Arsenic concentration in peripheral blood is correlated with efficacy of a Traditional Chinese Medicine regimen containing realgar for the treatment of myelodysplastic syndromes

作     者：WANG Dexiu XU Yonggang DU Yu WANG Hongzhi LI Liu HU Xiaomei YANG Xiupeng MA Rou ZHOU Qingbing WANG Dexiu;XU Yonggang;DU Yu;WANG Hongzhi;LI Liu;HU Xiaomei;YANG Xiupeng;MA Rou;ZHOU Qingbing

作者机构：Department of HematologyXiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Institute of Geriatric MedicineXiyuan HospitalChinese Academy of Chinese Medical SciencesBeijing 100091China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2021年第41卷第4期

页      面：630-635页

核心收录：

学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by China Academy of Chinese Medicine Scientific Foundation(ZZ13-YQ-010) National Natural Science Foundation of China(No.81603490) State Administration of Traditional Chinese Medicine Foundation(No.JDZX-2015264) 

主　　题：realgar arsenic myelodysplastic syndromes multiline dysplasia 

摘      要：OBJECTIVE:To explore the relationship between the efficacy of realgar for the treatment of myelodysplastic syndromes with multilineage dysplasia(MDS-MLD)and arsenic concentration in the peripheral blood of ***:In this prospective study,a total of 50 MDS-MLD patients were treated with traditional Chinese drugs containing realgar for 3 months in Xiyuan Hospital from March 2018 to January *** blood examination as well as liver and kidney function were monitored before and after *** concentration of arsenic in the peripheral blood was measured using an atomic fluorescence spectrometer after *** correlation between clinical effect and arsenic concentration was analyzed by Spearman’s ***:The treatment response rate was 54%.Two patients(4%)achieved complete remission,50%(25 of 50)showed hematologic improvement,and 23 patients had stable disease(23%).No disease progression was *** concentration in the peripheral blood ranged from 14.60 to 85.96μg/*** efficacy was positively correlated with arsenic concentration(P0.05).The incidence of mild adverse reactions was 16%.CONCLUSION:A relatively high concentration of arsenic in the peripheral blood may improve the clinical efficacy of realgar in MDS-MLD patients.