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Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions

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Regenerative Biomaterials 2020年第3期7卷 247-258页

作者： Marley j.Dewey Eileen M.johnson Simona T.Slater derek j.milner Matthew B.Wheeler Brendan A.C.Harley Department of Materials Science and Engineering University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Bioengineering University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Carl R.Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Animal Sciences University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA

Defects in craniofacial bones occur congenitally,after high-energy impacts,and during the course of treatment for stroke and *** injuries are difficult to heal due to the overwhelming size of the injury area and the inflammatory environment surrounding the *** inflammatory response after injury may greatly inhibit regenerative *** have developed mineralized collagen scaffolds that can induce osteogenic differentiation and matrix biosynthesis in the absence of osteogenic media or supplemental *** amniotic membrane is derived from placentas and has been recently investigated as an extracellular matrix to prevent chronic ***,we hypothesized that a mineralized collagen-amnion composite scaffold could increase osteogenic activity in the presence of inflammatory *** report mechanical properties of a mineralized collagen-amnion scaffold and investigated osteogenic differentiation and mineral deposition of porcine adipose-derived stem cells within these scaffolds as a function of inflammatory *** of amniotic membrane matrix promotes osteogenesis similarly to un-modified mineralized collagen scaffolds,and increases in mineralized collagen-amnion scaffolds under inflammatory ***,these findings suggest that a mineralized collagen-amnion scaffold may provide a beneficial environment to aid craniomaxillofacial bone repair,especially in the course of defects presenting significant inflammatory complications.

关键词： mineralized collagen scaffolds amniotic membrane inflammation stem cell osteogenesis

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Identification of a novel pathway involving a GATA transcription factor in yeast and possibly in plant Zn uptake and homeostasis

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journal of Integrative Plant Biology 2014年第3期56卷 271-280页

作者： Matthew j.milner Nicole S.Pence jiping Liu Leon V.Kochian Robert W.Holley Center for Agriculture and Health USDA‐ARS Cornell University Department of Plant Biology Cornell University

To gain a better understanding of the regulation of Zn homeostasis in plants and the degree of conservation of Zn homeostasis between plants and yeast, a cDNA library from the Zn/Cd hyperaccumulating plant species, Noccaea caerulescens, was screened for its ability to restore growth under Zn limiting conditions in the yeast mutant zaplA. ZAP1 is a transcription factor that activates the Zn dependent transcription of yeast genes involved in Zn uptake, including ZRT1, the yeast high affinity Zn transporter. From this screen two members of the E2F family of transcription factors were found to activate ZRT1 expression in a Zn independent manner. The activation of ZRTI by the plant E2F proteins involves E2F- mediated activation of a yeast GATA transcription factor which in turn activates ZRT1 expression. A ZRT1 promoter region necessary for activation by E2F and GATA proteins is upstream of two zinc responsive elements previously shown to bind ZAP1 in ZRT1. This activation may not involve direct binding of E2F to the ZRT1 promoter. The expression of E2F genes in yeast does not replace function of ZAP1; instead it appears to activate a novel GATA regulatory pathway involved in Zn uptake and homeostasis that is not Zn responsive.

关键词： E2F transcription factor GATA transcription factor ZRT1 Znhomeostasis

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Superchiral near fields detect virus structure

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Light(Science & Applications) 2020年第1期9卷 103-112页

作者： Tarun Kakkar Chantal Keijzer Marion Rodier Tatyana Bukharova Michael Taliansky Andrew j.Love joel j.milner Affar S.Karimullah Laurence D.Barron Nikolaj Gadegaard Adrian j.Lapthorn Malcolm Kadodwala School of Chemistry Joseph Black BuildingUniversity of GlasgowGlasgow G128QQUK Institute of Molecular Cell and Systems Biology and School of Life SciencesUniversity of GlasgowG128QQ GlasgowUK james Hutton Inst Cell&Mol SciDundee DD25DAUK Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS Moscow 117997Russia School of Engineering Rankine BuildingUniversity of GlasgowGlasgow G128LTUK

Optical spectroscopy can be used to quickly characterise the structural properties of individual ***,it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component *** insensitivity arises from the mismatch in length scales between the assemblies(a few tens of nm)and the wavelength of light required to excite chromophores(≥150 nm).Consequently,with conventional spectroscopy,ordered assemblies,such as the icosahedral capsids of viruses,appear to be indistinguishable isotropic spherical *** limits potential routes to rapid high-throughput portable detection appropriate for point-of-care ***,we demonstrate that chiral electromagnetic(EM)near fields,which have both enhanced chiral asymmetry(referred to as superchirality)and subwavelength spatial localisation(∼10 nm),can detect the icosahedral structure of virus ***,they can detect both the presence and relative orientation of a bound virus *** illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields,we have used them to successfully detect virus particles in the complex milieu of blood serum.

