检索结果-南通市图书馆

Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma

引用

Neural Regeneration Research 2023年第4期18卷 840-848页

作者： devaraj basavarajappa Vivek Gupta Nitin Chitranshi Roshana Vander Wall Rashi Rajput Kanishka Pushpitha Samridhi Sharma Mehdi Mirzaei Alexander Klistorner Stuart L.Graham Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie UniversityNorth RydeSydneyNSWAustralia

Sphingosine-1-phosphate receptor(S1PR)signaling regulates diverse pathophysiological processes in the central nervous system.The role of S1PR signaling in neurodegenerative conditions is still largely unidentified.Siponimod is a specific modulator of S1P1 and S1P5 receptors,an immunosuppressant drug for managing secondary progressive multiple sclerosis.We investigated its neuroprotective properties in vivo on the retina and the brain in an optic nerve injury model induced by a chronic increase in intraocular pressure or acute N-methyl-D-aspartate excitotoxicity.Neuronal-specific deletion of sphingosine-1-phosphate receptor(S1PR1)was carried out by expressing AAV-PHP.eB-Cre recombinase under Syn1 promoter in S1PR1mice to define the role of S1PR1 in neurons.Inner retinal electrophysiological responses,along with histological and immunofluorescence analysis of the retina and optic nerve tissues,indicated significant neuroprotective effects of siponimod when administered orally via diet in chronic and acute optic nerve injury models.Further,siponimod treatment showed significant protection against trans-neuronal degenerative changes in the higher visual center of the brain induced by optic nerve injury.Siponimod treatment also reduced microglial activation and reactive gliosis along the visual pathway.Our results showed that siponimod markedly upregulated neuroprotective Akt and Erk1/2 activation in the retina and the brain.Neuronal-specific deletion of S1PR1 enhanced retinal and dorsolateral geniculate nucleus degenerative changes in a chronic optic nerve injury condition and attenuated protective effects of siponimod.In summary,our data demonstrated that S1PR1signaling plays a vital role in the retinal ganglion cell and dorsolateral geniculate nucleus neuronal survival in experimental glaucoma,and siponimod exerts direct neuroprotective effects through S1PR1 in neurons in the central nervous system independent of its peripheral immuno-modulatory effects.Our findings suggest that neuronal S1PR1 is a neuroprotective

关键词： glaucoma intraocular pressure neurodegeneration neuroprotection optic nerve injury retinal ganglion cells siponimod sphingosine-1-phosphate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improved Integrated Deep Model for Pap-Smear Cell Analysis

引用

Journal of Systems Science and Information 2024年第1期12卷 113-124页

作者： Somasundaram devaraj Nirmala MADIAN Gnanasaravanan SUBRAMANIAM Rithaniya CHELLAMUTHU Muralitharan KRISHANAN School of Electronics Engineering Vellore Institute of TechnologyVellore 632014India Department of Biomedical Engineering Dr.N.G.P Institute of TechnologyCoimbatore 641045India Karunya Institute of Technology and Sciences Coimbatore 641114India Department of Computer Science Institute of Mathematical ScienceSungkyunkwan UniversitySuwon 16419South Korea

Cervical cancer is the fourth most common malignancy to strike a woman globally.If discovered early enough,it can be effectively treated.Although there is a chance of error owing to human error,the Pap smear is a good tool for first screening for cervical cancer.It also takes a lot of time and effort to complete.The aim of this study was to reduce the possibility of error by automating the process of classifying cervical cancer using Pap smear images.For the purpose of this study,dual convolution neural networks with LSTM were employed to classify images due to deep learning approaches inspire distinct features and powerful classifiers for many computer vision applications.The proposed deep learning model based on convolution neural networks(CNN)with the long short-term memory(LSTM)network is to learn features which give better recognition accuracy.The overall model is known as Smear-net.In which‘smear’indicates‘pap-smear cancer cells’and‘net’refers to neural network.The parameters such as,Accuracy,Precision,Recall,Accuracy,Sensitivity,and Specificity are used to validate the models.The proposed method provides the improved accuracy of 99.57 percentage for classification of the pap-smear cells.The proposed approaches demonstrate the effectiveness of our contributions by testing and comparing with the state-of-the-art techniques.

