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Streptococcus agalactiae Anterior Cervical Space and Superior Mediastinum Abscess in a liver Transplant Recipient

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Infectious Microbes & Diseases 2019年第2期1卷 75-77页

作者： derek l.l.hung Man-Fai leung jade l.l.teng Herman Tse susanna k.p.lau patrick C.Y.Woo Department of Microbiology The University of Hong KongHong KongChina State key laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Carol Yu Centre for Infection The University of Hong KongHong KongChina public Health laboratory Services Branch Centre for Health ProtectionHong Kong Department of HealthThe University of Hong KongHong KongChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The University of Hong KongHong KongChina

Introduction Streptococcus agalactiae is most commonly associated with pregnancy-related infections,neonatal sepsis,and infections in patients with immunocompromised states,such as diabetes mellitus and malignancies.1 Although abscesses caused by *** are sometimes encountered in immunocompromised patients,*** abscess in transplant recipients is extremely *** abscesses have never been reported in liver transplant *** this article,we report a case of *** abscess in the anterior cervical space extending to the superior mediastinum in a liver transplant recipient.

关键词： Streptococcus agalactiae liver transplant abscess

Severe Sepsis Caused by listeria monocytogenes in A patient Given Monoclonal Antibodies Against CD38 and proteosome Inhibitor

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Infectious Microbes & Diseases 2019年第1期1卷 30-31页

作者： derek l.l.hung susanna k.p.lau patrick C.Y.Woo Department of Microbiology The University of Hong KongHong KongChina State key laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The University of Hong KongHong KongChina

Introduction Target therapies are widely used for treatment of various kinds of hematological *** the cancer cells that are targeted,share the same markers with the non-cancerous cells of the immunological system,these therapies are often associated with infectious diseases that require the particular type of immune response for *** this article,we report a case of listeria monocytogenes bacteraemia complicating carfilzomib and daratumumab treatment for multiple *** the best of our knowledge,this is the first case report of listeriosis as a complication of monoclonal antibodies against CD38 and/or proteosome inhibitor therapy.

关键词： listeria multiple myeloma daratumumab carfilzomib

Next-Generation Sequencing-Based Diagnosis of Bacteremic listeria monocytogenes Meningitis in a patient with Anti-Interferon Gamma Autoantibodies:A Case Report

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Infectious Microbes & Diseases 2022年第1期4卷 44-46页

作者： Fanfan Xing derek l.l.hung Simon k.F.lo Shuang Chen susanna k.p.lau patrick C.Y.Woo Department of Clinical Microbiology and Infection Control The University of Hong Kong–Shenzhen HospitalShenzhenGuangdongChina Department of Microbiology The University of Hong KongHong KongChina Department of pathology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina

Although various opportunistic infections have been described in patients with anti-interferon gamma autoantibodies,so far there is no listeria monocytogenes infection reported to be associated with this primary ***,we describe the first case of bacteremic *** meningitis in a 59-year-old Chinese man with anti-interferon gamma autoantibodies,who presented with acute onset of fever and severe *** culture was positive but culture of the cerebrospinal fluid was negative,although it showed features suggestive of partially treated bacterial *** presence of *** in the cerebrospinal fluid was confirmed by next-generation *** of high-risk food items in these patients is important for the prevention of *** use of antibiotic regimens that cover listeria is crucial for empirical treatment,particularly if such patients develop acute or subacute ***-generation sequencing is becoming an important diagnostic modality for culture-negative infections.

关键词： listeria monocytogenes meningitis anti-interferon gamma autoantibody next-generation sequencing

First Report of Tsukamurella conjunctivitidis CApD-related peritonitis

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Infectious Microbes & Diseases 2020年第3期2卷 121-123页

作者： jade l.l.teng kenny M.N.Fok Jordan Y.H.Fong Tak-lun Que susanna k.p.lau patrick C.Y.Woo Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State key laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Carol Yu Centre for Infection The University of Hong KongHong KongChina Department of pathology Tuen Mun HospitalHong KongChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The University of Hong KongHong KongChina

Introduction Using the information obtained from analysis of 16S rRNA gene sequences,Tsukamurella was first proposed as a genus in 1988,1 despite the fact that the first strain of this group of bacteria was described in 1941,2 and the first human isolate was reported in 1971.3 Similar to related genera of the order Corynebacteriales,such as Nocardia,Rhodococcus,and Gordonia,members of Tsukamurella are Gram-positive,aerobic,catalase-positive,and partially acid-fast as a result of the presence of mycolic acid in the cell *** to their similar phenotypic properties,differentiation of these genera and speciation within these genera is difficult in most clinical microbiology laboratories.