关键词： chiral detect fields

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Control of Black field crickets,Teleogryllus commodus(Orthoptera:Grylloidea),with an experimental bioinsecticide containing conidia of Metarhizium anisopliae

Control of Black field crickets,Teleogryllus commodus(Orthop...

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International Conference:Technology Transfer in Biological Control:From Research to Practice

作者： Richard j.milner Lisa MILLER CSIRO Division of EntomologyGPO Box 1700ACT 2601Australia

The black field cricket,Teleogryllus commodus,is a serious pest of pastures in western Victoria,*** insect has an annual life cycle with the eggs hatching in *** nymphs live in cracks in the gound and emerge,mainly at night,to feed on pasture foliage and *** are particularly damaging in autumn(March/April) and they reduce the ability

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Sol-gel derived nanocrystalline and mesoporous barium strontium titanate prepared at room temperature

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Particuology 2011年第3期9卷 235-242页

作者： Mohammad Reza Mohammadi derek j.Fray Department of Materials Science & Engineering Sharif University of Technology Department of Materials Science & Metallurgy University of Cambridge

Perovskite-type barium strontium titanate （BST） thin films and powders with nanocrystalline and mesoporous structure were prepared by a straightforward particulate sol-gel route at room temperature. The prepared sol had a narrow particle size distribution of about 20 nm. X-ray diffraction （XRD） revealed that phase composition and preferable orientation growth of BST depended upon the annealing temperature. Transmission electron microscope （TEM） images showed that the crystallite size of the powders decreased with increasing annealing temperature from 8 nm at 25 ℃ down to 5 nm at 800 ℃. Field emission scanning electron microscope （FE-SEM） analysis and atomic force microscope （AFM） images revealed that BST thin films had mesoporous and nanocrystafiine structure with average grain size of 3Onm at 600 ℃. Based on Brunauer-Emmett-Teller （BET） analysis, the synthesized BST showed mesoporous structure containing nnres with needle, and nlate shanes and BET surface area in the range of 49-32 m^2/g at 500-800℃

关键词： Barium strontium titanate Room temperature Sol-gel chemistry Nanostructure

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p53在肿瘤中的抑制和促进功能

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自然杂志 1991年第7期14卷 520-523,537页

作者： j.milner 吴炯英国剑桥大学

什么是p53?现在认为p53基因在人类肿瘤发生过程中起着重要作用。野生型p53基因的功能是抑制异常细胞生长及向恶性状态发展。然而,一个点突变就可以使p53变成为细胞增殖和肿瘤发生的促进剂。本文将重点阐述有关p53基因对细胞增殖发挥功... 详细信息

什么是p53?现在认为p53基因在人类肿瘤发生过程中起着重要作用。野生型p53基因的功能是抑制异常细胞生长及向恶性状态发展。然而,一个点突变就可以使p53变成为细胞增殖和肿瘤发生的促进剂。本文将重点阐述有关p53基因对细胞增殖发挥功能效应的两个问题。首先,在正常细胞对生长刺激产生应答过程中野生型p53基因的抑制效应是如何被解除的?其次,野生型和突变型p53等位基因是如何发挥对细胞增殖抑制和促进这两个相对立的效应的?

关键词：细胞增殖细胞生长 p53 抑制效应野生型应答过程基因对构像细胞周期成纤维细胞

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绿僵菌对小菜蛾的感染反应分析

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中国生物防治 2000年第1期16卷 15-18页

作者：马骏 Richardj.milner 湖南农业大学植保系长沙410128 CSIRO Division of Entomology

用绿僵菌孢子悬浮液中浸渍过的甘蓝叶喂饲小菜蛾的方法 ,测定小菜蛾对 FI1 2 48菌株的感染反应。运用时间 -剂量 -死亡率模型 ,对死亡率随时间和剂量的变化作了拟合。接种后第9天的 L C5 0 为 4.1 7× 1 0 5～ 6 .33× 1 0 5孢子 / ml,... 详细信息

用绿僵菌孢子悬浮液中浸渍过的甘蓝叶喂饲小菜蛾的方法 ,测定小菜蛾对 FI1 2 48菌株的感染反应。运用时间 -剂量 -死亡率模型 ,对死亡率随时间和剂量的变化作了拟合。接种后第9天的 L C5 0 为 4.1 7× 1 0 5～ 6 .33× 1 0 5孢子 / ml,在 1 0 7孢子 / ml浓度下的 L T5 0 为 4.7天。结果表明 FI1 2 48菌株对小菜蛾具有较强的致死作用。

关键词：绿僵菌小菜蛾生物测定感染反应时间剂量

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Biomarkers for diet and cancer prevention research:potentials and challenges

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Acta Pharmacologica Sinica 2007年第9期28卷 1262-1273页

作者： Cindy D DAVIS john A milner Nutritional Science Research GroupNational Cancer InstituteRockvilleMD 20892USA