关键词： pap-smear deep learning convolution neural network smear-net

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wnt/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases

引用

Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 333-345页

作者： Karthik Shree Harini devaraj Ezhilarasan Department of Pharmacology Molecular Medicine and Toxicology LabSaveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)ChennaiTamil Nadu 600077India

Nonalcoholic fatty liver disease(NAFLD)is a global health concern associated with significant morbidity and mortality.NAFLD is a spectrum of diseases originating from simple steatosis,progressing through nonalcoholic steatohepatitis(NASH),fibrosis,and cirrhosis that may lead to hepatocellular carcinoma(HCC).The pathogenesis of NAFLD is mediated by the triglyceride accumulation followed by proinflam-matory cytokines expression leading to inflammation,oxidative stress,and mitochondrial dysfunction de-noted as“two-hit hypothesis”,advancing with a“third hit”of insufficient hepatocyte proliferation,lead-ing to the increase in hepatic progenitor cells contributing to fibrosis and HCC.Wnt/β-catenin signaling is responsible for normal liver development,regeneration,hepatic metabolic zonation,ammonia and drug detoxification,hepatobiliary development,etc.,maintaining the overall liver homeostasis.The key regula-tors of canonical Wnt signaling such as LRP6,Wnt1,Wnt3a,β-catenin,GSK-3β,and APC are abnormally regulated in NAFLD.Many experimental studies have shown the aberrated Wnt/β-catenin signaling dur-ing the NAFLD progression and NASH to hepatic fibrosis and HCC.Therefore,in this review,we have em-phasized the role of Wnt/β-catenin signaling and its modulators that can potentially aid in the inhibition of NAFLD.

关键词： Steatosis Fatty liver Oxidative stress Chronic liver diseases Fibrosis Wnt/β-catenin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reply to“Wnt/beta-catenin signaling inhibitors and nonalcoholic fatty liver disease:Potential therapeutic implications”

引用

Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 439-440页

The Author Reply:We sincerely appreciated the interest of Polyzos et al.,in our review article and sharing their improvised thoughts regarding the Wnt signaling modulators for the treatment of postmenopausal women with osteoporosis and nonalcoholic fatty liver disease(NAFLD).Several experimental studies have showed that the aberrant Wnt/β-catenin signaling promotes the development and/or progression of a variety of chronic liver diseases including NAFLD[1,2].Therefore,our review emphasized on the modulation of Wnt/β-catenin signaling and the role of its mediators in NAFLD progression.Given that NAFLD prevalence is constantly increas-ing,and that osteoporosis is associated with women over 50 years of age with NAFLD[3],there is an unmet need for an effective treatment.Sclerostin blocks the canonical Wnt signaling pathway of bone formation.Therefore,romosozumab,a humanized anti-sclerostin monoclonal antibody,was approved for the treatment of osteoporosis.Romosozumab binds to sclerostin,permitting the en-gagement of Wnt ligands with their co-receptors,resulting in an increase in bone formation and bone mineral density.

关键词： liver Wnt constantly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Early Detection Glaucoma and Stargardt’s Disease Using Deep Learning Techniques

引用

Intelligent Automation & Soft Computing 2023年第5期36卷 1283-1299页

作者： Somasundaram devaraj Senthil Kumar Arunachalam Department of Electronics and Communication Engineering Sri Shakthi Institute of Engineering and TechnologyCoimabatore641062TamilnaduIndia

Retinal fundus images are used to discover many diseases.Several Machine learning algorithms are designed to identify the Glaucoma disease.But the accuracy and time consumption performance were not improved.To address this problem Max Pool Convolution Neural Kuan Filtered Tobit Regres-sive Segmentation based Radial Basis Image Classiﬁer(MPCNKFTRS-RBIC)Model is used for detecting the Glaucoma and Stargardt’s disease by early period using higher accuracy and minimal time.In MPCNKFTRS-RBIC Model,the ret-inal fundus image is considered as an input which is preprocessed in hidden layer 1 using weighted adaptive Kuanﬁlter.Then,preprocessed retinal fundus is given for hidden layer 2 for extracting the features like color,intensity,texture with higher accuracy.After extracting these features,the Tobit Regressive Segmenta-tion process is performed by hidden layer 3 for partitioning preprocessed image within more segments by analyzing the pixel with the extracted features of the fundus image.Then,the segmented image was given to output layer.The radial basis function analyzes the testing image region of a particular class as well as training image region with higher accuracy and minimum time consumption.Simulation is performed with retinal fundus image dataset with various perfor-mance metrics namely peak signal-to-noise ratio,accuracy and time,error rate concerning several retina fundus image and image size.