关键词： Tsukamurella conjunctivitidis peritonitis continuous ambulatory peritoneal dialysis(CApD)

Romance of the three domains:how cladistics transformed the classifi cation of cellular organisms

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protein & Cell 2013年第9期4卷 664-676页

作者： Chi-Chun Ho susanna k.p.lau patrick C.Y.Woo Department of Microbiology The University of Hong KongHong KongChina State key laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Research Centre of Infection and Immunology The University of Hong KongHong KongChina Carol Yu Centre of Infection The University of Hong KongHong KongChina

Cladistics is a biological philosophy that uses genealogi-cal relationship among species and an inferred sequence of divergence as the basis of classifi *** review critically surveys the chronological development of bio-logical classification from Aristotle through our post-genomic era with a central focus on *** 1957,Julian Huxley coined cladogenesis to denote splitting from *** 1960,the English translation of Willi Hennig’s 1950 work,Systematic phylogenetics,was published,which received strong opposition from phenet-icists,such as numerical taxonomists peter Sneath and Robert Sokal,and evolutionary taxonomist,Ernst Mayr,and sparked acrimonious debates in *** 1977-1990,Carl Woese pioneered in using small subunit rRNA gene sequences to delimitate the three domains of cellu-lar life and established major prokaryotic *** has since dominated *** being compatible with modern microbiological observations,*** with unusual phenotypes,restricted expression of charac-teristics and occasionally being uncultivable,increasing recognition of pervasiveness and abundance of horizon-tal gene transfer has challenged relevance and validity of *** mosaic nature of eukaryotic and prokary-otic genomes was also gradually *** the mid-2000s,high-throughput and whole-genome sequencing became routine and complex geneologies of organisms have led to the proposal of a reticulated web of *** genomics only indirectly leads to understanding of func-tional adaptations to ecological niches,computational modeling of entire organisms is underway and the gap between genomics and phenetics may soon be *** are not expected to settle as taxonomic classifi cations shall remain subjective to serve the human scientist,not the classifi ed.

关键词： cladistics phenetics phylogeny classifi ca-tion evolution

leptotrichia hongkongensis ***.,a novel leptotrichia species with the oral cavity as its natural reservoir

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第6期11卷 391-401页

作者： patrick C. Y. WOO Samson S. Y. WONG jade l. l. teng kit-Wah lEUNG Antonio H. Y. NGAN Dong-qing ZHAO Herman TSE susanna k. p. lau kwok-Yung YUEN State key laboratory of Emerging Infectious Diseases The University of Hong Kong Hong Kong China Research Centre of Infection and Immunology The University of Hong Kong Hong Kong China Department of Microbiology The University of Hong Kong Hong Kong China Carol Yu Centre for Infection The University of Hong Kong Hong Kong China

A straight, non-sporulating, Gram-variable bacillus (HkU24T) was recovered from the blood culture of a patient with metastatic breast carcinoma. After repeated subculturing in BACTEC plus Anaerobic/F blood culture broth, HkU24T grew on brucella agar as non-hemolytic, pinpoint colonies after 96 h of incubation at 37 °C in an anaerobic environment and aerobic environment with 5% CO2. Growth was enhanced with a streak of Staphylococcus aureus. HkU24T was non-motile and catalase-negative, but positive for alkaline phosphatase, β-glucosidase, and α-glucosidase. It hydrolyzed phenylphosphonate and reduced resazurin. 16S rRNA, groEl, gyrB, recA, and rpoB sequencing showed that HkU24T occupies a distinct phylogenetic position among the leptotrichia species, being most closely related to leptotrichia trevisanii. Using HkU24T groEl, gyrB, recA, and rpoB gene-specific primers, fragments of these genes were amplified from one of 20 oral specimens. Based on phenotypic and genotypic characteristics, we propose a new species, leptotrichia hongkongensis sp. nov., to describe this bacterium.

关键词： leptotrichia hongkongensis Bacterium Blood culture Anaerobic bacteria Novel species

Two-dimensional gel electrophoresis in bacterial proteomics

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protein & Cell 2012年第5期3卷 346-363页

作者： Shirly O.T.Curreem Rory M.Watt susanna k.p.lau patrick C.Y.Woo Department of Microbiology The University of Hong KongQueen Mary HospitalHong KongChina Oral Biosciences Faculty of DentistryThe University of Hong KongQueen Mary HospitalHong KongChina State key laboratory of Emerging Infectious Diseases Department of MicrobiologyThe University of Hong KongQueen Mary HospitalHong KongChina Research Centre of Infection and Immunology The University of Hong KongQueen Mary HospitalHong KongChina Carol Yu Centre of Infection The University of Hong KongHong KongChina

Two-dimensional gel electrophoresis(2-DE)is a gel-based technique widely used for analyzing the pro-tein composition of biological *** is capable of resolving complex mixtures containing more than a thousand protein components into individual protein spots through the coupling of two orthogonal bio-physical separation techniques:isoelectric focusing(first dimension)and polyacrylamide gel electrophore-sis(second dimension).2-DE is ideally suited for ana-lyzing the entire expressed protein complement of a bacterial cell:its *** relative simplicity and good reproducibility have led to 2-DE being widely used for exploring proteomics within a wide range of envi-ronmental and medically-relevant *** we give a broad overview of the basic principles and his-torical development of gel-based proteomics,and how this powerful approach can be applied for studying bacterial biology and *** highlight specific 2-DE applications that can be used to analyze when,where and how much proteins are *** links between proteomics,genomics and mass spectrometry are *** explore how proteomics involving tandem mass spectrometry can be used to analyze(post-translational)protein modifications or to identify proteins of unknown origin by de novo peptide *** use of proteome fractionation tech-niques and non-gel-based proteomic approaches are also *** highlight how the analysis of pro-teins secreted by bacterial cells(secretomes or exo-proteomes)can be used to study infection processes or the immune *** review is aimed at non-specialists who wish to gain a concise,compre-hensive and contemporary overview of the nature and applications of bacterial proteomics.