As cancer incidence is projected to increase for decades there is a need for effec-tive preventive ***,evidence continues to mount that alteringdietary habits is an effective and cost-efficient approach for reducing cancer riskand for modifying the biological behavior of ***,validated andsensitive biomarkers,including those that reliably evaluate"intake"or exposureto a specific food or bioactive component,that assess one or more specific bio-logical"effects"that are linked to cancer,and that effectively predict individual"susceptibility"as a function of nutrient-nutrient interactions and genetics,arefundamental to evaluating who will benefit most from dietary *** must be readily accessible,easily and reliably assayed,and predictiveof a key process(es) involved in *** response to a food is determined notonly by the effective concentration of the bioactive food component(s) reachingthe target tissue,but also by the amount of the target requiring ***,this threshold response to foods and their components will vary from indi-vidual to *** key to understanding a personalized response is a greaterknowledge of nutrigenomics,proteomics and metabolomics.

关键词： exposure biomarker effect biomarker susceptibility biomarker nutrigenomics

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Effect of image registration on longitudinal analysis of retinal nerve fiber layer thickness of non-human primates using Optical Coherence Tomography(OCT)

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Eye and Vision 2015年第1期2卷 16-27页

作者： Shuang Liu Anjali Datta derek Ho jordan Dwelle Daifeng Wang Thomas E milner Henry Grady Rylander III Mia K Markey Department of Biomedical Engineering The University of Texas at AustinAustinTX 78712USA Department of Electrical and Computer Engineering The University of Texas at AustinAustinTX 78712USA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Present address:Clinical Neuroscience Imaging Center(CNIC) Department of NeurologyYale School of MedicineNew HavenCT 06510USA

Background:In this paper we determined the benefits of image registration on estimating longitudinal retinal nerve fiber layer thickness(RNFLT)***:RNFLT maps around the optic nerve head(ONH)of healthy primate eyes were measured using Optical Coherence Tomography(OCT)weekly for 30 *** automatic algorithm based on mutual information(MI)and the other semi-automatic algorithm based on log-polar transform cross-correlation using manually segmented blood vessels(LPCC_MSBV),were used to register retinal maps *** compared the precision and recall between manually segmented image pairs for the two algorithms using a linear mixed effects ***:We found that the precision calculated between manually segmented image pairs following registration by LPCC_MSBV algorithm is significantly better than the one following registration by MI algorithm(p<<0.0001).Trend of the all-rings and temporal,superior,nasal and inferior(TSNI)quadrants average of RNFLT over time in healthy primate eyes are not affected by *** of clock hours 1,2,and 10 showed significant change over 30 weeks(p=0.0058,0.0054,and 0.0298 for clock hours 1,2 and 10 respectively)without registration,but stayed constant over time with ***:The LPCC_MSBV provides better registration of RNFLT maps recorded on different dates than the automatic MI *** of RNFLT maps can improve clinical analysis of glaucoma progression.

关键词： Retinal nerve fiber layer thickness Glaucoma Image registration

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Template-based growth of titanium dioxide nanorods by a particulate sol-electrophoretic deposition process

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Particuology 2011年第2期9卷 161-169页

作者： Mohammad Reza Mohammadi Farideh Ordikhani derek j.Fray Farzad Khomamizadeh Department of Materials Science & Engineering Sharif University of Technology Department of Materials Science & Metallurgy University of Cambridge

TiO2 nanorods have been successfully grown into a track-etched polycarbonate （PC） membrane by a particulate sol-electrophoretic deposition from an aqueous medium. The prepared sols had a narrow particle size distribution around 17 nm and excellent stability against aging, with zeta potentials in the range of 47-50 mV at pH 2. It was found that TiO2 nanorods were grown from dilute aqueous sol with a low, 0.1-M concentration. Fourier transform infrared spectroscopy （FT-IR） analysis confirmed that a full conversion of titanium isopropoxide was obtained by hydrolysis, resulting in the formation of TiO2 particles. X-ray diffraction （XRD） results revealed that TiO2 nanorods dried at 100℃ were a mixture of anatase and brookite phases, whereas they were a mixture of anatase and futile structures at 500℃. Moreover, the rutile content of the TiO2 nanorods was higher than that of TiO2 powders. Transmission electron microscope （TEM） images confirmed that TiO2 nanorods had a smooth morphology and longi- tudinal uniformity in diameter. Field emission scanning electron microscope （FE-SEM） images showed that TiO2 nanorods grown by sol-electrophoresis from the dilute aqueous sol had a dense structure with a uniform diameter of 200 rim, containing small particles with an average size of 15 nm. Simultaneous differential thermal （SDT） analysis verified that individual TiO2 nanorods, grown into a PC template, were obtained after annealing at 500℃. Based on kinetic studies, it was found that uniform TiO2 nanorods with high-quality morphology were obtained under optimum conditions at an applied potential of 0.3 V/cm and a deposition time of 60 min.

关键词： Nanorod Crystal morphology Electrophoretic deposition Sol-electrophoresisTitanium dioxide

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