关键词： Glaucoma detection max pool convolution neural network kuanﬁlter radial basis function

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases

引用

Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 315-322页

作者： devaraj Ezhilarasan Department of Pharmacology the Blue LabMolecular Medicine and Toxicology DivisionSaveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)Chennai 600077Tamil NaduIndia

Background: Upon liver injury, quiescent hepatic stellate cells(q HSCs), reside in the perisinusoidal space, phenotypically transdifferentiate into myofibroblast-like cells(MFBs). The q HSCs in the normal liver are less fibrogenic, migratory, and also have less proliferative potential. However, activated HSCs(a HSCs) are more fibrogenic and have a high migratory and proliferative MFBs phenotype. HSCs activation is a highly energetic process that needs abundant intracellular energy in the form of adenosine triphosphate(ATP) for the synthesis of extracellular matrix(ECM) in the injured liver to substantiate the injury. Data sources: The articles were collected through Pub Med and EMBASE using search terms "mitochondria and hepatic stellate cells", "mitochondria and HSCs", "mitochondria and hepatic fibrosis", "mitochondria and liver diseases", and "mitochondria and chronic liver disease", and relevant publications published before September 31, 2020 were included in this review. Results: Mitochondria homeostasis is affected during HSCs activation. Mitochondria in a HSCs are highly energetic and are in a high metabolically active state exhibiting increased activity such as glycolysis and respiration. a HSCs have high glycolytic enzymes expression and glycolytic activity induced by Hedgehog(Hh) signaling from injured hepatocytes. Increased glycolysis and aerobic glycolysis(Warburg effect) endproducts in a HSCs consequently activate the ECM-related gene expressions. Increased Hh signaling from injured hepatocytes downregulates peroxisome proliferator-activated receptor-γ expression and decreases lipogenesis in a HSCs. Glutaminolysis and tricarboxylic acid cycle liberate ATPs that fuel HSCs to proliferate and produce ECM during their activation. Conclusions: Available studies suggest that mitochondria functions can increase in parallel with HSCs activation. Therefore, mitochondrial modulators should be tested in an elaborate manner to control or prevent the HSCs activation during liver injury to subsequently regress hep

关键词： Hepatic stellate cells Glutaminolysis Glycolysis Hedgehog Myofibroblasts

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Critical role of estrogen in the progression of chronic liver diseases

引用

Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 429-434页

作者： devaraj Ezhilarasan Department of Pharmacology Biomedical Research Unit and Laboratory Animal CentreSaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077Tamil NaduIndia

Background:Estrogens regulate sexual function and also have a significant role in various pathophysiological processes.Estrogens have a non-reproductive role as the modulators of the immune system,growth,neuronal function,and metabolism.Estrogen receptors are expressed in the liver and their impaired expression and function are implicated with obesity and liver associated metabolic dysfunctions.The purpose of the current review is to discuss the disparity role of estrogens on several forms of liver diseases.Data sources:A comprehensive search in PubMed and EMBASE was conducted using the keywords“estrogens and liver diseases”,“estradiol and liver diseases”,“hormones and liver diseases”,“endocrine function in liver diseases”,and“female hormones in liver diseases”.Relevant papers published before September 30,2019 were included.Results:The present review confirms the imperative role of estrogen in various forms of chronic liver diseases.Estrogens play a key role in maintaining homeostasis and make the liver less susceptible to several forms of chronic liver diseases in healthy premenopausal individuals.In contrast,clinical studies also showed increased estrogen levels with chronic liver diseases.Conclusions:Several studies reported the protective role of estrogens in chronic liver diseases and this has been widely accepted and confirmed in experimental studies using ovariectomized rat models.However,in a few clinical studies,increased estrogen levels are also implicated in chronic liver diseases.Therefore,further studies are warranted at molecular level to explore the role of estrogen in various forms of chronic liver diseases.

关键词： Estrogen Hepatic fibrosis Chronic liver diseases Hepatic stellate cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lower blood malondialdehyde is associated with past pesticide exposure:findings in Gulf War illness and healthy controls

引用

Military Medical Research 2022年第2期9卷 205-214页

作者： Beatrice Alexandra Golomb Sridevi devaraj Alexis K.Messner Hayley Jean Koslik Jun Hee Han Barnabas Yik Department of Medicine School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Department of Pathology and Immunology Baylor College of MedicineHoustonTX 77030USA Swedish Medical Center SeattleWA 98109USA Henry M.Jackson Foundation for the Advancement of Military Medicine San DiegoCA 92134USA Santa Clara Valley Medical Center San JoseCA 95128USA

Background: Malondialdehyde(MDA) is a candidate general marker of oxidative stress(OS). We sought to assess the relation of MDA to Gulf War illness(GWI) and to a variety of exposures.Methods: This is an observational study involving subjects from Southern California recruited from October 2011 to May 2014. MDA was assessed in 81 participants(41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. MDA case–control comparison was restricted to 40 matched pairs. The potential association between MDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific model.Results: Plasma MDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted MDA in the total sample, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate(OP) nerve gas was a strong predictor for lower MDA level in veterans with GWI.Conclusions: Past pesticide exposures predicted lower MDA in both veterans with GWI and in healthy controls.