关键词： two-dimensional gel electrophoresis bacte-ria proteomics

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互惠合作系统的非对称性和不确定性

Journal of plant Ecology 2024年第1期17卷 172-186页

作者： Rui-Wu Wang An-Na Shi Xiao-Wei Zhang Min liu k.Charlotte Jandér derek W.Dunn School of Ecology and Environment Northwestern Polytechnical UniversityXi’an 710072China Faculty of Education University of MalayaKuala Lumpur 50400Malaysia College of life Sciences Shaanxi Normal UniversityXi’an 710119China Department of Organismic and Evolutionary Biology Harvard UniversityMA 02138USA College of life Sciences Northwest UniversityXi’an 710069China

过去的几十年里,尽管对互惠合作系统稳定性的理解取得了较大的进展,但在解释互惠关系如何保持稳定方面仍然存在两个基本问题。(i)如何解决互惠合作双方之间的资源冲突?(ii)当存在不怎么合作和/或完全不合作的共生体时,为什么合作的共生... 详细信息

过去的几十年里,尽管对互惠合作系统稳定性的理解取得了较大的进展,但在解释互惠关系如何保持稳定方面仍然存在两个基本问题。(i)如何解决互惠合作双方之间的资源冲突?(ii)当存在不怎么合作和/或完全不合作的共生体时,为什么合作的共生体没有被不合作的个体竞争排斥掉?过去许多关于互惠稳定性的解释都假设互惠合作双方的相互作用是对称的。然而,在大多数共生关系中,宿主和共生体之间的相互作用在不同水平上表现出不同程度的非对称性。本文我们回顾了互惠合作系统中的三种主要的非对称相互作用:(i)收益非对称,也就是合作双方的实力非对称性;(ii)潜在进化速率非对称性;(iii)宿主和共生体之间的信息非对称性。我们认为,互惠合作系统非对称性有助于解释合作和冲突行为的不确定性(合作与竞争的内生不确定性),以及为什么宿主和共生体都呈现出多样化的表型特征,而合作仍可占主导地位。

关键词：互利共生不对称相互作用宿主惩罚进化速率欺骗

High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS

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Science China(life Sciences) 2009年第7期52卷 651-656页

作者： GAllIGAN derek C. lAMERS susanna l. YU Stephanie SHAGRUN lamia SAlEMI Marco MCGRATH Michael S. Department of laboratory Medicine Positive Health Program University of CaliforniaSan Francisco California 94110 USA Gene Johnson Inc. St.Augustine Florida32080USA pathologica Inc. Burlingame California 94010 USA Department of pathology Immunology and Laboratory Medicine University of FloridaGainesville Florida 32610 USA

Highly active antiretroviral treatment(HAART) has had a significant impact on survival of individuals with acquired immunodeficiency syndrome(AIDS);however,with the longer life-span of patients with AIDS,there is increasing prevalence of AIDS dementia complex(ADC) and other non-AIDS-defining illness,and cardiovascular diseases(CVD) are also *** influence of these varied disease processes on HIV-1 DNA concentration in brain tissues has not been thoroughly assessed in the post-HAART *** purpose of the current study is to clarify the impacts of ADC and other complications of HIV disease on the viral load in the brains in AIDS patients with *** examined autopsy specimens from the brains of thirteen patients who died from complications of AIDS with quantitative polymerase chain reaction(QpCR).All but one patient had received HAART prior to death since *** patients died with severe CVD,multiple cerebrovascular atherosclerosis(CVA) throughout the brain and five patients died with *** patients had no ADC/CVA.A QpCR was used to measure the presence of HIV-1 DNA in six brain tissues(meninges,frontal grey matter,frontal white matter,temporal subcortex,cerebellum and basal ganglia).In the post-HARRT era,for non-ADC/CVA patients,HIV-1 DNA concentration in brain tissues was statistically higher than that in patients with *** a new finding,two patients who suffered from severe CVD,especially CVA,also had high concentrations of HIV-1 in brain compartments not showing ADC related *** our knowledge,this is the first report of a relationship between the CVA and HIV-1 viral burden in *** current observations suggest that HAART-resistant HIV reservoirs may survive within ADC lesions of the brain as well as the macrophage rich atherosclerosis,which needs to be confirmed by more AIDS cases with CVA.

关键词： HIV-1 AIDS dementia complex quantitative pCR DNA cardiovascular disease cerebrovascular atherosclerosis