EGB761预处理组的Ng/P-GP和GFAP/GLT-1阳性细胞的IOD值较假手术组均明显增大(P<0.01);EGB761预处理组的Ng/P-GP和GFAP/GLT-1阳性细胞IOD值均显著高于模型组(P<0.01)。(4)Western Blot分析结果显示,模型组和EGB761预处理组大鼠海马CA1区P-GP和GLT-1蛋白表达的灰度值均比假手术组增大(P<0.01),EGB761预处理组大鼠海马CA1区P-GP和GLT-1蛋白表达的灰度值均显著大于模型组(P<0.01)。结论:EGB761预处理可能通过上调VD模型大鼠海马CA1区P-GP和GLT-1的表达来预防VD的发生。

关键词：血管性痴呆 P-糖蛋白谷氨酸转运体1 海马银杏叶提取物预处理大鼠

Discovery of a Novel Aminopeptidase N Inhibitor Dino-Leucine Borate

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Journal of Biosciences and Medicines 2022年第5期10卷 150-168页

作者： Yuqian Ma Minzhi Fang Yutian Li Dongqi Zhu Yanmei Du Binbin Ge Jiliang Song Xinyue Xu Chuhan Ma Xiaojun Jia Xiurong Zhang Jian Zhang dexiu wang Xuejian wang School of Pharmacy Weifang Medical University Weifang China School of Basic Medicine Weifang Medical University Weifang China School of Clinical Medicine Weifang Medical University Weifang China

Aminopeptidase N(APN/CD13), a Zn2+-dependent ectopeptidase localized on the cell surface, is widely considered to influence the invasion of tumor cells. We found that boroleucine and dino-leucine borate exhibited a strong inhibitory effect on the enzyme activity of aminopeptidase N. The tested assay indicated that both compounds had an anti-proliferative effect on triple-negative breast cancer cells. Wound healing assay, migration test and matrigel-coated transwell assay showed that both boroleucine and dino-leucine borate inhibited the migration and invasion of breast cancer cells. Immunoblot analysis showed that both compounds down-regulated the expression of matrix metalloproteinase-2/9. In the capillary tube formation assay of human umbilical vein endothelial cells (HUVECs), dino-leucine borate showed better antiangiogenic activity than ubenimex even at a low concentration (10 μM). Moreover, compared with ubenimex, the anti-metastatic activity of dino-leucine borate in vivo was similar to or even better than that of ubenimex in the H22 pulmonary metastasis mouse model. In this paper, we found the novel APN inhibitors to markedly suppress the enzyme activity of APN and inhibit the migration and invasion of tumor cells in vitro and in vivo.

关键词： Aminopeptidase Inhibitor Anti-Tumor Boroleucine Dino-Leucine Borate

Flexible tunable wavelength conversion exploiting cascaded sum- and difference-frequency generation in LiNbO3 waveguides

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Flexible tunable wavelength conversion exploiting cascaded s...

围术期颅内压检测指导治疗对重型颅脑损伤患者脑脊液BDNF、S100B蛋白水平及预后的影响

The Eighth Chinese Optoelectronics Symposium

作者： Junqiang Sun, dexiu Huang, Jian wang, Chuanhong Luo Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074

Flexible tunable wavelength conversion based on cascaded sum-frequency generation(SFG) and difference-frequency generation(DFG) is proposed and demonstrated in a quasi-phase matched LiNbO3 waveguide. For a launched optical signal with 40-GHz repetition rate and 1.57-ps pulse width, it is shown that the input signal wavelength in a range of 25nm can be converted to any output signal by changing the pump and control wavelengths appropriately. Approximate -18.9dB conversion efficiency and 25nm variable region of the input signal is achieved under the lower launched signal power. The experimental results imply that the proposed scheme can significantly enhance the possibility for practical applications.

关键词： Frequency conversion optical waveguides nonlinear optics optical communications

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中国基层医药 2023年第11期30卷 1646-1650页

作者：汪德秀王丰徐强孙孟坊温州市中西医结合医院神经外科温州325008

目的研究在重型脑颅损伤围术期给予颅内压检测指导治疗对患者脑脊液神经相关指标及预后的影响。方法采用病例对照研究,选取温州市中西医结合医院2015年3月至2020年8月收治的重型颅脑损伤患者84例,根据治疗方案不同分为研究组(n=48)与对... 详细信息

目的研究在重型脑颅损伤围术期给予颅内压检测指导治疗对患者脑脊液神经相关指标及预后的影响。方法采用病例对照研究,选取温州市中西医结合医院2015年3月至2020年8月收治的重型颅脑损伤患者84例,根据治疗方案不同分为研究组(n=48)与对照组(n=36)。对照组进行常规治疗,研究组以围术期颅内压检测指导治疗。比较两组患者的疗效,脑源性神经营养因子(BDNF)、中枢神经特异蛋白(S100B)蛋白水平和预后情况。结果研究组总有效率为87.5%(42/48),显著高于对照组的69.4%(25/36)(χ^(2)=4.15,P=0.042)。治疗后,与对照组相比,研究组脑脊液的BDNF水平[(0.181±0.021)μg/L]明显更高,S100B水平[(4.3±1.8)μg/L]明显更低(t=3.09、-4.86,P<0.001、<0.001)。研究组预后不良率为47.9%(23/48),明显低于对照组的69.4%(25/36)(χ^(2)=3.89,P=0.048)。根据患者预后情况分为预后良好组与预后不良组,预后不良组患者的颅内压水平明显更高(t=4.12,P<0.001)。颅内压水平对重型颅脑损伤患者预后的曲线下面积(AUC)为0.880(95%CI:0.809~0.950,P<0.001)。结论围术期颅内压监测指导治疗,可显著改善重型颅脑损伤患者脑脊液BDNF、S100B水平,并改善预后。

关键词：颅内压脑源性神经营养因子中枢神经特异蛋白重型颅脑损伤预后脑脊液预后不良围术期

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有线电视网络技术现状及发展趋势

影视技术 2001年第8期 47-52,27页

作者：王德秀湖北十堰市

从20世纪90年代开始,有线电视(CATV)在我国的发展极其迅速,尤其近几年来更是如此.现在各大中小城市基本上每户均有电缆入室,各县、镇、乡也在积极发展CATV,并且发展速度也很快.据统计,截止2000年底,我国有线电视用户已达到9000万户,现... 详细信息

从20世纪90年代开始,有线电视(CATV)在我国的发展极其迅速,尤其近几年来更是如此.现在各大中小城市基本上每户均有电缆入室,各县、镇、乡也在积极发展CATV,并且发展速度也很快.据统计,截止2000年底,我国有线电视用户已达到9000万户,现有电视机已超过3.5亿台,并且CATV用户每年以500-800万户的速度递增.

关键词： CATV 有线电视网络技术发展现状发展趋势