关键词： Malondialdehyde Oxidative stress Free radical Gulf War veterans Gulf War illness Pesticide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Active catalytic species generated in situ in zirconia incorporated hydrogen storage material magnesium hydride

引用

Journal of Magnesium and Alloys 2022年第3期10卷 852-861页

作者： D.Pukazhselvan K.S.Sandhya devaraj Ramasamy Aliaksandr Shaula Igor Bdikin Duncan Paul Fagg Department of Mechanical Engineering Nanoengineering Research GroupCentre for Mechanical Technology and Automation(TEMA)University of AveiroAveiro 3810-193Portugal Department of Chemistry Malankara Catholic CollegeKaliyakkavilaiTamil Nadu 629153India Department of Computational Biology and Bioinformatics University of KeralaThiruvananthapuramKerala 695581India UIDM ESTGPolytechnic Institute of Viana do CasteloViana do Castelo 4900Portugal

This study explores how zirconia additive interacts with MgH_(2)to improve its hydrogen storage performance.Initially it is confirmed that the zirconia added MgH_(2)powder releases hydrogen at a temperature of about 50℃below that of the additive free MgH_(2).Subsequent tests by X ray diffraction(XRD)and infrared(IR)spectroscopy techniques reveal that the ZrO_(2) mixed MgH_(2)powder contains ZrHx(21.5)and MgO secondary phases.This observation is supported by the negative Gibbs free energy values obtained for the formation of ZrH_(2)/MgO from ZrO_(2)/MgH_(2)powder samples.An X ray photoelectron spectroscopy(XPS)study reveals that apart from Zr^(4+)cations,Zr^(2+) and zero valent Zr exist in the powder.Atomic force microscopy(AFM)study reveals that the average grain size is 20 nm and the elemental line scan profiles further proves the existence of oxygen deficient Zr bearing phase(s).This study strengthens the belief that functional metal oxide additives in fact chemically interact with MgH_(2)to make active in-situ catalysts in the MgH_(2)system.

关键词： Hydrogen storage Binary hydrides Metal oxides Additives Nanocatalysis.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Silibinin alleviates N-nitrosodimethylamine-induced glutathione dysregulation and hepatotoxicity in rats

引用

Chinese Journal of Natural Medicines 2016年第1期14卷 40-47页

作者： devaraj Ezhilarasan Slvanesan Karthikeyan Food and Hepatotoxicology Laboratory Department of Pharmacology and Environmental Toxicology University of MadrasTaramani Chennai 600113 India

The present study was designed to evaluate the hepatoprotective and antioxidant potentials of silibinin(SBN)against N-nitrosodimethylamine(DMN)-induced toxic insults in the rat liver.The liver damage was induced in Wistar albino rats by repeated administration of DMN(10 mg·kg-1 b.w.,i.p.)on 3 consecutive days per week for 3 weeks.SBN(100 mg·kg-1 b.w.,p.o.)was given daily to the DMN treated rats for two weeks.The marker enzymes of liver toxicity and second-line enzymic and non-enzymic antioxidants were evaluated in serum and liver tissues before and after SBN treatment.Histopathology of the liver was evaluated by H & E staining.The DMN treatment produced a progressive increase in all the serum marker enzymes(AST,ALT,ALP,LDH,and γ-GT),peaking on Day 21.This treatment produced highly significant decreases in all the second-line antioxidant parameters(GSH,GST,GR,GPx,and vitamins C and E).The SBN treatment significantly reversed the DMN-induced damages,towards normalcy.Histopathological studies confirmed the development of liver toxicity in DMN-treated rats,which was reversed by SBN treatment in corroboration with the aforementioned biochemical results,indicating the hepatoprotective and antioxidant properties of SBN.In conclusion,the DMN-induced degenerative changes in the liver were alleviated by SBN treatment and this protective ability may be attributed to its antioxidant,free radical scavenging,and membrane stabilizing properties.

关键词： Dimethylnitrosamine Silibinin Oxidative stress Hepatotoxicity Glutathione dysregulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：